TissGeneSummary for DDX43 |
Gene summary |
Basic gene information | Gene symbol | DDX43 |
Gene name | DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 | |
Synonyms | CT13|HAGE | |
Cytomap | UCSC genome browser: 6q13 | |
Type of gene | protein-coding | |
RefGenes | NM_018665.2, | |
Description | DEAD box protein 43DEAD box protein HAGEDEAD-box protein 43cancer/testis antigen 13helical antigenprobable ATP-dependent RNA helicase DDX43 | |
Modification date | 20141207 | |
dbXrefs | MIM : 606286 | |
HGNC : HGNC | ||
Ensembl : ENSG00000080007 | ||
HPRD : 10448 | ||
Vega : OTTHUMG00000015033 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DDX43 | |
BioGPS: 55510 | ||
Pathway | NCI Pathway Interaction Database: DDX43 | |
KEGG: DDX43 | ||
REACTOME: DDX43 | ||
Pathway Commons: DDX43 | ||
Context | iHOP: DDX43 | |
ligand binding site mutation search in PubMed: DDX43 | ||
UCL Cancer Institute: DDX43 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of DDX43 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for DDX43 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | -1.26205525 | 1.070226106 | -2.332281356 | 6.12E-10 | 3.62E-09 |
LUSC | -0.656387021 | 1.481436508 | -2.137823529 | 1.17E-06 | 2.92E-06 |
KICH | -2.910734708 | 0.354157292 | -3.264892 | 1.43E-13 | 2.02E-12 |
BRCA | -1.464918497 | -0.070935164 | -1.393983333 | 3.58E-10 | 1.34E-09 |
LUAD | -0.50130788 | 1.178355913 | -1.679663793 | 4.29E-06 | 1.31E-05 |
BLCA | -1.693497445 | 0.04537624 | -1.738873684 | 0.00153 | 0.010127143 |
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TissGene-miRNA for DDX43 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for DDX43 |
TissGeneSNV for DDX43 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R37* | SKCM | 2 |
p.D520N | SKCM | 2 |
p.R521T | STAD | 1 |
p.Q482H | LGG | 1 |
p.D244Y | STAD | 1 |
p.M404I | SKCM | 1 |
p.R580T | BLCA | 1 |
p.Y139D | STAD | 1 |
p.F243L | THYM | 1 |
p.D399E | LIHC | 1 |
p.P57L | SKCM | 1 |
p.R29S | BRCA | 1 |
p.G144E | SKCM | 1 |
p.R19Q | HNSC | 1 |
p.E33K | LUAD | 1 |
p.R37X | SKCM | 1 |
p.R577C | STAD | 1 |
p.N98T | PRAD | 1 |
p.K363* | STAD | 1 |
p.V492A | LUAD | 1 |
p.S382G | LGG | 1 |
p.M637V | LIHC | 1 |
p.L376S | UCEC | 1 |
p.G284A | BLCA | 1 |
p.V492A | STAD | 1 |
p.H3N | MESO | 1 |
p.G46S | LGG | 1 |
p.K233E | SKCM | 1 |
p.H4Y | SKCM | 1 |
p.R436S | LUAD | 1 |
p.G84S | COAD | 1 |
p.R168W | UCEC | 1 |
p.G318S | READ | 1 |
p.R583S | OV | 1 |
p.A272V | UCEC | 1 |
p.P239H | ESCA | 1 |
p.P640S | BRCA | 1 |
p.R25X | READ | 1 |
p.G154A | STAD | 1 |
p.R436S | LIHC | 1 |
p.L35F | STAD | 1 |
p.S44G | BLCA | 1 |
p.R29K | SKCM | 1 |
p.F221V | UCEC | 1 |
p.T325N | CESC | 1 |
p.S158R | STAD | 1 |
p.L602F | CESC | 1 |
p.G166R | LGG | 1 |
p.K187N | PRAD | 1 |
p.R539I | COAD | 1 |
p.Q641* | BLCA | 1 |
p.A547V | UCS | 1 |
p.Q263* | SKCM | 1 |
p.T266I | COAD | 1 |
p.R37Q | SKCM | 1 |
p.G353E | SKCM | 1 |
p.L294S | LGG | 1 |
p.A63T | PAAD | 1 |
p.P317H | LUAD | 1 |
p.A500V | STAD | 1 |
p.N383K | UCEC | 1 |
p.G279R | SKCM | 1 |
p.A457D | UCEC | 1 |
p.P299T | HNSC | 1 |
p.R574Q | LUSC | 1 |
p.P565L | SKCM | 1 |
p.Q263X | SKCM | 1 |
p.P57L | COAD | 1 |
p.P299S | HNSC | 1 |
p.F115V | COAD | 1 |
p.R566W | LUAD | 1 |
p.I176V | SKCM | 1 |
p.K363X | STAD | 1 |
p.P27T | HNSC | 1 |
p.G157R | THYM | 1 |
p.L442F | CESC | 1 |
p.K400N | UCEC | 1 |
p.R85C | UCEC | 1 |
p.L35F | LUAD | 1 |
p.T426I | COAD | 1 |
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TissGeneCNV for DDX43 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for DDX43 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BI029590 | DDX43-NUDCD3 | chr6:74112988 | chr7:44466034 |
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TissGeneNet for DDX43 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for DDX43 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for DDX43 |
TissGeneDrug for DDX43 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for DDX43 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0023473 | Myeloid Leukemia, Chronic | 3 | BeFree |
umls:C0153594 | Malignant neoplasm of testis | 3 | BeFree |
umls:C0005699 | Blast Phase | 2 | BeFree |
umls:C0023467 | Leukemia, Myelocytic, Acute | 2 | BeFree |
umls:C0025202 | melanoma | 2 | BeFree,LHGDN |
umls:C0280100 | Solid tumour | 2 | BeFree |
umls:C0376545 | Hematologic Neoplasms | 2 | BeFree |
umls:C0022951 | Lactose Intolerance | 1 | BeFree |
umls:C0023418 | leukemia | 1 | BeFree |
umls:C0023470 | Myeloid Leukemia | 1 | BeFree |
umls:C0220633 | Uveal melanoma | 1 | BeFree |
umls:C0268181 | Lactose Intolerance, Adult Type | 1 | BeFree |
umls:C0494165 | Secondary malignant neoplasm of liver | 1 | BeFree |