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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for PTGDS
check button Gene summary
Basic gene informationGene symbolPTGDS
Gene nameprostaglandin D2 synthase 21kDa (brain)
SynonymsL-PGDS|LPGDS|PDS|PGD2|PGDS|PGDS2
CytomapUCSC genome browser: 9q34.2-q34.3
Type of geneprotein-coding
RefGenesNM_000954.5,
DescriptionPGD2 synthasebeta-trace proteincerebrin-28glutathione-independent PGD synthaseglutathione-independent PGD synthetaselipocalin-type prostaglandin D synthaselipocalin-type prostaglandin-D synthaseprostaglandin D synthaseprostaglandin-D2 synthasepro
Modification date20141207
dbXrefs MIM : 176803
HGNC : HGNC
Ensembl : ENSG00000107317
HPRD : 08904
Vega : OTTHUMG00000020957
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PTGDS
BioGPS: 5730
PathwayNCI Pathway Interaction Database: PTGDS
KEGG: PTGDS
REACTOME: PTGDS
Pathway Commons: PTGDS
ContextiHOP: PTGDS
ligand binding site mutation search in PubMed: PTGDS
UCL Cancer Institute: PTGDS
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)TestisEye
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)TGCTUVM
Reference showing the relevant tissue of PTGDS
Description by TissGene annotationsFused withOncogene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0001516prostaglandin biosynthetic process20667974
GO:0001516prostaglandin biosynthetic process20667974


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TissGeneExp for PTGDS

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUSC1.632013744.958721583-3.3267078436.60E-185.90E-17
BLCA0.9493404693.8563931-2.9070526321.57E-064.59E-05
LUAD2.5826923744.517156167-1.9344637933.91E-143.59E-13
KICH-2.8513530052.561974995-5.4133283.10E-112.69E-10
KIRC-0.1548823382.28355655-2.4384388897.88E-102.60E-09
HNSC-0.0284117962.044767274-2.073179072.32E-082.55E-07
BRCA0.000465032.241564153-2.2410991231.77E-231.60E-22
KIRP-0.882308383.31847912-4.20078752.14E-081.52E-07
PRAD3.7601644565.273879841-1.5137153857.06E-101.20E-08
LIHC0.3255249952.033218995-1.7076940.009350.01989114
COAD0.6370009952.10056638-1.4635653850.0003410.001093896
THCA0.0803798081.576413707-1.4960338980.0003190.0008118


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TissGene-miRNA for PTGDS

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for PTGDS
TissGeneSNV for PTGDS

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.F34YUCEC1
p.V69MKIRC1
p.R111CSKCM1
p.Y128*OV1
p.A163VLUAD1
p.S151FSKCM1
p.R42HSTAD1
p.F213SESCA1
p.T164NACC1
p.R111LLUAD1
p.Q21HCOAD1
p.Q204RSKCM1
p.F179SESCA1
p.A46TLUAD1
p.H111YSKCM1
p.A163TPAAD1
p.N87SUCEC1
p.A99ELUAD1
p.F200LHNSC1
p.T186ISKCM1
p.T130MPAAD1
p.A99VESCA1
p.A129TPAAD1
p.H4YBLCA1
p.D74NUCEC1
p.T198NACC1
p.E90KBRCA1
p.L130MCOAD1
p.A60VPAAD1
p.R108QSKCM1
p.S28IUCEC1
p.Q97HTHYM1
p.A128VSKCM1


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TissGeneCNV for PTGDS

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for PTGDS

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNACB153680PTGDS-HIP1Rchr9:139872044chr12:123343442
Chimerdb3.0ChiTaRsNADA811774PTGDS-HKR1chr9:139873699chr19:37853722
Chimerdb3.0ChiTaRsNAAJ711203PTGDS-MYL7chr9:139872044chr7:44178466
Chimerdb3.0ChiTaRsNADA262936PTGDS-DIP2Cchr9:139874447chr10:709466
Chimerdb3.0ChiTaRsNABQ950270PTGDS-PTGDSchr9:139876170chr9:139871961
Chimerdb3.0ChiTaRsNAAW316630PTGDS-FAM63Achr9:139876196chr1:150970227
Chimerdb3.0ChiTaRsNAEB387717PTGDS-SIDT2chr9:139872160chr11:117052160
Chimerdb3.0ChiTaRsNAZ17825SRRM2-PTGDSchr16:2813449chr9:139871956
Chimerdb3.0ChiTaRsNABC094690MYBPC2-PTGDSchr19:50945535chr9:139872062
Chimerdb3.0FusionScanLGGTCGA-P5-A5EZ-01APTGDS-HIP1RIn-Framechr9:139872144chr12:123342648
Chimerdb3.0FusionScanLGGTCGA-HT-7874-01APTGDS-HIP1RIn-Framechr9:139872144chr12:123342648
Chimerdb3.0FusionScanLGGTCGA-HW-7495-01APTGDS-HIP1RIn-Framechr9:139872144chr12:123342648
Chimerdb3.0FusionScanLGGTCGA-E1-A7YK-01APTGDS-HIP1RIn-Framechr9:139872144chr12:123342648
Chimerdb3.0TopHat-FusionLGGTCGA-E1-A7YK-01APTGDS-HIP1RIn-Framechr9:139872143chr12:123342648
TCGAfusionPortalPRADALGGTCGA-CS-6665-01APTGDS-EEA1NAChr9:139876193Chr12:93229203


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TissGeneNet for PTGDS

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
PTGDS, MLH1, SCN9A, SHBG, CACNA1A, EGFR, ATXN1, USF1, PHYH, HK2, HES1, CAPN1, HK3, TFAP2B, PTGFR, PTGER2, BCAT2 (tumor)PTGDS, MLH1, SCN9A, SHBG, CACNA1A, EGFR, ATXN1, USF1, PHYH, HK2, HES1, CAPN1, HK3, TFAP2B, PTGFR, PTGER2, BCAT2 (normal)
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COAD (tumor)COAD (normal)
PTGDS, MLH1, SCN9A, SHBG, CACNA1A, EGFR, ATXN1, USF1, PHYH, HK2, HES1, CAPN1, HK3, TFAP2B, PTGFR, PTGER2, BCAT2 (tumor)PTGDS, MLH1, SCN9A, SHBG, CACNA1A, EGFR, ATXN1, USF1, PHYH, HK2, HES1, CAPN1, HK3, TFAP2B, PTGFR, PTGER2, BCAT2 (normal)
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HNSC (tumor)HNSC (normal)
PTGDS, MLH1, SCN9A, SHBG, CACNA1A, EGFR, ATXN1, USF1, PHYH, HK2, HES1, CAPN1, HK3, TFAP2B, PTGFR, PTGER2, BCAT2 (tumor)PTGDS, MLH1, SCN9A, SHBG, CACNA1A, EGFR, ATXN1, USF1, PHYH, HK2, HES1, CAPN1, HK3, TFAP2B, PTGFR, PTGER2, BCAT2 (normal)
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KICH (tumor)KICH (normal)
PTGDS, MLH1, SCN9A, SHBG, CACNA1A, EGFR, ATXN1, USF1, PHYH, HK2, HES1, CAPN1, HK3, TFAP2B, PTGFR, PTGER2, BCAT2 (tumor)PTGDS, MLH1, SCN9A, SHBG, CACNA1A, EGFR, ATXN1, USF1, PHYH, HK2, HES1, CAPN1, HK3, TFAP2B, PTGFR, PTGER2, BCAT2 (normal)
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KIRC (tumor)KIRC (normal)
PTGDS, MLH1, SCN9A, SHBG, CACNA1A, EGFR, ATXN1, USF1, PHYH, HK2, HES1, CAPN1, HK3, TFAP2B, PTGFR, PTGER2, BCAT2 (tumor)PTGDS, MLH1, SCN9A, SHBG, CACNA1A, EGFR, ATXN1, USF1, PHYH, HK2, HES1, CAPN1, HK3, TFAP2B, PTGFR, PTGER2, BCAT2 (normal)
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KIRP (tumor)KIRP (normal)
PTGDS, MLH1, SCN9A, SHBG, CACNA1A, EGFR, ATXN1, USF1, PHYH, HK2, HES1, CAPN1, HK3, TFAP2B, PTGFR, PTGER2, BCAT2 (tumor)PTGDS, MLH1, SCN9A, SHBG, CACNA1A, EGFR, ATXN1, USF1, PHYH, HK2, HES1, CAPN1, HK3, TFAP2B, PTGFR, PTGER2, BCAT2 (normal)
