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| TissGeneSummary for CCL18 |
 Gene summary |
| Basic gene information | Gene symbol | CCL18 |
| Gene name | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) | |
| Synonyms | AMAC-1|AMAC1|CKb7|DC-CK1|DCCK1|MIP-4|PARC|SCYA18 | |
| Cytomap | UCSC genome browser: 17q11.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002988.3, | |
| Description | C-C motif chemokine 18CC chemokine PARCCC chemokine ligand 18alternative macrophage activation-associated CC chemokine 1chemokine (C-C), dendriticdendritic cell chemokine 1macrophage inflammatory protein 4pulmonary and activation-regulated chemokin | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603757 | |
| HGNC : HGNC | ||
| HPRD : 04784 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CCL18 | |
| BioGPS: 6362 | ||
| Pathway | NCI Pathway Interaction Database: CCL18 | |
| KEGG: CCL18 | ||
| REACTOME: CCL18 | ||
| Pathway Commons: CCL18 | ||
| Context | iHOP: CCL18 | |
| ligand binding site mutation search in PubMed: CCL18 | ||
| UCL Cancer Institute: CCL18 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Lung | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSC | |
| Reference showing the relevant tissue of CCL18 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CCL18 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | 0.886790013 | -4.611403737 | 5.49819375 | 4.30E-12 | 6.22E-11 |
| PRAD | -1.299579698 | -3.555350852 | 2.255771154 | 4.57E-08 | 4.70E-07 |
| KIRC | -0.15499957 | -4.88357457 | 4.728575 | 1.52E-20 | 1.27E-19 |
| LUSC | 3.29594994 | 5.054218567 | -1.758268627 | 3.89E-07 | 1.02E-06 |
| KICH | -1.923843237 | -4.998771237 | 3.074928 | 2.95E-06 | 1.02E-05 |
| HNSC | 1.683929693 | 0.431113414 | 1.252816279 | 0.00843 | 0.021383878 |
| THCA | 0.961886729 | -0.390798016 | 1.352684746 | 0.00792 | 0.015614319 |
| STAD | 1.517905638 | 0.027468138 | 1.4904375 | 0.0038 | 0.015595255 |
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| TissGene-miRNA for CCL18 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CCL18 |
| TissGeneSNV for CCL18 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.L32F | SKCM | 1 |
| p.M15V | LUAD | 1 |
| p.X90C | LIHC | 1 |
| p.W37X | THYM | 1 |
| p.A16S | STAD | 1 |
| p.A6S | LUAD | 1 |
| p.A89V | STAD | 1 |
| p.A7T | DLBC | 1 |
| p.W37* | THYM | 1 |
| p.C20F | UCEC | 1 |
| p.P52S | SKCM | 1 |
| p.R67L | ESCA | 1 |
| p.D84N | UCEC | 1 |
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| TissGeneCNV for CCL18 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CCL18 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for CCL18 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CCL18, TP53, C14orf1, EEF1A1, UNC119, CRMP1, TLE1, CCR3, PITPNM3 (tumor) | CCL18, TP53, C14orf1, EEF1A1, UNC119, CRMP1, TLE1, CCR3, PITPNM3 (normal) |
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| COAD (tumor) | COAD (normal) |
| CCL18, TP53, C14orf1, EEF1A1, UNC119, CRMP1, TLE1, CCR3, PITPNM3 (tumor) | CCL18, TP53, C14orf1, EEF1A1, UNC119, CRMP1, TLE1, CCR3, PITPNM3 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CCL18, TP53, C14orf1, EEF1A1, UNC119, CRMP1, TLE1, CCR3, PITPNM3 (tumor) | CCL18, TP53, C14orf1, EEF1A1, UNC119, CRMP1, TLE1, CCR3, PITPNM3 (normal) |
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| KICH (tumor) | KICH (normal) |
| CCL18, TP53, C14orf1, EEF1A1, UNC119, CRMP1, TLE1, CCR3, PITPNM3 (tumor) | CCL18, TP53, C14orf1, EEF1A1, UNC119, CRMP1, TLE1, CCR3, PITPNM3 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CCL18, TP53, C14orf1, EEF1A1, UNC119, CRMP1, TLE1, CCR3, PITPNM3 (tumor) | CCL18, TP53, C14orf1, EEF1A1, UNC119, CRMP1, TLE1, CCR3, PITPNM3 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| CCL18, TP53, C14orf1, EEF1A1, UNC119, CRMP1, TLE1, CCR3, PITPNM3 (tumor) | CCL18, TP53, C14orf1, EEF1A1, UNC119, CRMP1, TLE1, CCR3, PITPNM3 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CCL18, TP53, C14orf1, EEF1A1, UNC119, CRMP1, TLE1, CCR3, PITPNM3 (tumor) | CCL18, TP53, C14orf1, EEF1A1, UNC119, CRMP1, TLE1, CCR3, PITPNM3 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CCL18, TP53, C14orf1, EEF1A1, UNC119, CRMP1, TLE1, CCR3, PITPNM3 (tumor) | CCL18, TP53, C14orf1, EEF1A1, UNC119, CRMP1, TLE1, CCR3, PITPNM3 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CCL18, TP53, C14orf1, EEF1A1, UNC119, CRMP1, TLE1, CCR3, PITPNM3 (tumor) | CCL18, TP53, C14orf1, EEF1A1, UNC119, CRMP1, TLE1, CCR3, PITPNM3 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CCL18, TP53, C14orf1, EEF1A1, UNC119, CRMP1, TLE1, CCR3, PITPNM3 (tumor) | CCL18, TP53, C14orf1, EEF1A1, UNC119, CRMP1, TLE1, CCR3, PITPNM3 (normal) |
