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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for SCNN1G
check button Gene summary
Basic gene informationGene symbolSCNN1G
Gene namesodium channel, non-voltage-gated 1, gamma subunit
SynonymsBESC3|ENaCg|ENaCgamma|PHA1|SCNEG
CytomapUCSC genome browser: 16p12
Type of geneprotein-coding
RefGenesNM_001039.3,
DescriptionENaC gamma subunitamiloride-sensitive epithelial sodium channel gamma subunitamiloride-sensitive sodium channel gamma-subunitamiloride-sensitive sodium channel subunit gammaepithelial Na(+) channel subunit gammagamma-ENaCgamma-NaCHnonvoltage-gated
Modification date20141222
dbXrefs MIM : 600761
HGNC : HGNC
Ensembl : ENSG00000166828
HPRD : 02862
Vega : OTTHUMG00000131609
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SCNN1G
BioGPS: 6340
PathwayNCI Pathway Interaction Database: SCNN1G
KEGG: SCNN1G
REACTOME: SCNN1G
Pathway Commons: SCNN1G
ContextiHOP: SCNN1G
ligand binding site mutation search in PubMed: SCNN1G
UCL Cancer Institute: SCNN1G
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Kidney
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)KIRC,KIRP,KICH
Reference showing the relevant tissue of SCNN1G
Description by TissGene annotationsCancer gene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0035725sodium ion transmembrane transport24124190
GO:0050891multicellular organismal water homeostasis24124190
GO:0055078sodium ion homeostasis24124190
GO:0035725sodium ion transmembrane transport24124190
GO:0050891multicellular organismal water homeostasis24124190
GO:0055078sodium ion homeostasis24124190


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TissGeneExp for SCNN1G

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KICH-1.3642459467.609914054-8.974161.29E-199.17E-18
KIRP-2.4113746967.802334679-10.213709372.51E-285.63E-26
KIRC-0.4507948357.749791276-8.2005861111.61E-364.81E-35
HNSC2.0056475423.739331263-1.7336837217.20E-064.25E-05
LUAD2.8736337095.196911295-2.3232775863.21E-132.64E-12
COAD-1.6858405622.412551746-4.0983923082.21E-081.79E-07
LUSC2.5604215055.220439152-2.6600176474.07E-111.60E-10
PRAD3.0235132854.123245977-1.0997326920.0004460.001594077
STAD-1.4657246961.756972179-3.2226968753.91E-050.000351744


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TissGene-miRNA for SCNN1G

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for SCNN1G
TissGeneSNV for SCNN1G

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R564HGBM2
p.R111CUCEC2
p.V81FLUAD1
p.Y311CSTAD1
p.M403VSTAD1
p.M235ISKCM1
p.G376RESCA1
p.G203VSARC1
p.M194ILUAD1
p.R178KSKCM1
p.S212YSKCM1
p.D335NSKCM1
p.V329MSKCM1
p.E518KSKCM1
p.E477KCESC1
p.E548AMESO1
p.R43HLGG1
p.S212FSKCM1
p.T353NOV1
p.S323FSKCM1
p.S607YESCA1
p.L55FSKCM1
p.E477QCESC1
p.L34IUCEC1
p.P319QTHYM1
p.A22VLUAD1
p.R586CSKCM1
p.E461DSKCM1
p.R138QBRCA1
p.N430KCOAD1
p.P16SSKCM1
p.T218AKIRC1
p.F507ISKCM1
p.L501VESCA1
p.T18MESCA1
p.Q334RSTAD1
p.V546IPRAD1
p.E477KBLCA1
p.G344ESKCM1
p.L74FLUSC1
p.Y412NLIHC1
p.F76LUCEC1
p.G149RSKCM1
p.H332YSKCM1
p.S354TLIHC1
p.E445KSKCM1
p.P242HHNSC1
p.W462*SKCM1
p.R289KSKCM1
p.V17MSARC1
p.V340IUCEC1
p.G376RCOAD1
p.M29ITHYM1
p.P132SSKCM1
p.R172SLUAD1
p.E455KSKCM1
p.P625SSKCM1
p.R514KSKCM1
p.R135QESCA1
p.P338LSKCM1
p.E228ASKCM1
p.G326ESKCM1
p.M351ILUSC1
p.P613LSKCM1
p.D597NSKCM1
p.G149ESKCM1
p.H88LLIHC1
p.R586HUCEC1
p.P418SSKCM1
p.V340ALIHC1
p.I187LSKCM1
p.G356ESKCM1
p.V546LSKCM1
p.E167QHNSC1
p.L321FSKCM1
p.V546IHNSC1
p.Y627CUCEC1
p.E314KSKCM1
p.R563CPAAD1
p.S529YHNSC1
p.D487NBLCA1
p.H280YOV1
p.E583*LUSC1
p.C372YSKCM1
p.A22ELGG1
p.R333QSKCM1
p.Q444*SKCM1
p.E361KSKCM1
p.S458GUCEC1
p.A569DLIHC1
p.P594SSKCM1
p.R138QBLCA1
p.F531LGBM1
p.T465ISKCM1
p.L68VSTAD1
p.E446DBLCA1
p.L484ICOAD1
p.S476LCESC1
p.R137HGBM1
p.G590SSKCM1
p.E374GHNSC1
p.R48CSKCM1
p.C372FTHYM1
p.Q227HLUAD1
p.A410SSKCM1
p.V75ISARC1
p.R43HBLCA1
p.V110IDLBC1
p.V475ISTAD1
p.Q567HREAD1
p.P95SSKCM1


