TissGeneSummary for SLC17A7 |
Gene summary |
Basic gene information | Gene symbol | SLC17A7 |
Gene name | solute carrier family 17 (vesicular glutamate transporter), member 7 | |
Synonyms | BNPI|VGLUT1 | |
Cytomap | UCSC genome browser: 19q13 | |
Type of gene | protein-coding | |
RefGenes | NM_020309.3, | |
Description | brain-specific Na(+)-dependent inorganic phosphate cotransporterbrain-specific Na-dependent inorganic phosphate cotransportersolute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7solute carrier family 17 member 7vesicu | |
Modification date | 20141207 | |
dbXrefs | MIM : 605208 | |
HGNC : HGNC | ||
Ensembl : ENSG00000104888 | ||
HPRD : 05551 | ||
Vega : OTTHUMG00000183166 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLC17A7 | |
BioGPS: 57030 | ||
Pathway | NCI Pathway Interaction Database: SLC17A7 | |
KEGG: SLC17A7 | ||
REACTOME: SLC17A7 | ||
Pathway Commons: SLC17A7 | ||
Context | iHOP: SLC17A7 | |
ligand binding site mutation search in PubMed: SLC17A7 | ||
UCL Cancer Institute: SLC17A7 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of SLC17A7 | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0035435 | phosphate ion transmembrane transport | 10820226 | GO:0035725 | sodium ion transmembrane transport | 10820226 | GO:0035435 | phosphate ion transmembrane transport | 10820226 | GO:0035725 | sodium ion transmembrane transport | 10820226 |
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TissGeneExp for SLC17A7 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -2.759237386 | -1.272633386 | -1.486604 | 2.13E-07 | 9.13E-07 |
KIRP | -2.876883011 | -1.564473636 | -1.312409375 | 1.11E-06 | 5.58E-06 |
STAD | -1.670448636 | 0.377060739 | -2.047509375 | 9.46E-08 | 2.59E-06 |
COAD | -2.632078924 | 0.253697999 | -2.885776923 | 6.62E-14 | 2.38E-12 |
BRCA | -1.660383175 | 1.489817702 | -3.150200877 | 2.22E-51 | 1.95E-49 |
KIRC | -2.522097941 | -1.296102108 | -1.225995833 | 3.31E-14 | 1.58E-13 |
THCA | -2.121761454 | 0.38676736 | -2.508528814 | 2.71E-20 | 1.11E-18 |
BLCA | -1.427927912 | 0.141282614 | -1.569210526 | 0.00543 | 0.028084465 |
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TissGene-miRNA for SLC17A7 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SLC17A7 |
TissGeneSNV for SLC17A7 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.V511I | SKCM | 1 |
p.I474T | STAD | 1 |
p.A430D | COAD | 1 |
p.P556L | SKCM | 1 |
p.A404V | SKCM | 1 |
p.S232* | BLCA | 1 |
p.L288F | LGG | 1 |
p.S163L | BRCA | 1 |
p.G39E | SKCM | 1 |
p.G518C | LUSC | 1 |
p.S522N | LUAD | 1 |
p.R166H | STAD | 1 |
p.V129G | COAD | 1 |
p.A107V | SKCM | 1 |
p.R9Q | THYM | 1 |
p.C74F | LUAD | 1 |
p.D276N | UCEC | 1 |
p.P60S | SKCM | 1 |
p.E523K | GBM | 1 |
p.P538L | LAML | 1 |
p.V152L | LUAD | 1 |
p.T95M | STAD | 1 |
p.G341S | HNSC | 1 |
p.R552M | COAD | 1 |
p.K290N | UCEC | 1 |
p.H348N | THYM | 1 |
p.E523K | READ | 1 |
p.V394A | STAD | 1 |
p.G482C | UCEC | 1 |
p.W497C | LGG | 1 |
p.P531L | HNSC | 1 |
p.A207V | GBM | 1 |
p.W194* | SKCM | 1 |
p.W194X | SKCM | 1 |
p.Q230* | UCEC | 1 |
p.G421V | OV | 1 |
p.S267L | COAD | 1 |
p.F510L | HNSC | 1 |
p.G532V | UCEC | 1 |
p.I353T | THCA | 1 |
p.A418T | LUSC | 1 |
p.S420C | BLCA | 1 |
p.S540F | SKCM | 1 |
p.G492E | SKCM | 1 |
p.A225G | PAAD | 1 |
p.R432L | LUAD | 1 |
p.P431L | GBM | 1 |
p.T208M | UCEC | 1 |
p.I79M | LUSC | 1 |
p.A218V | COAD | 1 |
p.S324F | SKCM | 1 |
p.L391V | LUAD | 1 |
p.R61H | COAD | 1 |
p.W194X | LIHC | 1 |
p.F364C | UCEC | 1 |
p.P347S | LUAD | 1 |
p.S398L | STAD | 1 |
p.Y187* | LUSC | 1 |
p.I436M | CESC | 1 |
p.E527K | BLCA | 1 |
p.G39R | SKCM | 1 |
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TissGeneCNV for SLC17A7 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SLC17A7 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BU726961 | SLC17A7-FHIT | chr19:49932736 | chr3:60091684 | |
Chimerdb3.0 | ChiTaRs | NA | BQ345536 | PALM3-SLC17A7 | chr19:14165204 | chr19:49933485 |
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TissGeneNet for SLC17A7 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SLC17A7 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SLC17A7 |
TissGeneDrug for SLC17A7 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SLC17A7 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0036341 | Schizophrenia | 9 | BeFree,GAD,LHGDN |
umls:C0041696 | Unipolar Depression | 3 | BeFree |
umls:C1269683 | Major Depressive Disorder | 3 | BeFree |
umls:C0005586 | Bipolar Disorder | 2 | BeFree |
umls:C0007787 | Transient Ischemic Attack | 1 | RGD |
umls:C0014544 | Epilepsy | 1 | BeFree |
umls:C0017636 | Glioblastoma | 1 | BeFree |
umls:C0017639 | Gliosis | 1 | LHGDN |
umls:C0023186 | Learning Disorders | 1 | CTD_human |
umls:C0025261 | Memory Disorders | 1 | CTD_human |
umls:C0036572 | Seizures | 1 | CTD_human |
umls:C0043094 | Weight Gain | 1 | GAD |
umls:C0149940 | Sciatic Neuropathy | 1 | RGD |
umls:C0497327 | Dementia | 1 | LHGDN |
umls:C2911647 | Weight Gain Adverse Event | 1 | GAD |