TissGeneSummary for CASC5 |
Gene summary |
Basic gene information | Gene symbol | CASC5 |
Gene name | cancer susceptibility candidate 5 | |
Synonyms | AF15Q14|CT29|D40|KNL1|PPP1R55|Spc7|hKNL-1|hSpc105 | |
Cytomap | UCSC genome browser: 15q14 | |
Type of gene | protein-coding | |
RefGenes | NM_144508.4, NM_170589.4, | |
Description | ALL1-fused gene from chromosome 15q14 proteinblinkin, bub-linking kinetochore proteincancer susceptibility candidate gene 5 proteincancer/testis antigen 29kinetochore null 1 homologkinetochore-null protein 1protein CASC5protein phosphatase 1, regul | |
Modification date | 20141219 | |
dbXrefs | MIM : 609173 | |
HGNC : HGNC | ||
Ensembl : ENSG00000137812 | ||
HPRD : 10634 | ||
Vega : OTTHUMG00000166532 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CASC5 | |
BioGPS: 57082 | ||
Pathway | NCI Pathway Interaction Database: CASC5 | |
KEGG: CASC5 | ||
REACTOME: CASC5 | ||
Pathway Commons: CASC5 | ||
Context | iHOP: CASC5 | |
ligand binding site mutation search in PubMed: CASC5 | ||
UCL Cancer Institute: CASC5 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CASC5 | ||
Description by TissGene annotations | Cancer gene Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0008608 | attachment of spindle microtubules to kinetochore | 17981135 | GO:0010923 | negative regulation of phosphatase activity | 19389623 | GO:0034501 | protein localization to kinetochore | 22331848 | GO:0071173 | spindle assembly checkpoint | 17981135 | GO:0008608 | attachment of spindle microtubules to kinetochore | 17981135 | GO:0010923 | negative regulation of phosphatase activity | 19389623 | GO:0034501 | protein localization to kinetochore | 22331848 | GO:0071173 | spindle assembly checkpoint | 17981135 |
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TissGeneExp for CASC5 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | -0.370375273 | -3.097026997 | 2.726651724 | 2.63E-22 | 7.37E-21 |
BLCA | 0.737174001 | -2.536968104 | 3.274142105 | 2.66E-06 | 7.30E-05 |
STAD | 1.442962981 | -0.923265144 | 2.366228125 | 3.56E-06 | 4.79E-05 |
HNSC | 1.261183548 | -0.46092808 | 1.722111628 | 4.03E-07 | 3.42E-06 |
BRCA | 0.313724001 | -2.745587403 | 3.059311404 | 6.69E-46 | 3.21E-44 |
COAD | 1.002766106 | -0.211676202 | 1.214442308 | 5.14E-07 | 3.09E-06 |
LUSC | 1.094535714 | -2.676232913 | 3.770768627 | 2.42E-34 | 2.60E-32 |
PRAD | -2.663355048 | -3.924910817 | 1.261555769 | 1.61E-06 | 1.10E-05 |
KIRP | -2.579108894 | -1.530837019 | -1.048271875 | 0.00254 | 0.006348584 |
ESCA | 2.106743379 | -1.056874803 | 3.163618182 | 0.000268 | 0.006320842 |
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TissGene-miRNA for CASC5 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CASC5 |
TissGeneSNV for CASC5 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E840* | UCEC | 2 |
p.R1422Q | COAD | 1 |
p.D2179Y | ESCA | 1 |
p.S496P | LGG | 1 |
p.P1332L | BLCA | 1 |
p.E1959Q | CESC | 1 |
p.E832Q | BLCA | 1 |
p.H73Y | BLCA | 1 |
p.D240N | SARC | 1 |
p.F2167L | STAD | 1 |
p.P683S | SKCM | 1 |
p.Q1538* | SKCM | 1 |
p.S1105* | BLCA | 1 |
p.L138V | GBM | 1 |
p.V2326I | THYM | 1 |
p.E1648* | SKCM | 1 |
p.D1454H | BLCA | 1 |
p.Q2298E | LUAD | 1 |
p.D290G | THCA | 1 |
p.S271F | SKCM | 1 |
p.H415R | COAD | 1 |
p.R1897T | BRCA | 1 |
p.T438I | THYM | 1 |
p.P676S | UCEC | 1 |
p.A277T | ESCA | 1 |
p.E1826D | UCEC | 1 |
p.F1899L | READ | 1 |
p.E2094D | SARC | 1 |
p.K792N | SARC | 1 |
p.L192* | STAD | 1 |
p.P1684S | ESCA | 1 |
p.H2199Y | SKCM | 1 |
p.R247I | BLCA | 1 |
p.S32C | STAD | 1 |
p.R1940L | LUAD | 1 |
p.S629C | HNSC | 1 |
p.E2162* | UCEC | 1 |
p.L1885F | BLCA | 1 |
p.S140C | BLCA | 1 |
p.G1616* | LUAD | 1 |
p.I15M | LIHC | 1 |
p.P446S | SKCM | 1 |
p.L1436V | BLCA | 1 |
p.P29A | PAAD | 1 |
p.D1878Y | UCEC | 1 |
p.T2148I | SKCM | 1 |
p.K2172N | BRCA | 1 |
p.T2153M | KICH | 1 |
p.E507G | SARC | 1 |
p.E1711* | UCEC | 1 |
p.S629F | UCEC | 1 |
p.D1827G | LIHC | 1 |
p.E814K | CESC | 1 |
p.N116S | UCEC | 1 |
p.Q1601* | SKCM | 1 |
p.M74I | LUSC | 1 |
p.P2192S | SKCM | 1 |
p.Q1538X | SKCM | 1 |
p.G809R | STAD | 1 |
p.G1246E | COAD | 1 |
p.R2122I | UCEC | 1 |
p.Q1302R | STAD | 1 |
p.S578P | LGG | 1 |
p.L2085W | PRAD | 1 |
p.R1913X | COAD | 1 |
p.Q1713* | HNSC | 1 |
p.S441F | COAD | 1 |
p.T113A | BRCA | 1 |
p.M495L | ESCA | 1 |
p.R58* | UCEC | 1 |
p.S235L | BLCA | 1 |
p.D1352Y | UCEC | 1 |
p.E647K | LIHC | 1 |
p.Q149H | ESCA | 1 |
p.P683L | SKCM | 1 |
p.D2114H | BRCA | 1 |
p.G1616V | LUAD | 1 |
p.Q35E | BLCA | 1 |
p.E1793Q | UCEC | 1 |
p.V2326L | LUSC | 1 |
p.G1403A | LAML | 1 |
p.L179P | PRAD | 1 |
p.H2220L | TGCT | 1 |
p.S1444L | BLCA | 1 |
p.G595A | STAD | 1 |
p.E951X | COAD | 1 |
p.R651* | UCEC | 1 |
p.A2018T | STAD | 1 |
p.R58* | SKCM | 1 |
p.G2015* | STAD | 1 |
p.P865S | SKCM | 1 |
p.L192X | STAD | 1 |
p.T1813M | STAD | 1 |
p.E1739K | BRCA | 1 |
p.Q1468R | KICH | 1 |
p.D897N | HNSC | 1 |
p.C1689Y | LUSC | 1 |
p.R1953H | COAD | 1 |
p.M778I | BRCA | 1 |
p.Q318* | BRCA | 1 |
p.A486D | UCEC | 1 |
p.Y112H | LUAD | 1 |
p.K1956N | BLCA | 1 |
p.L2323M | STAD | 1 |
p.R2237I | LGG | 1 |
p.S553L | BLCA | 1 |
p.E2242D | BLCA | 1 |
p.S1275T | LUAD | 1 |
p.E2030D | BLCA | 1 |
p.S483I | LGG | 1 |
p.E464K | HNSC | 1 |
p.K2067X | SKCM | 1 |
p.F2229L | READ | 1 |
p.I698V | ACC | 1 |
p.E2241K | UCEC | 1 |
p.K2247N | HNSC | 1 |
p.R1953G | BLCA | 1 |
p.K2200N | PAAD | 1 |
p.K2067* | SKCM | 1 |
p.R159S | SKCM | 1 |
p.I1880V | LUAD | 1 |
p.I692V | ESCA | 1 |
p.T2311I | UCEC | 1 |
p.T297S | BLCA | 1 |
p.M74I | BLCA | 1 |
p.S1226F | SKCM | 1 |
p.V976F | KIRP | 1 |
p.R1672G | COAD | 1 |
p.S2211F | SKCM | 1 |
p.E126Q | SARC | 1 |
p.P1733L | SKCM | 1 |
p.T412A | READ | 1 |
p.G1482R | LIHC | 1 |
p.E2082Q | BLCA | 1 |
p.E1121G | BLCA | 1 |
p.R247I | UCEC | 1 |
p.T201P | LUSC | 1 |
p.E151G | UCEC | 1 |
p.E217D | UCEC | 1 |
p.S730L | SKCM | 1 |
p.E2241K | HNSC | 1 |
p.S1675Y | COAD | 1 |
p.L1590F | HNSC | 1 |
p.N1633T | BLCA | 1 |
p.H1822R | SKCM | 1 |
p.I416S | KIRC | 1 |
p.T996S | STAD | 1 |
p.R220I | UCEC | 1 |
p.E1280K | LUAD | 1 |
p.I1803S | UCEC | 1 |
p.L752I | READ | 1 |
p.S1324F | LUSC | 1 |
p.Q630* | BLCA | 1 |
p.K1109T | BLCA | 1 |
p.N371K | SKCM | 1 |
p.A2273T | HNSC | 1 |
p.A1964T | LGG | 1 |
p.G1616L | LUAD | 1 |
p.R1422Q | READ | 1 |
p.E541D | COAD | 1 |
p.G2015X | STAD | 1 |
p.P1927A | LUSC | 1 |
p.R57C | UCEC | 1 |
p.E331K | BLCA | 1 |
p.D894N | LGG | 1 |
p.R447X | KIRP | 1 |
p.M1439T | STAD | 1 |
p.M1060T | STAD | 1 |
p.L1417V | SARC | 1 |
p.R58X | SKCM | 1 |
p.E1807* | UCEC | 1 |
p.S1717I | UCEC | 1 |
p.P802L | SKCM | 1 |
p.E1125K | BLCA | 1 |
p.S723Y | STAD | 1 |
p.E71K | SKCM | 1 |
p.R473* | KIRP | 1 |
p.M788V | STAD | 1 |
p.F525L | STAD | 1 |
p.I524M | COAD | 1 |
p.I850S | COAD | 1 |
p.E640D | LIHC | 1 |
p.K1664N | COAD | 1 |
p.K1285E | COAD | 1 |
p.S2194F | SKCM | 1 |
p.R1804I | BLCA | 1 |
p.S2230L | LUSC | 1 |
p.M898T | STAD | 1 |
p.C1202Y | PRAD | 1 |
p.S594L | LIHC | 1 |
p.K1651R | HNSC | 1 |
p.R1033L | LUAD | 1 |
p.S441F | SKCM | 1 |
p.M2116V | KICH | 1 |
p.L2126V | SKCM | 1 |
p.R473X | KIRP | 1 |
p.Q449E | LUAD | 1 |
p.E263* | BLCA | 1 |
p.A1057V | STAD | 1 |
p.N1333I | HNSC | 1 |
p.M598T | COAD | 1 |
p.E2030K | BLCA | 1 |
p.G1566E | PRAD | 1 |
p.T552I | ESCA | 1 |
p.N136S | STAD | 1 |
p.S1004F | HNSC | 1 |
p.D1821H | BLCA | 1 |
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TissGeneCNV for CASC5 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CASC5 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BQ375909 | CASC5-ADAMTS9-AS2 | chr15:40942555 | chr3:64739630 | |
Chimerdb3.0 | FusionScan | CESC | TCGA-IR-A3LK-01A | CASC5-LIPC | 5'UTR-CDS | chr15:40886590 | chr15:58855703 |
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TissGeneNet for CASC5 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CASC5 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CASC5 |
TissGeneDrug for CASC5 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CASC5 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0023467 | Leukemia, Myelocytic, Acute | 2 | BeFree |
umls:C0023449 | Acute lymphocytic leukemia | 1 | BeFree |
umls:C0024121 | Lung Neoplasms | 1 | LHGDN |
umls:C0025202 | melanoma | 1 | BeFree,LHGDN |
umls:C0031117 | Peripheral Neuropathy | 1 | CTD_human |
umls:C0153594 | Malignant neoplasm of testis | 1 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0431350 | Primary microcephaly | 1 | BeFree |
umls:C1858516 | MICROCEPHALY 4, PRIMARY, AUTOSOMAL RECESSIVE | 1 | CLINVAR,UNIPROT |
umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | BeFree |
umls:C3711387 | Autosomal Recessive Primary Microcephaly | 1 | BeFree |