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TissGeneCNV for SCNN1G

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for SCNN1G

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
TCGAfusionPortalPRADABRCATCGA-A2-A04T-01ASCNN1G-COL27A1In-frameChr16:23224484Chr9:116924995


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TissGeneNet for SCNN1G

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
SCNN1G, UBC, COMMD1, MAPK1, WWP2, NEDD4, NEDD4L, USP10, SCNN1B, EPN1, STX1A, SCNN1A, USP2, AP1M2, SCNN1D (tumor)SCNN1G, UBC, COMMD1, MAPK1, WWP2, NEDD4, NEDD4L, USP10, SCNN1B, EPN1, STX1A, SCNN1A, USP2, AP1M2, SCNN1D (normal)
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COAD (tumor)COAD (normal)
SCNN1G, UBC, COMMD1, MAPK1, WWP2, NEDD4, NEDD4L, USP10, SCNN1B, EPN1, STX1A, SCNN1A, USP2, AP1M2, SCNN1D (tumor)SCNN1G, UBC, COMMD1, MAPK1, WWP2, NEDD4, NEDD4L, USP10, SCNN1B, EPN1, STX1A, SCNN1A, USP2, AP1M2, SCNN1D (normal)
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HNSC (tumor)HNSC (normal)
SCNN1G, UBC, COMMD1, MAPK1, WWP2, NEDD4, NEDD4L, USP10, SCNN1B, EPN1, STX1A, SCNN1A, USP2, AP1M2, SCNN1D (tumor)SCNN1G, UBC, COMMD1, MAPK1, WWP2, NEDD4, NEDD4L, USP10, SCNN1B, EPN1, STX1A, SCNN1A, USP2, AP1M2, SCNN1D (normal)
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KICH (tumor)KICH (normal)
SCNN1G, UBC, COMMD1, MAPK1, WWP2, NEDD4, NEDD4L, USP10, SCNN1B, EPN1, STX1A, SCNN1A, USP2, AP1M2, SCNN1D (tumor)SCNN1G, UBC, COMMD1, MAPK1, WWP2, NEDD4, NEDD4L, USP10, SCNN1B, EPN1, STX1A, SCNN1A, USP2, AP1M2, SCNN1D (normal)
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KIRC (tumor)KIRC (normal)
SCNN1G, UBC, COMMD1, MAPK1, WWP2, NEDD4, NEDD4L, USP10, SCNN1B, EPN1, STX1A, SCNN1A, USP2, AP1M2, SCNN1D (tumor)SCNN1G, UBC, COMMD1, MAPK1, WWP2, NEDD4, NEDD4L, USP10, SCNN1B, EPN1, STX1A, SCNN1A, USP2, AP1M2, SCNN1D (normal)
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KIRP (tumor)KIRP (normal)
SCNN1G, UBC, COMMD1, MAPK1, WWP2, NEDD4, NEDD4L, USP10, SCNN1B, EPN1, STX1A, SCNN1A, USP2, AP1M2, SCNN1D (tumor)SCNN1G, UBC, COMMD1, MAPK1, WWP2, NEDD4, NEDD4L, USP10, SCNN1B, EPN1, STX1A, SCNN1A, USP2, AP1M2, SCNN1D (normal)
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LIHC (tumor)LIHC (normal)
SCNN1G, UBC, COMMD1, MAPK1, WWP2, NEDD4, NEDD4L, USP10, SCNN1B, EPN1, STX1A, SCNN1A, USP2, AP1M2, SCNN1D (tumor)SCNN1G, UBC, COMMD1, MAPK1, WWP2, NEDD4, NEDD4L, USP10, SCNN1B, EPN1, STX1A, SCNN1A, USP2, AP1M2, SCNN1D (normal)
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LUAD (tumor)LUAD (normal)
SCNN1G, UBC, COMMD1, MAPK1, WWP2, NEDD4, NEDD4L, USP10, SCNN1B, EPN1, STX1A, SCNN1A, USP2, AP1M2, SCNN1D (tumor)SCNN1G, UBC, COMMD1, MAPK1, WWP2, NEDD4, NEDD4L, USP10, SCNN1B, EPN1, STX1A, SCNN1A, USP2, AP1M2, SCNN1D (normal)
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LUSC (tumor)LUSC (normal)
SCNN1G, UBC, COMMD1, MAPK1, WWP2, NEDD4, NEDD4L, USP10, SCNN1B, EPN1, STX1A, SCNN1A, USP2, AP1M2, SCNN1D (tumor)SCNN1G, UBC, COMMD1, MAPK1, WWP2, NEDD4, NEDD4L, USP10, SCNN1B, EPN1, STX1A, SCNN1A, USP2, AP1M2, SCNN1D (normal)
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PRAD (tumor)PRAD (normal)
SCNN1G, UBC, COMMD1, MAPK1, WWP2, NEDD4, NEDD4L, USP10, SCNN1B, EPN1, STX1A, SCNN1A, USP2, AP1M2, SCNN1D (tumor)SCNN1G, UBC, COMMD1, MAPK1, WWP2, NEDD4, NEDD4L, USP10, SCNN1B, EPN1, STX1A, SCNN1A, USP2, AP1M2, SCNN1D (normal)
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STAD (tumor)STAD (normal)
SCNN1G, UBC, COMMD1, MAPK1, WWP2, NEDD4, NEDD4L, USP10, SCNN1B, EPN1, STX1A, SCNN1A, USP2, AP1M2, SCNN1D (tumor)SCNN1G, UBC, COMMD1, MAPK1, WWP2, NEDD4, NEDD4L, USP10, SCNN1B, EPN1, STX1A, SCNN1A, USP2, AP1M2, SCNN1D (normal)
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THCA (tumor)THCA (normal)
SCNN1G, UBC, COMMD1, MAPK1, WWP2, NEDD4, NEDD4L, USP10, SCNN1B, EPN1, STX1A, SCNN1A, USP2, AP1M2, SCNN1D (tumor)SCNN1G, UBC, COMMD1, MAPK1, WWP2, NEDD4, NEDD4L, USP10, SCNN1B, EPN1, STX1A, SCNN1A, USP2, AP1M2, SCNN1D (normal)
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TissGeneProg for SCNN1G