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LIHC (tumor)LIHC (normal)
PTGDS, MLH1, SCN9A, SHBG, CACNA1A, EGFR, ATXN1, USF1, PHYH, HK2, HES1, CAPN1, HK3, TFAP2B, PTGFR, PTGER2, BCAT2 (tumor)PTGDS, MLH1, SCN9A, SHBG, CACNA1A, EGFR, ATXN1, USF1, PHYH, HK2, HES1, CAPN1, HK3, TFAP2B, PTGFR, PTGER2, BCAT2 (normal)
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LUAD (tumor)LUAD (normal)
PTGDS, MLH1, SCN9A, SHBG, CACNA1A, EGFR, ATXN1, USF1, PHYH, HK2, HES1, CAPN1, HK3, TFAP2B, PTGFR, PTGER2, BCAT2 (tumor)PTGDS, MLH1, SCN9A, SHBG, CACNA1A, EGFR, ATXN1, USF1, PHYH, HK2, HES1, CAPN1, HK3, TFAP2B, PTGFR, PTGER2, BCAT2 (normal)
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LUSC (tumor)LUSC (normal)
PTGDS, MLH1, SCN9A, SHBG, CACNA1A, EGFR, ATXN1, USF1, PHYH, HK2, HES1, CAPN1, HK3, TFAP2B, PTGFR, PTGER2, BCAT2 (tumor)PTGDS, MLH1, SCN9A, SHBG, CACNA1A, EGFR, ATXN1, USF1, PHYH, HK2, HES1, CAPN1, HK3, TFAP2B, PTGFR, PTGER2, BCAT2 (normal)
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PRAD (tumor)PRAD (normal)
PTGDS, MLH1, SCN9A, SHBG, CACNA1A, EGFR, ATXN1, USF1, PHYH, HK2, HES1, CAPN1, HK3, TFAP2B, PTGFR, PTGER2, BCAT2 (tumor)PTGDS, MLH1, SCN9A, SHBG, CACNA1A, EGFR, ATXN1, USF1, PHYH, HK2, HES1, CAPN1, HK3, TFAP2B, PTGFR, PTGER2, BCAT2 (normal)
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STAD (tumor)STAD (normal)
PTGDS, MLH1, SCN9A, SHBG, CACNA1A, EGFR, ATXN1, USF1, PHYH, HK2, HES1, CAPN1, HK3, TFAP2B, PTGFR, PTGER2, BCAT2 (tumor)PTGDS, MLH1, SCN9A, SHBG, CACNA1A, EGFR, ATXN1, USF1, PHYH, HK2, HES1, CAPN1, HK3, TFAP2B, PTGFR, PTGER2, BCAT2 (normal)
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THCA (tumor)THCA (normal)
PTGDS, MLH1, SCN9A, SHBG, CACNA1A, EGFR, ATXN1, USF1, PHYH, HK2, HES1, CAPN1, HK3, TFAP2B, PTGFR, PTGER2, BCAT2 (tumor)PTGDS, MLH1, SCN9A, SHBG, CACNA1A, EGFR, ATXN1, USF1, PHYH, HK2, HES1, CAPN1, HK3, TFAP2B, PTGFR, PTGER2, BCAT2 (normal)
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TissGeneProg for PTGDS

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for PTGDS
TissGeneDrug for PTGDS

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for PTGDS

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0271829Pendred's syndrome25BeFree
umls:C0004096Asthma8BeFree,GAD
umls:C0155552Hearing Loss, Mixed Conductive-Sensorineural6BeFree
umls:C1863752Enlarged Vestibular Aqueduct5BeFree
umls:C0002395Alzheimer's Disease4BeFree,LHGDN
umls:C0011175Dehydration4BeFree
umls:C0018021Goiter4BeFree
umls:C0032285Pneumonia4BeFree
umls:C0004153Atherosclerosis3BeFree,LHGDN
umls:C0016382Flushing3BeFree
umls:C0155877Allergic asthma3BeFree
umls:C0266589Congenital ear anomaly NOS (disorder)3BeFree
umls:C3711374Nonsyndromic Deafness3BeFree
umls:C0001430Adenoma2BeFree
umls:C0003850Arteriosclerosis2BeFree
umls:C0005586Bipolar Disorder2BeFree
umls:C0006118Brain Neoplasms2BeFree
umls:C0009319Colitis2BeFree
umls:C0009324Ulcerative Colitis2BeFree
umls:C0010278Craniosynostosis2BeFree
umls:C0014458Eosinophilia, Tropical2BeFree
umls:C0018784Sensorineural Hearing Loss (disorder)2BeFree,RGD
umls:C0025202melanoma2BeFree
umls:C0027430Nasal Polyps2BeFree
umls:C0029408Degenerative polyarthritis2BeFree
umls:C0029925Ovarian Carcinoma2BeFree
umls:C0040128Thyroid Diseases2BeFree
umls:C0085409Polyendocrinopathies, Autoimmune2BeFree
umls:C0149516Chronic sinusitis2BeFree
umls:C0178468Autoimmune thyroid disease2BeFree
umls:C0242339Dyslipidemias2BeFree
umls:C0338831Manic2BeFree
umls:C0549473Thyroid carcinoma2BeFree
umls:C0001849AIDS Dementia Complex1LHGDN
umls:C0004114Astrocytoma1BeFree
umls:C0006142Malignant neoplasm of breast1BeFree,GAD
umls:C0007102Malignant tumor of colon1BeFree
umls:C0009402Colorectal Carcinoma1BeFree
umls:C0010417Cryptorchidism1BeFree
umls:C0011603Dermatitis1BeFree
umls:C0011615Dermatitis, Atopic1BeFree
umls:C0011847Diabetes1BeFree
umls:C0011849Diabetes Mellitus1BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent1RGD
umls:C0011881Diabetic Nephropathy1BeFree
umls:C0013080Down Syndrome1BeFree
umls:C0013238Dry Eye Syndromes1BeFree
umls:C0013274Patent ductus arteriosus1BeFree
umls:C0013395Dyspepsia1BeFree
umls:C0013595Eczema1BeFree
umls:C0015230Exanthema1BeFree
umls:C0017152Gastritis1BeFree
umls:C0017636Glioblastoma1BeFree
umls:C0018213Graves Disease1BeFree
umls:C0018378Guillain-Barre Syndrome1BeFree
umls:C0020459Hyperinsulinism1BeFree
umls:C0020523Immediate hypersensitivity1GAD
umls:C0021841Intestinal Neoplasms1BeFree
umls:C0022578Keratoconus1BeFree
umls:C0022661Kidney Failure, Chronic1GAD
umls:C0024299Lymphoma1BeFree
umls:C0025149Medulloblastoma1BeFree
umls:C0025286Meningioma1BeFree
umls:C0027832Neurofibromatosis 21BeFree
umls:C0028754Obesity1BeFree
umls:C0031099Periodontitis1GAD
umls:C0032584polyps1BeFree
umls:C0032927Precancerous Conditions1BeFree
umls:C0033860Psoriasis1BeFree
umls:C0036341Schizophrenia1LHGDN
umls:C0037199Sinusitis1BeFree
umls:C0040136Thyroid Neoplasm1BeFree
umls:C0085129Bronchial Hyperreactivity1GAD
umls:C0151650Renal fibrosis1BeFree
umls:C0152021Congenital heart disease1BeFree
umls:C0220603childhood brain tumor1BeFree
umls:C0238463Papillary thyroid carcinoma1BeFree
umls:C0278510Medulloblastoma, Childhood1BeFree
umls:C0314719Dryness of eye1BeFree
umls:C0333463Senile Plaques1BeFree
umls:C0334579Anaplastic astrocytoma1BeFree
umls:C0340068Aspirin-sensitive asthma with nasal polyps1BeFree
umls:C0349619Medulloblastoma of cerebellum1BeFree
umls:C0374997Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site1BeFree
umls:C0376358Malignant neoplasm of prostate1BeFree
umls:C0431664Unilateral Cryptorchidism1BeFree
umls:C0524620Metabolic Syndrome X1BeFree
umls:C0546969Preauricular Fistulae, Congenital1BeFree
umls:C0577631Carotid Atherosclerosis1BeFree,GAD
umls:C0596263Carcinogenesis1BeFree
umls:C0600139Prostate carcinoma1BeFree
umls:C0677607Hashimoto Disease1BeFree
umls:C0678222Breast Carcinoma1BeFree
umls:C0699790Colon Carcinoma1BeFree
umls:C0848332Spots on skin1BeFree
umls:C0919267ovarian neoplasm1BeFree
umls:C1140680Malignant neoplasm of ovary1BeFree
umls:C1263846Attention deficit hyperactivity disorder1BeFree
umls:C1314694Astrocytoma, low grade1BeFree
umls:C1458155Mammary Neoplasms1BeFree
umls:C1527249Colorectal Cancer1BeFree
umls:C1561643Chronic Kidney Diseases1BeFree
umls:C1762616Meningioma, benign, no ICD-O subtype1BeFree
umls:C3542501Acute inflammatory demyelinating polyneuropathy1BeFree