TissGeneSummary for TDRD1 |
Gene summary |
Basic gene information | Gene symbol | TDRD1 |
Gene name | tudor domain containing 1 | |
Synonyms | CT41.1 | |
Cytomap | UCSC genome browser: 10q25.3 | |
Type of gene | protein-coding | |
RefGenes | NM_198795.1, | |
Description | cancer/testis antigen 41.1tudor domain containing protein 1tudor domain-containing protein 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 605796 | |
HGNC : HGNC | ||
Ensembl : ENSG00000095627 | ||
HPRD : 12047 | ||
Vega : OTTHUMG00000019083 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TDRD1 | |
BioGPS: 56165 | ||
Pathway | NCI Pathway Interaction Database: TDRD1 | |
KEGG: TDRD1 | ||
REACTOME: TDRD1 | ||
Pathway Commons: TDRD1 | ||
Context | iHOP: TDRD1 | |
ligand binding site mutation search in PubMed: TDRD1 | ||
UCL Cancer Institute: TDRD1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTExHPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TDRD1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TDRD1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | 0.022890588 | 3.122396838 | -3.09950625 | 7.74E-11 | 9.18E-10 |
LIHC | -1.052824162 | 0.517231838 | -1.570056 | 2.36E-08 | 1.91E-07 |
PRAD | 5.470966068 | 0.951127607 | 4.519838462 | 1.34E-14 | 1.43E-12 |
KICH | -1.032900162 | 3.272523838 | -4.305424 | 5.27E-15 | 1.09E-13 |
KIRC | -0.448439273 | 3.193788504 | -3.642227778 | 4.22E-34 | 1.05E-32 |
HNSC | 0.359350907 | 1.494888117 | -1.135537209 | 0.0083 | 0.021101695 |
ESCA | -0.575182708 | 2.261535474 | -2.836718182 | 0.000232 | 0.005732978 |
LUSC | -0.678843849 | 0.343711053 | -1.022554902 | 0.000507 | 0.000985129 |
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TissGene-miRNA for TDRD1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TDRD1 |
TissGeneSNV for TDRD1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G101R | SKCM | 2 |
p.R361K | SKCM | 2 |
p.S526F | SKCM | 2 |
p.P1049S | SKCM | 2 |
p.M264I | SKCM | 1 |
p.D310G | LIHC | 1 |
p.E228K | LGG | 1 |
p.E764D | UCEC | 1 |
p.D713N | CESC | 1 |
p.S178L | SKCM | 1 |
p.T269M | UCEC | 1 |
p.L1115R | LIHC | 1 |
p.V239I | SARC | 1 |
p.Q1129H | HNSC | 1 |
p.Q340* | LUAD | 1 |
p.K322N | STAD | 1 |
p.G994R | SKCM | 1 |
p.C625F | UCEC | 1 |
p.W558* | LUAD | 1 |
p.D799Y | HNSC | 1 |
p.R172C | SKCM | 1 |
p.D875N | SKCM | 1 |
p.V381A | BRCA | 1 |
p.W619* | HNSC | 1 |
p.M1137T | LIHC | 1 |
p.L161S | LIHC | 1 |
p.V631A | STAD | 1 |
p.M251I | BLCA | 1 |
p.K628R | LUAD | 1 |
p.D414N | SARC | 1 |
p.L644F | LUAD | 1 |
p.R812* | SKCM | 1 |
p.P163L | STAD | 1 |
p.T73S | LIHC | 1 |
p.C625F | ESCA | 1 |
p.E657D | LUAD | 1 |
p.N52D | SKCM | 1 |
p.S1087F | LUAD | 1 |
p.I942V | ESCA | 1 |
p.V281M | BLCA | 1 |
p.A304G | LGG | 1 |
p.A898V | UCEC | 1 |
p.E59K | SKCM | 1 |
p.Y445X | LIHC | 1 |
p.E843* | UCS | 1 |
p.E1105D | UCEC | 1 |
p.M627I | SKCM | 1 |
p.H660D | CESC | 1 |
p.E242K | BLCA | 1 |
p.R1009C | SKCM | 1 |
p.E1031K | BLCA | 1 |
p.P48S | SKCM | 1 |
p.S926C | BRCA | 1 |
p.K1102N | PRAD | 1 |
p.T1181A | ACC | 1 |
p.S648F | SKCM | 1 |
p.G698E | SKCM | 1 |
p.M1061I | SKCM | 1 |
p.E217K | BLCA | 1 |
p.V346A | ESCA | 1 |
p.D939Y | UCS | 1 |
p.M971L | LUAD | 1 |
p.Q524* | LUAD | 1 |
p.E843X | UCS | 1 |
p.L1035F | SKCM | 1 |
p.V700A | HNSC | 1 |
p.S220* | UCEC | 1 |
p.K794N | KIRP | 1 |
p.A859P | OV | 1 |
p.E1101D | LUSC | 1 |
p.S149F | SKCM | 1 |
p.E419V | KIRP | 1 |
p.G766R | LUAD | 1 |
p.A1025P | HNSC | 1 |
p.A1112T | SKCM | 1 |
p.L1046M | LGG | 1 |
p.H918N | READ | 1 |
p.T269M | STAD | 1 |
p.M443I | STAD | 1 |
p.P702L | SKCM | 1 |
p.W707L | LUSC | 1 |
p.E317K | SKCM | 1 |
p.K225T | UCEC | 1 |
p.Q824* | BLCA | 1 |
p.Q72X | KIRP | 1 |
p.D539Y | PAAD | 1 |
p.R12I | UCEC | 1 |
p.K740T | STAD | 1 |
p.R827W | OV | 1 |
p.Y445N | ESCA | 1 |
p.N13H | UCEC | 1 |
p.E301X | READ | 1 |
p.A543V | SKCM | 1 |
p.E948K | BLCA | 1 |
p.D1113H | CESC | 1 |
p.L668I | CESC | 1 |
p.T1166I | SKCM | 1 |
p.V917A | STAD | 1 |
p.E426* | UCEC | 1 |
p.W619* | SKCM | 1 |
p.E16K | CESC | 1 |
p.R1139G | LUAD | 1 |
p.L1046P | LIHC | 1 |
p.R781C | SKCM | 1 |
p.G1014E | CESC | 1 |
p.T658M | UCEC | 1 |
p.L440F | UCEC | 1 |
p.E967K | SKCM | 1 |
p.P485L | SKCM | 1 |
p.E118K | LUAD | 1 |
p.E935* | UCEC | 1 |
p.S1068C | BRCA | 1 |
p.R1054I | COAD | 1 |
p.R992T | LUAD | 1 |
p.G352E | SKCM | 1 |
p.V281L | LUAD | 1 |
p.Y576H | PRAD | 1 |
p.G801E | SKCM | 1 |
p.F510C | READ | 1 |
p.A604V | STAD | 1 |
p.P130L | UCEC | 1 |
p.F1050L | SKCM | 1 |
p.V680A | UCEC | 1 |
p.G389R | KIRP | 1 |
p.G101R | LUSC | 1 |
p.F273C | LUSC | 1 |
p.W619X | SKCM | 1 |
p.E217K | SKCM | 1 |
p.R860T | BLCA | 1 |
p.N49T | READ | 1 |
p.G575R | HNSC | 1 |
p.L585F | SKCM | 1 |
p.R361I | UCEC | 1 |
p.V938A | STAD | 1 |
p.F1078C | ESCA | 1 |
p.G617E | SKCM | 1 |
p.D546N | SKCM | 1 |
p.S1183A | SKCM | 1 |
p.E29Q | CESC | 1 |
p.G580E | SKCM | 1 |
p.A201S | LUSC | 1 |
p.R1037K | HNSC | 1 |
p.D466Y | PAAD | 1 |
p.A1047V | READ | 1 |
p.K740N | READ | 1 |
p.Q849H | LUSC | 1 |
p.G675R | SKCM | 1 |
p.E786K | SKCM | 1 |
p.F509L | READ | 1 |
p.D539N | HNSC | 1 |
p.K740N | UCEC | 1 |
p.D539Y | STAD | 1 |
p.V478I | UCEC | 1 |
p.E457K | SKCM | 1 |
p.E308K | SKCM | 1 |
p.E428K | SKCM | 1 |
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TissGeneCNV for TDRD1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TDRD1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for TDRD1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TDRD1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TDRD1 |
TissGeneDrug for TDRD1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TDRD1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0376358 | Malignant neoplasm of prostate | 3 | BeFree |
umls:C0600139 | Prostate carcinoma | 3 | BeFree |
umls:C0021364 | Male infertility | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | BeFree |
umls:C1704272 | Benign Prostatic Hyperplasia | 1 | BeFree |