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for SCNN1G
TissGeneDrug for SCNN1G

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status
DB00384TriamtereneInhibitorSmall moleculeApproved
DB00594AmilorideInhibitorSmall moleculeApproved


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TissGeneDisease for SCNN1G

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0020538Hypertensive disease13BeFree,CTD_human,GAD,LHGDN
umls:C0221043Liddle Syndrome6BeFree,CLINVAR,CTD_human,ORPHANET
umls:C0268436Pseudohypoaldosteronism, Type I5BeFree
umls:C0010674Cystic Fibrosis4BeFree,CTD_human,GAD,LHGDN
umls:C0033805Pseudohypoaldosteronism3BeFree,CTD_human,LHGDN
umls:C0004153Atherosclerosis1GAD
umls:C0006267Bronchiectasis1LHGDN
umls:C0007137Squamous cell carcinoma1BeFree
umls:C0009324Ulcerative Colitis1LHGDN
umls:C0015544Failure to Thrive1BeFree
umls:C0020437Hypercalcemia1BeFree
umls:C0020649Hypotension1CTD_human
umls:C0024115Lung diseases1BeFree
umls:C0235974Pancreatic carcinoma1BeFree
umls:C1272641Systemic arterial pressure1GAD
umls:C3163620Hypotension Adverse Event1GAD
umls:C0339985Idiopathic bronchiectasis0ORPHANET
umls:C1449843Pseudohypoaldosteronism, Type I, Autosomal Recessive0CLINVAR,MGD,ORPHANET
umls:C2751324BRONCHIECTASIS WITH OR WITHOUT ELEVATED SWEAT CHLORIDE 30CLINVAR,CTD_human