TissGeneSummary for PTGDS |
Gene summary |
Basic gene information | Gene symbol | PTGDS |
Gene name | prostaglandin D2 synthase 21kDa (brain) | |
Synonyms | L-PGDS|LPGDS|PDS|PGD2|PGDS|PGDS2 | |
Cytomap | UCSC genome browser: 9q34.2-q34.3 | |
Type of gene | protein-coding | |
RefGenes | NM_000954.5, | |
Description | PGD2 synthasebeta-trace proteincerebrin-28glutathione-independent PGD synthaseglutathione-independent PGD synthetaselipocalin-type prostaglandin D synthaselipocalin-type prostaglandin-D synthaseprostaglandin D synthaseprostaglandin-D2 synthasepro | |
Modification date | 20141207 | |
dbXrefs | MIM : 176803 | |
HGNC : HGNC | ||
Ensembl : ENSG00000107317 | ||
HPRD : 08904 | ||
Vega : OTTHUMG00000020957 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PTGDS | |
BioGPS: 5730 | ||
Pathway | NCI Pathway Interaction Database: PTGDS | |
KEGG: PTGDS | ||
REACTOME: PTGDS | ||
Pathway Commons: PTGDS | ||
Context | iHOP: PTGDS | |
ligand binding site mutation search in PubMed: PTGDS | ||
UCL Cancer Institute: PTGDS | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | TestisEye | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCTUVM | |
Reference showing the relevant tissue of PTGDS | ||
Description by TissGene annotations | Fused withOncogene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0001516 | prostaglandin biosynthetic process | 20667974 | GO:0001516 | prostaglandin biosynthetic process | 20667974 |
Top |
TissGeneExp for PTGDS |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 1.63201374 | 4.958721583 | -3.326707843 | 6.60E-18 | 5.90E-17 |
BLCA | 0.949340469 | 3.8563931 | -2.907052632 | 1.57E-06 | 4.59E-05 |
LUAD | 2.582692374 | 4.517156167 | -1.934463793 | 3.91E-14 | 3.59E-13 |
KICH | -2.851353005 | 2.561974995 | -5.413328 | 3.10E-11 | 2.69E-10 |
KIRC | -0.154882338 | 2.28355655 | -2.438438889 | 7.88E-10 | 2.60E-09 |
HNSC | -0.028411796 | 2.044767274 | -2.07317907 | 2.32E-08 | 2.55E-07 |
BRCA | 0.00046503 | 2.241564153 | -2.241099123 | 1.77E-23 | 1.60E-22 |
KIRP | -0.88230838 | 3.31847912 | -4.2007875 | 2.14E-08 | 1.52E-07 |
PRAD | 3.760164456 | 5.273879841 | -1.513715385 | 7.06E-10 | 1.20E-08 |
LIHC | 0.325524995 | 2.033218995 | -1.707694 | 0.00935 | 0.01989114 |
COAD | 0.637000995 | 2.10056638 | -1.463565385 | 0.000341 | 0.001093896 |
THCA | 0.080379808 | 1.576413707 | -1.496033898 | 0.000319 | 0.0008118 |
Top |
TissGene-miRNA for PTGDS |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for PTGDS |
TissGeneSNV for PTGDS |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.F34Y | UCEC | 1 |
p.V69M | KIRC | 1 |
p.R111C | SKCM | 1 |
p.Y128* | OV | 1 |
p.A163V | LUAD | 1 |
p.S151F | SKCM | 1 |
p.R42H | STAD | 1 |
p.F213S | ESCA | 1 |
p.T164N | ACC | 1 |
p.R111L | LUAD | 1 |
p.Q21H | COAD | 1 |
p.Q204R | SKCM | 1 |
p.F179S | ESCA | 1 |
p.A46T | LUAD | 1 |
p.H111Y | SKCM | 1 |
p.A163T | PAAD | 1 |
p.N87S | UCEC | 1 |
p.A99E | LUAD | 1 |
p.F200L | HNSC | 1 |
p.T186I | SKCM | 1 |
p.T130M | PAAD | 1 |
p.A99V | ESCA | 1 |
p.A129T | PAAD | 1 |
p.H4Y | BLCA | 1 |
p.D74N | UCEC | 1 |
p.T198N | ACC | 1 |
p.E90K | BRCA | 1 |
p.L130M | COAD | 1 |
p.A60V | PAAD | 1 |
p.R108Q | SKCM | 1 |
p.S28I | UCEC | 1 |
p.Q97H | THYM | 1 |
p.A128V | SKCM | 1 |
Top |
TissGeneCNV for PTGDS |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for PTGDS |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | CB153680 | PTGDS-HIP1R | chr9:139872044 | chr12:123343442 | |
Chimerdb3.0 | ChiTaRs | NA | DA811774 | PTGDS-HKR1 | chr9:139873699 | chr19:37853722 | |
Chimerdb3.0 | ChiTaRs | NA | AJ711203 | PTGDS-MYL7 | chr9:139872044 | chr7:44178466 | |
Chimerdb3.0 | ChiTaRs | NA | DA262936 | PTGDS-DIP2C | chr9:139874447 | chr10:709466 | |
Chimerdb3.0 | ChiTaRs | NA | BQ950270 | PTGDS-PTGDS | chr9:139876170 | chr9:139871961 | |
Chimerdb3.0 | ChiTaRs | NA | AW316630 | PTGDS-FAM63A | chr9:139876196 | chr1:150970227 | |
Chimerdb3.0 | ChiTaRs | NA | EB387717 | PTGDS-SIDT2 | chr9:139872160 | chr11:117052160 | |
Chimerdb3.0 | ChiTaRs | NA | Z17825 | SRRM2-PTGDS | chr16:2813449 | chr9:139871956 | |
Chimerdb3.0 | ChiTaRs | NA | BC094690 | MYBPC2-PTGDS | chr19:50945535 | chr9:139872062 | |
Chimerdb3.0 | FusionScan | LGG | TCGA-P5-A5EZ-01A | PTGDS-HIP1R | In-Frame | chr9:139872144 | chr12:123342648 |
Chimerdb3.0 | FusionScan | LGG | TCGA-HT-7874-01A | PTGDS-HIP1R | In-Frame | chr9:139872144 | chr12:123342648 |
Chimerdb3.0 | FusionScan | LGG | TCGA-HW-7495-01A | PTGDS-HIP1R | In-Frame | chr9:139872144 | chr12:123342648 |
Chimerdb3.0 | FusionScan | LGG | TCGA-E1-A7YK-01A | PTGDS-HIP1R | In-Frame | chr9:139872144 | chr12:123342648 |
Chimerdb3.0 | TopHat-Fusion | LGG | TCGA-E1-A7YK-01A | PTGDS-HIP1R | In-Frame | chr9:139872143 | chr12:123342648 |
TCGAfusionPortal | PRADA | LGG | TCGA-CS-6665-01A | PTGDS-EEA1 | NA | Chr9:139876193 | Chr12:93229203 |
Top |
TissGeneNet for PTGDS |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for PTGDS |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for PTGDS |
TissGeneDrug for PTGDS |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for PTGDS |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0271829 | Pendred's syndrome | 25 | BeFree |
umls:C0004096 | Asthma | 8 | BeFree,GAD |
umls:C0155552 | Hearing Loss, Mixed Conductive-Sensorineural | 6 | BeFree |
umls:C1863752 | Enlarged Vestibular Aqueduct | 5 | BeFree |
umls:C0002395 | Alzheimer's Disease | 4 | BeFree,LHGDN |
umls:C0011175 | Dehydration | 4 | BeFree |
umls:C0018021 | Goiter | 4 | BeFree |
umls:C0032285 | Pneumonia | 4 | BeFree |
umls:C0004153 | Atherosclerosis | 3 | BeFree,LHGDN |
umls:C0016382 | Flushing | 3 | BeFree |
umls:C0155877 | Allergic asthma | 3 | BeFree |
umls:C0266589 | Congenital ear anomaly NOS (disorder) | 3 | BeFree |
umls:C3711374 | Nonsyndromic Deafness | 3 | BeFree |
umls:C0001430 | Adenoma | 2 | BeFree |
umls:C0003850 | Arteriosclerosis | 2 | BeFree |
umls:C0005586 | Bipolar Disorder | 2 | BeFree |
umls:C0006118 | Brain Neoplasms | 2 | BeFree |
umls:C0009319 | Colitis | 2 | BeFree |
umls:C0009324 | Ulcerative Colitis | 2 | BeFree |
umls:C0010278 | Craniosynostosis | 2 | BeFree |
umls:C0014458 | Eosinophilia, Tropical | 2 | BeFree |
umls:C0018784 | Sensorineural Hearing Loss (disorder) | 2 | BeFree,RGD |
umls:C0025202 | melanoma | 2 | BeFree |
umls:C0027430 | Nasal Polyps | 2 | BeFree |
umls:C0029408 | Degenerative polyarthritis | 2 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 2 | BeFree |
umls:C0040128 | Thyroid Diseases | 2 | BeFree |
umls:C0085409 | Polyendocrinopathies, Autoimmune | 2 | BeFree |
umls:C0149516 | Chronic sinusitis | 2 | BeFree |
umls:C0178468 | Autoimmune thyroid disease | 2 | BeFree |
umls:C0242339 | Dyslipidemias | 2 | BeFree |
umls:C0338831 | Manic | 2 | BeFree |
umls:C0549473 | Thyroid carcinoma | 2 | BeFree |
umls:C0001849 | AIDS Dementia Complex | 1 | LHGDN |