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| STAD (tumor) | STAD (normal) |
| CCL18, TP53, C14orf1, EEF1A1, UNC119, CRMP1, TLE1, CCR3, PITPNM3 (tumor) | CCL18, TP53, C14orf1, EEF1A1, UNC119, CRMP1, TLE1, CCR3, PITPNM3 (normal) |
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| THCA (tumor) | THCA (normal) |
| CCL18, TP53, C14orf1, EEF1A1, UNC119, CRMP1, TLE1, CCR3, PITPNM3 (tumor) | CCL18, TP53, C14orf1, EEF1A1, UNC119, CRMP1, TLE1, CCR3, PITPNM3 (normal) |
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| TissGeneProg for CCL18 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CCL18 |
| TissGeneDrug for CCL18 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CCL18 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0004096 | Asthma | 6 | BeFree,GAD,LHGDN |
| umls:C0011615 | Dermatitis, Atopic | 6 | BeFree,LHGDN |
| umls:C0006142 | Malignant neoplasm of breast | 4 | BeFree |
| umls:C0678222 | Breast Carcinoma | 4 | BeFree |
| umls:C0013595 | Eczema | 3 | BeFree |
| umls:C0034069 | Pulmonary Fibrosis | 3 | BeFree |
| umls:C0036421 | Systemic Scleroderma | 3 | BeFree,LHGDN |
| umls:C0042029 | Urinary tract infection | 3 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 2 | BeFree,LHGDN |
| umls:C0027430 | Nasal Polyps | 2 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
| umls:C0029408 | Degenerative polyarthritis | 2 | BeFree |
| umls:C0030805 | Bullous pemphigoid | 2 | BeFree |
| umls:C0037274 | Dermatologic disorders | 2 | BeFree |
| umls:C0155877 | Allergic asthma | 2 | BeFree |
| umls:C0341106 | Eosinophilic esophagitis | 2 | BeFree |
| umls:C0596263 | Carcinogenesis | 2 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 2 | BeFree |
| umls:C0001175 | Acquired Immunodeficiency Syndrome | 1 | BeFree,LHGDN |
| umls:C0002390 | Extrinsic allergic alveolitis | 1 | BeFree |
| umls:C0003486 | Aortic Aneurysm | 1 | BeFree |
| umls:C0003850 | Arteriosclerosis | 1 | BeFree |
| umls:C0004153 | Atherosclerosis | 1 | BeFree |
| umls:C0006274 | Bronchiolitis, Viral | 1 | GAD |
| umls:C0007273 | Carotid Artery Diseases | 1 | BeFree |
| umls:C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| umls:C0017205 | Gaucher Disease | 1 | BeFree |
| umls:C0018078 | Gonococcal urethritis | 1 | BeFree |
| umls:C0019163 | Hepatitis B | 1 | BeFree |
| umls:C0019693 | HIV Infections | 1 | BeFree |
| umls:C0021368 | Inflammation | 1 | LHGDN |
| umls:C0023418 | leukemia | 1 | LHGDN |
| umls:C0023449 | Acute lymphocytic leukemia | 1 | BeFree |
| umls:C0023452 | Leukemia, Lymphocytic, Acute, L1 | 1 | BeFree |
| umls:C0023485 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 1 | BeFree |
| umls:C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | BeFree,LHGDN |
| umls:C0024115 | Lung diseases | 1 | BeFree |
| umls:C0024121 | Lung Neoplasms | 1 | CTD_human |
| umls:C0024205 | Lymphadenitis | 1 | BeFree |
| umls:C0027819 | Neuroblastoma | 1 | BeFree |
| umls:C0029456 | Osteoporosis | 1 | BeFree |
| umls:C0030354 | Papilloma | 1 | BeFree |
| umls:C0030809 | Pemphigus Vulgaris | 1 | BeFree |
| umls:C0032927 | Precancerous Conditions | 1 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 1 | BeFree |
| umls:C0035235 | Respiratory Syncytial Virus Infections | 1 | GAD |
| umls:C0036205 | Sarcoidosis, Pulmonary | 1 | BeFree,LHGDN |
| umls:C0041296 | Tuberculosis | 1 | BeFree |
| umls:C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | BeFree |
| umls:C0153676 | Secondary malignant neoplasm of lung | 1 | BeFree |
| umls:C0162871 | Aortic Aneurysm, Abdominal | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0242656 | Disease Progression | 1 | LHGDN |
| umls:C0268243 | Niemann-Pick Disease, Type B | 1 | BeFree,LHGDN |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0524910 | Hepatitis C, Chronic | 1 | BeFree |
| umls:C0598766 | Leukemogenesis | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0700095 | Central neuroblastoma | 1 | BeFree |
| umls:C1112709 | non-gonococcal urethritis (NGU) | 1 | BeFree |
| umls:C1168198 | Recurrent respiratory papillomatosis | 1 | BeFree |
| umls:C1292769 | Precursor B-cell lymphoblastic leukemia | 1 | BeFree |
| umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 1 | BeFree |
| umls:C1520166 | Xenograft Model | 1 | BeFree |
| umls:C1800706 | Idiopathic Pulmonary Fibrosis | 1 | BeFree |
| umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | BeFree |
| umls:C2350236 | Idiopathic Interstitial Pneumonias | 1 | BeFree |
| umls:C3714753 | RETINOSCHISIS 1, X-LINKED, JUVENILE | 1 | BeFree |
| umls:C3826758 | AIDS (Disease) | 1 | BeFree |
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