TissGeneSummary for PRKACG |
Gene summary |
Basic gene information | Gene symbol | PRKACG |
Gene name | protein kinase, cAMP-dependent, catalytic, gamma | |
Synonyms | KAPG|PKACg | |
Cytomap | UCSC genome browser: 9q13 | |
Type of gene | protein-coding | |
RefGenes | NM_002732.3, | |
Description | PKA C-gammacAMP-dependent protein kinase catalytic subunit gammaserine(threonine) protein kinase | |
Modification date | 20141207 | |
dbXrefs | MIM : 176893 | |
HGNC : HGNC | ||
Ensembl : ENSG00000165059 | ||
HPRD : 01483 | ||
Vega : OTTHUMG00000019974 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PRKACG | |
BioGPS: 5568 | ||
Pathway | NCI Pathway Interaction Database: PRKACG | |
KEGG: PRKACG | ||
REACTOME: PRKACG | ||
Pathway Commons: PRKACG | ||
Context | iHOP: PRKACG | |
ligand binding site mutation search in PubMed: PRKACG | ||
UCL Cancer Institute: PRKACG | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of PRKACG | ||
Description by TissGene annotations | Cancer gene TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for PRKACG |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for PRKACG |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PRKACG |
TissGeneSNV for PRKACG |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.V192M | UCEC | 2 |
p.L225P | LUAD | 1 |
p.D100N | KIRC | 1 |
p.R48M | UCEC | 1 |
p.R48K | SKCM | 1 |
p.Q134H | UCEC | 1 |
p.D242N | SKCM | 1 |
p.S160L | SKCM | 1 |
p.H159P | SKCM | 1 |
p.E209D | COAD | 1 |
p.R195C | UCEC | 1 |
p.S253P | OV | 1 |
p.K293N | UCEC | 1 |
p.V155I | PAAD | 1 |
p.E334K | SKCM | 1 |
p.H165Y | SKCM | 1 |
p.F146L | COAD | 1 |
p.R132H | KIRC | 1 |
p.L228F | STAD | 1 |
p.H268D | COAD | 1 |
p.A299T | STAD | 1 |
p.I245F | LUAD | 1 |
p.D330N | STAD | 1 |
p.F109L | STAD | 1 |
p.S131F | SKCM | 1 |
p.S326T | MESO | 1 |
p.R191H | LGG | 1 |
p.K93N | COAD | 1 |
p.V220M | STAD | 1 |
p.G56R | PAAD | 1 |
p.D330N | SKCM | 1 |
p.Y123C | LUSC | 1 |
p.A233D | BRCA | 1 |
p.A189V | KIRP | 1 |
p.R271W | UCEC | 1 |
p.L225P | LIHC | 1 |
p.R135H | STAD | 1 |
p.Q150R | UCEC | 1 |
p.Q178H | PAAD | 1 |
p.N91K | BLCA | 1 |
p.S15G | LIHC | 1 |
p.E92K | UCEC | 1 |
p.G51D | LUAD | 1 |
p.D324N | SKCM | 1 |
p.R337W | COAD | 1 |
p.V16M | STAD | 1 |
p.R191H | HNSC | 1 |
p.E45K | SKCM | 1 |
p.E92G | BLCA | 1 |
p.D42N | SKCM | 1 |
p.P208L | SKCM | 1 |
p.E18K | READ | 1 |
p.G2S | SKCM | 1 |
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TissGeneCNV for PRKACG |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PRKACG |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for PRKACG |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PRKACG |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PRKACG |
TissGeneDrug for PRKACG |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PRKACG |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0019348 | Herpes Simplex Infections | 5 | BeFree |
umls:C0031269 | Peutz-Jeghers Syndrome | 4 | BeFree |
umls:C0041296 | Tuberculosis | 2 | BeFree |
umls:C0178874 | Tumor Progression | 2 | BeFree |
umls:C0596263 | Carcinogenesis | 2 | BeFree |
umls:C0005818 | Blood Platelet Disorders | 1 | BeFree |
umls:C0007124 | Noninfiltrating Intraductal Carcinoma | 1 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
umls:C0025202 | melanoma | 1 | BeFree |
umls:C0036341 | Schizophrenia | 1 | BeFree |
umls:C0085400 | Neurofibrillary degeneration (morphologic abnormality) | 1 | BeFree |
umls:C0087012 | Ataxia, Spinocerebellar | 1 | LHGDN |
umls:C0234133 | Extrapyramidal sign | 1 | BeFree |
umls:C0238461 | Anaplastic thyroid carcinoma | 1 | BeFree |
umls:C0679395 | vascular ischemia | 1 | BeFree |
umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
umls:C4015405 | BLEEDING DISORDER, PLATELET-TYPE, 19 | 1 | UNIPROT |