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| TissGeneSummary for ARMC4 |
 Gene summary |
| Basic gene information | Gene symbol | ARMC4 |
| Gene name | armadillo repeat containing 4 | |
| Synonyms | CILD23 | |
| Cytomap | UCSC genome browser: 10p12.1-p11.23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001290020.1, NM_001290021.1,NM_018076.3, | |
| Description | armadillo repeat-containing protein 4 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 615408 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000169126 | ||
| HPRD : 10663 | ||
| Vega : OTTHUMG00000017867 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ARMC4 | |
| BioGPS: 55130 | ||
| Pathway | NCI Pathway Interaction Database: ARMC4 | |
| KEGG: ARMC4 | ||
| REACTOME: ARMC4 | ||
| Pathway Commons: ARMC4 | ||
| Context | iHOP: ARMC4 | |
| ligand binding site mutation search in PubMed: ARMC4 | ||
| UCL Cancer Institute: ARMC4 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of ARMC4 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for ARMC4 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -0.131721715 | -2.182825715 | 2.051104 | 2.70E-06 | 9.43E-06 |
| LUAD | 0.258038561 | 2.065457526 | -1.807418966 | 2.69E-05 | 7.40E-05 |
| LUSC | -0.931833245 | 2.10340401 | -3.035237255 | 7.56E-10 | 2.63E-09 |
| STAD | -2.743790965 | -1.379084715 | -1.36470625 | 0.00366 | 0.015103376 |
| BLCA | -2.37926761 | 0.158279759 | -2.537547368 | 4.73E-06 | 0.00011191 |
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| TissGene-miRNA for ARMC4 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ARMC4 |
| TissGeneSNV for ARMC4 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E22K | SKCM | 7 |
| p.E705K | SKCM | 4 |
| p.E520K | SKCM | 3 |
| p.W740* | SKCM | 3 |
| p.S302L | SKCM | 3 |
| p.R841C | SKCM | 3 |
| p.S306L | SKCM | 2 |
| p.Q466* | SKCM | 2 |
| p.D1019N | SKCM | 2 |
| p.G213E | SKCM | 2 |
| p.R244C | SKCM | 2 |
| p.E230K | SKCM | 2 |
| p.E121K | SKCM | 2 |
| p.S232L | SKCM | 2 |
| p.R491K | SKCM | 2 |
| p.F305V | STAD | 2 |
| p.G808R | SKCM | 2 |
| p.I343T | COAD | 1 |
| p.R794L | LIHC | 1 |
| p.N810Y | SKCM | 1 |
| p.K680N | UCEC | 1 |
| p.A445S | BRCA | 1 |
| p.E557K | STAD | 1 |
| p.D708Y | LUSC | 1 |
| p.G494* | LUAD | 1 |
| p.V582A | SKCM | 1 |
| p.S195G | SKCM | 1 |
| p.E730K | SKCM | 1 |
| p.L174R | COAD | 1 |
| p.R970H | UCEC | 1 |
| p.S597L | SKCM | 1 |
| p.G873E | SKCM | 1 |
| p.A583T | COAD | 1 |
| p.R836C | STAD | 1 |
| p.S289L | SARC | 1 |
| p.N935T | COAD | 1 |
| p.H45Q | SKCM | 1 |
| p.K511R | STAD | 1 |
| p.K86T | SKCM | 1 |
| p.D425Y | UVM | 1 |
| p.A994T | STAD | 1 |
| p.D204N | SKCM | 1 |
| p.L551V | CESC | 1 |
| p.R1032C | SKCM | 1 |
| p.E146* | STAD | 1 |
| p.D256N | UCEC | 1 |
| p.N683Y | OV | 1 |
| p.T933R | HNSC | 1 |
| p.R569W | UCEC | 1 |
| p.I517T | UCEC | 1 |
| p.G611V | COAD | 1 |
| p.K564M | HNSC | 1 |
| p.R570Q | LUAD | 1 |
| p.R787H | BRCA | 1 |
| p.R236* | SKCM | 1 |
| p.T200R | LUAD | 1 |
| p.K625I | LUSC | 1 |
| p.M144I | SKCM | 1 |
| p.A986T | SKCM | 1 |
| p.E442K | SKCM | 1 |
| p.S878Y | HNSC | 1 |
| p.G19X | COAD | 1 |
| p.T933_splice | LUSC | 1 |
| p.I190N | SKCM | 1 |
| p.V73A | BLCA | 1 |
| p.D446H | LUAD | 1 |
| p.E829K | SKCM | 1 |
| p.A982V | SKCM | 1 |
| p.A694T | UCEC | 1 |
| p.E507K | SKCM | 1 |
| p.G88E | SKCM | 1 |
| p.P547S | SKCM | 1 |
| p.S227* | CESC | 1 |
| p.L814F | SKCM | 1 |
| p.A560T | STAD | 1 |
| p.S644Y | UCEC | 1 |
| p.Q699R | LIHC | 1 |
| p.R753Q | STAD | 1 |
| p.E323K | SKCM | 1 |
| p.L764R | STAD | 1 |
| p.A694T | GBM | 1 |
| p.R528K | SKCM | 1 |
| p.R413G | READ | 1 |
| p.E318K | SKCM | 1 |
| p.R841C | UCEC | 1 |
| p.E146X | STAD | 1 |
| p.G19* | HNSC | 1 |
| p.R666W | LUAD | 1 |
| p.S66L | SKCM | 1 |
| p.M309V | COAD | 1 |
| p.K301R | HNSC | 1 |
| p.V880I | CESC | 1 |
| p.H921Y | SKCM | 1 |
| p.A445S | ESCA | 1 |
| p.E33K | SKCM | 1 |
| p.Q326* | LUAD | 1 |
| p.M476V | KIRC | 1 |
| p.E166K | SKCM | 1 |
| p.R836H | ESCA | 1 |
| p.V957L | OV | 1 |
| p.R841C | STAD | 1 |
| p.E874K | SKCM | 1 |
| p.G464R | SKCM | 1 |
| p.G781R | SKCM | 1 |
| p.P967L | SKCM | 1 |
| p.E279K | SKCM | 1 |
| p.I834T | CHOL | 1 |
| p.N914H | READ | 1 |
| p.S103R | LUAD | 1 |
| p.K32* | STAD | 1 |
| p.L885P | ESCA | 1 |
| p.A560S | BLCA | 1 |
| p.R340C | SKCM | 1 |
| p.E601K | SKCM | 1 |
| p.P651A | BLCA | 1 |
| p.R340C | READ | 1 |
| p.Q768H | STAD | 1 |
| p.R609C | UCEC | 1 |
| p.M832I | SKCM | 1 |
| p.W740X | SKCM | 1 |
| p.E788K | ESCA | 1 |
| p.A64V | GBM | 1 |
| p.I650M | GBM | 1 |
| p.R360K | THYM | 1 |
| p.G737E | SKCM | 1 |
| p.R1042G | SKCM | 1 |
| p.E611K | SKCM | 1 |
| p.R236X | SKCM | 1 |
| p.A612E | GBM | 1 |
| p.F305C | ESCA | 1 |
| p.S475L | SKCM | 1 |
| p.D911Y | READ | 1 |
| p.R794W | COAD | 1 |
| p.L719V | SKCM | 1 |
| p.A903T | BLCA | 1 |
| p.R970C | COAD | 1 |
| p.Q466X | SKCM | 1 |
| p.P238L | SKCM | 1 |
| p.V979M | COAD | 1 |
| p.E771* | PAAD | 1 |
| p.V282L | SKCM | 1 |
| p.A945G | LUAD | 1 |
| p.P239L | PRAD | 1 |
| p.D160H | STAD | 1 |
| p.E193X | COAD | 1 |
| p.A472P | LUSC | 1 |
| p.P850L | HNSC | 1 |
| p.Q811H | LUAD | 1 |
| p.K168N | READ | 1 |
| p.N888D | LGG | 1 |
| p.D708N | LUAD | 1 |
| p.K304T | STAD | 1 |
| p.R629C | UCEC | 1 |
| p.G839E | UCEC | 1 |
| p.F879Y | SKCM | 1 |
| p.A861T | UCEC | 1 |
| p.P925S | SKCM | 1 |
| p.R877C | SKCM | 1 |
| p.R1042K | SKCM | 1 |
| p.T78R | BLCA | 1 |
| p.E224Q | BLCA | 1 |
| p.M144I | UCEC | 1 |
| p.P635S | SKCM | 1 |
| p.R629H | PRAD | 1 |
| p.R753W | SKCM | 1 |
| p.S644F | SKCM | 1 |
| p.A982T | SKCM | 1 |
| p.E224K | SKCM | 1 |
| p.P850S | SKCM | 1 |
| p.P595L | SKCM | 1 |
| p.G737W | KIRP | 1 |
| p.S191L | SKCM | 1 |
| p.H921Y | HNSC | 1 |
| p.E246K | SKCM | 1 |
| p.T364N | ESCA | 1 |
| p.D767N | SKCM | 1 |
| p.T623M | KIRC | 1 |
| p.L814I | UCEC | 1 |
| p.Q177* | CESC | 1 |
| p.V1013G | SKCM | 1 |
| p.A583V | SKCM | 1 |
| p.G273S | SKCM | 1 |
| p.I500V | LGG | 1 |
| p.E55K | SKCM | 1 |
| p.A489D | KIRC | 1 |
| p.P525L | SKCM | 1 |
| p.Q800* | SKCM | 1 |
| p.G798D | SKCM | 1 |
| p.R609C | SKCM | 1 |
| p.V679A | HNSC | 1 |
| p.E754K | SKCM | 1 |
| p.D347Y | UCEC | 1 |
| p.R639Q | COAD | 1 |
| p.K156I | LUSC | 1 |
| p.S103I | LUAD | 1 |
| p.W59* | CESC | 1 |
| p.A445S | HNSC | 1 |
| p.V498M | READ | 1 |
| p.P254L | SKCM | 1 |
| p.V826I | SKCM | 1 |
| p.A931E | COAD | 1 |
| p.G267E | SKCM | 1 |
| p.S191L | BRCA | 1 |
| p.P163S | SKCM | 1 |
| p.G922V | BLCA | 1 |
| p.P801S | COAD | 1 |
| p.G715R | SKCM | 1 |
| p.R954K | HNSC | 1 |
| p.R970P | KIRC | 1 |
| p.R629H | UCEC | 1 |
| p.G215R | SKCM | 1 |
| p.E307A | KIRC | 1 |
| p.K353N | LGG | 1 |
| p.G495V | LUSC | 1 |
| p.D425Y | CESC | 1 |
| p.E33* | CESC | 1 |
| p.A982V | UCEC | 1 |
| p.E705D | SKCM | 1 |
| p.G273_splice | UCEC | 1 |
| p.E334K | SKCM | 1 |
| p.Q455* | HNSC | 1 |
| p.K32X | STAD | 1 |
| p.E771X | PAAD | 1 |
| p.A931V | ESCA | 1 |
| p.R666Q | COAD | 1 |
| p.R639Q | ESCA | 1 |
| p.K304E | UCS | 1 |
| p.G839* | SKCM | 1 |
| p.C587S | HNSC | 1 |
| p.G273A | UCEC | 1 |
| p.E827K | SKCM | 1 |
| p.L183F | SKCM | 1 |
| p.G960C | ESCA | 1 |
| p.G781R | LUSC | 1 |
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| TissGeneCNV for ARMC4 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ARMC4 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | HNSC | TCGA-CR-7377-01A | PARD3-ARMC4 | Out-of-frame | Chr10:35103804 | Chr10:28196706 |
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| TissGeneNet for ARMC4 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for ARMC4 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ARMC4 |
| TissGeneDrug for ARMC4 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ARMC4 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0008780 | Ciliary Motility Disorders | 2 | BeFree |
| umls:C0022521 | Kartagener Syndrome | 2 | BeFree,CLINVAR |
| umls:C0037221 | Situs Inversus | 1 | BeFree |
| umls:C3809548 | CILIARY DYSKINESIA, PRIMARY, 23 | 1 | CLINVAR,MGD,UNIPROT |
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