 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for PRKCG |
 Gene summary |
| Basic gene information | Gene symbol | PRKCG |
| Gene name | protein kinase C, gamma | |
| Synonyms | PKC-gamma|PKCC|PKCG|SCA14 | |
| Cytomap | UCSC genome browser: 19q13.4 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002739.3, | |
| Description | protein kinase C gamma type | |
| Modification date | 20141219 | |
| dbXrefs | MIM : 176980 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000126583 | ||
| HPRD : 01502 | ||
| Vega : OTTHUMG00000064846 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PRKCG | |
| BioGPS: 5582 | ||
| Pathway | NCI Pathway Interaction Database: PRKCG | |
| KEGG: PRKCG | ||
| REACTOME: PRKCG | ||
| Pathway Commons: PRKCG | ||
| Context | iHOP: PRKCG | |
| ligand binding site mutation search in PubMed: PRKCG | ||
| UCL Cancer Institute: PRKCG | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of PRKCG | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0016310 | phosphorylation | 15808853 | GO:0031397 | negative regulation of protein ubiquitination | 15808853 | GO:0032425 | positive regulation of mismatch repair | 15808853 | GO:0042177 | negative regulation of protein catabolic process | 15808853 | GO:0016310 | phosphorylation | 15808853 | GO:0031397 | negative regulation of protein ubiquitination | 15808853 | GO:0032425 | positive regulation of mismatch repair | 15808853 | GO:0042177 | negative regulation of protein catabolic process | 15808853 |
| Top |
| TissGeneExp for PRKCG |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| STAD | 1.288001111 | -1.333042639 | 2.62104375 | 1.29E-05 | 0.000144339 |
| COAD | 0.597807121 | -1.820673648 | 2.418480769 | 2.66E-05 | 0.000110171 |
| Top |
| TissGene-miRNA for PRKCG |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for PRKCG |
| TissGeneSNV for PRKCG |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R345C | STAD | 3 |
| p.S260F | SKCM | 2 |
| p.R181H | READ | 2 |
| p.R624* | STAD | 1 |
| p.H493Q | LUAD | 1 |
| p.H456Y | SKCM | 1 |
| p.D10N | UCEC | 1 |
| p.F327S | HNSC | 1 |
| p.R205Q | SKCM | 1 |
| p.V506I | BLCA | 1 |
| p.V315M | GBM | 1 |
| p.P188L | SKCM | 1 |
| p.T218M | STAD | 1 |
| p.K197Q | LUAD | 1 |
| p.S109R | LUAD | 1 |
| p.H682P | LUAD | 1 |
| p.A461T | UCEC | 1 |
| p.Q530R | STAD | 1 |
| p.C305F | BLCA | 1 |
| p.P97R | LUAD | 1 |
| p.D54Y | HNSC | 1 |
| p.R580Q | COAD | 1 |
| p.S577L | STAD | 1 |
| p.F646L | HNSC | 1 |
| p.W245* | KIRC | 1 |
| p.E32K | SKCM | 1 |
| p.P194S | HNSC | 1 |
| p.R336C | STAD | 1 |
| p.A461V | COAD | 1 |
| p.G533E | LUAD | 1 |
| p.A180V | STAD | 1 |
| p.V543I | CESC | 1 |
| p.L124P | LUSC | 1 |
| p.Y431F | SKCM | 1 |
| p.E32K | LUAD | 1 |
| p.R239Q | ESCA | 1 |
| p.R98Q | PAAD | 1 |
| p.H51Y | UCEC | 1 |
| p.R370C | PAAD | 1 |
| p.D246E | LGG | 1 |
| p.G190R | STAD | 1 |
| p.P327H | LUSC | 1 |
| p.G14R | SKCM | 1 |
| p.R205Q | GBM | 1 |
| p.G450C | UCEC | 1 |
| p.A269P | STAD | 1 |
| p.P15S | BLCA | 1 |
| p.Y521N | LUAD | 1 |
| p.M487I | HNSC | 1 |
| p.D193N | SKCM | 1 |
| p.D603E | LIHC | 1 |
| p.R580W | LAML | 1 |
| p.R659L | SKCM | 1 |
| p.R8* | BLCA | 1 |
| p.M501I | LUAD | 1 |
| p.D95Y | LUSC | 1 |
| p.S540F | SKCM | 1 |
| p.R686C | UCS | 1 |
| p.D498N | STAD | 1 |
| p.G23W | KIRP | 1 |
| p.R370G | HNSC | 1 |
| p.P334L | SKCM | 1 |
| p.P303L | HNSC | 1 |
| p.T94M | PRAD | 1 |
| p.D248N | SKCM | 1 |
| p.P308S | COAD | 1 |
| p.G533R | SKCM | 1 |
| p.W245X | KIRC | 1 |
| p.L4M | STAD | 1 |
| p.S422C | KIRP | 1 |
| p.G551* | UCEC | 1 |
| p.E375K | LUSC | 1 |
| p.S35N | LUSC | 1 |
| p.R238G | SKCM | 1 |
| p.E435K | SKCM | 1 |
| p.S600* | SARC | 1 |
| p.G517R | SKCM | 1 |
| p.F362L | UCEC | 1 |
| p.E79K | COAD | 1 |
| p.G588E | SKCM | 1 |
| p.D559V | LIHC | 1 |
| p.R181H | KICH | 1 |
| p.G406V | LUAD | 1 |
| p.D187N | SKCM | 1 |
| p.G19R | HNSC | 1 |
| p.N505K | LUSC | 1 |
| p.E569K | HNSC | 1 |
| p.I201F | STAD | 1 |
| p.R314W | STAD | 1 |
| p.P185S | SKCM | 1 |
| p.E454K | SKCM | 1 |
| p.C502R | COAD | 1 |
| p.K380N | LUAD | 1 |
| p.D537G | LUAD | 1 |
| p.R76* | BLCA | 1 |
| p.T510M | HNSC | 1 |
| p.A663V | THYM | 1 |
| p.S11T | HNSC | 1 |
| p.A650V | COAD | 1 |
| p.Y460* | LUAD | 1 |
| p.M186T | UCEC | 1 |
| p.Y521C | HNSC | 1 |
| p.T510M | COAD | 1 |
| p.P290L | SKCM | 1 |
| p.D254N | UCEC | 1 |
| p.C286* | LIHC | 1 |
| p.D95Y | LUAD | 1 |
| p.R513L | HNSC | 1 |
| p.C317* | LUAD | 1 |
| p.R213Q | SKCM | 1 |
| p.D537Y | STAD | 1 |
| p.K232M | UCEC | 1 |
| p.R98Q | DLBC | 1 |
| p.M186V | HNSC | 1 |
| p.M129I | BRCA | 1 |
| p.P554S | HNSC | 1 |
| p.S321F | SKCM | 1 |
| p.M129I | HNSC | 1 |
| p.R76Q | SKCM | 1 |
| p.S322T | ESCA | 1 |
| p.L311F | LUAD | 1 |
| p.A170V | LIHC | 1 |
| p.P628L | ESCA | 1 |
| p.G23E | COAD | 1 |
| p.D193N | OV | 1 |
| p.S687G | DLBC | 1 |
| p.E454K | BLCA | 1 |
| p.T218R | LUSC | 1 |
| p.Q62H | LUSC | 1 |
| p.A458E | KIRC | 1 |
| p.S535F | LIHC | 1 |
| p.E79K | UCEC | 1 |
| p.G533V | LUSC | 1 |
| p.E79K | SKCM | 1 |
| p.F680L | BLCA | 1 |
| p.G273C | STAD | 1 |
| p.M366L | BRCA | 1 |
| Top |
| TissGeneCNV for PRKCG |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for PRKCG |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Top |
| TissGeneNet for PRKCG |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| PRKCG, UBC, DVL2, YWHAG, YWHAE, CDC42, ANXA7, PARD3, YWHAB, MARK4, ADRBK1, GRIN1, PICK1, PEBP1, TOP2A, AFAP1, OCLN, CYTH2, HABP4, NOXA1, CCHCR1 (tumor) | PRKCG, UBC, MAP2K4, YWHAG, GRIN2D, STAT3, CDC42, ANXA7, MARK4, ADRBK1, DAB2, TOP2A, NFE2L2, VTN, PARD6B, NUMB, PARD6A, PA2G4, GJA1, PDLIM5, GSK3A (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| PRKCG, GRIN2D, RGS2, STAT3, CDC42, PTPN1, PARD3, ADRBK1, GRIN1, PICK1, PPP1R14A, EXOC5, EIF4E, PNMA1, CYTH2, HABP4, NOXA1, CD5, PDLIM5, CCHCR1, GABRA1 (tumor) | PRKCG, MAP2K4, GRIN2D, YWHAE, GRIN2B, PTPN1, YWHAB, MARK4, GRIN1, DAB2, STXBP1, VTN, PARD6B, NUMB, GJA3, PNMA1, CYTH2, NOXA1, PDLIM5, GSK3A, NRGN (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| PRKCG, MAP2K4, YWHAG, GRIN2D, GABRA4, CDC42, PARD3, YWHAB, STXBP1, EXOC5, AFAP1, GRM5, EIF4E, GJA3, OCLN, PNMA1, PARD6A, PA2G4, PDLIM5, GSK3A, CASR (tumor) | PRKCG, MAP2K4, YWHAG, GRIN2B, PARD3, YWHAB, GRIN1, IRS1, GRIA4, EXOC5, VTN, NUMB, EIF4E, PARD6A, HABP4, GJA1, PDLIM5, NRGN, CASR, CCHCR1, GABRA1 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| PRKCG, YWHAG, RGS2, STAT3, YWHAE, PTPN1, YWHAB, ADRBK1, GRIN1, EXOC5, PEBP1, TOP2A, AFAP1, NFE2L2, CYTH2, PARD6A, PA2G4, GJA1, PDLIM5, TIAM1, GABRA1 (tumor) | PRKCG, MAP2K4, GRIN2D, RGS2, STAT3, YWHAE, YWHAB, MARK4, ADRBK1, GRIN1, DDX58, EXOC5, TOP2A, GRM5, EIF4E, OCLN, CYTH2, PARD6A, NOXA1, GSK3A, CCHCR1 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| PRKCG, MAP2K4, GRIN2D, RGS2, YWHAE, GABRA4, PTPN1, PARD3, ADRBK1, GRIN1, DAB2, DDX58, IRS1, PICK1, STXBP1, GRM5, VTN, GJA3, PARD6A, PDLIM5, NRGN (tumor) | PRKCG, MAP2K4, GRIN2D, RGS2, CDC42, MARK4, ADRBK1, DAB2, PICK1, STXBP1, EXOC5, PEBP1, TOP2A, VTN, NUMB, OCLN, CYTH2, PA2G4, HABP4, GJA1, CHAT (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| PRKCG, UBC, DVL2, GRIN2D, STAT3, GABRA4, CDC42, PARD3, ADRBK1, GRIN1, DAB2, IRS1, PICK1, EXOC5, AFAP1, NFE2L2, NUMB, CYTH2, PA2G4, NOXA1, CCHCR1 (tumor) | PRKCG, DVL2, GRIN2D, YWHAE, CDC42, PARD3, GRIN1, DAB2, DDX58, IRS1, PICK1, EXOC5, GRM5, PARD6B, EIF4E, OCLN, PNMA1, CYTH2, HABP4, NOXA1, CCHCR1 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| PRKCG, DVL2, RGS2, GRIN2B, PTPN1, ANXA7, YWHAB, DAB2, IRS1, PPP1R14A, TOP2A, GRM5, VTN, EIF4E, PNMA1, CYTH2, PA2G4, HABP4, NOXA1, GJA1, NRGN (tumor) | PRKCG, DVL2, GRIN2D, YWHAE, GABRA4, ANXA7, GRIN1, IRS1, GRIA4, PEBP1, TOP2A, VTN, EIF4E, GJA3, PNMA1, CYTH2, PA2G4, PDLIM5, GSK3A, NRGN, GABRA1 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| PRKCG, UBC, MAP2K4, RGS2, STAT3, GRIN2B, PTPN1, ANXA7, PARD3, DAB2, STXBP1, PEBP1, GRM5, NFE2L2, PARD6B, OCLN, CYTH2, HABP4, GJA1, CD5, CCHCR1 (tumor) | PRKCG, MAP2K4, GRIN2D, YWHAE, CDC42, ANXA7, MARK4, ADRBK1, PEBP1, VTN, PARD6B, GJA3, OCLN, PNMA1, CYTH2, NOXA1, CD5, PDLIM5, GSK3A, TIAM1, CCHCR1 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| PRKCG, UBC, MAP2K4, YWHAG, RGS2, STAT3, PTPN1, YWHAB, MARK4, ADRBK1, DDX58, STXBP1, PEBP1, GRM5, NFE2L2, PARD6B, GJA3, CYTH2, GJA1, CD5, GSK3A (tumor) | PRKCG, MAP2K4, YWHAG, GRIN2D, YWHAE, GABRA4, ANXA7, PARD3, GRIN1, GRIA4, PPP1R14A, EXOC5, NFE2L2, EIF4E, CYTH2, PARD6A, HABP4, NOXA1, CD5, CASR, CCHCR1 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| PRKCG, GRIN2D, GABRA4, CDC42, GRIN2B, ANXA7, YWHAB, MARK4, ADRBK1, PICK1, EXOC5, PARD6B, NUMB, EIF4E, GJA3, NOXA1, CD5, NRGN, TIAM1, CCHCR1, GABRA1 (tumor) | PRKCG, UBC, MAP2K4, YWHAG, ANXA7, YWHAB, PPP1R14A, EXOC5, AFAP1, NFE2L2, VTN, NUMB, EIF4E, OCLN, CYTH2, HABP4, NOXA1, CD5, GSK3A, NRGN, CCHCR1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| PRKCG, MAP2K4, YWHAG, GRIN2D, PARD3, ADRBK1, GRIA4, PICK1, EXOC5, VTN, NUMB, EIF4E, GJA3, NOXA1, GJA1, CD5, PDLIM5, NRGN, CASR, CCHCR1, GABRA1 (tumor) | PRKCG, UBC, YWHAG, STAT3, YWHAE, GABRA4, ANXA7, ADRBK1, GRIN1, DDX58, GRIA4, PICK1, EXOC5, PEBP1, AFAP1, VTN, EIF4E, OCLN, CD5, GSK3A, TIAM1 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| PRKCG, UBC, MAP2K4, YWHAG, RGS2, CDC42, PTPN1, ANXA7, YWHAB, ADRBK1, GRIN1, DDX58, IRS1, PEBP1, TOP2A, AFAP1, OCLN, CYTH2, PARD6A, CD5, TIAM1 (tumor) | PRKCG, MAP2K4, GRIN2D, RGS2, YWHAE, PTPN1, ANXA7, PARD3, ADRBK1, DAB2, DDX58, STXBP1, EXOC5, PEBP1, TOP2A, AFAP1, NFE2L2, PARD6B, EIF4E, OCLN, CD5 (normal) |
 |  |
| Top |
| TissGeneProg for PRKCG |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for PRKCG |
| TissGeneDrug for PRKCG |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for PRKCG |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0087012 | Ataxia, Spinocerebellar | 27 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0524851 | Neurodegenerative Disorders | 13 | BeFree,LHGDN |
| umls:C0007758 | Cerebellar Ataxia | 9 | BeFree,LHGDN |
| umls:C0004134 | Ataxia | 6 | BeFree |
| umls:C0027066 | Myoclonus | 6 | BeFree |
| umls:C0018790 | Cardiac Arrest | 5 | BeFree |
| umls:C1854369 | Spinocerebellar ataxia 14 | 5 | BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT |
| umls:C0007760 | Cerebellar Diseases | 2 | BeFree |
| umls:C0013421 | Dystonia | 2 | BeFree |
| umls:C0029463 | Osteosarcoma | 2 | BeFree |
| umls:C0393593 | Dystonia Disorders | 2 | BeFree |
| umls:C0585442 | Osteosarcoma of bone | 2 | BeFree |
| umls:C0020429 | Hyperalgesia | 1 | CTD_human |
| umls:C0023890 | Liver Cirrhosis | 1 | GAD |
| umls:C0027796 | Neuralgia | 1 | BeFree |
| umls:C0028738 | Nystagmus | 1 | BeFree |
| umls:C0035333 | Retinitis | 1 | LHGDN |
| umls:C0035334 | Retinitis Pigmentosa | 1 | LHGDN |
| umls:C0036341 | Schizophrenia | 1 | LHGDN |
| umls:C0242422 | Parkinsonian Disorders | 1 | BeFree |
| umls:C0600452 | Hepatopulmonary Syndrome | 1 | GAD |
| umls:C0751214 | Hyperalgesia, Thermal | 1 | BeFree |
| umls:C0751837 | Gait Ataxia | 1 | BeFree |
| umls:C0752120 | Spinocerebellar Ataxia Type 1 | 1 | BeFree |
| umls:C1519689 | Tumor Promotion | 1 | BeFree |
| umls:C1720189 | Episodic Ataxia | 1 | BeFree |
| umls:C2936719 | Mechanical Allodynia | 1 | BeFree |
| umls:C3714756 | Intellectual Disability | 1 | CTD_human |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |