TissGeneSummary for SCNN1G |
Gene summary |
Basic gene information | Gene symbol | SCNN1G |
Gene name | sodium channel, non-voltage-gated 1, gamma subunit | |
Synonyms | BESC3|ENaCg|ENaCgamma|PHA1|SCNEG | |
Cytomap | UCSC genome browser: 16p12 | |
Type of gene | protein-coding | |
RefGenes | NM_001039.3, | |
Description | ENaC gamma subunitamiloride-sensitive epithelial sodium channel gamma subunitamiloride-sensitive sodium channel gamma-subunitamiloride-sensitive sodium channel subunit gammaepithelial Na(+) channel subunit gammagamma-ENaCgamma-NaCHnonvoltage-gated | |
Modification date | 20141222 | |
dbXrefs | MIM : 600761 | |
HGNC : HGNC | ||
Ensembl : ENSG00000166828 | ||
HPRD : 02862 | ||
Vega : OTTHUMG00000131609 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SCNN1G | |
BioGPS: 6340 | ||
Pathway | NCI Pathway Interaction Database: SCNN1G | |
KEGG: SCNN1G | ||
REACTOME: SCNN1G | ||
Pathway Commons: SCNN1G | ||
Context | iHOP: SCNN1G | |
ligand binding site mutation search in PubMed: SCNN1G | ||
UCL Cancer Institute: SCNN1G | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of SCNN1G | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0035725 | sodium ion transmembrane transport | 24124190 | GO:0050891 | multicellular organismal water homeostasis | 24124190 | GO:0055078 | sodium ion homeostasis | 24124190 | GO:0035725 | sodium ion transmembrane transport | 24124190 | GO:0050891 | multicellular organismal water homeostasis | 24124190 | GO:0055078 | sodium ion homeostasis | 24124190 |
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TissGeneExp for SCNN1G |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -1.364245946 | 7.609914054 | -8.97416 | 1.29E-19 | 9.17E-18 |
KIRP | -2.411374696 | 7.802334679 | -10.21370937 | 2.51E-28 | 5.63E-26 |
KIRC | -0.450794835 | 7.749791276 | -8.200586111 | 1.61E-36 | 4.81E-35 |
HNSC | 2.005647542 | 3.739331263 | -1.733683721 | 7.20E-06 | 4.25E-05 |
LUAD | 2.873633709 | 5.196911295 | -2.323277586 | 3.21E-13 | 2.64E-12 |
COAD | -1.685840562 | 2.412551746 | -4.098392308 | 2.21E-08 | 1.79E-07 |
LUSC | 2.560421505 | 5.220439152 | -2.660017647 | 4.07E-11 | 1.60E-10 |
PRAD | 3.023513285 | 4.123245977 | -1.099732692 | 0.000446 | 0.001594077 |
STAD | -1.465724696 | 1.756972179 | -3.222696875 | 3.91E-05 | 0.000351744 |
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TissGene-miRNA for SCNN1G |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SCNN1G |
TissGeneSNV for SCNN1G |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R564H | GBM | 2 |
p.R111C | UCEC | 2 |
p.V81F | LUAD | 1 |
p.Y311C | STAD | 1 |
p.M403V | STAD | 1 |
p.M235I | SKCM | 1 |
p.G376R | ESCA | 1 |
p.G203V | SARC | 1 |
p.M194I | LUAD | 1 |
p.R178K | SKCM | 1 |
p.S212Y | SKCM | 1 |
p.D335N | SKCM | 1 |
p.V329M | SKCM | 1 |
p.E518K | SKCM | 1 |
p.E477K | CESC | 1 |
p.E548A | MESO | 1 |
p.R43H | LGG | 1 |
p.S212F | SKCM | 1 |
p.T353N | OV | 1 |
p.S323F | SKCM | 1 |
p.S607Y | ESCA | 1 |
p.L55F | SKCM | 1 |
p.E477Q | CESC | 1 |
p.L34I | UCEC | 1 |
p.P319Q | THYM | 1 |
p.A22V | LUAD | 1 |
p.R586C | SKCM | 1 |
p.E461D | SKCM | 1 |
p.R138Q | BRCA | 1 |
p.N430K | COAD | 1 |
p.P16S | SKCM | 1 |
p.T218A | KIRC | 1 |
p.F507I | SKCM | 1 |
p.L501V | ESCA | 1 |
p.T18M | ESCA | 1 |
p.Q334R | STAD | 1 |
p.V546I | PRAD | 1 |
p.E477K | BLCA | 1 |
p.G344E | SKCM | 1 |
p.L74F | LUSC | 1 |
p.Y412N | LIHC | 1 |
p.F76L | UCEC | 1 |
p.G149R | SKCM | 1 |
p.H332Y | SKCM | 1 |
p.S354T | LIHC | 1 |
p.E445K | SKCM | 1 |
p.P242H | HNSC | 1 |
p.W462* | SKCM | 1 |
p.R289K | SKCM | 1 |
p.V17M | SARC | 1 |
p.V340I | UCEC | 1 |
p.G376R | COAD | 1 |
p.M29I | THYM | 1 |
p.P132S | SKCM | 1 |
p.R172S | LUAD | 1 |
p.E455K | SKCM | 1 |
p.P625S | SKCM | 1 |
p.R514K | SKCM | 1 |
p.R135Q | ESCA | 1 |
p.P338L | SKCM | 1 |
p.E228A | SKCM | 1 |
p.G326E | SKCM | 1 |
p.M351I | LUSC | 1 |
p.P613L | SKCM | 1 |
p.D597N | SKCM | 1 |
p.G149E | SKCM | 1 |
p.H88L | LIHC | 1 |
p.R586H | UCEC | 1 |
p.P418S | SKCM | 1 |
p.V340A | LIHC | 1 |
p.I187L | SKCM | 1 |
p.G356E | SKCM | 1 |
p.V546L | SKCM | 1 |
p.E167Q | HNSC | 1 |
p.L321F | SKCM | 1 |
p.V546I | HNSC | 1 |
p.Y627C | UCEC | 1 |
p.E314K | SKCM | 1 |
p.R563C | PAAD | 1 |
p.S529Y | HNSC | 1 |
p.D487N | BLCA | 1 |
p.H280Y | OV | 1 |
p.E583* | LUSC | 1 |
p.C372Y | SKCM | 1 |
p.A22E | LGG | 1 |
p.R333Q | SKCM | 1 |
p.Q444* | SKCM | 1 |
p.E361K | SKCM | 1 |
p.S458G | UCEC | 1 |
p.A569D | LIHC | 1 |
p.P594S | SKCM | 1 |
p.R138Q | BLCA | 1 |
p.F531L | GBM | 1 |
p.T465I | SKCM | 1 |
p.L68V | STAD | 1 |
p.E446D | BLCA | 1 |
p.L484I | COAD | 1 |
p.S476L | CESC | 1 |
p.R137H | GBM | 1 |
p.G590S | SKCM | 1 |
p.E374G | HNSC | 1 |
p.R48C | SKCM | 1 |
p.C372F | THYM | 1 |
p.Q227H | LUAD | 1 |
p.A410S | SKCM | 1 |
p.V75I | SARC | 1 |
p.R43H | BLCA | 1 |
p.V110I | DLBC | 1 |
p.V475I | STAD | 1 |
p.Q567H | READ | 1 |
p.P95S | SKCM | 1 |
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TissGeneCNV for SCNN1G |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SCNN1G |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-A2-A04T-01A | SCNN1G-COL27A1 | In-frame | Chr16:23224484 | Chr9:116924995 |
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TissGeneNet for SCNN1G |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SCNN1G |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SCNN1G |
TissGeneDrug for SCNN1G |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
DB00384 | Triamterene | Inhibitor | Small molecule | Approved |
DB00594 | Amiloride | Inhibitor | Small molecule | Approved |
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TissGeneDisease for SCNN1G |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0020538 | Hypertensive disease | 13 | BeFree,CTD_human,GAD,LHGDN |
umls:C0221043 | Liddle Syndrome | 6 | BeFree,CLINVAR,CTD_human,ORPHANET |
umls:C0268436 | Pseudohypoaldosteronism, Type I | 5 | BeFree |
umls:C0010674 | Cystic Fibrosis | 4 | BeFree,CTD_human,GAD,LHGDN |
umls:C0033805 | Pseudohypoaldosteronism | 3 | BeFree,CTD_human,LHGDN |
umls:C0004153 | Atherosclerosis | 1 | GAD |
umls:C0006267 | Bronchiectasis | 1 | LHGDN |
umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
umls:C0009324 | Ulcerative Colitis | 1 | LHGDN |
umls:C0015544 | Failure to Thrive | 1 | BeFree |
umls:C0020437 | Hypercalcemia | 1 | BeFree |
umls:C0020649 | Hypotension | 1 | CTD_human |
umls:C0024115 | Lung diseases | 1 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
umls:C1272641 | Systemic arterial pressure | 1 | GAD |
umls:C3163620 | Hypotension Adverse Event | 1 | GAD |
umls:C0339985 | Idiopathic bronchiectasis | 0 | ORPHANET |
umls:C1449843 | Pseudohypoaldosteronism, Type I, Autosomal Recessive | 0 | CLINVAR,MGD,ORPHANET |
umls:C2751324 | BRONCHIECTASIS WITH OR WITHOUT ELEVATED SWEAT CHLORIDE 3 | 0 | CLINVAR,CTD_human |