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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for RPS27
check button Gene summary
Basic gene informationGene symbolRPS27
Gene nameribosomal protein S27
SynonymsMPS-1|MPS1|S27
CytomapUCSC genome browser: 1q21
Type of geneprotein-coding
RefGenesNM_001030.4,
Description40S ribosomal protein S27metallopan-stimulin 1metallopanstimulin 1
Modification date20141207
dbXrefs MIM : 603702
HGNC : HGNC
Ensembl : ENSG00000177954
HPRD : 04744
Vega : OTTHUMG00000036591
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_RPS27
BioGPS: 6232
PathwayNCI Pathway Interaction Database: RPS27
KEGG: RPS27
REACTOME: RPS27
Pathway Commons: RPS27
ContextiHOP: RPS27
ligand binding site mutation search in PubMed: RPS27
UCL Cancer Institute: RPS27
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Bone marrowOvaryThymus
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LAMLOVTHYM
Reference showing the relevant tissue of RPS27
Description by TissGene annotationsTissgsLTS
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for RPS27

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KIRC0.44931471-0.7261755681.1754902784.91E-050.000107349


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TissGene-miRNA for RPS27

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for RPS27
TissGeneSNV for RPS27

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.G68*PAAD1
p.T44AUCEC1
p.E14AKIRC1
p.S78FSKCM1
p.S78FREAD1
p.E40QBRCA1
p.D6NLIHC1
p.F32VSTAD1
p.S11FLUAD1


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TissGeneCNV for RPS27

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for RPS27

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNAM31520RPS27-RPS24chr1:153964629chr10:79793623


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TissGeneNet for RPS27

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
RPS27, CUL2, APC, RTN4, NFKB2, MDM2, KIAA0101, TNFRSF1A, MAP3K1, COPS5, MAP3K3, RIPK3, TNFRSF1B, PXN, C2orf44, TAB2, TRADD, MARS, SKIL, PPBP, ENOPH1 (tumor)RPS27, CAND1, APC, UBC, RTN4, NFKB2, MDM2, TNFRSF1A, VHL, CUL3, COPS5, MAP3K3, RIPK3, PXN, ACTN4, TAB2, TRADD, SKIL, PPBP, TOM1, ENOPH1 (normal)
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COAD (tumor)COAD (normal)
RPS27, CAND1, CUL2, APC, RTN4, NFKB2, KIAA0101, TNFRSF1A, VHL, MAP3K1, CUL1, COPS5, MAP3K3, RIPK3, PXN, ACTN4, TRADD, ACTN1, SKIL, NACAD, ENOPH1 (tumor)RPS27, CUL2, APC, UBC, NFKB2, KIAA0101, TNFRSF1A, VHL, MAP3K1, COPS5, MAP3K3, PXN, C2orf44, TRADD, MARS, ACTN1, SKIL, NACAD, PPBP, ENOPH1, ENTPD4 (normal)
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HNSC (tumor)HNSC (normal)
RPS27, CAND1, CUL2, APC, UBC, MDM2, IKBKG, VHL, CUL3, MAP3K1, CUL1, COPS5, MAP3K3, ACTN4, TAB2, TRADD, MARS, ACTN1, SKIL, TOM1, ENTPD4 (tumor)RPS27, CAND1, CUL2, APC, UBC, RTN4, NFKB2, IKBKG, KIAA0101, TNFRSF1A, VHL, MAP3K1, COPS5, MAP3K3, PXN, ACTN4, TAB2, TRADD, ACTN1, SKIL, ENTPD4 (normal)
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KICH (tumor)KICH (normal)
RPS27, CAND1, CUL2, APC, RTN4, MDM2, KIAA0101, TNFRSF1A, MAP3K1, COPS5, TNFRSF1B, PXN, ACTN4, C2orf44, TAB2, TRADD, MARS, ACTN1, NACAD, PPBP, TOM1 (tumor)RPS27, CUL2, UBC, NFKB2, IKBKG, KIAA0101, TNFRSF1A, CUL3, CUL1, COPS5, MAP3K3, TNFRSF1B, PXN, C2orf44, TAB2, TRADD, MARS, ACTN1, SKIL, PPBP, ENTPD4 (normal)
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KIRC (tumor)KIRC (normal)
RPS27, CAND1, APC, UBC, RTN4, NFKB2, IKBKG, VHL, CUL3, CUL1, COPS5, RIPK3, TNFRSF1B, ACTN4, TRADD, MARS, ACTN1, SKIL, NACAD, ENOPH1, ENTPD4 (tumor)RPS27, CAND1, APC, UBC, NFKB2, IKBKG, KIAA0101, TNFRSF1A, VHL, CUL3, CUL1, COPS5, MAP3K3, TNFRSF1B, PXN, C2orf44, TAB2, TRADD, SKIL, TOM1, ENTPD4 (normal)
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KIRP (tumor)KIRP (normal)
RPS27, CAND1, APC, NFKB2, IKBKG, CUL3, CUL1, COPS5, MAP3K3, RIPK3, TNFRSF1B, PXN, ACTN4, C2orf44, TAB2, MARS, ACTN1, SKIL, NACAD, TOM1, ENOPH1 (tumor)RPS27, CAND1, CUL2, UBC, KIAA0101, CUL1, COPS5, MAP3K3, RIPK3, TNFRSF1B, PXN, ACTN4, C2orf44, TAB2, TRADD, MARS, ACTN1, SKIL, NACAD, PPBP, ENOPH1 (normal)
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LIHC (tumor)LIHC (normal)
RPS27, RTN4, MDM2, IKBKG, KIAA0101, TNFRSF1A, VHL, CUL1, MAP3K3, RIPK3, TNFRSF1B, C2orf44, TRADD, MARS, ACTN1, SKIL, NACAD, PPBP, TOM1, ENOPH1, ENTPD4 (tumor)RPS27, CAND1, CUL2, APC, RTN4, MDM2, KIAA0101, VHL, CUL1, MAP3K3, RIPK3, TNFRSF1B, C2orf44, TAB2, TRADD, MARS, SKIL, NACAD, PPBP, TOM1, ENTPD4 (normal)
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LUAD (tumor)LUAD (normal)
RPS27, CAND1, CUL2, NFKB2, IKBKG, TNFRSF1A, VHL, CUL3, COPS5, MAP3K3, RIPK3, TNFRSF1B, ACTN4, TAB2, TRADD, MARS, ACTN1, NACAD, TOM1, ENOPH1, ENTPD4 (tumor)RPS27, CAND1, CUL2, UBC, NFKB2, MDM2, IKBKG, CUL3, CUL1, COPS5, RIPK3, TNFRSF1B, PXN, ACTN4, C2orf44, TRADD, MARS, ACTN1, TOM1, ENOPH1, ENTPD4 (normal)
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LUSC (tumor)LUSC (normal)
RPS27, APC, UBC, RTN4, IKBKG, KIAA0101, VHL, CUL1, COPS5, MAP3K3, TNFRSF1B, PXN, C2orf44, TRADD, MARS, ACTN1, SKIL, NACAD, TOM1, ENOPH1, ENTPD4 (tumor)RPS27, CAND1, CUL2, APC, RTN4, NFKB2, IKBKG, KIAA0101, VHL, CUL3, MAP3K1, COPS5, MAP3K3, PXN, ACTN4, C2orf44, MARS, SKIL, TOM1, ENOPH1, ENTPD4 (normal)
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PRAD (tumor)PRAD (normal)
RPS27, CAND1, CUL2, APC, UBC, RTN4, NFKB2, MDM2, KIAA0101, MAP3K1, CUL1, COPS5, MAP3K3, PXN, C2orf44, MARS, SKIL, PPBP, TOM1, ENOPH1, ENTPD4 (tumor)RPS27, CAND1, CUL2, APC, RTN4, NFKB2, MDM2, IKBKG, KIAA0101, CUL3, CUL1, COPS5, MAP3K3, PXN, ACTN4, C2orf44, TAB2, TRADD, ACTN1, SKIL, ENTPD4 (normal)
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STAD (tumor)STAD (normal)
RPS27, CAND1, CUL2, APC, UBC, RTN4, NFKB2, IKBKG, VHL, CUL1, COPS5, PXN, ACTN4, C2orf44, TRADD, MARS, SKIL, PPBP, TOM1, ENOPH1, ENTPD4 (tumor)RPS27, CAND1, CUL2, APC, UBC, NFKB2, MDM2, VHL, CUL3, CUL1, RIPK3, TNFRSF1B, ACTN4, C2orf44, TRADD, MARS, ACTN1, SKIL, NACAD, TOM1, ENTPD4 (normal)
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THCA (tumor)THCA (normal)
RPS27, CAND1, CUL2, APC, UBC, RTN4, NFKB2, MDM2, IKBKG, VHL, CUL3, MAP3K1, COPS5, RIPK3, C2orf44, TAB2, TRADD, MARS, SKIL, TOM1, ENTPD4 (tumor)RPS27, CUL2, APC, RTN4, NFKB2, MDM2, TNFRSF1A, VHL, COPS5, TNFRSF1B, C2orf44, TAB2, TRADD, MARS, ACTN1, SKIL, NACAD, PPBP, TOM1, ENOPH1, ENTPD4 (normal)
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TissGeneProg for RPS27

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for RPS27
TissGeneDrug for RPS27

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for RPS27

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0086795Pfaundler-Hurler Syndrome6BeFree
umls:C0023786Mucopolysaccharidosis I5BeFree
umls:C0025202melanoma4BeFree
umls:C0026703Mucopolysaccharidoses4BeFree
umls:C0596263Carcinogenesis4BeFree
umls:C0006142Malignant neoplasm of breast3BeFree
umls:C0024623Malignant neoplasm of stomach3BeFree
umls:C0699791Stomach Carcinoma3BeFree
umls:C0018609Hartnup Disease2BeFree
umls:C0026708Mucopolysaccharidosis V2BeFree
umls:C0027627Neoplasm Metastasis2BeFree
umls:C0085078Lysosomal Storage Diseases2BeFree
umls:C0086431Hurler-Scheie Syndrome2BeFree
umls:C0086647Mucopolysaccharidosis Type IIIA2BeFree
umls:C0678222Breast Carcinoma2BeFree
umls:C1335302Pancreatic Ductal Adenocarcinoma2BeFree
umls:C2713321alpha-L-Iduronidase Deficiency2BeFree
umls:C0002395Alzheimer's Disease1BeFree
umls:C0006111Brain Diseases1BeFree
umls:C0017636Glioblastoma1BeFree
umls:C0019189Hepatitis, Chronic1BeFree
umls:C0025517Metabolic Diseases1BeFree
umls:C0028259Nodule1BeFree
umls:C0038356Stomach Neoplasms1LHGDN
umls:C0079748Precursor cell lymphoblastic lymphoma1BeFree
umls:C0410528Skeletal dysplasia1BeFree
umls:C1168401Squamous cell carcinoma of the head and neck1BeFree
umls:C1260899Anemia, Diamond-Blackfan1BeFree
umls:C1332225Aggressive Non-Hodgkin Lymphoma1BeFree
umls:C1512409Hepatocarcinogenesis1BeFree
umls:C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1BeFree
umls:C2239176Liver carcinoma1BeFree