TissGeneSummary for KIF15 |
Gene summary |
Basic gene information | Gene symbol | KIF15 |
Gene name | kinesin family member 15 | |
Synonyms | HKLP2|KNSL7|NY-BR-62 | |
Cytomap | UCSC genome browser: 3p21.31 | |
Type of gene | protein-coding | |
RefGenes | NM_020242.2, | |
Description | kinesin-like 7kinesin-like protein 2kinesin-like protein 7kinesin-like protein KIF15serologically defined breast cancer antigen NY-BR-62 | |
Modification date | 20141215 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000163808 | ||
HPRD : 10037 | ||
Vega : OTTHUMG00000156307 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KIF15 | |
BioGPS: 56992 | ||
Pathway | NCI Pathway Interaction Database: KIF15 | |
KEGG: KIF15 | ||
REACTOME: KIF15 | ||
Pathway Commons: KIF15 | ||
Context | iHOP: KIF15 | |
ligand binding site mutation search in PubMed: KIF15 | ||
UCL Cancer Institute: KIF15 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of KIF15 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for KIF15 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BLCA | 1.512070296 | -1.777092862 | 3.289163158 | 1.94E-07 | 9.81E-06 |
LUAD | -0.16557308 | -3.125742045 | 2.960168966 | 3.59E-22 | 9.70E-21 |
BRCA | 0.499852752 | -2.277357774 | 2.777210526 | 2.58E-42 | 9.23E-41 |
KIRP | -2.546511119 | -4.174711119 | 1.6282 | 1.81E-06 | 8.69E-06 |
LUSC | 1.05636235 | -2.839696474 | 3.896058824 | 1.15E-32 | 8.63E-31 |
STAD | 0.935220131 | -1.375954869 | 2.311175 | 1.94E-08 | 7.65E-07 |
KIRC | -2.242563549 | -3.902844105 | 1.660280556 | 5.66E-17 | 3.32E-16 |
LIHC | -1.611263494 | -4.677393494 | 3.06613 | 3.78E-16 | 1.40E-14 |
COAD | 1.570335276 | 0.518246814 | 1.052088462 | 1.77E-07 | 1.19E-06 |
ESCA | 1.342209052 | -1.875963675 | 3.218172727 | 0.00015 | 0.004332468 |
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TissGene-miRNA for KIF15 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KIF15 |
TissGeneSNV for KIF15 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E538* | UCEC | 2 |
p.R488C | SKCM | 2 |
p.A200V | STAD | 2 |
p.E607* | UCEC | 2 |
p.R1358* | LGG | 1 |
p.F1148Y | LUAD | 1 |
p.S396P | STAD | 1 |
p.Q1332H | UCEC | 1 |
p.R521G | KIRC | 1 |
p.P575S | STAD | 1 |
p.R34C | STAD | 1 |
p.R939C | COAD | 1 |
p.E1281Q | BLCA | 1 |
p.Q1149E | GBM | 1 |
p.D126H | CESC | 1 |
p.E1320Q | CESC | 1 |
p.V12L | BLCA | 1 |
p.S17F | LUAD | 1 |
p.R509T | HNSC | 1 |
p.R12* | UCEC | 1 |
p.S58T | SKCM | 1 |
p.H518Y | SKCM | 1 |
p.T996S | COAD | 1 |
p.K1080N | READ | 1 |
p.E783Q | BLCA | 1 |
p.E858D | BLCA | 1 |
p.R60W | SKCM | 1 |
p.E1207X | ESCA | 1 |
p.S798G | HNSC | 1 |
p.G681E | SKCM | 1 |
p.N287S | STAD | 1 |
p.A211V | COAD | 1 |
p.A908S | LUAD | 1 |
p.H652Y | KIRC | 1 |
p.G329E | THCA | 1 |
p.S836F | SKCM | 1 |
p.S1083L | UCEC | 1 |
p.D79N | STAD | 1 |
p.I1100N | LIHC | 1 |
p.E594Q | BLCA | 1 |
p.G134* | UCEC | 1 |
p.E891Q | BLCA | 1 |
p.L899R | UCEC | 1 |
p.L899M | PAAD | 1 |
p.K432N | UCEC | 1 |
p.R1286K | HNSC | 1 |
p.Q886* | SKCM | 1 |
p.E893K | BLCA | 1 |
p.Q1303H | STAD | 1 |
p.N413K | SKCM | 1 |
p.A181V | THYM | 1 |
p.F425V | STAD | 1 |
p.G397V | LIHC | 1 |
p.L1206M | COAD | 1 |
p.E252Q | LUAD | 1 |
p.R1374H | HNSC | 1 |
p.S823L | SKCM | 1 |
p.V1344L | BLCA | 1 |
p.D44H | SARC | 1 |
p.Q572H | BLCA | 1 |
p.E1091D | COAD | 1 |
p.E574Q | COAD | 1 |
p.L500M | LIHC | 1 |
p.T57M | UCEC | 1 |
p.A367V | UCEC | 1 |
p.T946M | UCEC | 1 |
p.R32* | STAD | 1 |
p.P1097S | UCEC | 1 |
p.H1151N | LUSC | 1 |
p.S815F | UCEC | 1 |
p.K1383N | BLCA | 1 |
p.L863P | LUAD | 1 |
p.L1173V | READ | 1 |
p.E66Q | BLCA | 1 |
p.P1139S | SKCM | 1 |
p.I659V | BLCA | 1 |
p.N1108Y | HNSC | 1 |
p.G41A | LUSC | 1 |
p.E829D | ACC | 1 |
p.T88I | THYM | 1 |
p.Q886X | SKCM | 1 |
p.I1056K | SKCM | 1 |
p.T826M | UCEC | 1 |
p.K1331T | STAD | 1 |
p.E245Q | BLCA | 1 |
p.M539I | THYM | 1 |
p.V1333M | SKCM | 1 |
p.L447P | THYM | 1 |
p.L902F | OV | 1 |
p.T1288S | LIHC | 1 |
p.E516K | SKCM | 1 |
p.R526K | UCEC | 1 |
p.E1077G | COAD | 1 |
p.T57M | STAD | 1 |
p.Q82E | BLCA | 1 |
p.M1315L | SKCM | 1 |
p.E911Q | BLCA | 1 |
p.G329E | SKCM | 1 |
p.R1374C | UCEC | 1 |
p.V1273A | PRAD | 1 |
p.T1046A | STAD | 1 |
p.S754F | COAD | 1 |
p.S159N | UCEC | 1 |
p.N1020K | PAAD | 1 |
p.E1368K | BRCA | 1 |
p.Q1090H | ESCA | 1 |
p.G375E | SKCM | 1 |
p.E1314K | CESC | 1 |
p.E820* | HNSC | 1 |
p.F551C | HNSC | 1 |
p.Q758K | LGG | 1 |
p.R43* | UCEC | 1 |
p.C999F | THYM | 1 |
p.M415V | UCEC | 1 |
p.S236P | LIHC | 1 |
p.E582K | HNSC | 1 |
p.E1387Q | LUAD | 1 |
p.A1168P | ESCA | 1 |
p.A550V | UCEC | 1 |
p.D304Y | LUAD | 1 |
p.E1325D | STAD | 1 |
p.R1205C | UCEC | 1 |
p.E1387K | LUAD | 1 |
p.Q1149* | SKCM | 1 |
p.R977T | BLCA | 1 |
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TissGeneCNV for KIF15 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KIF15 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | LUAD | TCGA-55-6969-01A | KIF15-ZNF167 | In-frame | Chr3:44803376 | Chr3:44609404 |
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TissGeneNet for KIF15 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KIF15 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KIF15 |
TissGeneDrug for KIF15 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KIF15 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0017661 | IGA Glomerulonephritis | 1 | CTD_human |
umls:C0334579 | Anaplastic astrocytoma | 1 | BeFree |