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| TissGeneSummary for AKR1B10 |
 Gene summary |
| Basic gene information | Gene symbol | AKR1B10 |
| Gene name | aldo-keto reductase family 1, member B10 (aldose reductase) | |
| Synonyms | AKR1B11|AKR1B12|ALDRLn|ARL-1|ARL1|HIS|HSI | |
| Cytomap | UCSC genome browser: 7q33 | |
| Type of gene | protein-coding | |
| RefGenes | NM_020299.4, | |
| Description | ARPSI reductasealdo-keto reductase family 1 member B10aldo-keto reductase family 1, member B11 (aldose reductase-like)aldose reductase-like 1aldose reductase-like peptidealdose reductase-related proteinhARPsmall intestine reductase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604707 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000198074 | ||
| HPRD : 05271 | ||
| Vega : OTTHUMG00000155356 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_AKR1B10 | |
| BioGPS: 57016 | ||
| Pathway | NCI Pathway Interaction Database: AKR1B10 | |
| KEGG: AKR1B10 | ||
| REACTOME: AKR1B10 | ||
| Pathway Commons: AKR1B10 | ||
| Context | iHOP: AKR1B10 | |
| ligand binding site mutation search in PubMed: AKR1B10 | ||
| UCL Cancer Institute: AKR1B10 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | ||
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LungStomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSCSTAD | |
| Reference showing the relevant tissue of AKR1B10 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0016488 | farnesol catabolic process | 21187079 | GO:0016488 | farnesol catabolic process | 21187079 |
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| TissGeneExp for AKR1B10 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | 1.15246478 | 5.748749395 | -4.596284615 | 2.21E-11 | 4.00E-10 |
| LUSC | 4.35561478 | -2.88408522 | 7.2397 | 3.50E-19 | 3.70E-18 |
| LUAD | -0.054214531 | -3.848924876 | 3.794710345 | 6.27E-10 | 3.41E-09 |
| STAD | 3.15330853 | 5.471767905 | -2.318459375 | 0.0146 | 0.046312271 |
| LIHC | 5.52712878 | 2.49908878 | 3.02804 | 0.000199 | 0.000637776 |
| KIRP | 2.95123978 | -0.881963345 | 3.833203125 | 0.000182 | 0.00058459 |
| KICH | -4.88088922 | -2.57898122 | -2.301908 | 9.91E-05 | 0.000258481 |
| PRAD | -4.705329451 | -3.689464067 | -1.015865385 | 4.06E-05 | 0.000188765 |
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| TissGene-miRNA for AKR1B10 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for AKR1B10 |
| TissGeneSNV for AKR1B10 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G134R | SKCM | 2 |
| p.A136V | UCEC | 1 |
| p.G115V | LUAD | 1 |
| p.R269S | LUAD | 1 |
| p.E236K | SKCM | 1 |
| p.K66R | STAD | 1 |
| p.G115E | SKCM | 1 |
| p.E146K | LUAD | 1 |
| p.A35V | STAD | 1 |
| p.G56E | SKCM | 1 |
| p.D217N | SKCM | 1 |
| p.T137M | LGG | 1 |
| p.P87L | SKCM | 1 |
| p.E194D | COAD | 1 |
| p.F138L | SKCM | 1 |
| p.D72N | SKCM | 1 |
| p.P262H | LUAD | 1 |
| p.Q275K | COAD | 1 |
| p.S163R | KIRC | 1 |
| p.N130Y | COAD | 1 |
| p.I43L | HNSC | 1 |
| p.P124L | SKCM | 1 |
| p.F123I | SKCM | 1 |
| p.P81S | LUAD | 1 |
| p.K243N | SKCM | 1 |
| p.L100M | UCEC | 1 |
| p.G26C | SKCM | 1 |
| p.L97F | SKCM | 1 |
| p.A238V | STAD | 1 |
| p.F138S | SKCM | 1 |
| p.E52* | LUAD | 1 |
| p.D99N | SKCM | 1 |
| p.Q255H | LUAD | 1 |
| p.D150E | LGG | 1 |
| p.R251L | LUAD | 1 |
| p.E94D | BLCA | 1 |
| p.L25V | SARC | 1 |
| p.A268V | STAD | 1 |
| p.V301L | ESCA | 1 |
| p.L196R | UCEC | 1 |
| p.D150H | HNSC | 1 |
| p.E61* | UCEC | 1 |
| p.S304F | COAD | 1 |
| p.T206I | SKCM | 1 |
| p.H253Y | SKCM | 1 |
| p.H241N | LUAD | 1 |
| p.Q255P | LUSC | 1 |
| p.A245T | LUAD | 1 |
| p.E94Q | HNSC | 1 |
| p.A141V | ESCA | 1 |
| p.E186Q | LUSC | 1 |
| p.L157I | HNSC | 1 |
| p.T3M | GBM | 1 |
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| TissGeneCNV for AKR1B10 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for AKR1B10 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-LN-A8I1-01A | AKR1B10-POLR2I | In-Frame | chr7:134215562 | chr19:36605314 |
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| TissGeneNet for AKR1B10 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| AKR1B10, TERF2IP, ACACA (tumor) | AKR1B10, TERF2IP, ACACA (normal) |
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| COAD (tumor) | COAD (normal) |
| AKR1B10, TERF2IP, ACACA (tumor) | AKR1B10, TERF2IP, ACACA (normal) |
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| HNSC (tumor) | HNSC (normal) |
| AKR1B10, TERF2IP, ACACA (tumor) | AKR1B10, TERF2IP, ACACA (normal) |
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| KICH (tumor) | KICH (normal) |
| AKR1B10, TERF2IP, ACACA (tumor) | AKR1B10, TERF2IP, ACACA (normal) |
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| KIRC (tumor) | KIRC (normal) |
| AKR1B10, TERF2IP, ACACA (tumor) | AKR1B10, TERF2IP, ACACA (normal) |
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| KIRP (tumor) | KIRP (normal) |
| AKR1B10, TERF2IP, ACACA (tumor) | AKR1B10, TERF2IP, ACACA (normal) |
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| LIHC (tumor) | LIHC (normal) |
| AKR1B10, TERF2IP, ACACA (tumor) | AKR1B10, TERF2IP, ACACA (normal) |
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| LUAD (tumor) | LUAD (normal) |
| AKR1B10, TERF2IP, ACACA (tumor) | AKR1B10, TERF2IP, ACACA (normal) |
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| LUSC (tumor) | LUSC (normal) |
| AKR1B10, TERF2IP, ACACA (tumor) | AKR1B10, TERF2IP, ACACA (normal) |
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| PRAD (tumor) | PRAD (normal) |
| AKR1B10, TERF2IP, ACACA (tumor) | AKR1B10, TERF2IP, ACACA (normal) |
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| STAD (tumor) | STAD (normal) |
| AKR1B10, TERF2IP, ACACA (tumor) | AKR1B10, TERF2IP, ACACA (normal) |
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| THCA (tumor) | THCA (normal) |
| AKR1B10, TERF2IP, ACACA (tumor) | AKR1B10, TERF2IP, ACACA (normal) |
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| TissGeneProg for AKR1B10 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for AKR1B10 |
| TissGeneDrug for AKR1B10 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for AKR1B10 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C2239176 | Liver carcinoma | 9 | BeFree,CTD_human |
| umls:C0009402 | Colorectal Carcinoma | 6 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 6 | BeFree |
| umls:C0684249 | Carcinoma of lung | 6 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 5 | BeFree |
| umls:C0596263 | Carcinogenesis | 5 | BeFree |
| umls:C0001418 | Adenocarcinoma | 4 | BeFree,LHGDN |
| umls:C0007137 | Squamous cell carcinoma | 4 | BeFree,LHGDN |
| umls:C1512409 | Hepatocarcinogenesis | 4 | BeFree |
| umls:C1527249 | Colorectal Cancer | 4 | BeFree |
| umls:C0011884 | Diabetic Retinopathy | 3 | GAD,LHGDN |
| umls:C0007103 | Malignant neoplasm of endometrium | 2 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 2 | BeFree,CTD_human |
| umls:C0024121 | Lung Neoplasms | 2 | LHGDN |
| umls:C0024623 | Malignant neoplasm of stomach | 2 | BeFree |
| umls:C0039128 | Syphilis | 2 | BeFree |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 2 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 2 | BeFree |
| umls:C0345904 | Malignant neoplasm of liver | 2 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 2 | BeFree |
| umls:C0476089 | Endometrial Carcinoma | 2 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 2 | BeFree |
| umls:C1883486 | Uterine Corpus Cancer | 2 | BeFree |
| umls:C0001430 | Adenoma | 1 | BeFree |
| umls:C0001618 | Tumors of Adrenal Cortex | 1 | BeFree |
| umls:C0004153 | Atherosclerosis | 1 | LHGDN |
| umls:C0004763 | Barrett Esophagus | 1 | LHGDN |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
| umls:C0009324 | Ulcerative Colitis | 1 | BeFree |
| umls:C0011616 | Contact Dermatitis | 1 | CTD_human |
| umls:C0014170 | Endometrial Neoplasms | 1 | CTD_human |
| umls:C0018523 | Hallervorden-Spatz Syndrome | 1 | BeFree |
| umls:C0022658 | Kidney Diseases | 1 | GAD |
| umls:C0023903 | Liver neoplasms | 1 | BeFree |
| umls:C0025202 | melanoma | 1 | CTD_human |
| umls:C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| umls:C0028043 | Nicotine Dependence | 1 | BeFree |
| umls:C0029408 | Degenerative polyarthritis | 1 | BeFree |
| umls:C0206698 | Cholangiocarcinoma | 1 | BeFree |
| umls:C0267375 | Chronic colitis | 1 | BeFree |
| umls:C0278512 | Metastatic osteosarcoma | 1 | BeFree |
| umls:C0279000 | Liver and Intrahepatic Biliary Tract Carcinoma | 1 | BeFree |
| umls:C0279628 | Adenocarcinoma Of Esophagus | 1 | BeFree |
| umls:C0281361 | Adenocarcinoma of pancreas | 1 | BeFree |
| umls:C0302592 | Cervix carcinoma | 1 | BeFree |
| umls:C0521158 | Recurrent tumor | 1 | BeFree |
| umls:C0524910 | Hepatitis C, Chronic | 1 | BeFree |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C0877024 | Schimke immunoosseous dysplasia | 1 | BeFree |
| umls:C1301034 | Pancreatic intraepithelial neoplasia | 1 | BeFree |
| umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 1 | BeFree |
| umls:C1336840 | Type 2 Papillary Renal Cell Carcinoma | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | LHGDN |
| umls:C1516170 | Cancer Cell Growth | 1 | BeFree |
| umls:C1709246 | Non-Neoplastic Disorder | 1 | BeFree |
| umls:C1846582 | Hypoprebetalipoproteinemia, Acanthocytosis, Retinitis Pigmentosa, And Pallidal Degeneration | 1 | BeFree |
| umls:C2711227 | Steatohepatitis | 1 | BeFree |
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