TissGeneSummary for POU4F2 |
Gene summary |
Basic gene information | Gene symbol | POU4F2 |
Gene name | POU class 4 homeobox 2 | |
Synonyms | BRN3.2|BRN3B|Brn-3b | |
Cytomap | UCSC genome browser: 4q31.2 | |
Type of gene | protein-coding | |
RefGenes | NM_004575.2, | |
Description | Brn3b POU domain transcription factorPOU domain class 4 transcription factor 2POU domain proteinPOU domain, class 4, transcription factor 2brain-3Bbrain-specific homeobox/POU domain protein 3B | |
Modification date | 20141207 | |
dbXrefs | MIM : 113725 | |
HGNC : HGNC | ||
Ensembl : ENSG00000151615 | ||
HPRD : 00220 | ||
Vega : OTTHUMG00000162045 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_POU4F2 | |
BioGPS: 5458 | ||
Pathway | NCI Pathway Interaction Database: POU4F2 | |
KEGG: POU4F2 | ||
REACTOME: POU4F2 | ||
Pathway Commons: POU4F2 | ||
Context | iHOP: POU4F2 | |
ligand binding site mutation search in PubMed: POU4F2 | ||
UCL Cancer Institute: POU4F2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of POU4F2 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0000165 | MAPK cascade | 21241485 | GO:0030520 | intracellular estrogen receptor signaling pathway | 21241485 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 17637757 | GO:0000165 | MAPK cascade | 21241485 | GO:0030520 | intracellular estrogen receptor signaling pathway | 21241485 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 17637757 |
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TissGeneExp for POU4F2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for POU4F2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for POU4F2 |
TissGeneSNV for POU4F2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A154T | UCEC | 2 |
p.I40T | COAD | 2 |
p.G80C | LUAD | 1 |
p.R390C | COAD | 1 |
p.Q367H | GBM | 1 |
p.H173Y | LUAD | 1 |
p.A253S | BRCA | 1 |
p.E361K | BRCA | 1 |
p.E324K | UCEC | 1 |
p.R369Q | UCEC | 1 |
p.D139E | DLBC | 1 |
p.S359* | LUAD | 1 |
p.A407S | ESCA | 1 |
p.A113V | BLCA | 1 |
p.M225I | PAAD | 1 |
p.R269H | STAD | 1 |
p.E85K | BLCA | 1 |
p.D254N | STAD | 1 |
p.A223S | STAD | 1 |
p.A219T | STAD | 1 |
p.A377V | UCEC | 1 |
p.G35V | CESC | 1 |
p.W322* | SKCM | 1 |
p.E105D | UCEC | 1 |
p.A343V | LUAD | 1 |
p.I366S | STAD | 1 |
p.T275N | LUSC | 1 |
p.R110G | STAD | 1 |
p.R269L | LUAD | 1 |
p.P198S | SKCM | 1 |
p.V291M | COAD | 1 |
p.E325K | SKCM | 1 |
p.R358H | STAD | 1 |
p.M4I | COAD | 1 |
p.R369Q | BRCA | 1 |
p.V120I | LUSC | 1 |
p.S37W | BLCA | 1 |
p.A343V | BLCA | 1 |
p.L92H | HNSC | 1 |
p.W322X | SKCM | 1 |
p.A377T | STAD | 1 |
p.A154T | COAD | 1 |
p.S27L | PAAD | 1 |
p.G67E | CESC | 1 |
p.P164S | SKCM | 1 |
p.V120I | COAD | 1 |
p.S74G | UCEC | 1 |
p.G290S | ESCA | 1 |
p.A238T | STAD | 1 |
p.D209N | STAD | 1 |
p.A38T | COAD | 1 |
p.S158L | COAD | 1 |
p.R347H | GBM | 1 |
p.E325D | LUAD | 1 |
p.Q320H | THYM | 1 |
p.S74C | TGCT | 1 |
p.H330Y | SKCM | 1 |
p.R369W | HNSC | 1 |
p.E361K | COAD | 1 |
p.A253S | LUAD | 1 |
p.G199W | BLCA | 1 |
p.L334F | STAD | 1 |
p.I375M | LUAD | 1 |
p.Y363C | UCEC | 1 |
p.R347C | LUSC | 1 |
p.G199R | CESC | 1 |
p.E373K | BLCA | 1 |
p.P135L | LUAD | 1 |
p.F100L | PAAD | 1 |
p.F393L | UCEC | 1 |
p.A166T | UCEC | 1 |
p.L305P | LIHC | 1 |
p.A314G | PRAD | 1 |
p.E105* | BLCA | 1 |
p.A365G | LUAD | 1 |
p.M145I | UCEC | 1 |
p.A166V | STAD | 1 |
p.P220L | GBM | 1 |
p.V389M | UCEC | 1 |
p.V251M | HNSC | 1 |
p.N311S | HNSC | 1 |
p.R264L | LUAD | 1 |
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TissGeneCNV for POU4F2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for POU4F2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for POU4F2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for POU4F2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for POU4F2 |
TissGeneDrug for POU4F2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for POU4F2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 7 | BeFree |
umls:C0678222 | Breast Carcinoma | 7 | BeFree |
umls:C1458155 | Mammary Neoplasms | 5 | BeFree,LHGDN |
umls:C0027819 | Neuroblastoma | 3 | BeFree,LHGDN |
umls:C0700095 | Central neuroblastoma | 3 | BeFree |
umls:C0032002 | Pituitary Diseases | 2 | BeFree |
umls:C0024141 | Lupus Erythematosus, Systemic | 1 | BeFree |
umls:C0030354 | Papilloma | 1 | BeFree |
umls:C0085648 | Synovial Cyst | 1 | BeFree |
umls:C0149925 | Small cell carcinoma of lung | 1 | BeFree |
umls:C0206708 | Cervical Intraepithelial Neoplasia | 1 | BeFree |
umls:C0262407 | cervical abnormality | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C1258666 | Myxoid cyst | 1 | BeFree |
umls:C1511934 | Differentiating Neuroblastoma | 1 | BeFree |