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| TissGeneSummary for ALOXE3 |
 Gene summary |
| Basic gene information | Gene symbol | ALOXE3 |
| Gene name | arachidonate lipoxygenase 3 | |
| Synonyms | ARCI3|E-LOX|eLOX-3|eLOX3 | |
| Cytomap | UCSC genome browser: 17p13.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001165960.1, NM_021628.2, | |
| Description | e-LOX-3epidermal LOX-3epidermal lipoxygenaseepidermis-type lipoxygenase 3hydroperoxide isomerase ALOXE3hydroperoxy icosatetraenoate dehydratase | |
| Modification date | 20141219 | |
| dbXrefs | MIM : 607206 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000179148 | ||
| HPRD : 06231 | ||
| Vega : OTTHUMG00000108179 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ALOXE3 | |
| BioGPS: 59344 | ||
| Pathway | NCI Pathway Interaction Database: ALOXE3 | |
| KEGG: ALOXE3 | ||
| REACTOME: ALOXE3 | ||
| Pathway Commons: ALOXE3 | ||
| Context | iHOP: ALOXE3 | |
| ligand binding site mutation search in PubMed: ALOXE3 | ||
| UCL Cancer Institute: ALOXE3 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
| Reference showing the relevant tissue of ALOXE3 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006665 | sphingolipid metabolic process | 21558561 | GO:0019369 | arachidonic acid metabolic process | 12881489 | GO:0019372 | lipoxygenase pathway | 20921226 | GO:0043651 | linoleic acid metabolic process | 12881489 | GO:0051122 | hepoxilin biosynthetic process | 12881489 | GO:0006665 | sphingolipid metabolic process | 21558561 | GO:0019369 | arachidonic acid metabolic process | 12881489 | GO:0019372 | lipoxygenase pathway | 20921226 | GO:0043651 | linoleic acid metabolic process | 12881489 | GO:0051122 | hepoxilin biosynthetic process | 12881489 |
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| TissGeneExp for ALOXE3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | 1.124215386 | -2.136345398 | 3.260560784 | 4.75E-15 | 2.96E-14 |
| LUAD | -0.488061118 | -2.100016291 | 1.611955172 | 3.28E-11 | 2.13E-10 |
| COAD | -1.507919606 | -2.679146529 | 1.171226923 | 0.00057 | 0.001729737 |
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| TissGene-miRNA for ALOXE3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ALOXE3 |
| TissGeneSNV for ALOXE3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.M312I | SKCM | 1 |
| p.E298Q | BLCA | 1 |
| p.S866F | BLCA | 1 |
| p.T349M | PAAD | 1 |
| p.T215I | UCEC | 1 |
| p.P762Q | SARC | 1 |
| p.M249T | READ | 1 |
| p.C287G | KIRC | 1 |
| p.C567F | PRAD | 1 |
| p.E631G | UCEC | 1 |
| p.S6F | UCEC | 1 |
| p.D176E | KIRC | 1 |
| p.A365T | STAD | 1 |
| p.R321W | ACC | 1 |
| p.S217G | COAD | 1 |
| p.V632I | DLBC | 1 |
| p.T242I | KIRC | 1 |
| p.C311G | KIRC | 1 |
| p.V747L | UCEC | 1 |
| p.E192K | SKCM | 1 |
| p.P504T | THYM | 1 |
| p.E572* | UCEC | 1 |
| p.S740F | SKCM | 1 |
| p.E216K | SKCM | 1 |
| p.A497T | STAD | 1 |
| p.R826Q | SKCM | 1 |
| p.E142* | UCEC | 1 |
| p.P800S | SKCM | 1 |
| p.H794N | THYM | 1 |
| p.P88T | READ | 1 |
| p.R371C | SKCM | 1 |
| p.S213* | HNSC | 1 |
| p.K548T | LUAD | 1 |
| p.P781H | THYM | 1 |
| p.V655A | LIHC | 1 |
| p.G453W | ESCA | 1 |
| p.T373M | PAAD | 1 |
| p.R100G | COAD | 1 |
| p.G668S | SKCM | 1 |
| p.W302* | SKCM | 1 |
| p.L632F | LIHC | 1 |
| p.R395C | SKCM | 1 |
| p.D841N | HNSC | 1 |
| p.P660S | SKCM | 1 |
| p.R802Q | SKCM | 1 |
| p.K197N | UCEC | 1 |
| p.K326T | BLCA | 1 |
| p.D280Y | LUAD | 1 |
| p.P256S | SKCM | 1 |
| p.E142Q | BLCA | 1 |
| p.N789D | HNSC | 1 |
| p.V291I | COAD | 1 |
| p.H98R | UCEC | 1 |
| p.D685N | HNSC | 1 |
| p.P702H | STAD | 1 |
| p.T266I | KIRC | 1 |
| p.P824S | SKCM | 1 |
| p.R289G | LUSC | 1 |
| p.A328V | KIRP | 1 |
| p.Q182H | LUAD | 1 |
| p.Q611H | LUAD | 1 |
| p.A674T | UCEC | 1 |
| p.R343X | ACC | 1 |
| p.T217M | PAAD | 1 |
| p.A2V | STAD | 1 |
| p.L129P | CESC | 1 |
| p.S217N | COAD | 1 |
| p.Q847H | LUAD | 1 |
| p.G644S | SKCM | 1 |
| p.D152E | KIRC | 1 |
| p.T775I | SKCM | 1 |
| p.T611M | STAD | 1 |
| p.P824L | SKCM | 1 |
| p.P834H | STAD | 1 |
| p.C494* | ACC | 1 |
| p.A673V | THCA | 1 |
| p.S764F | SKCM | 1 |
| p.Q382K | THYM | 1 |
| p.E715* | SKCM | 1 |
| p.R652W | LUAD | 1 |
| p.E475Q | BLCA | 1 |
| p.G187V | UCEC | 1 |
| p.T479M | STAD | 1 |
| p.S161I | UCEC | 1 |
| p.A649V | THCA | 1 |
| p.R291W | BLCA | 1 |
| p.K623N | UCEC | 1 |
| p.I705F | BRCA | 1 |
| p.A346V | COAD | 1 |
| p.P33A | PRAD | 1 |
| p.V591L | UCEC | 1 |
| p.I814M | CESC | 1 |
| p.A516T | SKCM | 1 |
| p.Y410H | COAD | 1 |
| p.D93N | BRCA | 1 |
| p.T261P | UCEC | 1 |
| p.R845L | UCEC | 1 |
| p.R196Q | SKCM | 1 |
| p.Y642D | BLCA | 1 |
| p.Q767H | LUAD | 1 |
| p.S135C | UCEC | 1 |
| p.A492T | SKCM | 1 |
| p.R345W | ACC | 1 |
| p.R496W | LUAD | 1 |
| p.Q338H | LUAD | 1 |
| p.G250S | BLCA | 1 |
| p.S369* | HNSC | 1 |
| p.R135W | BLCA | 1 |
| p.S251R | SKCM | 1 |
| p.M362I | SKCM | 1 |
| p.A673T | STAD | 1 |
| p.Y530D | BRCA | 1 |
| p.E780X | READ | 1 |
| p.R367* | ACC | 1 |
| p.N633D | HNSC | 1 |
| p.Y486D | BLCA | 1 |
| p.G343E | SKCM | 1 |
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| TissGeneCNV for ALOXE3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ALOXE3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AK122822 | BAI3-ALOXE3 | chr6:69582199 | chr17:7999219 | |
| Chimerdb3.0 | ChiTaRs | NA | DA096644 | BAI3-ALOXE3 | chr6:69582199 | chr17:8021569 |
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| TissGeneNet for ALOXE3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for ALOXE3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ALOXE3 |
| TissGeneDrug for ALOXE3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ALOXE3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0079154 | Congenital Nonbullous Ichthyosiform Erythroderma | 6 | BeFree,CTD_human,ORPHANET |
| umls:C0020758 | Congenital ichthyosis | 5 | BeFree |
| umls:C0079583 | Ichthyosiform Erythroderma, Congenital | 5 | BeFree,GAD,LHGDN |
| umls:C3539888 | ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 3 | 4 | UNIPROT |
| umls:C0020757 | Ichthyoses | 2 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| umls:C0677886 | Epithelial ovarian cancer | 1 | GAD |
| umls:C1847849 | ICHTHYOSIS, LAMELLAR, 5 | 0 | CLINVAR |
| umls:C1855792 | ICHTHYOSIFORM ERYTHRODERMA, CONGENITAL, NONBULLOUS, 1 | 0 | CTD_human |
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