TissGeneSummary for RNF17 |
Gene summary |
Basic gene information | Gene symbol | RNF17 |
Gene name | ring finger protein 17 | |
Synonyms | Mmip-2|SPATA23|TDRD4 | |
Cytomap | UCSC genome browser: 13q12.12 | |
Type of gene | protein-coding | |
RefGenes | NM_001184993.1, NM_031277.2,NM_031994.1, | |
Description | RING finger protein 17spermatogenesis associated 23tudor domain containing 4tudor domain-containing protein 4 | |
Modification date | 20141207 | |
dbXrefs | MIM : 605793 | |
HGNC : HGNC | ||
Ensembl : ENSG00000132972 | ||
HPRD : 05779 | ||
HPRD : 15482 | ||
Vega : OTTHUMG00000016589 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RNF17 | |
BioGPS: 56163 | ||
Pathway | NCI Pathway Interaction Database: RNF17 | |
KEGG: RNF17 | ||
REACTOME: RNF17 | ||
Pathway Commons: RNF17 | ||
Context | iHOP: RNF17 | |
ligand binding site mutation search in PubMed: RNF17 | ||
UCL Cancer Institute: RNF17 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of RNF17 | ||
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for RNF17 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for RNF17 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for RNF17 |
TissGeneSNV for RNF17 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E712K | SKCM | 4 |
p.W1229* | SKCM | 2 |
p.I710V | LGG | 2 |
p.D841N | SKCM | 2 |
p.R1238K | SKCM | 1 |
p.T562I | SKCM | 1 |
p.R214K | SKCM | 1 |
p.M609I | SKCM | 1 |
p.E319K | SKCM | 1 |
p.D739Y | UCEC | 1 |
p.H1373Y | STAD | 1 |
p.R1538Q | UCEC | 1 |
p.P1410S | SKCM | 1 |
p.E1505D | HNSC | 1 |
p.S1406Y | UCEC | 1 |
p.R1246H | STAD | 1 |
p.A1392G | LUSC | 1 |
p.E1105* | UCEC | 1 |
p.T1043A | STAD | 1 |
p.G617D | SKCM | 1 |
p.P1533L | SKCM | 1 |
p.V1451A | STAD | 1 |
p.E1560G | STAD | 1 |
p.E717K | SKCM | 1 |
p.E163K | UCEC | 1 |
p.G467S | SKCM | 1 |
p.S161R | STAD | 1 |
p.A642V | BLCA | 1 |
p.T562S | SKCM | 1 |
p.R264Q | COAD | 1 |
p.D440N | COAD | 1 |
p.E1592K | SKCM | 1 |
p.H1535Y | CESC | 1 |
p.A154T | STAD | 1 |
p.F1159L | KIRP | 1 |
p.Q178K | LUSC | 1 |
p.R986K | STAD | 1 |
p.Q16* | SKCM | 1 |
p.E333K | SKCM | 1 |
p.D873Y | UCEC | 1 |
p.T1478M | GBM | 1 |
p.E808* | LUAD | 1 |
p.D1604N | BLCA | 1 |
p.P846S | SKCM | 1 |
p.D338Y | ACC | 1 |
p.T1072I | STAD | 1 |
p.A547T | STAD | 1 |
p.D1321Y | ESCA | 1 |
p.P1077S | LGG | 1 |
p.F693L | UCS | 1 |
p.R433W | UCEC | 1 |
p.D739N | SKCM | 1 |
p.V728I | SKCM | 1 |
p.C733Y | LIHC | 1 |
p.E1560K | SKCM | 1 |
p.G1343R | SKCM | 1 |
p.L1547R | SKCM | 1 |
p.S6T | MESO | 1 |
p.S1437C | CESC | 1 |
p.E720Q | LUAD | 1 |
p.E232D | READ | 1 |
p.S456L | SKCM | 1 |
p.S523T | SKCM | 1 |
p.N495D | UCEC | 1 |
p.A1236E | LUAD | 1 |
p.A745G | BRCA | 1 |
p.K1499E | STAD | 1 |
p.C209F | LUAD | 1 |
p.R1538W | PCPG | 1 |
p.R482G | BLCA | 1 |
p.E994K | BLCA | 1 |
p.D426Y | READ | 1 |
p.C428* | LUAD | 1 |
p.G36E | CESC | 1 |
p.I262V | UCEC | 1 |
p.I263N | LUSC | 1 |
p.R1242C | SKCM | 1 |
p.A239T | UCEC | 1 |
p.R775H | UCEC | 1 |
p.P1504S | SKCM | 1 |
p.D1479N | SKCM | 1 |
p.P361L | SKCM | 1 |
p.E811K | SKCM | 1 |
p.S1391L | GBM | 1 |
p.D779N | SKCM | 1 |
p.E597K | SKCM | 1 |
p.D338N | COAD | 1 |
p.E1213K | SKCM | 1 |
p.D338N | SARC | 1 |
p.H895R | LUAD | 1 |
p.P502L | SKCM | 1 |
p.F660I | LIHC | 1 |
p.P1595S | HNSC | 1 |
p.E1408K | COAD | 1 |
p.D641V | HNSC | 1 |
p.L1018V | COAD | 1 |
p.428_429CH>*N | LUAD | 1 |
p.I687M | SKCM | 1 |
p.P899A | CESC | 1 |
p.L1554P | COAD | 1 |
p.R264P | SKCM | 1 |
p.Q322R | STAD | 1 |
p.H46Y | LUSC | 1 |
p.D1604N | ESCA | 1 |
p.D1263Y | KIRC | 1 |
p.K778Q | HNSC | 1 |
p.Q911H | ESCA | 1 |
p.S250L | SKCM | 1 |
p.E48K | SKCM | 1 |
p.K108N | COAD | 1 |
p.L1543R | SKCM | 1 |
p.P1508S | SKCM | 1 |
p.K116N | COAD | 1 |
p.W1332* | SKCM | 1 |
p.Y914D | SKCM | 1 |
p.P1406S | SKCM | 1 |
p.N1017K | GBM | 1 |
p.G36R | SKCM | 1 |
p.Y1602H | SKCM | 1 |
p.R1106K | SKCM | 1 |
p.E1213K | BLCA | 1 |
p.N1468T | BLCA | 1 |
p.E1184Q | BLCA | 1 |
p.G397R | SKCM | 1 |
p.K605N | UCEC | 1 |
p.A1046V | LUAD | 1 |
p.V1182I | UCEC | 1 |
p.R744Q | LGG | 1 |
p.V1252D | UCEC | 1 |
p.T1073P | PAAD | 1 |
p.Q856K | LUSC | 1 |
p.E860K | SKCM | 1 |
p.K610N | COAD | 1 |
p.A1463V | UCEC | 1 |
p.L1014R | ESCA | 1 |
p.R1538W | LGG | 1 |
p.E947* | UCEC | 1 |
p.E294G | OV | 1 |
p.V611I | UCEC | 1 |
p.W1229* | LUAD | 1 |
p.G19E | SKCM | 1 |
p.E954K | SKCM | 1 |
p.C59F | HNSC | 1 |
p.M1210I | LIHC | 1 |
p.N1291D | COAD | 1 |
p.K812T | STAD | 1 |
p.P1073S | LGG | 1 |
p.N585H | HNSC | 1 |
p.K746N | STAD | 1 |
p.L1407V | CESC | 1 |
p.L578F | LIHC | 1 |
p.H429N | LUAD | 1 |
p.W1042* | SKCM | 1 |
p.S1371L | SKCM | 1 |
p.K1155E | BRCA | 1 |
p.D519V | LUAD | 1 |
p.E465K | SKCM | 1 |
p.R1089C | GBM | 1 |
p.R1481I | UCEC | 1 |
p.E597Q | HNSC | 1 |
p.E232Q | BLCA | 1 |
p.E1376K | COAD | 1 |
p.V324F | UCEC | 1 |
p.E1596K | SKCM | 1 |
p.I513V | SARC | 1 |
p.V602I | SKCM | 1 |
p.C1291R | HNSC | 1 |
p.V607F | LUAD | 1 |
p.M99I | SKCM | 1 |
p.V734A | STAD | 1 |
p.M1591T | HNSC | 1 |
p.H1420Y | LIHC | 1 |
p.E150G | LUAD | 1 |
p.Q84H | ESCA | 1 |
p.D258Y | THYM | 1 |
p.R1246C | SKCM | 1 |
p.K133M | LUAD | 1 |
p.E946Q | LUAD | 1 |
p.R17* | STAD | 1 |
p.N375H | READ | 1 |
p.P359T | ESCA | 1 |
p.P502S | SKCM | 1 |
p.L695V | CESC | 1 |
p.D730Y | READ | 1 |
p.R85S | LUAD | 1 |
p.A1256T | UCEC | 1 |
p.P1471S | SKCM | 1 |
p.P1475S | SKCM | 1 |
p.S904F | GBM | 1 |
p.H45Y | ACC | 1 |
p.E100K | SKCM | 1 |
p.E487X | COAD | 1 |
p.I853V | PRAD | 1 |
p.R981K | SKCM | 1 |
p.P10L | SKCM | 1 |
p.I672V | BLCA | 1 |
p.S355G | LUAD | 1 |
p.G397E | SKCM | 1 |
p.C51Y | LUAD | 1 |
p.S1520* | HNSC | 1 |
p.S250L | UCEC | 1 |
p.Y714C | STAD | 1 |
p.D1445G | LGG | 1 |
p.L843V | BLCA | 1 |
p.I70V | COAD | 1 |
p.N300K | GBM | 1 |
p.E153X | READ | 1 |
p.R497G | KIRP | 1 |
p.A28T | LUAD | 1 |
p.F693I | KIRP | 1 |
p.C824F | HNSC | 1 |
p.D218N | COAD | 1 |
p.K133N | UCEC | 1 |
p.R613I | THYM | 1 |
p.R454K | SKCM | 1 |
p.P460S | SKCM | 1 |
p.L1389F | ESCA | 1 |
p.K115T | STAD | 1 |
p.A1498E | LUSC | 1 |
p.G467_splice | GBM | 1 |
p.W1328X | SKCM | 1 |
p.G483R | SKCM | 1 |
p.D580Y | UCEC | 1 |
p.T68A | HNSC | 1 |
p.L1004V | BLCA | 1 |
p.P846S | LIHC | 1 |
p.P490L | SKCM | 1 |
p.D401N | LUSC | 1 |
p.E917A | PAAD | 1 |
p.D113N | READ | 1 |
p.F430I | SKCM | 1 |
p.K206N | READ | 1 |
p.K206M | UCEC | 1 |
p.W757C | UCEC | 1 |
p.S1429F | COAD | 1 |
p.E676K | SKCM | 1 |
p.L1524Q | LIHC | 1 |
p.I1308T | BLCA | 1 |
p.G169E | SKCM | 1 |
p.T1478A | STAD | 1 |
p.S42L | SKCM | 1 |
p.P341R | STAD | 1 |
p.S852I | LUAD | 1 |
p.G1339R | SKCM | 1 |
p.S1051* | UCEC | 1 |
p.F376V | STAD | 1 |
p.P1331S | SKCM | 1 |
p.R34M | PAAD | 1 |
p.V531A | HNSC | 1 |
p.R980X | COAD | 1 |
p.H686Y | UCEC | 1 |
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TissGeneCNV for RNF17 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for RNF17 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for RNF17 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for RNF17 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for RNF17 |
TissGeneDrug for RNF17 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for RNF17 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |