TissGeneSummary for USP29 |
Gene summary |
Basic gene information | Gene symbol | USP29 |
Gene name | ubiquitin specific peptidase 29 | |
Synonyms | HOM-TES-84/86 | |
Cytomap | UCSC genome browser: 19q13.43 | |
Type of gene | protein-coding | |
RefGenes | NM_020903.2, | |
Description | deubiquitinating enzyme 29ubiquitin carboxyl-terminal hydrolase 29ubiquitin thioesterase 29ubiquitin thiolesterase 29ubiquitin-specific processing proteaseubiquitin-specific-processing protease 29 | |
Modification date | 20141207 | |
dbXrefs | MIM : 609546 | |
HGNC : HGNC | ||
Ensembl : ENSG00000131864 | ||
HPRD : 07163 | ||
Vega : OTTHUMG00000183101 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_USP29 | |
BioGPS: 57663 | ||
Pathway | NCI Pathway Interaction Database: USP29 | |
KEGG: USP29 | ||
REACTOME: USP29 | ||
Pathway Commons: USP29 | ||
Context | iHOP: USP29 | |
ligand binding site mutation search in PubMed: USP29 | ||
UCL Cancer Institute: USP29 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of USP29 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for USP29 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for USP29 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for USP29 |
TissGeneSNV for USP29 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D858N | SKCM | 5 |
p.Q52* | SKCM | 3 |
p.G291E | SKCM | 3 |
p.P307L | SKCM | 2 |
p.Q52X | SKCM | 2 |
p.K546T | ESCA | 2 |
p.S302L | SKCM | 2 |
p.P236S | SKCM | 2 |
p.P307S | SKCM | 2 |
p.D116N | SKCM | 2 |
p.P466S | SKCM | 2 |
p.M569I | SKCM | 2 |
p.S153L | SKCM | 2 |
p.E349K | BLCA | 1 |
p.E527K | SKCM | 1 |
p.L465P | UCEC | 1 |
p.N209K | LUAD | 1 |
p.S588R | HNSC | 1 |
p.N517S | READ | 1 |
p.R123K | SKCM | 1 |
p.E809* | LUSC | 1 |
p.Q284L | LUSC | 1 |
p.Q904H | LUSC | 1 |
p.F341L | UCEC | 1 |
p.G788C | HNSC | 1 |
p.E631Q | BLCA | 1 |
p.E400* | BRCA | 1 |
p.P423T | LUAD | 1 |
p.C541Y | LIHC | 1 |
p.Q460* | SKCM | 1 |
p.Y856C | LUSC | 1 |
p.K719* | OV | 1 |
p.Q11* | LUSC | 1 |
p.S553I | HNSC | 1 |
p.L126M | LUAD | 1 |
p.Q736K | STAD | 1 |
p.P819S | SKCM | 1 |
p.H262Y | COAD | 1 |
p.N192K | LUSC | 1 |
p.N188H | SKCM | 1 |
p.D656Y | LUAD | 1 |
p.E679K | BLCA | 1 |
p.R899L | KIRC | 1 |
p.E773K | HNSC | 1 |
p.C610Y | LGG | 1 |
p.S308F | SKCM | 1 |
p.F51L | SKCM | 1 |
p.L283M | LUAD | 1 |
p.P147S | PRAD | 1 |
p.M296R | COAD | 1 |
p.G402E | SKCM | 1 |
p.D115N | SKCM | 1 |
p.K418T | UCEC | 1 |
p.Q301P | HNSC | 1 |
p.S902T | LUSC | 1 |
p.C422* | LUAD | 1 |
p.V633I | UCEC | 1 |
p.E375* | CESC | 1 |
p.S536G | LUAD | 1 |
p.C342R | LUSC | 1 |
p.G793E | SKCM | 1 |
p.H840P | SKCM | 1 |
p.A639T | SKCM | 1 |
p.K201R | LUAD | 1 |
p.N451T | SKCM | 1 |
p.N794S | UCS | 1 |
p.P319S | SKCM | 1 |
p.Q619H | LUSC | 1 |
p.E527D | CESC | 1 |
p.K16N | HNSC | 1 |
p.P752H | UCEC | 1 |
p.G754S | SKCM | 1 |
p.G911E | SKCM | 1 |
p.S88F | SKCM | 1 |
p.M330I | SKCM | 1 |
p.K390N | LUAD | 1 |
p.L314H | KIRP | 1 |
p.C65X | COAD | 1 |
p.E561K | SKCM | 1 |
p.K668T | STAD | 1 |
p.E479K | SKCM | 1 |
p.P548L | HNSC | 1 |
p.I129L | ESCA | 1 |
p.P110S | BRCA | 1 |
p.N791K | CHOL | 1 |
p.C737Y | PAAD | 1 |
p.E732* | SKCM | 1 |
p.D116Y | LUAD | 1 |
p.Q619K | LUAD | 1 |
p.K196* | LUAD | 1 |
p.G253S | SKCM | 1 |
p.L222S | PRAD | 1 |
p.M388I | SKCM | 1 |
p.E259X | KIRC | 1 |
p.K808M | LUAD | 1 |
p.V177L | LUSC | 1 |
p.I102L | BLCA | 1 |
p.E128* | LUSC | 1 |
p.L583M | LUAD | 1 |
p.E568K | BLCA | 1 |
p.H71Y | BRCA | 1 |
p.D176H | BLCA | 1 |
p.Q316H | SKCM | 1 |
p.G886R | SKCM | 1 |
p.S174* | HNSC | 1 |
p.Q777X | SKCM | 1 |
p.L38M | LUAD | 1 |
p.D277N | BLCA | 1 |
p.E912K | BLCA | 1 |
p.P689Q | LUAD | 1 |
p.P466H | LUAD | 1 |
p.L549V | LUAD | 1 |
p.T903I | STAD | 1 |
p.M581I | SKCM | 1 |
p.S113F | SKCM | 1 |
p.Y530D | COAD | 1 |
p.G641S | UCEC | 1 |
p.E679K | SKCM | 1 |
p.G833E | KIRC | 1 |
p.A373D | LUAD | 1 |
p.E404K | BLCA | 1 |
p.F854L | SKCM | 1 |
p.S571T | GBM | 1 |
p.D589N | SKCM | 1 |
p.D653N | SKCM | 1 |
p.E259* | KIRC | 1 |
p.S876F | LUAD | 1 |
p.L475I | UCEC | 1 |
p.Y295* | LUAD | 1 |
p.E186* | LUAD | 1 |
p.E702Q | HNSC | 1 |
p.E809K | SKCM | 1 |
p.V529G | ESCA | 1 |
p.E259K | UCEC | 1 |
p.N427D | SKCM | 1 |
p.E261Q | BLCA | 1 |
p.R49I | UCS | 1 |
p.Q491H | CHOL | 1 |
p.Q460X | SKCM | 1 |
p.S771Y | PRAD | 1 |
p.R220T | HNSC | 1 |
p.F81L | UCEC | 1 |
p.E217Q | LUSC | 1 |
p.K490T | LUSC | 1 |
p.S199P | UCEC | 1 |
p.E596* | HNSC | 1 |
p.T197I | HNSC | 1 |
p.V424F | LUSC | 1 |
p.V595I | KICH | 1 |
p.I2L | LUAD | 1 |
p.L521F | LUAD | 1 |
p.G166S | SKCM | 1 |
p.L446P | STAD | 1 |
p.Q604H | BLCA | 1 |
p.L622M | UCEC | 1 |
p.K668N | LUAD | 1 |
p.K668E | SKCM | 1 |
p.I137V | SKCM | 1 |
p.S614I | COAD | 1 |
p.S472Y | BLCA | 1 |
p.W320X | SKCM | 1 |
p.E739Q | BLCA | 1 |
p.R513L | LIHC | 1 |
p.S538Y | UCEC | 1 |
p.Q334K | HNSC | 1 |
p.L350I | SKCM | 1 |
p.E543K | SKCM | 1 |
p.K492Q | CHOL | 1 |
p.M19I | LUSC | 1 |
p.G655E | SKCM | 1 |
p.D665Y | UCEC | 1 |
p.D176N | SKCM | 1 |
p.L224F | SKCM | 1 |
p.S136R | LUAD | 1 |
p.Q615R | DLBC | 1 |
p.D649N | HNSC | 1 |
p.D277E | OV | 1 |
p.K599T | ESCA | 1 |
p.T397A | GBM | 1 |
p.G18E | SKCM | 1 |
p.Q736L | LUAD | 1 |
p.R49K | SKCM | 1 |
p.L53Q | LUAD | 1 |
p.R608T | BLCA | 1 |
p.T545A | STAD | 1 |
p.G906V | LUAD | 1 |
p.K196E | LUAD | 1 |
p.L290F | READ | 1 |
p.Q851H | LUAD | 1 |
p.D114Y | BLCA | 1 |
p.S70I | LUSC | 1 |
p.V357A | STAD | 1 |
p.P466T | LUAD | 1 |
p.L328F | SKCM | 1 |
p.A760S | HNSC | 1 |
p.E480D | STAD | 1 |
p.I797L | BRCA | 1 |
p.M111I | SKCM | 1 |
p.D790E | DLBC | 1 |
p.Q849H | UCEC | 1 |
p.S3F | SKCM | 1 |
p.W320* | SKCM | 1 |
p.T333S | UCEC | 1 |
p.Q282K | HNSC | 1 |
p.S865T | LUAD | 1 |
p.G45E | SKCM | 1 |
p.D382H | KIRP | 1 |
p.S3T | LIHC | 1 |
p.D115N | BLCA | 1 |
p.P210Q | LUAD | 1 |
p.A327T | THYM | 1 |
p.S14N | LUSC | 1 |
p.P324R | OV | 1 |
p.G442C | ESCA | 1 |
p.E564K | SKCM | 1 |
p.F341L | READ | 1 |
p.H688N | HNSC | 1 |
p.T712A | LUAD | 1 |
p.R638K | SKCM | 1 |
p.R756K | ESCA | 1 |
p.E181G | COAD | 1 |
p.P324S | SKCM | 1 |
p.E400* | UCEC | 1 |
p.G726E | SKCM | 1 |
p.N79I | LUAD | 1 |
p.Q654K | LUAD | 1 |
p.D474H | CESC | 1 |
p.A627T | COAD | 1 |
p.F47C | UCS | 1 |
p.K390T | STAD | 1 |
p.N79K | LUAD | 1 |
p.K140T | UCEC | 1 |
p.D637N | SKCM | 1 |
p.I508N | PAAD | 1 |
p.P646L | BLCA | 1 |
p.S515R | SKCM | 1 |
p.L549F | CESC | 1 |
p.G291R | LUSC | 1 |
p.L314I | KIRP | 1 |
p.Q777* | SKCM | 1 |
p.F476L | UCEC | 1 |
p.D130H | BLCA | 1 |
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TissGeneCNV for USP29 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for USP29 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for USP29 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for USP29 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for USP29 |
TissGeneDrug for USP29 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for USP29 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |