TissGeneSummary for KIF27 |
Gene summary |
Basic gene information | Gene symbol | KIF27 |
Gene name | kinesin family member 27 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 9q21.32 | |
Type of gene | protein-coding | |
RefGenes | NM_001271927.1, NM_001271928.1,NM_017576.2, | |
Description | kinesin-like protein KIF27 | |
Modification date | 20141207 | |
dbXrefs | MIM : 611253 | |
HGNC : HGNC | ||
Ensembl : ENSG00000165115 | ||
HPRD : 11179 | ||
Vega : OTTHUMG00000020109 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KIF27 | |
BioGPS: 55582 | ||
Pathway | NCI Pathway Interaction Database: KIF27 | |
KEGG: KIF27 | ||
REACTOME: KIF27 | ||
Pathway Commons: KIF27 | ||
Context | iHOP: KIF27 | |
ligand binding site mutation search in PubMed: KIF27 | ||
UCL Cancer Institute: KIF27 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of KIF27 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for KIF27 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -1.35600562 | -0.25708962 | -1.098916 | 1.27E-05 | 3.93E-05 |
Top |
TissGene-miRNA for KIF27 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for KIF27 |
TissGeneSNV for KIF27 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.K925N | UCEC | 3 |
p.Q668E | BRCA | 1 |
p.G747V | STAD | 1 |
p.R939C | GBM | 1 |
p.H1035Q | HNSC | 1 |
p.L332V | HNSC | 1 |
p.K896* | KIRP | 1 |
p.I987V | DLBC | 1 |
p.E433K | READ | 1 |
p.Q35L | SARC | 1 |
p.G1253E | SKCM | 1 |
p.K311R | KIRP | 1 |
p.S675F | SKCM | 1 |
p.R206K | PAAD | 1 |
p.S289L | STAD | 1 |
p.L589S | COAD | 1 |
p.A573T | STAD | 1 |
p.D390A | UCEC | 1 |
p.E263* | UCEC | 1 |
p.R939C | HNSC | 1 |
p.R939C | BRCA | 1 |
p.Q851* | BLCA | 1 |
p.R1336G | BLCA | 1 |
p.I616R | PAAD | 1 |
p.R662I | LUSC | 1 |
p.M153I | UCEC | 1 |
p.R621Q | SKCM | 1 |
p.T151I | LGG | 1 |
p.K1214N | BLCA | 1 |
p.R995C | SKCM | 1 |
p.D283N | LGG | 1 |
p.E540K | UCEC | 1 |
p.Y334H | DLBC | 1 |
p.E655D | UCEC | 1 |
p.E536K | SKCM | 1 |
p.A296T | SARC | 1 |
p.I538V | HNSC | 1 |
p.A280T | PAAD | 1 |
p.S1017L | SKCM | 1 |
p.K1040N | THCA | 1 |
p.E1391K | HNSC | 1 |
p.R598S | LUAD | 1 |
p.K896X | KIRP | 1 |
p.S1292F | SKCM | 1 |
p.M512R | STAD | 1 |
p.E259* | LGG | 1 |
p.R260W | PRAD | 1 |
p.E1362X | READ | 1 |
p.E104G | STAD | 1 |
p.K1027N | LUAD | 1 |
p.R1144W | STAD | 1 |
p.N1321S | HNSC | 1 |
p.V423I | LAML | 1 |
p.Q800H | UCEC | 1 |
p.E59K | LUAD | 1 |
p.V1022F | KIRC | 1 |
p.R1092C | SKCM | 1 |
p.D586N | CESC | 1 |
p.E842D | UCEC | 1 |
p.R458* | UCEC | 1 |
p.S305Y | UCEC | 1 |
p.R623* | ESCA | 1 |
p.R159* | UCEC | 1 |
p.R623X | ESCA | 1 |
p.N1036D | COAD | 1 |
p.E352A | ACC | 1 |
p.S1367F | SKCM | 1 |
p.R1218W | STAD | 1 |
p.K798Q | LUAD | 1 |
p.D648E | SKCM | 1 |
p.S1389F | SKCM | 1 |
p.S456L | SKCM | 1 |
p.L555R | STAD | 1 |
p.G910A | BLCA | 1 |
p.R1047Q | SKCM | 1 |
p.K364Q | HNSC | 1 |
p.K1001N | BLCA | 1 |
p.R866K | STAD | 1 |
p.R717C | STAD | 1 |
p.E1174K | LGG | 1 |
p.K1222N | UCEC | 1 |
p.L855I | STAD | 1 |
p.R1234Q | LIHC | 1 |
p.A527V | PRAD | 1 |
p.T254M | STAD | 1 |
p.V429A | PAAD | 1 |
p.S758C | BLCA | 1 |
p.K780X | PAAD | 1 |
p.R623Q | STAD | 1 |
p.E1051K | ESCA | 1 |
p.L185F | SKCM | 1 |
p.E1136D | UCS | 1 |
p.G590W | PRAD | 1 |
p.Q266E | HNSC | 1 |
p.V318I | STAD | 1 |
p.K636E | LIHC | 1 |
p.R727T | OV | 1 |
p.I667M | LUAD | 1 |
p.R621X | SKCM | 1 |
p.R1144W | BRCA | 1 |
p.K943N | THCA | 1 |
p.E1077K | LGG | 1 |
p.D1398N | UCEC | 1 |
p.L68I | LUAD | 1 |
p.I832L | UCEC | 1 |
p.E706* | UCEC | 1 |
p.R939H | STAD | 1 |
p.R1092C | UCEC | 1 |
p.S920L | SKCM | 1 |
p.V522A | BRCA | 1 |
p.R1144W | PRAD | 1 |
p.S126N | PAAD | 1 |
p.H588Y | SKCM | 1 |
p.E1136X | COAD | 1 |
p.M848T | BLCA | 1 |
p.G1156E | SKCM | 1 |
p.E960K | SKCM | 1 |
p.Q199E | HNSC | 1 |
p.R621* | SKCM | 1 |
p.S321F | SKCM | 1 |
p.M726I | LUAD | 1 |
p.R717C | OV | 1 |
p.E923A | LIHC | 1 |
p.R813G | LUSC | 1 |
p.C17F | LUAD | 1 |
p.H1351Y | BLCA | 1 |
p.E633Q | LUAD | 1 |
p.M848I | BLCA | 1 |
p.E769Q | CESC | 1 |
p.E692Q | LUAD | 1 |
p.K780* | PAAD | 1 |
p.I213V | COAD | 1 |
p.R621Q | COAD | 1 |
p.R1144Q | SKCM | 1 |
p.R234W | BLCA | 1 |
p.Q634H | LUAD | 1 |
p.G469V | KIRC | 1 |
p.S824I | KIRP | 1 |
p.P608L | ACC | 1 |
p.D1209Y | BLCA | 1 |
p.R393W | LUAD | 1 |
p.Q683H | SKCM | 1 |
Top |
TissGeneCNV for KIF27 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for KIF27 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | BRCA | TCGA-EW-A1OY-01A | SRGAP2-KIF27 | CDS-5'UTR | chr1:206628370 | chr9:86530593 |
Top |
TissGeneNet for KIF27 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for KIF27 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for KIF27 |
TissGeneDrug for KIF27 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for KIF27 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |