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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for SLC2A9
check button Gene summary
Basic gene informationGene symbolSLC2A9
Gene namesolute carrier family 2 (facilitated glucose transporter), member 9
SynonymsGLUT9|GLUTX|UAQTL2|URATv1
CytomapUCSC genome browser: 4p16.1
Type of geneprotein-coding
RefGenesNM_001001290.1,
NM_020041.2,
DescriptionGLUT-9glucose transporter type 9human glucose transporter-like protein-9solute carrier family 2, facilitated glucose transporter member 9urate voltage-driven efflux transporter 1
Modification date20141211
dbXrefs MIM : 606142
HGNC : HGNC
Ensembl : ENSG00000109667
HPRD : 05848
Vega : OTTHUMG00000044263
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SLC2A9
BioGPS: 56606
PathwayNCI Pathway Interaction Database: SLC2A9
KEGG: SLC2A9
REACTOME: SLC2A9
Pathway Commons: SLC2A9
ContextiHOP: SLC2A9
ligand binding site mutation search in PubMed: SLC2A9
UCL Cancer Institute: SLC2A9
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Kidney
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)KIRC,KIRP,KICH
Reference showing the relevant tissue of SLC2A9
Description by TissGene annotationsProtective TissGene in OS
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for SLC2A9

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LIHC0.2678362962.161030296-1.8931941.13E-077.87E-07
KICH-1.3527657041.080062296-2.4328289.36E-105.93E-09
PRAD-1.6424526270.176501219-1.8189538464.12E-111.05E-09


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TissGene-miRNA for SLC2A9

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for SLC2A9
TissGeneSNV for SLC2A9

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.N61SLGG1
p.S432FPRAD1
p.R169HCOAD1
p.P165LSKCM1
p.Q188LLUAD1
p.R169HPRAD1
p.G170*UCEC1
p.G45CUCEC1
p.I116MLUAD1
p.R198HPRAD1
p.I56MBLCA1
p.Q316EBRCA1
p.A118TPAAD1
p.L364FSKCM1
p.S9PREAD1
p.Q473HLUAD1
p.P434QLUAD1
p.Q217LLUAD1
p.G491VLUSC1
p.D225GLUAD1
p.R49SCOAD1
p.F69SKIRP1
p.M126ILUAD1
p.E237KSKCM1
p.L135IHNSC1
p.S264NSKCM1
p.M145ISKCM1
p.S254FBLCA1
p.R8QHNSC1
p.G432DLUSC1
p.K535ELIHC1
p.V457ISTAD1
p.F172LCESC1
p.R8QBLCA1
p.P405QLUAD1
p.S486FSKCM1
p.L354FSKCM1
p.G278SESCA1
p.Q444*SKCM1
p.T401KESCA1
p.P500HUCEC1
p.S82FSKCM1
p.E194KTHCA1
p.E10*LUAD1
p.X512YSKCM1
p.E191DOV1
p.T113APAAD1
p.G25RCOAD1
p.R285CSKCM1
p.G117RSKCM1
p.Q245RLUAD1
p.L106IHNSC1
p.G9RLGG1
p.R257HSTAD1
p.V105ISKCM1
p.A491ESARC1
p.T368NSARC1
p.I87MLUAD1
p.P321SSKCM1
p.G362SSTAD1
p.Q415RCOAD1
p.G46RSKCM1
p.S359RSTAD1
p.V151ICOAD1
p.S330RSTAD1
p.A463VREAD1
p.G249SESCA1
p.L220HSKCM1
p.L385MCOAD1
p.G361EUCEC1
p.A513TBRCA1
p.S482NSKCM1
p.P380LSARC1
p.R476KSKCM1
p.A161VUCEC1
p.M158VLUAD1
p.T502NKIRC1
p.T84APAAD1
p.R142CLGG1
p.Q274RLUAD1
p.F469SUCEC1
p.A89TPAAD1
p.Y188*LUAD1
p.R171CSTAD1
p.I180MLUAD1
p.D281NPAAD1
p.T374ISKCM1
p.A454TUCEC1
p.Y159*LUAD1
p.V151IPRAD1


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TissGeneCNV for SLC2A9

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for SLC2A9

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
TCGAfusionPortalPRADABLCATCGA-DK-A3X1-01ASLC2A9-RAD51In-frameChr4:10020599Chr15:40998375
TCGAfusionPortalPRADABRCATCGA-A8-A09M-01ASLC30A9-SLC2A9Out-of-frameChr4:42003797Chr4:9909969


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TissGeneNet for SLC2A9

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)


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TissGeneProg for SLC2A9

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for SLC2A9
TissGeneDrug for SLC2A9

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for SLC2A9

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0473219Renal hypouricemia16BeFree,CTD_human
umls:C0018099Gout12CTD_human,GAD,GWASCAT
umls:C0740394Hyperuricemia10BeFree,CTD_human,GAD
umls:C0022660Kidney Failure, Acute5BeFree
umls:C2677549Hypouricemia, Renal, 23CLINVAR,CTD_human,UNIPROT
umls:C3160858Posterior reversible encephalopathy syndrome3BeFree
umls:C0007222Cardiovascular Diseases2BeFree
umls:C0010054Coronary Arteriosclerosis2BeFree
umls:C0010068Coronary heart disease2BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent2BeFree,GAD
umls:C0524620Metabolic Syndrome X2BeFree,GAD
umls:C0744466gout tophaceous2BeFree
umls:C1561643Chronic Kidney Diseases2BeFree
umls:C0002395Alzheimer's Disease1GAD
umls:C0003469Anxiety Disorders1BeFree
umls:C0003850Arteriosclerosis1BeFree
umls:C0003868Arthritis, Gouty1BeFree
umls:C0004153Atherosclerosis1BeFree
umls:C0008925Cleft Palate1BeFree
umls:C0009451Communicating Hydrocephalus1BeFree
umls:C0020538Hypertensive disease1BeFree
umls:C0026764Multiple Myeloma1BeFree
umls:C0027051Myocardial Infarction1BeFree,GAD,LHGDN
umls:C0028754Obesity1GAD
umls:C0031572Phobia, Social1BeFree
umls:C0040336Tobacco Use Disorder1GAD
umls:C0221248Tophus1BeFree
umls:C0392525Nephrolithiasis1BeFree,GAD
umls:C0700634Serum uric acid observed1GAD
umls:C0852949Arteriopathic disease1BeFree
umls:C1956346Coronary Artery Disease1BeFree,GAD,LHGDN