TissGeneSummary for OGDHL |
Gene summary |
Basic gene information | Gene symbol | OGDHL |
Gene name | oxoglutarate dehydrogenase-like | |
Synonyms | - | |
Cytomap | UCSC genome browser: 10q11.23 | |
Type of gene | protein-coding | |
RefGenes | NM_001143996.1, NM_001143997.1,NM_018245.2, | |
Description | 2-oxoglutarate dehydrogenase complex component E1-like2-oxoglutarate dehydrogenase-like, mitochondrialOGDC-E1-likealpha-ketoglutarate dehydrogenase-like | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000197444 | ||
HPRD : 07704 | ||
Vega : OTTHUMG00000018200 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_OGDHL | |
BioGPS: 55753 | ||
Pathway | NCI Pathway Interaction Database: OGDHL | |
KEGG: OGDHL | ||
REACTOME: OGDHL | ||
Pathway Commons: OGDHL | ||
Context | iHOP: OGDHL | |
ligand binding site mutation search in PubMed: OGDHL | ||
UCL Cancer Institute: OGDHL | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of OGDHL | ||
Description by TissGene annotations | Have significant anti-correlated miRNA |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for OGDHL |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 0.207280002 | -3.578851371 | 3.786131373 | 1.37E-14 | 7.99E-14 |
LUAD | -1.854388321 | -3.756314183 | 1.901925862 | 2.09E-07 | 7.77E-07 |
KIRC | 4.235730165 | 7.098130165 | -2.8624 | 6.27E-22 | 5.60E-21 |
THCA | 2.735055542 | 5.190458932 | -2.45540339 | 2.65E-17 | 5.15E-16 |
COAD | -2.445161929 | 0.461818841 | -2.906980769 | 5.56E-07 | 3.30E-06 |
LIHC | 4.78349361 | 7.11959961 | -2.336106 | 1.29E-08 | 1.11E-07 |
STAD | -2.828066015 | -0.984491015 | -1.843575 | 0.0118 | 0.039026765 |
KICH | 8.74641561 | 7.02738761 | 1.719028 | 9.65E-05 | 0.000252596 |
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TissGene-miRNA for OGDHL |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
LUAD | hsa-miR-9-5p | MIMAT0000441 | 0.018 | -0.31 | 60 |
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TissGeneMut for OGDHL |
TissGeneSNV for OGDHL |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E286K | SKCM | 3 |
p.R30C | UCEC | 3 |
p.R383Q | SKCM | 2 |
p.S574F | SKCM | 2 |
p.G595R | SKCM | 2 |
p.R57C | UCEC | 2 |
p.A400T | UCEC | 2 |
p.R440Q | SKCM | 2 |
p.S517F | SKCM | 2 |
p.E909K | SKCM | 2 |
p.Q3L | LUAD | 1 |
p.G538R | SKCM | 1 |
p.L926P | MESO | 1 |
p.S819F | SKCM | 1 |
p.G1007D | UCS | 1 |
p.A877S | DLBC | 1 |
p.R902L | LUAD | 1 |
p.A186V | SKCM | 1 |
p.W259* | SKCM | 1 |
p.Q848L | SKCM | 1 |
p.T629R | SKCM | 1 |
p.M296I | LUAD | 1 |
p.D792A | STAD | 1 |
p.L190M | CHOL | 1 |
p.M231I | BLCA | 1 |
p.R443S | UCEC | 1 |
p.Q651H | READ | 1 |
p.P417T | BRCA | 1 |
p.R104Q | SKCM | 1 |
p.A630V | SARC | 1 |
p.R985K | SKCM | 1 |
p.R195W | SKCM | 1 |
p.P923S | SKCM | 1 |
p.C591* | LUAD | 1 |
p.I656V | LGG | 1 |
p.Q905L | SKCM | 1 |
p.N62I | HNSC | 1 |
p.G983E | SKCM | 1 |
p.D794N | SKCM | 1 |
p.R165W | SKCM | 1 |
p.R382C | UCS | 1 |
p.E236K | SKCM | 1 |
p.G45D | SKCM | 1 |
p.S356L | SKCM | 1 |
p.P8Q | ESCA | 1 |
p.M646I | LIHC | 1 |
p.E479K | SKCM | 1 |
p.V827L | HNSC | 1 |
p.G654E | SKCM | 1 |
p.T580M | COAD | 1 |
p.A191T | READ | 1 |
p.A647V | SKCM | 1 |
p.E545K | CESC | 1 |
p.S904I | LGG | 1 |
p.F40L | SKCM | 1 |
p.N817Y | ESCA | 1 |
p.G668D | MESO | 1 |
p.A366T | ESCA | 1 |
p.E783K | SKCM | 1 |
p.F508L | LUAD | 1 |
p.Q807L | LUAD | 1 |
p.V827A | STAD | 1 |
p.K354T | READ | 1 |
p.S606N | ESCA | 1 |
p.M513I | LUAD | 1 |
p.A81V | SKCM | 1 |
p.P592Q | LUAD | 1 |
p.R497Q | STAD | 1 |
p.A400T | BLCA | 1 |
p.A590V | SKCM | 1 |
p.M770T | STAD | 1 |
p.G383* | SKCM | 1 |
p.S248F | BLCA | 1 |
p.M804I | SKCM | 1 |
p.R239Q | SKCM | 1 |
p.L808R | SKCM | 1 |
p.Y472C | LUAD | 1 |
p.R758Q | BLCA | 1 |
p.D737N | SKCM | 1 |
p.N703I | SKCM | 1 |
p.T538N | DLBC | 1 |
p.F320L | STAD | 1 |
p.I913V | LUAD | 1 |
p.A306T | UCEC | 1 |
p.I927L | UCEC | 1 |
p.G807E | SKCM | 1 |
p.K843Q | SKCM | 1 |
p.T686R | SKCM | 1 |
p.K900Q | SKCM | 1 |
p.D615Y | LUAD | 1 |
p.G558D | SARC | 1 |
p.Y527* | LUAD | 1 |
p.W423X | SKCM | 1 |
p.A400S | LUAD | 1 |
p.N760I | SKCM | 1 |
p.A924V | COAD | 1 |
p.S648N | READ | 1 |
p.A243V | SKCM | 1 |
p.R812W | SKCM | 1 |
p.K224R | STAD | 1 |
p.R440Q | LGG | 1 |
p.A427T | UCEC | 1 |
p.P872S | SKCM | 1 |
p.E185K | SKCM | 1 |
p.S920C | BLCA | 1 |
p.R497W | STAD | 1 |
p.R470S | UCEC | 1 |
p.E534D | UCEC | 1 |
p.C818S | BRCA | 1 |
p.E709K | SKCM | 1 |
p.A366T | UCEC | 1 |
p.E172K | SKCM | 1 |
p.R496H | SKCM | 1 |
p.A720S | LIHC | 1 |
p.R190H | COAD | 1 |
p.P782H | BRCA | 1 |
p.I565M | THCA | 1 |
p.G926E | SKCM | 1 |
p.S9F | SKCM | 1 |
p.R902Q | CESC | 1 |
p.S85T | LUAD | 1 |
p.V490M | STAD | 1 |
p.S108R | HNSC | 1 |
p.H674Q | STAD | 1 |
p.R382L | LUAD | 1 |
p.D615Y | SKCM | 1 |
p.V247M | COAD | 1 |
p.I224L | COAD | 1 |
p.P866S | SKCM | 1 |
p.A931T | SARC | 1 |
p.D151Y | LUAD | 1 |
p.M513I | ESCA | 1 |
p.V348I | STAD | 1 |
p.D925N | UCEC | 1 |
p.R244K | SKCM | 1 |
p.P839L | STAD | 1 |
p.V406M | LUAD | 1 |
p.M861I | SKCM | 1 |
p.V375G | UCEC | 1 |
p.R290C | COAD | 1 |
p.E487K | SKCM | 1 |
p.E343Q | HNSC | 1 |
p.R244W | UCS | 1 |
p.R196C | KIRC | 1 |
p.D562N | HNSC | 1 |
p.E554K | BLCA | 1 |
p.R301K | SKCM | 1 |
p.E852K | SKCM | 1 |
p.D312N | SKCM | 1 |
p.G128C | LUAD | 1 |
p.A491S | LUSC | 1 |
p.I316F | BLCA | 1 |
p.I842F | HNSC | 1 |
p.A877T | LUAD | 1 |
p.G209R | LUSC | 1 |
p.A798S | LUAD | 1 |
p.Y514* | LUAD | 1 |
p.D225N | READ | 1 |
p.Q929R | LUAD | 1 |
p.R222W | SKCM | 1 |
p.A400T | ESCA | 1 |
p.G295E | SKCM | 1 |
p.P63T | LGG | 1 |
p.R908C | COAD | 1 |
p.V51F | LUSC | 1 |
p.K617R | UCS | 1 |
p.E96D | LUAD | 1 |
p.H692Y | SKCM | 1 |
p.G711E | SKCM | 1 |
p.G326X | SKCM | 1 |
p.E534K | CESC | 1 |
p.R104Q | LUAD | 1 |
p.E873Q | BLCA | 1 |
p.E370D | GBM | 1 |
p.S762F | SKCM | 1 |
p.R497Q | LGG | 1 |
p.P815S | SKCM | 1 |
p.V246L | LUAD | 1 |
p.A243S | HNSC | 1 |
p.P751T | LUSC | 1 |
p.Y557C | HNSC | 1 |
p.P864T | SKCM | 1 |
p.D214N | STAD | 1 |
p.F889L | BLCA | 1 |
p.H853L | LUSC | 1 |
p.F401L | HNSC | 1 |
p.R382H | PAAD | 1 |
p.L152V | STAD | 1 |
p.R104W | UCEC | 1 |
p.R684H | HNSC | 1 |
p.R624H | LUAD | 1 |
p.R837C | STAD | 1 |
p.G238E | SKCM | 1 |
p.R636W | STAD | 1 |
p.R351Q | BLCA | 1 |
p.W286C | GBM | 1 |
p.K564N | UCEC | 1 |
p.Q929K | LUAD | 1 |
p.N352D | UCEC | 1 |
p.S362P | STAD | 1 |
p.R559M | UCEC | 1 |
p.D135Y | UCEC | 1 |
p.M249V | LUAD | 1 |
p.A100V | LUAD | 1 |
p.H635Y | SKCM | 1 |
p.R310L | LUAD | 1 |
p.R915H | BRCA | 1 |
p.V370I | READ | 1 |
p.S723N | KIRC | 1 |
p.R182Q | SKCM | 1 |
p.W480* | SKCM | 1 |
p.V427I | UCEC | 1 |
p.G711R | SKCM | 1 |
p.G403V | LUAD | 1 |
p.D466G | UCEC | 1 |
p.R869W | SKCM | 1 |
p.H678Y | SKCM | 1 |
p.E887K | SKCM | 1 |
p.K507N | COAD | 1 |
p.P921T | SKCM | 1 |
p.W202X | SKCM | 1 |
p.A490V | COAD | 1 |
p.R453L | UCEC | 1 |
p.R829H | THYM | 1 |
p.R624H | ESCA | 1 |
p.S857N | LUAD | 1 |
p.E944K | SKCM | 1 |
p.Y527C | SKCM | 1 |
p.A464S | MESO | 1 |
p.G752D | LIHC | 1 |
p.M231I | LUAD | 1 |
p.S574Y | LUAD | 1 |
p.E409Q | THCA | 1 |
p.A722V | SKCM | 1 |
p.R1001W | GBM | 1 |
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TissGeneCNV for OGDHL |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for OGDHL |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BP348542 | OGDHL-OGDHL | chr10:50970356 | chr10:50964915 |
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TissGeneNet for OGDHL |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for OGDHL |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for OGDHL |
TissGeneDrug for OGDHL |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for OGDHL |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
umls:C0022658 | Kidney Diseases | 1 | GAD |
umls:C0038454 | Cerebrovascular accident | 1 | GAD |
umls:C0038525 | Subarachnoid Hemorrhage | 1 | GAD |
umls:C0151699 | Intracranial Hemorrhages | 1 | GAD |
umls:C0302592 | Cervix carcinoma | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C2937358 | Cerebral Hemorrhage | 1 | GAD |