TissGeneSummary for TSNAXIP1 |
Gene summary |
Basic gene information | Gene symbol | TSNAXIP1 |
Gene name | translin-associated factor X interacting protein 1 | |
Synonyms | TXI1 | |
Cytomap | UCSC genome browser: 16q22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001288990.1, NM_001288991.1,NM_001288992.1,NM_001288993.1,NM_001288994.1, NM_018430.3, | |
Description | translin-associated factor X-interacting protein 1trax-interacting protein 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 607720 | |
HGNC : HGNC | ||
Ensembl : ENSG00000102904 | ||
HPRD : 09656 | ||
Vega : OTTHUMG00000137545 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TSNAXIP1 | |
BioGPS: 55815 | ||
Pathway | NCI Pathway Interaction Database: TSNAXIP1 | |
KEGG: TSNAXIP1 | ||
REACTOME: TSNAXIP1 | ||
Pathway Commons: TSNAXIP1 | ||
Context | iHOP: TSNAXIP1 | |
ligand binding site mutation search in PubMed: TSNAXIP1 | ||
UCL Cancer Institute: TSNAXIP1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TSNAXIP1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TSNAXIP1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -1.948449572 | 1.313730428 | -3.26218 | 2.02E-17 | 8.40E-16 |
THCA | -1.460463538 | 0.30147714 | -1.761940678 | 2.29E-15 | 3.09E-14 |
LUAD | -1.250982123 | 0.468879946 | -1.719862069 | 7.60E-07 | 2.59E-06 |
LUSC | -1.312273807 | 0.517200703 | -1.82947451 | 4.16E-08 | 1.22E-07 |
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TissGene-miRNA for TSNAXIP1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TSNAXIP1 |
TissGeneSNV for TSNAXIP1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R78I | UCEC | 2 |
p.E265K | THYM | 2 |
p.L292R | UCEC | 1 |
p.M137I | SKCM | 1 |
p.A487T | SKCM | 1 |
p.R21X | SKCM | 1 |
p.S539* | BRCA | 1 |
p.K344N | LGG | 1 |
p.K166N | UCEC | 1 |
p.E356K | BLCA | 1 |
p.K287N | ACC | 1 |
p.L197I | UCEC | 1 |
p.E141D | ESCA | 1 |
p.R652G | HNSC | 1 |
p.R114W | SKCM | 1 |
p.S168L | SKCM | 1 |
p.R640Q | KIRC | 1 |
p.F261S | STAD | 1 |
p.E151X | ESCA | 1 |
p.K626Q | KIRP | 1 |
p.D200N | BLCA | 1 |
p.E563X | SKCM | 1 |
p.R363W | STAD | 1 |
p.R315H | COAD | 1 |
p.A193T | LUAD | 1 |
p.Q15H | HNSC | 1 |
p.R245* | UCEC | 1 |
p.D210E | ACC | 1 |
p.T416K | HNSC | 1 |
p.P509T | STAD | 1 |
p.E265K | SKCM | 1 |
p.X659Q | STAD | 1 |
p.S298N | KIRC | 1 |
p.F307L | UCEC | 1 |
p.E498Q | BLCA | 1 |
p.Y537* | LUAD | 1 |
p.E475K | SKCM | 1 |
p.R31L | LUAD | 1 |
p.P86T | UCEC | 1 |
p.Q490* | LUAD | 1 |
p.R240C | UCEC | 1 |
p.G524S | HNSC | 1 |
p.D27N | SKCM | 1 |
p.V649M | BLCA | 1 |
p.K301R | LIHC | 1 |
p.R336H | STAD | 1 |
p.D200E | LIHC | 1 |
p.D200H | STAD | 1 |
p.P76A | CESC | 1 |
p.S346I | THYM | 1 |
p.F421C | UCEC | 1 |
p.I445M | COAD | 1 |
p.A78V | UCEC | 1 |
p.G333C | BLCA | 1 |
p.E443* | LUAD | 1 |
p.R21* | SKCM | 1 |
p.G333D | STAD | 1 |
p.E172K | UCEC | 1 |
p.E563* | SKCM | 1 |
p.K232Q | SKCM | 1 |
p.A199T | LGG | 1 |
p.E521K | BLCA | 1 |
p.R208W | COAD | 1 |
p.M542I | SKCM | 1 |
p.R31* | UCEC | 1 |
p.R320Q | STAD | 1 |
p.E205Q | LUSC | 1 |
p.E203K | SKCM | 1 |
p.F88L | HNSC | 1 |
p.T234A | LIHC | 1 |
p.K564E | LIHC | 1 |
p.V630M | STAD | 1 |
p.E582K | SKCM | 1 |
p.D129G | COAD | 1 |
p.S432N | KIRP | 1 |
p.S298C | KIRC | 1 |
p.S658R | STAD | 1 |
p.F448V | LGG | 1 |
p.R640L | STAD | 1 |
p.R31Q | SKCM | 1 |
p.W323R | STAD | 1 |
p.R191* | UCEC | 1 |
p.A611T | UCEC | 1 |
p.A522E | PRAD | 1 |
p.R303W | PAAD | 1 |
p.L292P | READ | 1 |
p.E103D | UCEC | 1 |
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TissGeneCNV for TSNAXIP1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TSNAXIP1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AI286092 | TSNAXIP1-GPSM1 | chr16:67861970 | chr9:139244244 | |
Chimerdb3.0 | FusionScan | ACC | TCGA-OR-A5K2-01A | NUTF2-TSNAXIP1 | 5'UTR-CDS | chr16:67880888 | chr16:67861151 |
Chimerdb3.0 | FusionScan | ACC | TCGA-OR-A5K2-01A | NUTF2-TSNAXIP1 | 5'UTR-CDS | chr16:67880888 | chr16:67860865 |
Chimerdb3.0 | TopHat-Fusion | ACC | TCGA-OR-A5K2-01A | TSNAXIP1-CENPT | CDS-5'UTR | chr16:67860865 | chr16:67880887 |
Chimerdb3.0 | TopHat-Fusion | ACC | TCGA-OR-A5K2-01A | TSNAXIP1-CENPT | CDS-5'UTR | chr16:67861151 | chr16:67881358 |
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TissGeneNet for TSNAXIP1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TSNAXIP1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TSNAXIP1 |
TissGeneDrug for TSNAXIP1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TSNAXIP1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |