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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for PRSS3
check button Gene summary
Basic gene informationGene symbolPRSS3
Gene nameprotease, serine, 3
SynonymsMTG|PRSS4|T9|TRY3|TRY4
CytomapUCSC genome browser: 9p11.2
Type of geneprotein-coding
RefGenesNM_001197097.2,
NM_001197098.1,NM_002771.3,NM_007343.3,
Descriptionbrain trypsinogenmesotrypsinmesotrypsinogenpancreatic trypsinogen IIIprotease, serine, 4 (trypsin 4, brain)trypsin IIItrypsin IVtrypsin-3trypsinogen 4trypsinogen 5trypsinogen IV
Modification date20141207
dbXrefs MIM : 613578
HGNC : HGNC
Ensembl : ENSG00000010438
HPRD : 06685
Vega : OTTHUMG00000019798
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PRSS3
BioGPS: 5646
PathwayNCI Pathway Interaction Database: PRSS3
KEGG: PRSS3
REACTOME: PRSS3
Pathway Commons: PRSS3
ContextiHOP: PRSS3
ligand binding site mutation search in PubMed: PRSS3
UCL Cancer Institute: PRSS3
Assigned class in TissGDB*B
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Pancreas
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)PAAD
Reference showing the relevant tissue of PRSS3
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0006508proteolysis6698368
GO:0031638zymogen activation6698368
GO:0006508proteolysis6698368
GO:0031638zymogen activation6698368


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TissGeneExp for PRSS3

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
HNSC0.9603143584.33912366-3.3788093026.17E-063.72E-05
LUSC0.126875507-3.0948597873.2217352948.84E-123.71E-11
THCA-1.558781622-3.8069731472.2481915253.73E-133.62E-12
KIRC-3.097655539-0.051990261-3.0456652782.15E-222.02E-21
KIRP-3.6894958160.103504184-3.7931.03E-132.01E-12
LUAD-0.463331592-3.3890246962.9256931032.52E-091.26E-08
KICH-2.453883316-0.318715316-2.1351688.68E-050.000229661


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TissGene-miRNA for PRSS3

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for PRSS3
TissGeneSNV for PRSS3

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R179HPCPG4
p.S7NTGCT2
p.S7NESCA2
p.G8VESCA2
p.G106CSTAD1
p.E247KSKCM1
p.S100CLUSC1
p.S7NTHYM1
p.N146HLUAD1
p.E88DTHYM1
p.S199FSKCM1
p.A15VCOAD1
p.G8VTHYM1
p.L130QESCA1
p.E89KSKCM1
p.V137DACC1
p.T299ISKCM1
p.R158SLUSC1
p.G208RCOAD1
p.I168MBRCA1
p.L205PKIRP1
p.P176SSKCM1
p.R125HKIRP1
p.K136NUCEC1
p.L5PKIRC1
p.D107NSKCM1
p.K216NSKCM1
p.D241YCOAD1
p.G11RSKCM1
p.W273*SKCM1
p.C196SKIRC1
p.S7NSARC1
p.T242ISKCM1
p.R125HLGG1
p.P233SSKCM1
p.S7NCESC1
p.G8VTGCT1
p.V175ALGG1
p.L109IPRAD1
p.G107DLIHC1
p.G200SHNSC1
p.G8VCESC1
p.R152HSTAD1
p.R95CSKCM1
p.R152CSKCM1
p.V271FSTAD1
p.G244SSKCM1
p.D164NSKCM1
p.D213HKIRC1
p.L7FLAML1
p.T182AKIRP1
p.D213YUCEC1
p.E190KSKCM1
p.R125CTGCT1
p.S252FKIRC1
p.V80DACC1


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TissGeneCNV for PRSS3

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for PRSS3

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0TopHat-FusionLUSCTCGA-21-1080-01ARNF19A-PRSS35'UTR-CDSchr8:101322094chr9:33796640
Chimerdb3.0TopHat-FusionLUSCTCGA-56-7582-11APRSS3-PRSS1Out-of-Framechr9:33798078chr7:142460280
TCGAfusionPortalPRADALUSCTCGA-21-1080-01ARNF19A-PRSS35UTR-CDSChr8:101322095Chr9:33796641
TCGAfusionPortalPRADALUSCTCGA-60-2719-01AUBE2R2-PRSS3Out-of-frameChr9:33817932Chr9:33796641
TCGAfusionPortalPRADAOVTCGA-10-0934-01AZCCHC7-PRSS3Out-of-frameChr9:37302228Chr9:33797827


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TissGeneNet for PRSS3

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
PRSS3, SERPINA1, HDGF, APP, TFPI (tumor)PRSS3, SERPINA1, HDGF, APP, TFPI (normal)
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COAD (tumor)COAD (normal)
PRSS3, SERPINA1, HDGF, APP, TFPI (tumor)PRSS3, SERPINA1, HDGF, APP, TFPI (normal)
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HNSC (tumor)HNSC (normal)
PRSS3, SERPINA1, HDGF, APP, TFPI (tumor)PRSS3, SERPINA1, HDGF, APP, TFPI (normal)
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KICH (tumor)KICH (normal)
PRSS3, SERPINA1, HDGF, APP, TFPI (tumor)PRSS3, SERPINA1, HDGF, APP, TFPI (normal)
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KIRC (tumor)KIRC (normal)
PRSS3, SERPINA1, HDGF, APP, TFPI (tumor)PRSS3, SERPINA1, HDGF, APP, TFPI (normal)
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KIRP (tumor)KIRP (normal)
PRSS3, SERPINA1, HDGF, APP, TFPI (tumor)PRSS3, SERPINA1, HDGF, APP, TFPI (normal)
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LIHC (tumor)LIHC (normal)
PRSS3, SERPINA1, HDGF, APP, TFPI (tumor)PRSS3, SERPINA1, HDGF, APP, TFPI (normal)
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LUAD (tumor)LUAD (normal)
PRSS3, SERPINA1, HDGF, APP, TFPI (tumor)PRSS3, SERPINA1, HDGF, APP, TFPI (normal)
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LUSC (tumor)LUSC (normal)
PRSS3, SERPINA1, HDGF, APP, TFPI (tumor)PRSS3, SERPINA1, HDGF, APP, TFPI (normal)
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PRAD (tumor)PRAD (normal)
PRSS3, SERPINA1, HDGF, APP, TFPI (tumor)PRSS3, SERPINA1, HDGF, APP, TFPI (normal)
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STAD (tumor)STAD (normal)
PRSS3, SERPINA1, HDGF, APP, TFPI (tumor)PRSS3, SERPINA1, HDGF, APP, TFPI (normal)
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THCA (tumor)THCA (normal)
PRSS3, SERPINA1, HDGF, APP, TFPI (tumor)PRSS3, SERPINA1, HDGF, APP, TFPI (normal)
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TissGeneProg for PRSS3

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for PRSS3
TissGeneDrug for PRSS3

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for PRSS3

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0149521Pancreatitis, Chronic5BeFree,GAD,LHGDN
umls:C0005684Malignant neoplasm of urinary bladder3BeFree
umls:C0235974Pancreatic carcinoma3BeFree
umls:C0346647Malignant neoplasm of pancreas3BeFree
umls:C0699885Carcinoma of bladder3BeFree
umls:C0006142Malignant neoplasm of breast2BeFree
umls:C0007131Non-Small Cell Lung Carcinoma2BeFree
umls:C0022104Irritable Bowel Syndrome2BeFree
umls:C0027627Neoplasm Metastasis2BeFree
umls:C0178874Tumor Progression2BeFree
umls:C0432306Ichthyosis Bullosa of Siemens2BeFree
umls:C0678222Breast Carcinoma2BeFree
umls:C0001339Acute pancreatitis1BeFree
umls:C0004997Benign Ovarian Neoplasm1BeFree
umls:C0005586Bipolar Disorder1GAD
umls:C0005695Bladder Neoplasm1CTD_human,LHGDN
umls:C0011226Hepatitis D Infection1BeFree
umls:C0019189Hepatitis, Chronic1BeFree
umls:C0019829Hodgkin Disease1BeFree
umls:C0020429Hyperalgesia1LHGDN
umls:C0021368Inflammation1LHGDN
umls:C0026769Multiple Sclerosis1LHGDN
umls:C0029925Ovarian Carcinoma1BeFree
umls:C0033578Prostatic Neoplasms1BeFree
umls:C0036341Schizophrenia1BeFree
umls:C0206180Ki-1+ Anaplastic Large Cell Lymphoma1BeFree
umls:C0278701Gastric Adenocarcinoma1BeFree
umls:C0279626Squamous cell carcinoma of esophagus1BeFree
umls:C0376358Malignant neoplasm of prostate1BeFree
umls:C0600139Prostate carcinoma1BeFree
umls:C0677886Epithelial ovarian cancer1BeFree
umls:C0686619Secondary malignant neoplasm of lymph node1BeFree
umls:C0877015Pelvic Organ Prolapse1BeFree
umls:C0936223Metastatic Prostate Carcinoma1BeFree
umls:C1140680Malignant neoplasm of ovary1BeFree