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| TissGeneSummary for RGR |
 Gene summary |
| Basic gene information | Gene symbol | RGR |
| Gene name | retinal G protein coupled receptor | |
| Synonyms | RP44 | |
| Cytomap | UCSC genome browser: 10q23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001012720.1, NM_001012722.1,NM_002921.3, | |
| Description | RGR-opsinRPE retinal G-protein coupled receptorRPE-retinal G protein-coupled receptor | |
| Modification date | 20141219 | |
| dbXrefs | MIM : 600342 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000148604 | ||
| HPRD : 02642 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RGR | |
| BioGPS: 5995 | ||
| Pathway | NCI Pathway Interaction Database: RGR | |
| KEGG: RGR | ||
| REACTOME: RGR | ||
| Pathway Commons: RGR | ||
| Context | iHOP: RGR | |
| ligand binding site mutation search in PubMed: RGR | ||
| UCL Cancer Institute: RGR | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BrainEye | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGGUVM | |
| Reference showing the relevant tissue of RGR | ||
| Description by TissGene annotations | Protective TissGene in OS Protective TissGene in RFS TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for RGR |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for RGR |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for RGR |
| TissGeneSNV for RGR |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S171Y | PAAD | 1 |
| p.A72P | THYM | 1 |
| p.H82N | LUAD | 1 |
| p.G173R | SKCM | 1 |
| p.R84C | STAD | 1 |
| p.A112D | LUAD | 1 |
| p.S81F | SKCM | 1 |
| p.P220S | UCEC | 1 |
| p.R218K | SKCM | 1 |
| p.R80C | STAD | 1 |
| p.D242Y | UCEC | 1 |
| p.T263M | UCEC | 1 |
| p.G163V | UCEC | 1 |
| p.V139A | UCEC | 1 |
| p.A241T | PRAD | 1 |
| p.L149V | BLCA | 1 |
| p.P230S | GBM | 1 |
| p.S114F | CESC | 1 |
| p.L284P | LIHC | 1 |
| p.T174S | THCA | 1 |
| p.K209N | HNSC | 1 |
| p.H95Y | SKCM | 1 |
| p.L219V | HNSC | 1 |
| p.T178S | THCA | 1 |
| p.I257V | ESCA | 1 |
| p.L219V | BLCA | 1 |
| p.G45R | PRAD | 1 |
| p.A39S | LUAD | 1 |
| p.K205Q | SKCM | 1 |
| p.R222K | SKCM | 1 |
| p.S199F | SKCM | 1 |
| p.G223D | SKCM | 1 |
| p.D48N | SKCM | 1 |
| p.G227D | SKCM | 1 |
| p.P53S | SKCM | 1 |
| p.A103V | UCEC | 1 |
| p.G229D | BLCA | 1 |
| p.T219K | HNSC | 1 |
| p.W115* | SKCM | 1 |
| p.K205N | HNSC | 1 |
| p.A186V | STAD | 1 |
| p.K209Q | SKCM | 1 |
| p.L151F | SKCM | 1 |
| p.T223K | HNSC | 1 |
| p.G82R | SKCM | 1 |
| p.E290D | SKCM | 1 |
| p.A190V | STAD | 1 |
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| TissGeneCNV for RGR |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for RGR |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for RGR |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| RGR, KIAA1279, RDH5 (tumor) | RGR, KIAA1279, RDH5 (normal) |
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| COAD (tumor) | COAD (normal) |
| RGR, KIAA1279, RDH5 (tumor) | RGR, KIAA1279, RDH5 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| RGR, KIAA1279, RDH5 (tumor) | RGR, KIAA1279, RDH5 (normal) |
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| KICH (tumor) | KICH (normal) |
| RGR, KIAA1279, RDH5 (tumor) | RGR, KIAA1279, RDH5 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| RGR, KIAA1279, RDH5 (tumor) | RGR, KIAA1279, RDH5 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| RGR, KIAA1279, RDH5 (tumor) | RGR, KIAA1279, RDH5 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| RGR, KIAA1279, RDH5 (tumor) | RGR, KIAA1279, RDH5 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| RGR, KIAA1279, RDH5 (tumor) | RGR, KIAA1279, RDH5 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| RGR, KIAA1279, RDH5 (tumor) | RGR, KIAA1279, RDH5 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| RGR, KIAA1279, RDH5 (tumor) | RGR, KIAA1279, RDH5 (normal) |
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| STAD (tumor) | STAD (normal) |
| RGR, KIAA1279, RDH5 (tumor) | RGR, KIAA1279, RDH5 (normal) |
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| THCA (tumor) | THCA (normal) |
| RGR, KIAA1279, RDH5 (tumor) | RGR, KIAA1279, RDH5 (normal) |
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| TissGeneProg for RGR |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for RGR |
| TissGeneDrug for RGR |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for RGR |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0035334 | Retinitis Pigmentosa | 4 | BeFree,CTD_human,GAD,ORPHANET |
| umls:C0483368 | Human anaplasmosis due to Anaplasma phagocytophilum | 4 | BeFree |
| umls:C0854723 | Retinal Dystrophies | 2 | BeFree,GAD |
| umls:C0024198 | Lyme Disease | 1 | BeFree |
| umls:C0035304 | Retinal Degeneration | 1 | LHGDN |
| umls:C0035309 | Retinal Diseases | 1 | GAD |
| umls:C0085648 | Synovial Cyst | 1 | BeFree |
| umls:C0242383 | Age related macular degeneration | 1 | BeFree |
| umls:C1258666 | Myxoid cyst | 1 | BeFree |
| umls:C1260959 | Drusen | 1 | BeFree |
| umls:C3151068 | RETINITIS PIGMENTOSA 44 | 1 | CLINVAR,UNIPROT |
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