TissGeneSummary for OLAH |
Gene summary |
Basic gene information | Gene symbol | OLAH |
Gene name | oleoyl-ACP hydrolase | |
Synonyms | AURA1|SAST|THEDC1 | |
Cytomap | UCSC genome browser: 10p13 | |
Type of gene | protein-coding | |
RefGenes | NM_001039702.2, NM_018324.2, | |
Description | S-acyl fatty acid synthase thioesterase, medium chainaugmented in rheumatoid arthritis 1thioesterase IIthioesterase domain containing 1thioesterase domain-containing protein 1 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000152463 | ||
HPRD : 07731 | ||
Vega : OTTHUMG00000017724 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_OLAH | |
BioGPS: 55301 | ||
Pathway | NCI Pathway Interaction Database: OLAH | |
KEGG: OLAH | ||
REACTOME: OLAH | ||
Pathway Commons: OLAH | ||
Context | iHOP: OLAH | |
ligand binding site mutation search in PubMed: OLAH | ||
UCL Cancer Institute: OLAH | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of OLAH | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for OLAH |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -2.572521298 | -1.169598491 | -1.402922807 | 1.25E-15 | 6.79E-15 |
THCA | 0.969017224 | -1.893050573 | 2.862067797 | 2.21E-18 | 5.69E-17 |
KIRC | -2.176509895 | -0.654211284 | -1.522298611 | 4.33E-24 | 4.78E-23 |
LUAD | -2.077747826 | -0.84564955 | -1.232098276 | 6.95E-08 | 2.77E-07 |
KICH | -2.860373895 | -0.095985895 | -2.764388 | 7.19E-17 | 2.52E-15 |
LUSC | -2.32452362 | -0.823035385 | -1.501488235 | 5.40E-10 | 1.90E-09 |
HNSC | -2.075902918 | -0.992884313 | -1.083018605 | 0.00274 | 0.008101183 |
KIRP | -2.204941145 | -0.76781927 | -1.437121875 | 0.00133 | 0.003545612 |
Top |
TissGene-miRNA for OLAH |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for OLAH |
TissGeneSNV for OLAH |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E299K | SKCM | 2 |
p.G156E | SKCM | 2 |
p.P33S | SKCM | 1 |
p.K303N | UCEC | 1 |
p.S263F | SKCM | 1 |
p.R63I | LUAD | 1 |
p.A235T | SKCM | 1 |
p.E122X | COAD | 1 |
p.L200H | HNSC | 1 |
p.W191R | LUAD | 1 |
p.G279E | SKCM | 1 |
p.E203K | LUSC | 1 |
p.G160* | LUAD | 1 |
p.I302F | SKCM | 1 |
p.P80L | UCEC | 1 |
p.P287Q | ESCA | 1 |
p.D197Y | HNSC | 1 |
p.G262V | LUAD | 1 |
p.R69W | UCEC | 1 |
p.L124I | LUAD | 1 |
p.G4R | BLCA | 1 |
p.G213* | LUAD | 1 |
p.H124N | LUAD | 1 |
p.E122K | SKCM | 1 |
p.H177N | LUAD | 1 |
p.V247I | UCEC | 1 |
p.L253H | HNSC | 1 |
p.E299K | UCEC | 1 |
p.S201L | BLCA | 1 |
p.E55* | UCEC | 1 |
p.I283T | UCS | 1 |
p.D80H | LUAD | 1 |
p.P15S | CESC | 1 |
p.E117Q | ACC | 1 |
p.G262R | SKCM | 1 |
p.V312G | COAD | 1 |
p.H207Y | SKCM | 1 |
p.R193H | STAD | 1 |
p.R193H | BRCA | 1 |
p.Q144X | SKCM | 1 |
p.R116I | LUAD | 1 |
p.G288R | LUSC | 1 |
p.L100P | ESCA | 1 |
p.R162K | SKCM | 1 |
p.E199X | THYM | 1 |
p.D144Y | HNSC | 1 |
p.K223E | UCEC | 1 |
p.E224K | SKCM | 1 |
p.F260I | KIRC | 1 |
p.D145N | SKCM | 1 |
p.H290D | BLCA | 1 |
p.S126Y | UCEC | 1 |
p.L139V | LUAD | 1 |
p.D133H | LUAD | 1 |
p.G214S | KIRP | 1 |
p.Q144* | SKCM | 1 |
p.Y20H | HNSC | 1 |
p.L124I | BLCA | 1 |
Top |
TissGeneCNV for OLAH |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for OLAH |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Top |
TissGeneNet for OLAH |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for OLAH |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for OLAH |
TissGeneDrug for OLAH |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for OLAH |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |