TissGeneSummary for HEMGN |
Gene summary |
Basic gene information | Gene symbol | HEMGN |
Gene name | hemogen | |
Synonyms | CT155|EDAG|EDAG-1|NDR | |
Cytomap | UCSC genome browser: 9q22.33 | |
Type of gene | protein-coding | |
RefGenes | NM_018437.4, NM_197978.2, | |
Description | erythroid differentiation-associated gene proteinhemopoietic gene proteinnegative differentiation regulator protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 610715 | |
HGNC : HGNC | ||
Ensembl : ENSG00000136929 | ||
HPRD : 17100 | ||
Vega : OTTHUMG00000020336 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_HEMGN | |
BioGPS: 55363 | ||
Pathway | NCI Pathway Interaction Database: HEMGN | |
KEGG: HEMGN | ||
REACTOME: HEMGN | ||
Pathway Commons: HEMGN | ||
Context | iHOP: HEMGN | |
ligand binding site mutation search in PubMed: HEMGN | ||
UCL Cancer Institute: HEMGN | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LiverTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHCTGCT | |
Reference showing the relevant tissue of HEMGN | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for HEMGN |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | 0.337154934 | 2.229388832 | -1.892233898 | 3.19E-16 | 5.27E-15 |
LUSC | -0.065787838 | 1.829365103 | -1.895152941 | 2.17E-18 | 2.07E-17 |
LUAD | 0.280537517 | 1.697635793 | -1.417098276 | 1.60E-12 | 1.22E-11 |
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TissGene-miRNA for HEMGN |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for HEMGN |
TissGeneSNV for HEMGN |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E457K | SKCM | 2 |
p.T388I | OV | 1 |
p.I333S | UCS | 1 |
p.L297I | UCEC | 1 |
p.E149* | LUSC | 1 |
p.S339Y | LUSC | 1 |
p.E364K | SKCM | 1 |
p.G112V | LUAD | 1 |
p.L242R | COAD | 1 |
p.E51X | LIHC | 1 |
p.W32* | SKCM | 1 |
p.P111L | SKCM | 1 |
p.V97E | ESCA | 1 |
p.G269D | UCEC | 1 |
p.E95* | UCEC | 1 |
p.K263T | UCEC | 1 |
p.H427Q | LUAD | 1 |
p.E471D | BRCA | 1 |
p.E345X | STAD | 1 |
p.V47A | GBM | 1 |
p.E350K | SKCM | 1 |
p.P174H | KIRC | 1 |
p.E283D | STAD | 1 |
p.P202T | LUAD | 1 |
p.E93K | SKCM | 1 |
p.E331K | GBM | 1 |
p.A337T | UCEC | 1 |
p.E93X | READ | 1 |
p.E421K | READ | 1 |
p.D221Y | UCEC | 1 |
p.V97A | LUAD | 1 |
p.D221Y | PAAD | 1 |
p.E331K | UCEC | 1 |
p.E130G | STAD | 1 |
p.R37I | UCEC | 1 |
p.K195N | LUSC | 1 |
p.S173C | SKCM | 1 |
p.P239H | THYM | 1 |
p.R73Q | HNSC | 1 |
p.H24N | LUAD | 1 |
p.Q212K | THYM | 1 |
p.E59D | UCEC | 1 |
p.Q65K | ACC | 1 |
p.P433T | LUSC | 1 |
p.P405L | SKCM | 1 |
p.P129R | LUSC | 1 |
p.E331K | COAD | 1 |
p.A102V | PRAD | 1 |
p.P361H | COAD | 1 |
p.E331K | SKCM | 1 |
p.K263N | LUSC | 1 |
p.Q316H | HNSC | 1 |
p.L242F | LUAD | 1 |
p.E93K | KICH | 1 |
p.E345* | STAD | 1 |
p.V482A | SKCM | 1 |
p.E387K | BLCA | 1 |
p.R73Q | SKCM | 1 |
p.S349F | SKCM | 1 |
p.E369Q | BLCA | 1 |
p.E145D | UCEC | 1 |
p.E83K | LGG | 1 |
p.E95K | SKCM | 1 |
p.A154S | OV | 1 |
p.E179X | READ | 1 |
p.D309Y | STAD | 1 |
p.E51* | LIHC | 1 |
p.Q60H | UCEC | 1 |
p.H348Q | SKCM | 1 |
p.E475X | READ | 1 |
p.Q20R | GBM | 1 |
p.D213Y | COAD | 1 |
p.I96M | LIHC | 1 |
p.L297P | ESCA | 1 |
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TissGeneCNV for HEMGN |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for HEMGN |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | R29048 | INS-IGF2-HEMGN | chr11:2153395 | chr9:100692665 |
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TissGeneNet for HEMGN |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for HEMGN |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for HEMGN |
TissGeneDrug for HEMGN |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for HEMGN |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0023418 | leukemia | 2 | BeFree,LHGDN |
umls:C0023440 | Acute Erythroblastic Leukemia | 2 | BeFree,LHGDN |
umls:C0008924 | Cleft Lip | 1 | GAD |
umls:C0008925 | Cleft Palate | 1 | GAD |
umls:C0009952 | Febrile Convulsions | 1 | BeFree |
umls:C0011884 | Diabetic Retinopathy | 1 | BeFree |
umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | BeFree |
umls:C0036572 | Seizures | 1 | BeFree |
umls:C0085669 | Acute leukemia | 1 | BeFree |
umls:C0162872 | Aortic Aneurysm, Thoracic | 1 | BeFree |
umls:C1956346 | Coronary Artery Disease | 1 | GAD |
umls:C2062593 | Mesial temporal sclerosis | 1 | BeFree |