TissGeneSummary for STK31 |
Gene summary |
Basic gene information | Gene symbol | STK31 |
Gene name | serine/threonine kinase 31 | |
Synonyms | SGK396|TDRD8 | |
Cytomap | UCSC genome browser: 7p15.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001260504.1, NM_001260505.1,NM_031414.4,NM_032944.3,NR_048542.1, NM_001122833.1, | |
Description | serine/threonine-protein kinase 31serine/threonine-protein kinase NYD-SPKsugen kinase 396tudor domain containing 8 | |
Modification date | 20141207 | |
dbXrefs | MIM : 605790 | |
HGNC : HGNC | ||
Ensembl : ENSG00000196335 | ||
HPRD : 10427 | ||
Vega : OTTHUMG00000023053 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_STK31 | |
BioGPS: 56164 | ||
Pathway | NCI Pathway Interaction Database: STK31 | |
KEGG: STK31 | ||
REACTOME: STK31 | ||
Pathway Commons: STK31 | ||
Context | iHOP: STK31 | |
ligand binding site mutation search in PubMed: STK31 | ||
UCL Cancer Institute: STK31 | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of STK31 | Identification of cell-specific targets of sumoylation during mouse spermatogenesis. Reproduction. 2016 Feb;151(2):149-66. doi: 10.1530/REP-15-0239. (pmid:26701181) go to article | |
Description by TissGene annotations | Protective TissGene in OS Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for STK31 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | 1.266782354 | -2.611106108 | 3.877888462 | 4.26E-11 | 6.81E-10 |
LUSC | 1.197228357 | -0.120030467 | 1.317258824 | 2.69E-06 | 6.45E-06 |
STAD | 0.8284487 | -2.3045263 | 3.132975 | 5.27E-10 | 4.74E-08 |
HNSC | 0.471659456 | -1.549617289 | 2.021276744 | 2.30E-06 | 1.57E-05 |
LUAD | 1.520555165 | -0.132058628 | 1.652613793 | 2.13E-09 | 1.08E-08 |
BLCA | 0.424588831 | -2.167990116 | 2.592578947 | 0.000371 | 0.003173477 |
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TissGene-miRNA for STK31 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for STK31 |
TissGeneSNV for STK31 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E470K | SKCM | 3 |
p.E151K | SKCM | 3 |
p.S805L | SKCM | 3 |
p.D31N | UCEC | 2 |
p.M341I | SKCM | 2 |
p.G94E | SKCM | 2 |
p.G879E | SKCM | 2 |
p.E155* | UCEC | 2 |
p.E807K | SKCM | 2 |
p.H570Y | SKCM | 2 |
p.D549N | SKCM | 2 |
p.E715K | SKCM | 2 |
p.V501A | LGG | 1 |
p.D627N | STAD | 1 |
p.R705Q | SKCM | 1 |
p.G465V | SARC | 1 |
p.E991K | SKCM | 1 |
p.H661Y | SKCM | 1 |
p.E961K | SKCM | 1 |
p.R467C | KIRC | 1 |
p.S959R | STAD | 1 |
p.R859Q | BLCA | 1 |
p.C503W | LUSC | 1 |
p.S828L | PAAD | 1 |
p.P780S | SKCM | 1 |
p.S7F | SKCM | 1 |
p.P721L | SKCM | 1 |
p.I373M | PAAD | 1 |
p.H17D | COAD | 1 |
p.S560* | HNSC | 1 |
p.M804I | KIRC | 1 |
p.I35M | BLCA | 1 |
p.P151S | CESC | 1 |
p.P128S | CESC | 1 |
p.D69H | HNSC | 1 |
p.M781I | KIRC | 1 |
p.E642Q | BLCA | 1 |
p.P128L | SKCM | 1 |
p.V68D | LUSC | 1 |
p.K446Q | COAD | 1 |
p.S137C | ESCA | 1 |
p.E210D | UCEC | 1 |
p.E772K | CESC | 1 |
p.K245N | COAD | 1 |
p.Q93H | LUSC | 1 |
p.K278R | SKCM | 1 |
p.R101Q | SKCM | 1 |
p.G411R | BLCA | 1 |
p.A819V | CHOL | 1 |
p.A524T | LUAD | 1 |
p.D175N | PAAD | 1 |
p.G287D | LUSC | 1 |
p.L101M | THYM | 1 |
p.P769L | SKCM | 1 |
p.T187A | UCEC | 1 |
p.G163E | SKCM | 1 |
p.I21F | STAD | 1 |
p.E929G | OV | 1 |
p.V373M | LGG | 1 |
p.E349K | SKCM | 1 |
p.E238K | COAD | 1 |
p.G465E | SKCM | 1 |
p.E588Q | BLCA | 1 |
p.A696T | UCEC | 1 |
p.D764E | ESCA | 1 |
p.E665Q | BLCA | 1 |
p.S183C | OV | 1 |
p.P218L | SKCM | 1 |
p.E389D | COAD | 1 |
p.M701I | SKCM | 1 |
p.E978Q | HNSC | 1 |
p.R728* | GBM | 1 |
p.A312V | SKCM | 1 |
p.P884S | COAD | 1 |
p.D198N | PAAD | 1 |
p.R988K | SKCM | 1 |
p.E200V | KIRC | 1 |
p.S67F | LIHC | 1 |
p.Q564* | BLCA | 1 |
p.A710V | SKCM | 1 |
p.E286K | BLCA | 1 |
p.E508* | LUAD | 1 |
p.S368L | SKCM | 1 |
p.E536D | LUAD | 1 |
p.D381N | UCEC | 1 |
p.C776F | LUAD | 1 |
p.L268* | SKCM | 1 |
p.S909* | HNSC | 1 |
p.Q422H | LUAD | 1 |
p.E704A | SKCM | 1 |
p.I617T | UCEC | 1 |
p.N654D | STAD | 1 |
p.Q207H | BLCA | 1 |
p.D454Y | UCEC | 1 |
p.E14X | STAD | 1 |
p.P624S | STAD | 1 |
p.Q135H | LGG | 1 |
p.E353A | PAAD | 1 |
p.D481V | HNSC | 1 |
p.G410* | OV | 1 |
p.S886* | HNSC | 1 |
p.E681D | UCEC | 1 |
p.E97K | SKCM | 1 |
p.E973* | LUAD | 1 |
p.N863S | SKCM | 1 |
p.Q858H | LGG | 1 |
p.T349A | BRCA | 1 |
p.R211M | LGG | 1 |
p.L931F | SKCM | 1 |
p.P241H | LUSC | 1 |
p.L630I | UCEC | 1 |
p.R747P | BRCA | 1 |
p.V3I | COAD | 1 |
p.Q50H | LUAD | 1 |
p.M961I | UCEC | 1 |
p.Q445R | LIHC | 1 |
p.E573K | SKCM | 1 |
p.T967A | SKCM | 1 |
p.Q48H | COAD | 1 |
p.R441I | UCEC | 1 |
p.C983* | LGG | 1 |
p.A757D | LGG | 1 |
p.X1020S | UCS | 1 |
p.A752V | LUAD | 1 |
p.R865C | BRCA | 1 |
p.S454C | CESC | 1 |
p.D358N | READ | 1 |
p.K627N | UCS | 1 |
p.E14* | STAD | 1 |
p.S861L | LUAD | 1 |
p.S628N | SKCM | 1 |
p.K650N | UCS | 1 |
p.D787E | ESCA | 1 |
p.S114C | ESCA | 1 |
p.R483K | SKCM | 1 |
p.S538I | LUAD | 1 |
p.Q550* | SKCM | 1 |
p.A319T | UCEC | 1 |
p.S537* | HNSC | 1 |
p.I179S | UCEC | 1 |
p.S561I | LUAD | 1 |
p.K388* | LUAD | 1 |
p.M835I | BRCA | 1 |
p.I413R | LUAD | 1 |
p.K357N | LUSC | 1 |
p.L242F | LUSC | 1 |
p.I350T | SKCM | 1 |
p.D130H | HNSC | 1 |
p.G377R | SKCM | 1 |
p.Q168H | LUAD | 1 |
p.V786I | SKCM | 1 |
p.E533K | SKCM | 1 |
p.A547T | LUAD | 1 |
p.K591N | UCEC | 1 |
p.E972K | SKCM | 1 |
p.E259K | SKCM | 1 |
p.K325R | LIHC | 1 |
p.S90F | LIHC | 1 |
p.R467C | GBM | 1 |
p.D153H | HNSC | 1 |
p.P128S | SKCM | 1 |
p.E679* | LUAD | 1 |
p.E149K | SKCM | 1 |
p.Q550X | SKCM | 1 |
p.S805L | PAAD | 1 |
p.S514F | LIHC | 1 |
p.E433V | LUSC | 1 |
p.K256R | LUAD | 1 |
p.L468X | COAD | 1 |
p.A485T | STAD | 1 |
p.K233R | LUAD | 1 |
p.R652H | COAD | 1 |
p.K473X | COAD | 1 |
p.L943V | LUSC | 1 |
p.D381Y | BRCA | 1 |
p.T753I | SKCM | 1 |
p.K365* | LUAD | 1 |
p.I350M | PAAD | 1 |
p.E376A | PAAD | 1 |
p.S227* | BLCA | 1 |
p.A992G | BLCA | 1 |
p.P802T | LUAD | 1 |
p.A774T | UCEC | 1 |
p.K633N | UCEC | 1 |
p.N598K | COAD | 1 |
p.P405Q | LUSC | 1 |
p.D92Y | COAD | 1 |
p.P825T | LUAD | 1 |
p.R444C | KIRC | 1 |
p.S937L | SKCM | 1 |
p.A322V | HNSC | 1 |
p.S884L | LUAD | 1 |
p.A345D | UCEC | 1 |
p.N993S | SKCM | 1 |
p.R728* | UCEC | 1 |
p.T558S | BRCA | 1 |
p.M724V | LIHC | 1 |
p.T844R | KIRC | 1 |
p.N836T | BLCA | 1 |
p.K1009M | LUSC | 1 |
p.G763R | SKCM | 1 |
p.Q587* | BLCA | 1 |
p.E430D | SKCM | 1 |
p.S586G | OV | 1 |
p.R444C | COAD | 1 |
p.I394L | LUSC | 1 |
p.D849N | SKCM | 1 |
p.R97K | BRCA | 1 |
p.R882* | GBM | 1 |
p.E866G | GBM | 1 |
p.A462T | STAD | 1 |
p.E223V | KIRC | 1 |
p.S514F | SKCM | 1 |
p.Q445X | THYM | 1 |
p.M781L | COAD | 1 |
p.A10S | PAAD | 1 |
p.E762K | HNSC | 1 |
p.D887N | SKCM | 1 |
p.R529I | UCEC | 1 |
p.I528T | LGG | 1 |
p.S600I | COAD | 1 |
p.R499C | SKCM | 1 |
p.C983X | LGG | 1 |
p.H833Y | SKCM | 1 |
p.G911R | SKCM | 1 |
p.G434R | BLCA | 1 |
p.N629Y | BLCA | 1 |
p.N677D | STAD | 1 |
p.P913L | SKCM | 1 |
p.M701V | LIHC | 1 |
p.S541L | BRCA | 1 |
p.D92H | HNSC | 1 |
p.E806K | SKCM | 1 |
p.H328Y | SKCM | 1 |
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TissGeneCNV for STK31 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for STK31 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-A8-A08R-01A | SLC25A13-STK31 | Out-of-frame | Chr7:95906508 | Chr7:23792336 |
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TissGeneNet for STK31 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for STK31 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for STK31 |
TissGeneDrug for STK31 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for STK31 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0009402 | Colorectal Carcinoma | 2 | BeFree |
umls:C0153594 | Malignant neoplasm of testis | 2 | BeFree |
umls:C1527249 | Colorectal Cancer | 2 | BeFree |
umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
umls:C0014859 | Esophageal Neoplasms | 1 | BeFree |
umls:C0031117 | Peripheral Neuropathy | 1 | CTD_human |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0152018 | Esophageal carcinoma | 1 | BeFree |
umls:C0546837 | Malignant neoplasm of esophagus | 1 | BeFree |
umls:C0685938 | Malignant neoplasm of gastrointestinal tract | 1 | BeFree |
umls:C0699790 | Colon Carcinoma | 1 | BeFree |