umls:C0004114 | Astrocytoma | 1 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree,GAD |
umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
umls:C0010417 | Cryptorchidism | 1 | BeFree |
umls:C0011603 | Dermatitis | 1 | BeFree |
umls:C0011615 | Dermatitis, Atopic | 1 | BeFree |
umls:C0011847 | Diabetes | 1 | BeFree |
umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | RGD |
umls:C0011881 | Diabetic Nephropathy | 1 | BeFree |
umls:C0013080 | Down Syndrome | 1 | BeFree |
umls:C0013238 | Dry Eye Syndromes | 1 | BeFree |
umls:C0013274 | Patent ductus arteriosus | 1 | BeFree |
umls:C0013395 | Dyspepsia | 1 | BeFree |
umls:C0013595 | Eczema | 1 | BeFree |
umls:C0015230 | Exanthema | 1 | BeFree |
umls:C0017152 | Gastritis | 1 | BeFree |
umls:C0017636 | Glioblastoma | 1 | BeFree |
umls:C0018213 | Graves Disease | 1 | BeFree |
umls:C0018378 | Guillain-Barre Syndrome | 1 | BeFree |
umls:C0020459 | Hyperinsulinism | 1 | BeFree |
umls:C0020523 | Immediate hypersensitivity | 1 | GAD |
umls:C0021841 | Intestinal Neoplasms | 1 | BeFree |
umls:C0022578 | Keratoconus | 1 | BeFree |
umls:C0022661 | Kidney Failure, Chronic | 1 | GAD |
umls:C0024299 | Lymphoma | 1 | BeFree |
umls:C0025149 | Medulloblastoma | 1 | BeFree |
umls:C0025286 | Meningioma | 1 | BeFree |
umls:C0027832 | Neurofibromatosis 2 | 1 | BeFree |
umls:C0028754 | Obesity | 1 | BeFree |
umls:C0031099 | Periodontitis | 1 | GAD |
umls:C0032584 | polyps | 1 | BeFree |
umls:C0032927 | Precancerous Conditions | 1 | BeFree |
umls:C0033860 | Psoriasis | 1 | BeFree |
umls:C0036341 | Schizophrenia | 1 | LHGDN |
umls:C0037199 | Sinusitis | 1 | BeFree |
umls:C0040136 | Thyroid Neoplasm | 1 | BeFree |
umls:C0085129 | Bronchial Hyperreactivity | 1 | GAD |
umls:C0151650 | Renal fibrosis | 1 | BeFree |
umls:C0152021 | Congenital heart disease | 1 | BeFree |
umls:C0220603 | childhood brain tumor | 1 | BeFree |
umls:C0238463 | Papillary thyroid carcinoma | 1 | BeFree |
umls:C0278510 | Medulloblastoma, Childhood | 1 | BeFree |
umls:C0314719 | Dryness of eye | 1 | BeFree |
umls:C0333463 | Senile Plaques | 1 | BeFree |
umls:C0334579 | Anaplastic astrocytoma | 1 | BeFree |
umls:C0340068 | Aspirin-sensitive asthma with nasal polyps | 1 | BeFree |
umls:C0349619 | Medulloblastoma of cerebellum | 1 | BeFree |
umls:C0374997 | Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 1 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
umls:C0431664 | Unilateral Cryptorchidism | 1 | BeFree |
umls:C0524620 | Metabolic Syndrome X | 1 | BeFree |
umls:C0546969 | Preauricular Fistulae, Congenital | 1 | BeFree |
umls:C0577631 | Carotid Atherosclerosis | 1 | BeFree,GAD |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0600139 | Prostate carcinoma | 1 | BeFree |
umls:C0677607 | Hashimoto Disease | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C0699790 | Colon Carcinoma | 1 | BeFree |
umls:C0848332 | Spots on skin | 1 | BeFree |
umls:C0919267 | ovarian neoplasm | 1 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
umls:C1263846 | Attention deficit hyperactivity disorder | 1 | BeFree |
umls:C1314694 | Astrocytoma, low grade | 1 | BeFree |
umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
umls:C1527249 | Colorectal Cancer | 1 | BeFree |
umls:C1561643 | Chronic Kidney Diseases | 1 | BeFree |
umls:C1762616 | Meningioma, benign, no ICD-O subtype | 1 | BeFree |
umls:C3542501 | Acute inflammatory demyelinating polyneuropathy | 1 | BeFree |