TissGeneSummary for FEZF2 |
Gene summary |
Basic gene information | Gene symbol | FEZF2 |
Gene name | FEZ family zinc finger 2 | |
Synonyms | FEZ|FEZL|TOF|ZFP312|ZNF312 | |
Cytomap | UCSC genome browser: 3p14.2 | |
Type of gene | protein-coding | |
RefGenes | NM_018008.3, | |
Description | fez family zinc finger protein 2forebrain embryonic zinc finger-like protein 2zinc finger protein 312 | |
Modification date | 20141207 | |
dbXrefs | MIM : 607414 | |
HGNC : HGNC | ||
Ensembl : ENSG00000153266 | ||
HPRD : 07596 | ||
Vega : OTTHUMG00000158705 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FEZF2 | |
BioGPS: 55079 | ||
Pathway | NCI Pathway Interaction Database: FEZF2 | |
KEGG: FEZF2 | ||
REACTOME: FEZF2 | ||
Pathway Commons: FEZF2 | ||
Context | iHOP: FEZF2 | |
ligand binding site mutation search in PubMed: FEZF2 | ||
UCL Cancer Institute: FEZF2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of FEZF2 | ||
Description by TissGene annotations | TissgsKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for FEZF2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -2.027884119 | -0.582628856 | -1.445255263 | 2.14E-17 | 1.28E-16 |
Top |
TissGene-miRNA for FEZF2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for FEZF2 |
TissGeneSNV for FEZF2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E82K | CESC | 2 |
p.E248K | SKCM | 2 |
p.P84L | STAD | 1 |
p.A288T | COAD | 1 |
p.G115R | LIHC | 1 |
p.R428G | BLCA | 1 |
p.A203T | COAD | 1 |
p.S85* | LUAD | 1 |
p.D413H | BLCA | 1 |
p.N173S | SARC | 1 |
p.P181R | HNSC | 1 |
p.R294G | LUSC | 1 |
p.E364X | LIHC | 1 |
p.N395K | ESCA | 1 |
p.H355L | LAML | 1 |
p.A203V | LUSC | 1 |
p.T350M | UCEC | 1 |
p.Q316K | STAD | 1 |
p.T421A | LGG | 1 |
p.G19E | BLCA | 1 |
p.K433N | UCEC | 1 |
p.N375S | SKCM | 1 |
p.P239R | STAD | 1 |
p.G339C | BRCA | 1 |
p.Q337E | STAD | 1 |
p.A37V | LGG | 1 |
p.S98N | BRCA | 1 |
p.K414N | COAD | 1 |
p.L88M | LUAD | 1 |
p.V83M | SKCM | 1 |
p.H371Q | LIHC | 1 |
p.G385C | STAD | 1 |
p.V285_splice | LUSC | 1 |
p.G60D | STAD | 1 |
p.D452N | SKCM | 1 |
p.E364K | READ | 1 |
p.E82Q | CESC | 1 |
p.P182L | COAD | 1 |
p.S177L | STAD | 1 |
Top |
TissGeneCNV for FEZF2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for FEZF2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Top |
TissGeneNet for FEZF2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for FEZF2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for FEZF2 |
TissGeneDrug for FEZF2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for FEZF2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007682 | CNS disorder | 1 | BeFree |
umls:C0025958 | Microcephaly | 1 | BeFree |
umls:C2931822 | Nasopharyngeal carcinoma | 1 | BeFree |