TissGeneSummary for PAPOLB |
Gene summary |
Basic gene information | Gene symbol | PAPOLB |
Gene name | poly(A) polymerase beta (testis specific) | |
Synonyms | PAPT|TPAP | |
Cytomap | UCSC genome browser: 7p22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_020144.4, | |
Description | PAP-betapoly(A) polymerase betapolynucleotide adenylyltransferase betatestis-specific poly(A) polymerase | |
Modification date | 20141207 | |
dbXrefs | MIM : 607436 | |
HGNC : HGNC | ||
Ensembl : ENSG00000218823 | ||
HPRD : 08467 | ||
Vega : OTTHUMG00000151759 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PAPOLB | |
BioGPS: 56903 | ||
Pathway | NCI Pathway Interaction Database: PAPOLB | |
KEGG: PAPOLB | ||
REACTOME: PAPOLB | ||
Pathway Commons: PAPOLB | ||
Context | iHOP: PAPOLB | |
ligand binding site mutation search in PubMed: PAPOLB | ||
UCL Cancer Institute: PAPOLB | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of PAPOLB | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for PAPOLB |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | -0.641365857 | 0.441362957 | -1.082728814 | 7.42E-15 | 9.33E-14 |
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TissGene-miRNA for PAPOLB |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PAPOLB |
TissGeneSNV for PAPOLB |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P418L | SKCM | 2 |
p.R400Q | READ | 2 |
p.T34M | STAD | 2 |
p.H500Y | SKCM | 2 |
p.E592K | UCEC | 2 |
p.R400Q | UCEC | 2 |
p.S575F | SKCM | 1 |
p.S238F | SKCM | 1 |
p.P558S | UCEC | 1 |
p.E531Q | BLCA | 1 |
p.P498H | BLCA | 1 |
p.N418D | STAD | 1 |
p.R127Q | UCEC | 1 |
p.E451* | LUAD | 1 |
p.A528T | STAD | 1 |
p.C234Y | UCEC | 1 |
p.L68I | STAD | 1 |
p.E58K | LUSC | 1 |
p.E55K | SKCM | 1 |
p.E56K | LUSC | 1 |
p.N236T | UCEC | 1 |
p.L548X | SKCM | 1 |
p.A112T | LUAD | 1 |
p.D129N | UCEC | 1 |
p.R60H | PRAD | 1 |
p.D518Y | UCEC | 1 |
p.S239F | SKCM | 1 |
p.R513S | SKCM | 1 |
p.R127Q | HNSC | 1 |
p.E427G | UCEC | 1 |
p.G481C | LUSC | 1 |
p.A250V | SKCM | 1 |
p.L245F | SKCM | 1 |
p.A251T | OV | 1 |
p.N220K | UCEC | 1 |
p.E450* | LUAD | 1 |
p.L46F | CESC | 1 |
p.E55* | UCEC | 1 |
p.K544R | LIHC | 1 |
p.C197F | LUAD | 1 |
p.R126Q | HNSC | 1 |
p.S549I | LUAD | 1 |
p.A507S | STAD | 1 |
p.G587R | SKCM | 1 |
p.I114T | SARC | 1 |
p.E573Q | HNSC | 1 |
p.P299S | STAD | 1 |
p.A508S | STAD | 1 |
p.R514S | SKCM | 1 |
p.G586R | SKCM | 1 |
p.D209N | READ | 1 |
p.E78Q | LUAD | 1 |
p.T35M | COAD | 1 |
p.R256I | UCEC | 1 |
p.R127Q | UCS | 1 |
p.L244F | SKCM | 1 |
p.V614A | STAD | 1 |
p.S550I | LUAD | 1 |
p.I602V | LUAD | 1 |
p.K356N | LUSC | 1 |
p.E79K | COAD | 1 |
p.L635I | PAAD | 1 |
p.L547* | SKCM | 1 |
p.R126Q | UCS | 1 |
p.P419L | SKCM | 1 |
p.P307H | UCEC | 1 |
p.E151K | UCEC | 1 |
p.P18L | HNSC | 1 |
p.E385X | COAD | 1 |
p.E351K | UCEC | 1 |
p.P17L | HNSC | 1 |
p.R61H | STAD | 1 |
p.A364T | HNSC | 1 |
p.L634I | PAAD | 1 |
p.R61M | BLCA | 1 |
p.R20H | UCEC | 1 |
p.K137E | LUSC | 1 |
p.R255I | BLCA | 1 |
p.V23I | STAD | 1 |
p.H501Y | SKCM | 1 |
p.L69I | STAD | 1 |
p.V613L | ESCA | 1 |
p.D146Y | UCEC | 1 |
p.R271W | READ | 1 |
p.S367N | UCEC | 1 |
p.M437I | LIHC | 1 |
p.R294Q | LUSC | 1 |
p.M251I | LGG | 1 |
p.E151D | COAD | 1 |
p.D518E | THYM | 1 |
p.S550N | UCEC | 1 |
p.P16L | COAD | 1 |
p.A29V | PRAD | 1 |
p.E574Q | HNSC | 1 |
p.M436I | LIHC | 1 |
p.D520N | PAAD | 1 |
p.A565T | UCEC | 1 |
p.R271W | UCEC | 1 |
p.V614F | LUAD | 1 |
p.D302G | COAD | 1 |
p.S453C | BLCA | 1 |
p.K342N | LUAD | 1 |
p.V614L | ESCA | 1 |
p.E530Q | BLCA | 1 |
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TissGeneCNV for PAPOLB |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PAPOLB |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for PAPOLB |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PAPOLB |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PAPOLB |
TissGeneDrug for PAPOLB |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PAPOLB |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |