TissGeneSummary for CCDC87 |
Gene summary |
Basic gene information | Gene symbol | CCDC87 |
Gene name | coiled-coil domain containing 87 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 11q13.2 | |
Type of gene | protein-coding | |
RefGenes | NM_018219.2, | |
Description | coiled-coil domain-containing protein 87 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000182791 | ||
HPRD : 07699 | ||
Vega : OTTHUMG00000167237 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CCDC87 | |
BioGPS: 55231 | ||
Pathway | NCI Pathway Interaction Database: CCDC87 | |
KEGG: CCDC87 | ||
REACTOME: CCDC87 | ||
Pathway Commons: CCDC87 | ||
Context | iHOP: CCDC87 | |
ligand binding site mutation search in PubMed: CCDC87 | ||
UCL Cancer Institute: CCDC87 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CCDC87 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CCDC87 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | -1.091115711 | 0.24496734 | -1.336083051 | 1.83E-19 | 6.05E-18 |
HNSC | -1.393283429 | -2.47060901 | 1.077325581 | 4.87E-07 | 4.03E-06 |
BRCA | -0.449904114 | -1.7410585 | 1.291154386 | 6.36E-18 | 3.91E-17 |
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TissGene-miRNA for CCDC87 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CCDC87 |
TissGeneSNV for CCDC87 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P200S | SKCM | 1 |
p.A322V | ESCA | 1 |
p.R723Q | LUAD | 1 |
p.P389L | SKCM | 1 |
p.T840A | COAD | 1 |
p.R184M | STAD | 1 |
p.G244E | SKCM | 1 |
p.P290L | SKCM | 1 |
p.E791D | PRAD | 1 |
p.G74R | PAAD | 1 |
p.H837L | LUAD | 1 |
p.R723L | LUAD | 1 |
p.P423Q | UCEC | 1 |
p.V75L | LUAD | 1 |
p.P328S | SKCM | 1 |
p.R827C | BLCA | 1 |
p.E516K | HNSC | 1 |
p.W523C | LUAD | 1 |
p.R803Q | STAD | 1 |
p.V594L | LUAD | 1 |
p.I84F | OV | 1 |
p.E652X | READ | 1 |
p.R825Q | UCEC | 1 |
p.S285L | UCEC | 1 |
p.V284A | PCPG | 1 |
p.M481I | LGG | 1 |
p.P293S | SKCM | 1 |
p.D510H | SARC | 1 |
p.V625L | SKCM | 1 |
p.M499I | PRAD | 1 |
p.S60G | STAD | 1 |
p.A188V | COAD | 1 |
p.S94R | SARC | 1 |
p.Y131* | BLCA | 1 |
p.C207Y | LUAD | 1 |
p.P418T | THYM | 1 |
p.R115Q | UCEC | 1 |
p.D178N | COAD | 1 |
p.E617K | HNSC | 1 |
p.R394C | SKCM | 1 |
p.P21T | SKCM | 1 |
p.P32L | STAD | 1 |
p.G664A | CESC | 1 |
p.Q35E | CESC | 1 |
p.P804S | COAD | 1 |
p.E97K | BRCA | 1 |
p.K363N | PRAD | 1 |
p.D595Y | LUAD | 1 |
p.F179L | BLCA | 1 |
p.S298F | LUAD | 1 |
p.G42S | SKCM | 1 |
p.R307Q | LIHC | 1 |
p.R296S | KIRC | 1 |
p.E796K | GBM | 1 |
p.P727L | SKCM | 1 |
p.E692* | BLCA | 1 |
p.V440M | SKCM | 1 |
p.R447L | LUAD | 1 |
p.E97K | LUAD | 1 |
p.M563I | UCEC | 1 |
p.E317D | UCEC | 1 |
p.K562N | BRCA | 1 |
p.E125K | UCEC | 1 |
p.I483V | BLCA | 1 |
p.H425Y | BLCA | 1 |
p.S421F | SKCM | 1 |
p.H675N | PRAD | 1 |
p.R173L | LUSC | 1 |
p.V494F | LUAD | 1 |
p.P646Q | UCEC | 1 |
p.N485D | COAD | 1 |
p.K536N | KIRC | 1 |
p.E739* | SKCM | 1 |
p.A159T | SARC | 1 |
p.D643N | SKCM | 1 |
p.K708R | SKCM | 1 |
p.T840S | STAD | 1 |
p.H506R | STAD | 1 |
p.P621L | SKCM | 1 |
p.P293L | SKCM | 1 |
p.G802W | ESCA | 1 |
p.G377D | SKCM | 1 |
p.A354T | KIRP | 1 |
p.D450H | CESC | 1 |
p.D484H | HNSC | 1 |
p.P372L | SKCM | 1 |
p.E780Q | HNSC | 1 |
p.D505N | LUAD | 1 |
p.T294I | SKCM | 1 |
p.F145L | UCEC | 1 |
p.Q282H | LUSC | 1 |
p.Q46L | LIHC | 1 |
p.W655* | HNSC | 1 |
p.E791Q | SKCM | 1 |
p.M809I | LUAD | 1 |
p.E41K | SKCM | 1 |
p.E355K | BLCA | 1 |
p.G70E | LUAD | 1 |
p.H393Y | UCEC | 1 |
p.E535X | COAD | 1 |
p.L678M | CESC | 1 |
p.R825Q | BRCA | 1 |
p.S558P | LUAD | 1 |
p.A519S | PRAD | 1 |
p.R710C | PAAD | 1 |
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TissGeneCNV for CCDC87 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CCDC87 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for CCDC87 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CCDC87 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CCDC87 |
TissGeneDrug for CCDC87 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CCDC87 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |