TissGeneSummary for PRKCG |
Gene summary |
Basic gene information | Gene symbol | PRKCG |
Gene name | protein kinase C, gamma | |
Synonyms | PKC-gamma|PKCC|PKCG|SCA14 | |
Cytomap | UCSC genome browser: 19q13.4 | |
Type of gene | protein-coding | |
RefGenes | NM_002739.3, | |
Description | protein kinase C gamma type | |
Modification date | 20141219 | |
dbXrefs | MIM : 176980 | |
HGNC : HGNC | ||
Ensembl : ENSG00000126583 | ||
HPRD : 01502 | ||
Vega : OTTHUMG00000064846 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PRKCG | |
BioGPS: 5582 | ||
Pathway | NCI Pathway Interaction Database: PRKCG | |
KEGG: PRKCG | ||
REACTOME: PRKCG | ||
Pathway Commons: PRKCG | ||
Context | iHOP: PRKCG | |
ligand binding site mutation search in PubMed: PRKCG | ||
UCL Cancer Institute: PRKCG | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of PRKCG | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0016310 | phosphorylation | 15808853 | GO:0031397 | negative regulation of protein ubiquitination | 15808853 | GO:0032425 | positive regulation of mismatch repair | 15808853 | GO:0042177 | negative regulation of protein catabolic process | 15808853 | GO:0016310 | phosphorylation | 15808853 | GO:0031397 | negative regulation of protein ubiquitination | 15808853 | GO:0032425 | positive regulation of mismatch repair | 15808853 | GO:0042177 | negative regulation of protein catabolic process | 15808853 |
Top |
TissGeneExp for PRKCG |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
STAD | 1.288001111 | -1.333042639 | 2.62104375 | 1.29E-05 | 0.000144339 |
COAD | 0.597807121 | -1.820673648 | 2.418480769 | 2.66E-05 | 0.000110171 |
Top |
TissGene-miRNA for PRKCG |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for PRKCG |
TissGeneSNV for PRKCG |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R345C | STAD | 3 |
p.S260F | SKCM | 2 |
p.R181H | READ | 2 |
p.R624* | STAD | 1 |
p.H493Q | LUAD | 1 |
p.H456Y | SKCM | 1 |
p.D10N | UCEC | 1 |
p.F327S | HNSC | 1 |
p.R205Q | SKCM | 1 |
p.V506I | BLCA | 1 |
p.V315M | GBM | 1 |
p.P188L | SKCM | 1 |
p.T218M | STAD | 1 |
p.K197Q | LUAD | 1 |
p.S109R | LUAD | 1 |
p.H682P | LUAD | 1 |
p.A461T | UCEC | 1 |
p.Q530R | STAD | 1 |
p.C305F | BLCA | 1 |
p.P97R | LUAD | 1 |
p.D54Y | HNSC | 1 |
p.R580Q | COAD | 1 |
p.S577L | STAD | 1 |
p.F646L | HNSC | 1 |
p.W245* | KIRC | 1 |
p.E32K | SKCM | 1 |
p.P194S | HNSC | 1 |
p.R336C | STAD | 1 |
p.A461V | COAD | 1 |
p.G533E | LUAD | 1 |
p.A180V | STAD | 1 |
p.V543I | CESC | 1 |
p.L124P | LUSC | 1 |
p.Y431F | SKCM | 1 |
p.E32K | LUAD | 1 |
p.R239Q | ESCA | 1 |
p.R98Q | PAAD | 1 |
p.H51Y | UCEC | 1 |
p.R370C | PAAD | 1 |
p.D246E | LGG | 1 |
p.G190R | STAD | 1 |
p.P327H | LUSC | 1 |
p.G14R | SKCM | 1 |
p.R205Q | GBM | 1 |
p.G450C | UCEC | 1 |
p.A269P | STAD | 1 |
p.P15S | BLCA | 1 |
p.Y521N | LUAD | 1 |
p.M487I | HNSC | 1 |
p.D193N | SKCM | 1 |
p.D603E | LIHC | 1 |
p.R580W | LAML | 1 |
p.R659L | SKCM | 1 |
p.R8* | BLCA | 1 |
p.M501I | LUAD | 1 |
p.D95Y | LUSC | 1 |
p.S540F | SKCM | 1 |
p.R686C | UCS | 1 |
p.D498N | STAD | 1 |
p.G23W | KIRP | 1 |
p.R370G | HNSC | 1 |
p.P334L | SKCM | 1 |
p.P303L | HNSC | 1 |
p.T94M | PRAD | 1 |
p.D248N | SKCM | 1 |
p.P308S | COAD | 1 |
p.G533R | SKCM | 1 |
p.W245X | KIRC | 1 |
p.L4M | STAD | 1 |
p.S422C | KIRP | 1 |
p.G551* | UCEC | 1 |
p.E375K | LUSC | 1 |
p.S35N | LUSC | 1 |
p.R238G | SKCM | 1 |
p.E435K | SKCM | 1 |
p.S600* | SARC | 1 |
p.G517R | SKCM | 1 |
p.F362L | UCEC | 1 |
p.E79K | COAD | 1 |
p.G588E | SKCM | 1 |
p.D559V | LIHC | 1 |
p.R181H | KICH | 1 |
p.G406V | LUAD | 1 |
p.D187N | SKCM | 1 |
p.G19R | HNSC | 1 |
p.N505K | LUSC | 1 |
p.E569K | HNSC | 1 |
p.I201F | STAD | 1 |
p.R314W | STAD | 1 |
p.P185S | SKCM | 1 |
p.E454K | SKCM | 1 |
p.C502R | COAD | 1 |
p.K380N | LUAD | 1 |
p.D537G | LUAD | 1 |
p.R76* | BLCA | 1 |
p.T510M | HNSC | 1 |
p.A663V | THYM | 1 |
p.S11T | HNSC | 1 |
p.A650V | COAD | 1 |
p.Y460* | LUAD | 1 |
p.M186T | UCEC | 1 |
p.Y521C | HNSC | 1 |
p.T510M | COAD | 1 |
p.P290L | SKCM | 1 |
p.D254N | UCEC | 1 |
p.C286* | LIHC | 1 |
p.D95Y | LUAD | 1 |
p.R513L | HNSC | 1 |
p.C317* | LUAD | 1 |
p.R213Q | SKCM | 1 |
p.D537Y | STAD | 1 |
p.K232M | UCEC | 1 |
p.R98Q | DLBC | 1 |
p.M186V | HNSC | 1 |
p.M129I | BRCA | 1 |
p.P554S | HNSC | 1 |
p.S321F | SKCM | 1 |
p.M129I | HNSC | 1 |
p.R76Q | SKCM | 1 |
p.S322T | ESCA | 1 |
p.L311F | LUAD | 1 |
p.A170V | LIHC | 1 |
p.P628L | ESCA | 1 |
p.G23E | COAD | 1 |
p.D193N | OV | 1 |
p.S687G | DLBC | 1 |
p.E454K | BLCA | 1 |
p.T218R | LUSC | 1 |
p.Q62H | LUSC | 1 |
p.A458E | KIRC | 1 |
p.S535F | LIHC | 1 |
p.E79K | UCEC | 1 |
p.G533V | LUSC | 1 |
p.E79K | SKCM | 1 |
p.F680L | BLCA | 1 |
p.G273C | STAD | 1 |
p.M366L | BRCA | 1 |
Top |
TissGeneCNV for PRKCG |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for PRKCG |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Top |
TissGeneNet for PRKCG |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for PRKCG |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for PRKCG |
TissGeneDrug for PRKCG |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for PRKCG |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0087012 | Ataxia, Spinocerebellar | 27 | BeFree,CTD_human,GAD,LHGDN |
umls:C0524851 | Neurodegenerative Disorders | 13 | BeFree,LHGDN |
umls:C0007758 | Cerebellar Ataxia | 9 | BeFree,LHGDN |
umls:C0004134 | Ataxia | 6 | BeFree |
umls:C0027066 | Myoclonus | 6 | BeFree |
umls:C0018790 | Cardiac Arrest | 5 | BeFree |
umls:C1854369 | Spinocerebellar ataxia 14 | 5 | BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT |
umls:C0007760 | Cerebellar Diseases | 2 | BeFree |
umls:C0013421 | Dystonia | 2 | BeFree |
umls:C0029463 | Osteosarcoma | 2 | BeFree |
umls:C0393593 | Dystonia Disorders | 2 | BeFree |
umls:C0585442 | Osteosarcoma of bone | 2 | BeFree |
umls:C0020429 | Hyperalgesia | 1 | CTD_human |
umls:C0023890 | Liver Cirrhosis | 1 | GAD |
umls:C0027796 | Neuralgia | 1 | BeFree |
umls:C0028738 | Nystagmus | 1 | BeFree |
umls:C0035333 | Retinitis | 1 | LHGDN |
umls:C0035334 | Retinitis Pigmentosa | 1 | LHGDN |
umls:C0036341 | Schizophrenia | 1 | LHGDN |
umls:C0242422 | Parkinsonian Disorders | 1 | BeFree |
umls:C0600452 | Hepatopulmonary Syndrome | 1 | GAD |
umls:C0751214 | Hyperalgesia, Thermal | 1 | BeFree |
umls:C0751837 | Gait Ataxia | 1 | BeFree |
umls:C0752120 | Spinocerebellar Ataxia Type 1 | 1 | BeFree |
umls:C1519689 | Tumor Promotion | 1 | BeFree |
umls:C1720189 | Episodic Ataxia | 1 | BeFree |
umls:C2936719 | Mechanical Allodynia | 1 | BeFree |
umls:C3714756 | Intellectual Disability | 1 | CTD_human |