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| TissGeneSummary for DNAH3 |
 Gene summary |
| Basic gene information | Gene symbol | DNAH3 |
| Gene name | dynein, axonemal, heavy chain 3 | |
| Synonyms | DLP3|DNAHC3B|HEL-36|Hsadhc3 | |
| Cytomap | UCSC genome browser: 16p12.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_017539.1, | |
| Description | axonemal beta dynein heavy chain 3axonemal dynein, heavy chainciliary dynein heavy chain 3dnahc3-bdynein heavy chain 3, axonemaldynein, axonemal, heavy polypeptide 3epididymis luminal protein 36 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603334 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000158486 | ||
| HPRD : 04513 | ||
| Vega : OTTHUMG00000090677 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DNAH3 | |
| BioGPS: 55567 | ||
| Pathway | NCI Pathway Interaction Database: DNAH3 | |
| KEGG: DNAH3 | ||
| REACTOME: DNAH3 | ||
| Pathway Commons: DNAH3 | ||
| Context | iHOP: DNAH3 | |
| ligand binding site mutation search in PubMed: DNAH3 | ||
| UCL Cancer Institute: DNAH3 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of DNAH3 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for DNAH3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | 1.251189376 | -1.071379374 | 2.32256875 | 2.44E-08 | 1.73E-07 |
| BLCA | 1.603639869 | 0.178060922 | 1.425578947 | 0.00779 | 0.036940213 |
| LUSC | 2.650645442 | 3.838084658 | -1.187439216 | 0.0077 | 0.012511111 |
| ESCA | 2.783847046 | -0.330507499 | 3.114354545 | 3.38E-05 | 0.001565878 |
| STAD | 2.267314376 | 0.586576876 | 1.6807375 | 2.27E-05 | 0.000225895 |
| Top |
| TissGene-miRNA for DNAH3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| THYM | hsa-miR-371a-5p | MIMAT0004687 | 0.029 | -0.26 | 122 |
| Top |
| TissGeneMut for DNAH3 |
| TissGeneSNV for DNAH3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E3758K | SKCM | 5 |
| p.R1274Q | SKCM | 5 |
| p.E3387K | SKCM | 4 |
| p.D1987N | SKCM | 3 |
| p.R678Q | SKCM | 2 |
| p.E2713K | SKCM | 2 |
| p.R2896C | SKCM | 2 |
| p.S2211F | SKCM | 2 |
| p.D2277N | SKCM | 2 |
| p.Q1366* | SKCM | 2 |
| p.D459N | SKCM | 2 |
| p.E305K | SKCM | 2 |
| p.Q1323* | SKCM | 2 |
| p.W1767* | SKCM | 2 |
| p.W3955* | SKCM | 2 |
| p.E3367Q | CESC | 2 |
| p.P3865L | SKCM | 2 |
| p.V659M | STAD | 2 |
| p.S2226L | UCEC | 2 |
| p.H1598Y | SKCM | 2 |
| p.V2073M | UCEC | 2 |
| p.E1937K | SKCM | 2 |
| p.E3275K | SKCM | 2 |
| p.R432Q | SKCM | 2 |
| p.P942L | SKCM | 2 |
| p.S3765F | SKCM | 2 |
| p.E2035K | SKCM | 2 |
| p.S2226L | STAD | 2 |
| p.T268M | BRCA | 1 |
| p.R2858Q | STAD | 1 |
| p.R233S | UCEC | 1 |
| p.T89R | LIHC | 1 |
| p.D2142G | COAD | 1 |
| p.G1985C | LUAD | 1 |
| p.L400R | PRAD | 1 |
| p.E972K | UCEC | 1 |
| p.R2644Q | SKCM | 1 |
| p.A2452T | COAD | 1 |
| p.L3790I | BRCA | 1 |
| p.S2360R | BLCA | 1 |
| p.R3345H | THCA | 1 |
| p.I3346M | HNSC | 1 |
| p.R3745H | PAAD | 1 |
| p.R2678H | KIRC | 1 |
| p.E2378Q | LUAD | 1 |
| p.K3188R | SKCM | 1 |
| p.R750W | CESC | 1 |
| p.G3559S | SKCM | 1 |
| p.K3663N | STAD | 1 |
| p.Q2937R | STAD | 1 |
| p.D3108E | BLCA | 1 |
| p.E885K | SKCM | 1 |
| p.D210N | SKCM | 1 |
| p.E811K | UCEC | 1 |
| p.A1639T | PAAD | 1 |
| p.P319S | SKCM | 1 |
| p.W3955L | UCEC | 1 |
| p.A13T | STAD | 1 |
| p.I2874L | SKCM | 1 |
| p.E3841K | LUAD | 1 |
| p.S654Y | KIRC | 1 |
| p.K830N | COAD | 1 |
| p.I1799N | BRCA | 1 |
| p.Q3468R | LIHC | 1 |
| p.R243H | KIRP | 1 |
| p.Y2096X | COAD | 1 |
| p.P3655S | LUAD | 1 |
| p.P1523S | LIHC | 1 |
| p.S2226L | BLCA | 1 |
| p.A3411V | SKCM | 1 |
| p.A4057T | STAD | 1 |
| p.E1165K | SKCM | 1 |
| p.R1550W | HNSC | 1 |
| p.F1739L | HNSC | 1 |
| p.M1555T | LUAD | 1 |
| p.T4031M | HNSC | 1 |
| p.L2089I | LUSC | 1 |
| p.D1409N | PRAD | 1 |
| p.P3412S | SKCM | 1 |
| p.D2498N | SKCM | 1 |
| p.T669M | CESC | 1 |
| p.L3246V | HNSC | 1 |
| p.H2206D | STAD | 1 |
| p.E878D | SKCM | 1 |
| p.E2630Q | BLCA | 1 |
| p.R1919I | LUAD | 1 |
| p.D2182N | SKCM | 1 |
| p.A3664T | SKCM | 1 |
| p.R2421H | ESCA | 1 |
| p.T1295S | HNSC | 1 |
| p.S1595C | BLCA | 1 |
| p.D2218N | SKCM | 1 |
| p.A1724V | ESCA | 1 |
| p.S2225C | GBM | 1 |
| p.D2257H | COAD | 1 |
| p.T181M | UCEC | 1 |
| p.R2410M | UCEC | 1 |
| p.T3337M | STAD | 1 |
| p.P942S | SKCM | 1 |
| p.D1988H | STAD | 1 |
| p.A1143T | SKCM | 1 |
| p.E2955D | STAD | 1 |
| p.H392Q | CESC | 1 |
| p.D3067N | ESCA | 1 |
| p.E2671V | LUSC | 1 |
| p.V2541I | OV | 1 |
| p.R2576H | GBM | 1 |
| p.D2504N | SKCM | 1 |
| p.D3256N | SKCM | 1 |
| p.S1399F | SKCM | 1 |
| p.E3731K | SKCM | 1 |
| p.A409T | STAD | 1 |
| p.R1141W | STAD | 1 |
| p.N718K | BLCA | 1 |
| p.E2656D | UCEC | 1 |
| p.K1060I | BLCA | 1 |
| p.F359L | GBM | 1 |
| p.A1969T | UCEC | 1 |
| p.A1443T | LUAD | 1 |
| p.S1782* | LUAD | 1 |
| p.A3585T | STAD | 1 |
| p.Y4065* | UCS | 1 |
| p.A2769V | SKCM | 1 |
| p.E2539K | LUSC | 1 |
| p.L1951F | STAD | 1 |
| p.D2836N | SKCM | 1 |
| p.H3433D | LUAD | 1 |
| p.I1967V | UCEC | 1 |
| p.E3096K | CESC | 1 |
| p.E2699K | SKCM | 1 |
| p.R3077C | READ | 1 |
| p.M1220I | SKCM | 1 |
| p.E4023* | UCEC | 1 |
| p.S2711F | SKCM | 1 |
| p.A627V | LIHC | 1 |
| p.D1078G | LGG | 1 |
| p.A3011T | SKCM | 1 |
| p.E3838_splice | GBM | 1 |
| p.R1401Q | COAD | 1 |
| p.R3052S | UCEC | 1 |
| p.I2804N | STAD | 1 |
| p.E1833D | ESCA | 1 |
| p.V1763L | LUAD | 1 |
| p.I2115N | THCA | 1 |
| p.E2330K | SKCM | 1 |
| p.R1075L | CHOL | 1 |
| p.P1229S | SKCM | 1 |
| p.T2027A | UCEC | 1 |
| p.R1631W | SKCM | 1 |
| p.S263Y | UCEC | 1 |
| p.W2469X | COAD | 1 |
| p.G3573R | LUAD | 1 |
| p.P3689L | SKCM | 1 |
| p.P3616L | ESCA | 1 |
| p.G3131A | BRCA | 1 |
| p.Q383* | ESCA | 1 |
| p.E1001K | SKCM | 1 |
| p.K2951T | BRCA | 1 |
| p.S4073R | HNSC | 1 |
| p.E1005D | READ | 1 |
| p.G3688D | COAD | 1 |
| p.V1741L | STAD | 1 |
| p.Q3878K | LUAD | 1 |
| p.A1127T | LUAD | 1 |
| p.W4103* | SKCM | 1 |
| p.K1208N | LGG | 1 |
| p.R2202Q | HNSC | 1 |
| p.Q2028* | HNSC | 1 |
| p.P2156L | STAD | 1 |
| p.A2402T | LGG | 1 |
| p.G2194R | SKCM | 1 |
| p.R3077C | COAD | 1 |
| p.A2452S | LUAD | 1 |
| p.S1916* | LUAD | 1 |
| p.E1625* | KICH | 1 |
| p.Q1366X | SKCM | 1 |
| p.E3870* | PRAD | 1 |
| p.R2359Q | STAD | 1 |
| p.Y531* | OV | 1 |
| p.Y477* | LUAD | 1 |
| p.R2124Q | SKCM | 1 |
| p.N831S | SKCM | 1 |
| p.E2067K | SKCM | 1 |
| p.G2364E | BLCA | 1 |
| p.V3680I | LIHC | 1 |
| p.Q871X | STAD | 1 |
| p.L3863X | SKCM | 1 |
| p.E3618D | UCEC | 1 |
| p.V2603A | LIHC | 1 |
| p.A3011T | STAD | 1 |
| p.N2605K | UCEC | 1 |
| p.F3676L | BLCA | 1 |
| p.A409T | UCEC | 1 |
| p.T268M | KIRC | 1 |
| p.P2651T | LUAD | 1 |
| p.N522H | HNSC | 1 |
| p.I2399N | DLBC | 1 |
| p.E972D | OV | 1 |
| p.G3628R | LUSC | 1 |
| p.M3666T | BLCA | 1 |
| p.N2102K | UCS | 1 |
| p.A2902V | SKCM | 1 |
| p.T193K | COAD | 1 |
| p.I299N | ESCA | 1 |
| p.E2755K | SKCM | 1 |
| p.Q2704* | BLCA | 1 |
| p.S2783L | HNSC | 1 |
| p.L2490F | SKCM | 1 |
| p.M2246V | OV | 1 |
| p.E1881G | SKCM | 1 |
| p.K3188N | PAAD | 1 |
| p.A3487E | CESC | 1 |
| p.E493K | SKCM | 1 |
| p.T1212A | COAD | 1 |
| p.E2149Q | BLCA | 1 |
| p.P1621S | SKCM | 1 |
| p.T2076R | LUAD | 1 |
| p.K2925I | STAD | 1 |
| p.E3458K | BRCA | 1 |
| p.P1910H | THYM | 1 |
| p.R4026H | UCEC | 1 |
| p.E2699X | COAD | 1 |
| p.Y3358H | STAD | 1 |
| p.W3955X | SKCM | 1 |
| p.R2578Q | BRCA | 1 |
| p.F1915L | COAD | 1 |
| p.E3237K | SKCM | 1 |
| p.S1355F | LUAD | 1 |
| p.K1225* | SKCM | 1 |
| p.P1910A | LUSC | 1 |
| p.I1096T | LIHC | 1 |
| p.T1408I | SKCM | 1 |
| p.I994F | LUAD | 1 |
| p.I3033T | STAD | 1 |
| p.L2347S | SKCM | 1 |
| p.H2231R | HNSC | 1 |
| p.A409T | COAD | 1 |
| p.A3402T | STAD | 1 |
| p.P2069L | SKCM | 1 |
| p.S1223L | SARC | 1 |
| p.E2841Q | HNSC | 1 |
| p.V3979I | UCEC | 1 |
| p.S3553C | STAD | 1 |
| p.P1663L | SKCM | 1 |
| p.G1110E | SKCM | 1 |
| p.L457P | LUAD | 1 |
| p.D1316H | LUSC | 1 |
| p.R2421H | UCEC | 1 |
| p.R648W | UCEC | 1 |
| p.A3259T | UCEC | 1 |
| p.V3485G | SKCM | 1 |
| p.Q2924H | OV | 1 |
| p.E3502* | OV | 1 |
| p.A2694E | LUAD | 1 |
| p.G4024D | SKCM | 1 |
| p.K1903I | ESCA | 1 |
| p.A1579T | LGG | 1 |
| p.A1732S | LUAD | 1 |
| p.A580T | GBM | 1 |
| p.D1162N | SKCM | 1 |
| p.I1266N | LIHC | 1 |
| p.T193R | UCEC | 1 |
| p.A560T | UCEC | 1 |
| p.R432Q | CESC | 1 |
| p.P3461L | SKCM | 1 |
| p.R810C | UCEC | 1 |
| p.I2859T | PRAD | 1 |
| p.E2395* | BLCA | 1 |
| p.R1777W | STAD | 1 |
| p.I3989V | LUAD | 1 |
| p.L1648P | LGG | 1 |
| p.E451Q | THYM | 1 |
| p.F1467V | UCEC | 1 |
| p.E1881X | READ | 1 |
| p.E1937K | LIHC | 1 |
| p.Q1040* | CESC | 1 |
| p.R1604H | PAAD | 1 |
| p.R1401Q | SKCM | 1 |
| p.Q2384H | LUAD | 1 |
| p.E8K | BLCA | 1 |
| p.C1202* | HNSC | 1 |
| p.V1583I | DLBC | 1 |
| p.D2277N | COAD | 1 |
| p.Q3509X | SKCM | 1 |
| p.R1787C | STAD | 1 |
| p.P3635T | ACC | 1 |
| p.A861D | LUSC | 1 |
| p.P2568Q | UCEC | 1 |
| p.K1692E | SKCM | 1 |
| p.R243H | STAD | 1 |
| p.W3420G | SKCM | 1 |
| p.S430X | KIRC | 1 |
| p.A3118V | STAD | 1 |
| p.R1326Q | UCEC | 1 |
| p.N3884S | LUAD | 1 |
| p.E631* | UCEC | 1 |
| p.D1645N | SKCM | 1 |
| p.F2661L | BLCA | 1 |
| p.E582K | ESCA | 1 |
| p.E3870X | PRAD | 1 |
| p.L2315V | BLCA | 1 |
| p.D1836N | LUAD | 1 |
| p.R3480W | LUAD | 1 |
| p.R545Q | SKCM | 1 |
| p.E884Q | SARC | 1 |
| p.R2618W | SKCM | 1 |
| p.G3497R | SKCM | 1 |
| p.R1111K | SKCM | 1 |
| p.A2770V | COAD | 1 |
| p.F1468L | SKCM | 1 |
| p.Q3120* | STAD | 1 |
| p.P3655S | SKCM | 1 |
| p.I2003M | BLCA | 1 |
| p.Q591E | BLCA | 1 |
| p.R432* | UCEC | 1 |
| p.L2127F | SKCM | 1 |
| p.R2896H | STAD | 1 |
| p.V280M | UCEC | 1 |
| p.V1963M | LGG | 1 |
| p.G1432E | BLCA | 1 |
| p.H345N | CESC | 1 |
| p.D2355N | COAD | 1 |
| p.R415Q | SKCM | 1 |
| p.R2122* | UCEC | 1 |
| p.A560T | BLCA | 1 |
| p.L1423I | UCEC | 1 |
| p.P3990S | SKCM | 1 |
| p.E3390K | SKCM | 1 |
| p.S1866F | SKCM | 1 |
| p.R88H | STAD | 1 |
| p.I3066M | BLCA | 1 |
| p.G2167C | LUAD | 1 |
| p.R2644* | SKCM | 1 |
| p.K3757R | HNSC | 1 |
| p.T2663M | STAD | 1 |
| p.T3378I | SKCM | 1 |
| p.A3664V | PAAD | 1 |
| p.R88S | LUAD | 1 |
| p.R2991C | LUAD | 1 |
| p.E1487K | SKCM | 1 |
| p.E3315K | SKCM | 1 |
| p.R3425C | SKCM | 1 |
| p.P3084S | SKCM | 1 |
| p.Q3023* | SKCM | 1 |
| p.E3116K | SKCM | 1 |
| p.M1853I | SKCM | 1 |
| p.E981K | SKCM | 1 |
| p.R233K | CESC | 1 |
| p.A922V | STAD | 1 |
| p.A1143V | LUAD | 1 |
| p.G2133R | SKCM | 1 |
| p.A3312T | PAAD | 1 |
| p.G3573E | SKCM | 1 |
| p.S414X | ESCA | 1 |
| p.S2279L | SKCM | 1 |
| p.G2428S | SKCM | 1 |
| p.D1316N | SKCM | 1 |
| p.L2834I | STAD | 1 |
| p.Q1650X | SKCM | 1 |
| p.P19T | LUAD | 1 |
| p.V332I | LUAD | 1 |
| p.E2306K | HNSC | 1 |
| p.M818I | CESC | 1 |
| p.R3477Q | STAD | 1 |
| p.G2129E | SKCM | 1 |
| p.S2653P | STAD | 1 |
| p.R925H | LUAD | 1 |
| p.P970L | THYM | 1 |
| p.Q383H | COAD | 1 |
| p.R3077H | THYM | 1 |
| p.M755I | SKCM | 1 |
| p.P1427L | SKCM | 1 |
| p.R2535W | BLCA | 1 |
| p.I1074F | OV | 1 |
| p.M3436I | SKCM | 1 |
| p.A2534V | LUAD | 1 |
| p.A709T | HNSC | 1 |
| p.G2466S | LUAD | 1 |
| p.E2755K | BLCA | 1 |
| p.E33K | BLCA | 1 |
| p.D1191N | BLCA | 1 |
| p.F3523L | SKCM | 1 |
| p.D1213N | LUAD | 1 |
| p.E714X | COAD | 1 |
| p.W3454* | SKCM | 1 |
| p.Y73F | COAD | 1 |
| p.D1316N | THYM | 1 |
| p.P4011H | LUAD | 1 |
| p.K416Q | SKCM | 1 |
| p.T1341M | COAD | 1 |
| p.L2683M | LUAD | 1 |
| p.S2267L | SKCM | 1 |
| p.K1200N | UCEC | 1 |
| p.A336T | GBM | 1 |
| p.L607V | LUAD | 1 |
| p.R1410H | UCEC | 1 |
| p.E372G | LIHC | 1 |
| p.T669M | COAD | 1 |
| p.E3390Q | SKCM | 1 |
| p.E3387K | SARC | 1 |
| p.Q383E | BLCA | 1 |
| p.M246L | LGG | 1 |
| p.D1543N | STAD | 1 |
| p.R1604H | STAD | 1 |
| p.T3123A | BLCA | 1 |
| p.V2181M | PRAD | 1 |
| p.S182L | CESC | 1 |
| p.G1465R | SKCM | 1 |
| p.M1918I | STAD | 1 |
| p.P2581S | SKCM | 1 |
| p.E4023Q | OV | 1 |
| p.S2211Y | ESCA | 1 |
| p.E4036K | SKCM | 1 |
| p.A2694T | LUAD | 1 |
| p.R2421H | KICH | 1 |
| p.K2925L | STAD | 1 |
| p.E190D | LUSC | 1 |
| p.K2523N | BLCA | 1 |
| p.E1188K | STAD | 1 |
| p.H3678Q | SKCM | 1 |
| p.R2576H | STAD | 1 |
| p.Q1695H | LUAD | 1 |
| p.C3518R | LUSC | 1 |
| p.L4038F | SKCM | 1 |
| p.P3961S | SKCM | 1 |
| p.E2378* | BLCA | 1 |
| p.I2476T | ESCA | 1 |
| p.P17A | BLCA | 1 |
| p.G2434D | SKCM | 1 |
| p.R1334* | SKCM | 1 |
| p.K2925Q | STAD | 1 |
| p.Q320R | LUSC | 1 |
| p.Q688X | SKCM | 1 |
| p.R3077C | BLCA | 1 |
| p.R834G | LUAD | 1 |
| p.D2355H | BLCA | 1 |
| p.S654F | SKCM | 1 |
| p.I1653M | THCA | 1 |
| p.P106L | KIRP | 1 |
| p.Q3509* | SKCM | 1 |
| p.R1274Q | UCEC | 1 |
| p.R3363H | ESCA | 1 |
| p.R1899H | GBM | 1 |
| p.D1729N | UCEC | 1 |
| p.N471D | UCEC | 1 |
| p.Q3023X | SKCM | 1 |
| p.L3825I | LUAD | 1 |
| p.G1205E | SKCM | 1 |
| p.K1225X | SKCM | 1 |
| p.E1108D | STAD | 1 |
| p.M2717L | UCEC | 1 |
| p.P3486L | PRAD | 1 |
| p.Q1249H | BLCA | 1 |
| p.G2194E | SKCM | 1 |
| p.K1313M | BLCA | 1 |
| p.D618Y | COAD | 1 |
| p.G5R | PRAD | 1 |
| p.L3790I | UCEC | 1 |
| p.T1019M | STAD | 1 |
| p.A3419T | SKCM | 1 |
| p.H2415N | LUAD | 1 |
| p.A1584V | BLCA | 1 |
| p.Q383X | ESCA | 1 |
| p.Q1449E | UCEC | 1 |
| p.D1558N | SKCM | 1 |
| p.G3469R | SKCM | 1 |
| p.A3428D | ACC | 1 |
| p.P3960H | STAD | 1 |
| p.A3453S | PAAD | 1 |
| p.W1961C | OV | 1 |
| p.L616V | UCEC | 1 |
| p.T3197I | LUSC | 1 |
| p.L116* | THYM | 1 |
| p.Q3120X | STAD | 1 |
| p.E3184K | LUAD | 1 |
| p.D1349N | SKCM | 1 |
| p.E2727X | COAD | 1 |
| p.M1142I | SKCM | 1 |
| p.Q688* | SKCM | 1 |
| p.L378F | LUAD | 1 |
| p.S194Y | UCEC | 1 |
| p.R1075H | KIRP | 1 |
| p.A3947T | UCEC | 1 |
| p.M2566I | CESC | 1 |
| p.S80N | UCEC | 1 |
| p.V2999M | ESCA | 1 |
| p.T2107I | SKCM | 1 |
| p.Q4003H | SKCM | 1 |
| p.R1787C | SKCM | 1 |
| p.S3265F | OV | 1 |
| p.H1276Y | SKCM | 1 |
| p.G105E | LUAD | 1 |
| p.P950A | KIRC | 1 |
| p.D1409N | UCEC | 1 |
| p.S1223* | SARC | 1 |
| p.R2470Q | SKCM | 1 |
| p.A1127S | STAD | 1 |
| p.E1778G | ESCA | 1 |
| p.R2421C | LUAD | 1 |
| p.L1509V | LUAD | 1 |
| p.H1912N | UCEC | 1 |
| p.E765* | BLCA | 1 |
| p.Y2255S | BLCA | 1 |
| p.L3115M | LUAD | 1 |
| p.S1291Y | LUAD | 1 |
| p.A1478S | STAD | 1 |
| p.E518D | UCEC | 1 |
| p.Y3615F | KIRC | 1 |
| p.R1899C | PRAD | 1 |
| p.G2244* | LUAD | 1 |
| p.R1980L | LUAD | 1 |
| p.C2960* | PAAD | 1 |
| p.A1605T | THYM | 1 |
| p.R834W | STAD | 1 |
| p.P4099T | LUAD | 1 |
| p.R2644X | SKCM | 1 |
| p.R1576K | SKCM | 1 |
| p.H421Y | READ | 1 |
| p.P249T | PRAD | 1 |
| p.I2209V | UCEC | 1 |
| p.G3831E | SKCM | 1 |
| p.D3740N | SKCM | 1 |
| p.D3351G | PAAD | 1 |
| p.T4031M | SKCM | 1 |
| p.Q1650* | SKCM | 1 |
| p.P3296S | SKCM | 1 |
| p.R2986Q | SKCM | 1 |
| p.Y4065X | UCS | 1 |
| p.I3629M | BRCA | 1 |
| p.G3510R | SKCM | 1 |
| p.V4000L | BRCA | 1 |
| p.A1104T | GBM | 1 |
| p.G3434D | STAD | 1 |
| p.M292I | BLCA | 1 |
| p.D2493E | MESO | 1 |
| p.H956Q | LUAD | 1 |
| p.Y1921H | STAD | 1 |
| p.R1075C | UCEC | 1 |
| p.G3004R | SKCM | 1 |
| p.V2387M | LUAD | 1 |
| p.G1429S | LUSC | 1 |
| p.V1669I | SARC | 1 |
| p.K912T | PAAD | 1 |
| p.V2632I | COAD | 1 |
| p.S1958F | SKCM | 1 |
| p.A1463V | HNSC | 1 |
| p.H1912P | KIRC | 1 |
| p.E1625X | KICH | 1 |
| p.V2150A | LIHC | 1 |
| p.D1676N | SKCM | 1 |
| p.A2766V | LUAD | 1 |
| p.Q3468E | BLCA | 1 |
| p.E798Q | UCEC | 1 |
| p.R2991H | READ | 1 |
| p.K2606T | UCEC | 1 |
| p.T3337M | UCEC | 1 |
| p.A2444T | LUSC | 1 |
| p.R3704S | BLCA | 1 |
| p.W1860* | SKCM | 1 |
| p.E436K | SKCM | 1 |
| p.M1681I | SKCM | 1 |
| p.V2259M | SKCM | 1 |
| p.G1332V | CESC | 1 |
| p.G2570E | SKCM | 1 |
| p.P3461S | SKCM | 1 |
| p.D3541N | SKCM | 1 |
| p.E417D | HNSC | 1 |
| p.A3402T | COAD | 1 |
| p.G1265E | SKCM | 1 |
| p.A3402T | THYM | 1 |
| p.E417K | SKCM | 1 |
| p.R2314H | STAD | 1 |
| p.E2955K | SKCM | 1 |
| p.T2331I | UCEC | 1 |
| p.K1973X | SKCM | 1 |
| p.L3848V | HNSC | 1 |
| p.L344P | STAD | 1 |
| p.G3545R | ESCA | 1 |
| p.T3389M | PRAD | 1 |
| p.I1292V | BLCA | 1 |
| p.E2158K | SKCM | 1 |
| p.T134I | SKCM | 1 |
| p.V2387M | COAD | 1 |
| p.F1897C | UCEC | 1 |
| p.R810H | COAD | 1 |
| p.S1456Y | STAD | 1 |
| p.D2615E | LAML | 1 |
| p.E3139K | COAD | 1 |
| p.W1246L | KIRC | 1 |
| p.W3454R | GBM | 1 |
| p.L3263M | UCEC | 1 |
| p.G1219D | ESCA | 1 |
| p.A1319V | PAAD | 1 |
| p.A1969T | READ | 1 |
| p.D2687N | SKCM | 1 |
| p.W1800C | LUAD | 1 |
| p.E651K | SKCM | 1 |
| p.G3046E | SKCM | 1 |
| p.R2309W | UCEC | 1 |
| p.R2123Q | SKCM | 1 |
| p.A1732T | LGG | 1 |
| p.G2538X | COAD | 1 |
| p.H467Y | STAD | 1 |
| p.L85F | GBM | 1 |
| p.D2895N | BRCA | 1 |
| p.M3382L | SKCM | 1 |
| p.Y428H | SKCM | 1 |
| p.E981K | READ | 1 |
| p.D2114N | SKCM | 1 |
| p.D1213G | BLCA | 1 |
| p.Q1139* | SKCM | 1 |
| p.W3454X | SKCM | 1 |
| p.K3267R | SKCM | 1 |
| p.Q871* | STAD | 1 |
| p.Q1735* | SKCM | 1 |
| p.H467P | LIHC | 1 |
| p.G3469* | UCS | 1 |
| p.W3464L | SKCM | 1 |
| p.V3245A | SKCM | 1 |
| p.E2958K | SKCM | 1 |
| p.A1605T | COAD | 1 |
| p.E3315D | LUAD | 1 |
| p.F2103L | UCEC | 1 |
| p.R2440W | UCEC | 1 |
| p.G376E | SKCM | 1 |
| p.Y3008X | THYM | 1 |
| p.A3533T | OV | 1 |
| p.A1426D | LGG | 1 |
| p.M2718I | SKCM | 1 |
| p.R2359* | UCEC | 1 |
| p.P15S | THCA | 1 |
| p.S430* | BLCA | 1 |
| p.G2751E | SKCM | 1 |
| p.A3211V | LGG | 1 |
| p.Q1284E | HNSC | 1 |
| p.T4096A | UCS | 1 |
| p.K809T | COAD | 1 |
| p.L238P | STAD | 1 |
| p.P503S | LUAD | 1 |
| p.R3425H | UCEC | 1 |
| p.G2364R | SKCM | 1 |
| p.E3133Q | LUAD | 1 |
| p.R1141Q | SKCM | 1 |
| p.D3108N | CESC | 1 |
| p.K2951R | TGCT | 1 |
| p.A1127V | UCEC | 1 |
| p.F1514V | UCEC | 1 |
| p.E555Q | BLCA | 1 |
| p.L2771Q | OV | 1 |
| p.L1548F | KIRP | 1 |
| p.A2572V | SKCM | 1 |
| p.R1075C | PAAD | 1 |
| p.L116F | HNSC | 1 |
| p.V2603A | COAD | 1 |
| p.R308W | BRCA | 1 |
| p.M1531I | SKCM | 1 |
| p.R1075C | READ | 1 |
| p.K1813N | SKCM | 1 |
| p.I2340M | LUSC | 1 |
| p.D2365N | BRCA | 1 |
| p.E1927K | CESC | 1 |
| p.E3289K | SKCM | 1 |
| p.M2808I | SKCM | 1 |
| p.D1180N | COAD | 1 |
| p.Q1323X | SKCM | 1 |
| p.E3387* | LUSC | 1 |
| p.L2834I | UCEC | 1 |
| p.C3478W | OV | 1 |
| p.L3863* | SKCM | 1 |
| p.E3457* | CESC | 1 |
| p.V3860A | PCPG | 1 |
| p.I3561V | BRCA | 1 |
| p.D2012N | SKCM | 1 |
| p.I3242V | LGG | 1 |
| p.P1647S | SKCM | 1 |
| p.G2751* | UCEC | 1 |
| p.V347A | STAD | 1 |
| p.I2477K | SKCM | 1 |
| p.L209R | KIRC | 1 |
| p.R1972K | COAD | 1 |
| p.L261M | SARC | 1 |
| p.S2211P | SKCM | 1 |
| p.D3030N | SKCM | 1 |
| p.L1169P | HNSC | 1 |
| p.Q2373K | ESCA | 1 |
| p.R2256T | BLCA | 1 |
| p.E2006* | SARC | 1 |
| p.R3175H | ESCA | 1 |
| p.L775F | SKCM | 1 |
| p.N2605S | BLCA | 1 |
| p.T3337M | COAD | 1 |
| p.E451K | SKCM | 1 |
| p.M1984T | STAD | 1 |
| p.G3469X | UCS | 1 |
| p.E582X | READ | 1 |
| p.E2471Q | LUAD | 1 |
| p.Q3878K | ESCA | 1 |
| p.R3877G | UCEC | 1 |
| p.P1095L | GBM | 1 |
| p.D1543G | PRAD | 1 |
| p.P3961L | SKCM | 1 |
| p.G3510E | SKCM | 1 |
| p.G4024S | SKCM | 1 |
| p.L1871M | LUAD | 1 |
| p.K864N | UCEC | 1 |
| p.S1782L | SKCM | 1 |
| p.K1166N | LUSC | 1 |
| p.R2314C | COAD | 1 |
| p.Y705H | STAD | 1 |
| p.R3640Q | SKCM | 1 |
| p.R802I | PRAD | 1 |
| p.S414T | UCEC | 1 |
| p.E3284K | SKCM | 1 |
| p.D1364N | SKCM | 1 |
| p.K1973* | SKCM | 1 |
| p.E3340K | SKCM | 1 |
| p.E2739K | SKCM | 1 |
| p.A1418T | COAD | 1 |
| p.W3054C | COAD | 1 |
| p.Y3320C | COAD | 1 |
| p.V2897M | STAD | 1 |
| p.E1437X | COAD | 1 |
| p.P3183L | SKCM | 1 |
| p.R1485K | SKCM | 1 |
| p.P3408L | SKCM | 1 |
| p.E902K | SKCM | 1 |
| p.L85F | BRCA | 1 |
| Top |
| TissGeneCNV for DNAH3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| Top |
| TissGeneFusions for DNAH3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AL039583 | DNAH3-DNAH3 | chr16:20981278 | chr16:20976481 | |
| TCGAfusionPortal | PRADA | BRCA | TCGA-AR-A0TS-01A | GNL2-DNAH3 | Out-of-frame | Chr1:38061360 | Chr16:21128660 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-AR-A0TX-01A | TMEM159-DNAH3 | In-frame | Chr16:21185469 | Chr16:21074004 |
| Top |
| TissGeneNet for DNAH3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| DNAH3, ARRB1, PXN (tumor) | DNAH3, ARRB1, PXN (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| DNAH3, ARRB1, PXN (tumor) | DNAH3, ARRB1, PXN (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| DNAH3, ARRB1, PXN (tumor) | DNAH3, ARRB1, PXN (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| DNAH3, ARRB1, PXN (tumor) | DNAH3, ARRB1, PXN (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| DNAH3, ARRB1, PXN (tumor) | DNAH3, ARRB1, PXN (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| DNAH3, ARRB1, PXN (tumor) | DNAH3, ARRB1, PXN (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| DNAH3, ARRB1, PXN (tumor) | DNAH3, ARRB1, PXN (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| DNAH3, ARRB1, PXN (tumor) | DNAH3, ARRB1, PXN (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| DNAH3, ARRB1, PXN (tumor) | DNAH3, ARRB1, PXN (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| DNAH3, ARRB1, PXN (tumor) | DNAH3, ARRB1, PXN (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| DNAH3, ARRB1, PXN (tumor) | DNAH3, ARRB1, PXN (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| DNAH3, ARRB1, PXN (tumor) | DNAH3, ARRB1, PXN (normal) |
 |  |
| Top |
| TissGeneProg for DNAH3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for DNAH3 |
| TissGeneDrug for DNAH3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for DNAH3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0020255 | Hydrocephalus | 2 | BeFree |
| umls:C0022521 | Kartagener Syndrome | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
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