TissGeneSummary for G2E3 |
Gene summary |
Basic gene information | Gene symbol | G2E3 |
Gene name | G2/M-phase specific E3 ubiquitin protein ligase | |
Synonyms | KIAA1333|PHF7B | |
Cytomap | UCSC genome browser: 14q12 | |
Type of gene | protein-coding | |
RefGenes | NM_017769.3, | |
Description | G2/M phase-specific E3 ubiquitin-protein ligaseG2/M-phase specific E3 ubiquitin ligasePHD finger protein 7B | |
Modification date | 20141207 | |
dbXrefs | MIM : 611299 | |
HGNC : HGNC | ||
Ensembl : ENSG00000092140 | ||
HPRD : 13851 | ||
Vega : OTTHUMG00000140204 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_G2E3 | |
BioGPS: 55632 | ||
Pathway | NCI Pathway Interaction Database: G2E3 | |
KEGG: G2E3 | ||
REACTOME: G2E3 | ||
Pathway Commons: G2E3 | ||
Context | iHOP: G2E3 | |
ligand binding site mutation search in PubMed: G2E3 | ||
UCL Cancer Institute: G2E3 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of G2E3 | ||
Description by TissGene annotations | Have significant anti-correlated miRNA TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for G2E3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for G2E3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
ACC | hsa-miR-155-5p | MIMAT0000646 | 0.0067 | -0.31 | 78 |
ACC | hsa-miR-155-5p | MIMAT0000646 | 0.0067 | -0.31 | 78 |
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TissGeneMut for G2E3 |
TissGeneSNV for G2E3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.K358* | LGG | 2 |
p.L544V | HNSC | 1 |
p.G60V | LUAD | 1 |
p.R100Q | CESC | 1 |
p.E570G | LIHC | 1 |
p.H171Y | MESO | 1 |
p.V658L | ESCA | 1 |
p.D488G | LUAD | 1 |
p.I69V | LIHC | 1 |
p.N668K | STAD | 1 |
p.R161Q | COAD | 1 |
p.V235A | SKCM | 1 |
p.P484S | UCS | 1 |
p.G460C | LUAD | 1 |
p.R343T | BLCA | 1 |
p.Y518C | LUAD | 1 |
p.D334H | STAD | 1 |
p.R286S | LUAD | 1 |
p.G28V | ESCA | 1 |
p.S591C | BLCA | 1 |
p.L595F | SKCM | 1 |
p.K360* | BLCA | 1 |
p.K358X | ESCA | 1 |
p.R382Q | COAD | 1 |
p.Y575H | PRAD | 1 |
p.R100Q | COAD | 1 |
p.Q10H | UCEC | 1 |
p.S468C | BLCA | 1 |
p.P462S | LIHC | 1 |
p.G293* | HNSC | 1 |
p.R161* | STAD | 1 |
p.R237I | STAD | 1 |
p.R363I | UCEC | 1 |
p.K432N | COAD | 1 |
p.Y42C | COAD | 1 |
p.E59K | SKCM | 1 |
p.Y520* | GBM | 1 |
p.E557K | BLCA | 1 |
p.R161X | STAD | 1 |
p.F342L | KIRC | 1 |
p.N74S | LUSC | 1 |
p.R325K | HNSC | 1 |
p.D68N | UCEC | 1 |
p.E294K | HNSC | 1 |
p.H706R | LUSC | 1 |
p.G460V | THYM | 1 |
p.A393P | UCEC | 1 |
p.N305K | STAD | 1 |
p.S700R | STAD | 1 |
p.Y43H | COAD | 1 |
p.I530L | READ | 1 |
p.D68Y | ESCA | 1 |
p.K297I | LUSC | 1 |
p.D22N | LUSC | 1 |
p.R325K | UCEC | 1 |
p.F187L | DLBC | 1 |
p.A182V | ESCA | 1 |
p.P386S | SKCM | 1 |
p.D535N | OV | 1 |
p.F295L | SKCM | 1 |
p.K432N | UCEC | 1 |
p.R100Q | UCEC | 1 |
p.D22N | UCEC | 1 |
p.E680Q | BLCA | 1 |
p.K300N | COAD | 1 |
p.K608R | STAD | 1 |
p.G183V | LUAD | 1 |
p.G118D | UCEC | 1 |
p.W169R | READ | 1 |
p.A671V | KIRP | 1 |
p.T677I | PAAD | 1 |
p.H702N | UCEC | 1 |
p.N345H | UCEC | 1 |
p.I357N | ESCA | 1 |
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TissGeneCNV for G2E3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for G2E3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AV751440 | G2E3-UBR3 | chr14:31086848 | chr2:170775185 | |
Chimerdb3.0 | FusionScan | LUSC | TCGA-O2-A52N-01A | G2E3-SCFD1 | 5'UTR-5'UTR | chr14:31028478 | chr14:31163978 |
Chimerdb3.0 | FusionScan | LUAD | TCGA-69-7760-01A | G2E3-NAP1L1 | Out-of-Frame | chr14:31050322 | chr12:76443565 |
TCGAfusionPortal | PRADA | GBM | TCGA-28-2514-01A | SPRED2-G2E3 | CDS-5UTR | Chr2:65659096 | Chr14:31050282 |
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TissGeneNet for G2E3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for G2E3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for G2E3 |
TissGeneDrug for G2E3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for G2E3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |