TissGeneSummary for LRRC36 |
Gene summary |
Basic gene information | Gene symbol | LRRC36 |
Gene name | leucine rich repeat containing 36 | |
Synonyms | RORBP70|XLHSRF2 | |
Cytomap | UCSC genome browser: 16q22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001161575.1, NM_018296.5, | |
Description | ROR gamma binding protein 70ROR gamma-binding protein 70heat shock regulated 2leucine-rich repeat-containing protein 36 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000159708 | ||
HPRD : 08558 | ||
Vega : OTTHUMG00000173030 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_LRRC36 | |
BioGPS: 55282 | ||
Pathway | NCI Pathway Interaction Database: LRRC36 | |
KEGG: LRRC36 | ||
REACTOME: LRRC36 | ||
Pathway Commons: LRRC36 | ||
Context | iHOP: LRRC36 | |
ligand binding site mutation search in PubMed: LRRC36 | ||
UCL Cancer Institute: LRRC36 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of LRRC36 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for LRRC36 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 0.072879977 | -1.385514468 | 1.458394444 | 2.14E-13 | 9.59E-13 |
LUAD | -0.113645885 | 4.255078252 | -4.368724138 | 7.48E-29 | 6.21E-27 |
LUSC | -1.541374925 | 3.742881937 | -5.284256863 | 1.01E-36 | 2.07E-34 |
COAD | 0.810245361 | -1.86442387 | 2.674669231 | 9.25E-12 | 1.84E-10 |
STAD | -1.411407523 | -2.768151273 | 1.35674375 | 0.00125 | 0.006303251 |
KICH | -2.403328023 | -0.998028023 | -1.4053 | 3.51E-05 | 0.000100078 |
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TissGene-miRNA for LRRC36 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for LRRC36 |
TissGeneSNV for LRRC36 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S306* | UCEC | 1 |
p.S471L | UCEC | 1 |
p.H678Q | TGCT | 1 |
p.P710H | STAD | 1 |
p.V276A | BLCA | 1 |
p.S389C | THYM | 1 |
p.L104F | BLCA | 1 |
p.S497T | BLCA | 1 |
p.R448W | STAD | 1 |
p.F406Y | UCS | 1 |
p.E10* | CESC | 1 |
p.M655L | COAD | 1 |
p.G441V | BLCA | 1 |
p.S261P | UCS | 1 |
p.E237K | SKCM | 1 |
p.E711K | HNSC | 1 |
p.A494D | UCEC | 1 |
p.S317G | COAD | 1 |
p.R264* | BLCA | 1 |
p.L52I | UCEC | 1 |
p.N332I | COAD | 1 |
p.H301Y | SKCM | 1 |
p.H374R | BLCA | 1 |
p.A372T | LUAD | 1 |
p.P95L | ACC | 1 |
p.S188I | UCEC | 1 |
p.S728Y | UCEC | 1 |
p.R59S | UCEC | 1 |
p.Q570* | CESC | 1 |
p.L589I | LUAD | 1 |
p.Y690* | SKCM | 1 |
p.K606E | KIRC | 1 |
p.S30L | READ | 1 |
p.D115N | BLCA | 1 |
p.G67E | SKCM | 1 |
p.P517H | HNSC | 1 |
p.C573Y | STAD | 1 |
p.G197R | HNSC | 1 |
p.H489N | COAD | 1 |
p.E27Q | BLCA | 1 |
p.M269I | HNSC | 1 |
p.E154D | UCEC | 1 |
p.E159V | BRCA | 1 |
p.P266S | ACC | 1 |
p.V276A | UCEC | 1 |
p.V412A | HNSC | 1 |
p.S50* | STAD | 1 |
p.K309T | COAD | 1 |
p.S265F | COAD | 1 |
p.I190T | PRAD | 1 |
p.E417Q | BLCA | 1 |
p.G43V | ESCA | 1 |
p.R473T | HNSC | 1 |
p.V745I | UCEC | 1 |
p.N356Y | UCEC | 1 |
p.K295N | UCEC | 1 |
p.A734T | THYM | 1 |
p.M192V | KIRP | 1 |
p.S545C | LUSC | 1 |
p.F147I | SKCM | 1 |
p.S382F | COAD | 1 |
p.R350K | LGG | 1 |
p.G138D | HNSC | 1 |
p.L292F | LUAD | 1 |
p.S178C | BLCA | 1 |
p.I623N | STAD | 1 |
p.Q234R | COAD | 1 |
p.A411V | ESCA | 1 |
p.W477S | PRAD | 1 |
p.S306L | BLCA | 1 |
p.F49L | LUAD | 1 |
p.L157I | COAD | 1 |
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TissGeneCNV for LRRC36 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for LRRC36 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | LUAD | TCGA-91-A4BC-01A | FAM65A-LRRC36 | 5UTR-CDS | Chr16:67562817 | Chr16:67375860 |
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TissGeneNet for LRRC36 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for LRRC36 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for LRRC36 |
TissGeneDrug for LRRC36 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for LRRC36 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |