TissGeneSummary for TTYH1 |
Gene summary |
Basic gene information | Gene symbol | TTYH1 |
Gene name | tweety family member 1 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 19q13.4 | |
Type of gene | protein-coding | |
RefGenes | NM_001005367.2, NM_001201461.1,NM_020659.3, | |
Description | hTTY1protein tweety homolog 1tweety homolog 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 605784 | |
HGNC : HGNC | ||
Ensembl : ENSG00000167614 | ||
HPRD : 12043 | ||
Vega : OTTHUMG00000065544 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TTYH1 | |
BioGPS: 57348 | ||
Pathway | NCI Pathway Interaction Database: TTYH1 | |
KEGG: TTYH1 | ||
REACTOME: TTYH1 | ||
Pathway Commons: TTYH1 | ||
Context | iHOP: TTYH1 | |
ligand binding site mutation search in PubMed: TTYH1 | ||
UCL Cancer Institute: TTYH1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of TTYH1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0006821 | chloride transport | 16219661 | GO:0044070 | regulation of anion transport | 16219661 | GO:0006821 | chloride transport | 16219661 | GO:0044070 | regulation of anion transport | 16219661 |
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TissGeneExp for TTYH1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | -3.052345649 | -1.094422572 | -1.957923077 | 1.87E-06 | 9.87E-06 |
LUSC | -2.202219556 | -4.477084261 | 2.274864706 | 1.09E-12 | 4.99E-12 |
HNSC | -2.202478744 | 0.026030558 | -2.228509302 | 2.79E-09 | 4.00E-08 |
BRCA | -1.264823787 | 2.386415687 | -3.651239474 | 1.02E-28 | 1.24E-27 |
LUAD | -3.095826418 | -4.38149366 | 1.285667241 | 2.90E-08 | 1.23E-07 |
LIHC | -2.745402418 | -1.486608418 | -1.258794 | 0.0013 | 0.003491294 |
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TissGene-miRNA for TTYH1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TTYH1 |
TissGeneSNV for TTYH1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.Q339* | BLCA | 3 |
p.G359* | UCEC | 1 |
p.I136T | HNSC | 1 |
p.T357R | KIRC | 1 |
p.A418S | KIRP | 1 |
p.G101S | STAD | 1 |
p.E386K | SKCM | 1 |
p.R334* | ESCA | 1 |
p.G56C | LUSC | 1 |
p.A97T | LUAD | 1 |
p.N304K | READ | 1 |
p.G188R | THCA | 1 |
p.A427T | READ | 1 |
p.D117N | BLCA | 1 |
p.S84L | SKCM | 1 |
p.D137E | LUSC | 1 |
p.G259D | LUSC | 1 |
p.R415Q | READ | 1 |
p.A100V | SKCM | 1 |
p.V64A | ACC | 1 |
p.T286S | BRCA | 1 |
p.412_412insT | SKCM | 1 |
p.R415* | LUAD | 1 |
p.R442H | STAD | 1 |
p.I67T | GBM | 1 |
p.S120C | BLCA | 1 |
p.R371H | ESCA | 1 |
p.A43D | KIRP | 1 |
p.R177W | THYM | 1 |
p.R443H | STAD | 1 |
p.A216V | LUAD | 1 |
p.P75T | BRCA | 1 |
p.Q438X | SKCM | 1 |
p.R177Q | COAD | 1 |
p.L439F | LGG | 1 |
p.R173P | BLCA | 1 |
p.C89X | KIRC | 1 |
p.T267K | LUAD | 1 |
p.L55* | SKCM | 1 |
p.H138Y | LUSC | 1 |
p.E351D | READ | 1 |
p.R68C | SKCM | 1 |
p.L381M | COAD | 1 |
p.S347F | TGCT | 1 |
p.E390K | HNSC | 1 |
p.G108S | STAD | 1 |
p.G118V | LUAD | 1 |
p.A172T | COAD | 1 |
p.R334X | ESCA | 1 |
p.E154* | UCEC | 1 |
p.A125V | KIRP | 1 |
p.S84W | LIHC | 1 |
p.P74H | CESC | 1 |
p.A129D | UCS | 1 |
p.Q438* | SKCM | 1 |
p.A51T | STAD | 1 |
p.Q344* | UCEC | 1 |
p.R73Q | STAD | 1 |
p.S402F | BRCA | 1 |
p.A343V | UCEC | 1 |
p.S342L | ESCA | 1 |
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TissGeneCNV for TTYH1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TTYH1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BI754520 | NRXN1-TTYH1 | chr2:51259252 | chr19:54926798 | |
Chimerdb3.0 | FusionScan | LUAD | TCGA-49-4488-01A | COX6B1-TTYH1 | Out-of-Frame | chr19:36142251 | chr19:54937849 |
TCGAfusionPortal | PRADA | LUSC | TCGA-66-2781-01A | CNTN5-TTYH1 | 5UTR-CDS | Chr11:98892000 | Chr19:54946722 |
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TissGeneNet for TTYH1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TTYH1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TTYH1 |
TissGeneDrug for TTYH1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TTYH1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006118 | Brain Neoplasms | 2 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |