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| TissGeneSummary for BCAN |
 Gene summary |
| Basic gene information | Gene symbol | BCAN |
| Gene name | brevican | |
| Synonyms | BEHAB|CSPG7 | |
| Cytomap | UCSC genome browser: 1q31 | |
| Type of gene | protein-coding | |
| RefGenes | NM_021948.4, NM_198427.1, | |
| Description | brain-enriched hyaluronan-binding proteinbrevican core proteinchondroitin sulfate proteoglycan 7chondroitin sulfate proteoglycan BEHAB | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 600347 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000132692 | ||
| HPRD : 02644 | ||
| HPRD : 09821 | ||
| Vega : OTTHUMG00000033322 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_BCAN | |
| BioGPS: 63827 | ||
| Pathway | NCI Pathway Interaction Database: BCAN | |
| KEGG: BCAN | ||
| REACTOME: BCAN | ||
| Pathway Commons: BCAN | ||
| Context | iHOP: BCAN | |
| ligand binding site mutation search in PubMed: BCAN | ||
| UCL Cancer Institute: BCAN | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of BCAN | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for BCAN |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | -1.596783481 | -2.887983481 | 1.2912 | 2.32E-07 | 8.56E-07 |
| LIHC | -0.377652929 | -3.412270929 | 3.034618 | 6.24E-10 | 7.09E-09 |
| BRCA | -1.845007982 | -0.719916754 | -1.125091228 | 3.36E-08 | 1.05E-07 |
| PRAD | -2.701792699 | -1.558369622 | -1.143423077 | 0.00027 | 0.001020354 |
| KIRP | 0.583363071 | -1.301324429 | 1.8846875 | 8.80E-05 | 0.00030494 |
| LUSC | -1.336792812 | -2.662877125 | 1.326084314 | 0.000103 | 0.000213195 |
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| TissGene-miRNA for BCAN |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for BCAN |
| TissGeneSNV for BCAN |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R579Q | HNSC | 2 |
| p.E279K | SKCM | 2 |
| p.R36C | BLCA | 1 |
| p.N614D | BRCA | 1 |
| p.A123P | LUAD | 1 |
| p.L197H | LUSC | 1 |
| p.P129R | CHOL | 1 |
| p.I735S | LUSC | 1 |
| p.R162Q | CESC | 1 |
| p.G262C | UCEC | 1 |
| p.A115V | HNSC | 1 |
| p.D229N | PRAD | 1 |
| p.P774S | UCEC | 1 |
| p.A195T | LUAD | 1 |
| p.A115V | UCEC | 1 |
| p.H345Y | LUAD | 1 |
| p.A361T | STAD | 1 |
| p.P592L | SKCM | 1 |
| p.G414E | HNSC | 1 |
| p.P189L | STAD | 1 |
| p.V643M | LGG | 1 |
| p.D375H | ESCA | 1 |
| p.E435G | CHOL | 1 |
| p.P610S | SKCM | 1 |
| p.P428S | COAD | 1 |
| p.D476N | SARC | 1 |
| p.Q46K | LIHC | 1 |
| p.D243Y | LUAD | 1 |
| p.V381I | BLCA | 1 |
| p.G658S | SKCM | 1 |
| p.A369G | OV | 1 |
| p.P342S | SKCM | 1 |
| p.R162Q | ESCA | 1 |
| p.P817L | UCEC | 1 |
| p.A187T | READ | 1 |
| p.E454K | SKCM | 1 |
| p.A273T | SKCM | 1 |
| p.R105G | DLBC | 1 |
| p.G206V | LUSC | 1 |
| p.W207C | LGG | 1 |
| p.R669L | HNSC | 1 |
| p.E606K | HNSC | 1 |
| p.R347H | LUAD | 1 |
| p.G206D | LUSC | 1 |
| p.T339I | LUAD | 1 |
| p.E258* | UCEC | 1 |
| p.V641E | LUSC | 1 |
| p.A194G | SKCM | 1 |
| p.G639V | SKCM | 1 |
| p.R579* | BLCA | 1 |
| p.N748K | LUSC | 1 |
| p.Q191* | LUAD | 1 |
| p.A646T | STAD | 1 |
| p.R669C | STAD | 1 |
| p.A698T | UCEC | 1 |
| p.P592S | SKCM | 1 |
| p.G415R | PAAD | 1 |
| p.V158I | PAAD | 1 |
| p.A656S | UCEC | 1 |
| p.S704Y | LGG | 1 |
| p.E385K | ESCA | 1 |
| p.E258Q | HNSC | 1 |
| p.G415X | STAD | 1 |
| p.P18H | LUAD | 1 |
| p.P220T | MESO | 1 |
| p.R829L | LUAD | 1 |
| p.R107H | STAD | 1 |
| p.A20S | SARC | 1 |
| p.T728K | LUAD | 1 |
| p.G603C | LUAD | 1 |
| p.R347C | LUAD | 1 |
| p.A19V | UCEC | 1 |
| p.R235W | HNSC | 1 |
| p.A43V | STAD | 1 |
| p.R105W | LIHC | 1 |
| p.K458I | COAD | 1 |
| p.G233W | LUAD | 1 |
| p.Y104* | OV | 1 |
| p.E504K | COAD | 1 |
| p.D295E | LUAD | 1 |
| p.K465T | KIRP | 1 |
| p.D679N | SKCM | 1 |
| p.E87D | PRAD | 1 |
| p.P264S | SKCM | 1 |
| p.R347H | PRAD | 1 |
| p.D227N | SKCM | 1 |
| p.E426K | SKCM | 1 |
| p.A275V | LIHC | 1 |
| p.S171F | SKCM | 1 |
| p.R274Q | LUAD | 1 |
| p.L657V | CHOL | 1 |
| p.R107H | COAD | 1 |
| p.S407F | HNSC | 1 |
| p.E456* | UCEC | 1 |
| p.R347H | PAAD | 1 |
| p.I405M | LUAD | 1 |
| p.R321H | UCEC | 1 |
| p.L432I | STAD | 1 |
| p.E472K | CESC | 1 |
| p.P873T | LUAD | 1 |
| p.D682Y | LUAD | 1 |
| p.R354* | PRAD | 1 |
| p.R851H | UCEC | 1 |
| p.R638L | CESC | 1 |
| p.V213A | UCEC | 1 |
| p.Y251C | LGG | 1 |
| p.E138G | KIRC | 1 |
| p.D775E | SKCM | 1 |
| p.S30L | CESC | 1 |
| p.S366C | LUAD | 1 |
| p.L657I | LUAD | 1 |
| p.D885H | KIRC | 1 |
| p.R280W | UCEC | 1 |
| p.G720R | OV | 1 |
| p.R162Q | HNSC | 1 |
| p.S360F | BLCA | 1 |
| p.P521S | BRCA | 1 |
| p.G288D | COAD | 1 |
| p.R841C | ACC | 1 |
| p.Q391H | SARC | 1 |
| p.L259R | SKCM | 1 |
| p.S615F | SKCM | 1 |
| p.G490S | LUAD | 1 |
| p.S356L | DLBC | 1 |
| p.G257A | LIHC | 1 |
| p.E272D | SKCM | 1 |
| p.E26Q | KIRP | 1 |
| p.K330N | BLCA | 1 |
| p.P620T | LUAD | 1 |
| p.T443K | LUSC | 1 |
| p.S776R | SARC | 1 |
| p.E583K | KICH | 1 |
| p.S346I | UCEC | 1 |
| p.R669C | UCEC | 1 |
| p.P596S | SKCM | 1 |
| p.A591D | SKCM | 1 |
| p.S419Y | UCEC | 1 |
| p.P114S | LUSC | 1 |
| p.R845P | SKCM | 1 |
| p.D204H | BLCA | 1 |
| p.S654L | SKCM | 1 |
| p.P264H | ESCA | 1 |
| p.P822H | LIHC | 1 |
| p.P578S | SKCM | 1 |
| p.Y200N | LIHC | 1 |
| p.P610L | SKCM | 1 |
| p.D148N | STAD | 1 |
| p.P56T | LUAD | 1 |
| p.R167C | LAML | 1 |
| p.G415* | STAD | 1 |
| p.G667V | LUSC | 1 |
| p.L853M | KIRP | 1 |
| p.R669C | PRAD | 1 |
| p.A600S | BRCA | 1 |
| p.D119N | STAD | 1 |
| p.R875K | LUAD | 1 |
| p.R136C | SKCM | 1 |
| p.S209L | CESC | 1 |
| p.G586E | SKCM | 1 |
| p.E433D | UCEC | 1 |
| p.H722Y | COAD | 1 |
| p.R863H | THCA | 1 |
| p.L723V | HNSC | 1 |
| p.R321H | STAD | 1 |
| p.D355Y | STAD | 1 |
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| TissGeneCNV for BCAN |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for BCAN |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | KIRC | TCGA-CW-5584-01A | ABCC3-BCAN | In-frame | Chr17:48751019 | Chr1:156627467 |
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| TissGeneNet for BCAN |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| BCAN, PCBD1, MMP1, MMP2, ADAMTS4, TNR, MMP7, FBLN2, MMP13, MMP3, MMP10, MMP8 (tumor) | BCAN, PCBD1, MMP1, MMP2, ADAMTS4, TNR, MMP7, FBLN2, MMP13, MMP3, MMP10, MMP8 (normal) |
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| COAD (tumor) | COAD (normal) |
| BCAN, PCBD1, MMP1, MMP2, ADAMTS4, TNR, MMP7, FBLN2, MMP13, MMP3, MMP10, MMP8 (tumor) | BCAN, PCBD1, MMP1, MMP2, ADAMTS4, TNR, MMP7, FBLN2, MMP13, MMP3, MMP10, MMP8 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| BCAN, PCBD1, MMP1, MMP2, ADAMTS4, TNR, MMP7, FBLN2, MMP13, MMP3, MMP10, MMP8 (tumor) | BCAN, PCBD1, MMP1, MMP2, ADAMTS4, TNR, MMP7, FBLN2, MMP13, MMP3, MMP10, MMP8 (normal) |
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| KICH (tumor) | KICH (normal) |
| BCAN, PCBD1, MMP1, MMP2, ADAMTS4, TNR, MMP7, FBLN2, MMP13, MMP3, MMP10, MMP8 (tumor) | BCAN, PCBD1, MMP1, MMP2, ADAMTS4, TNR, MMP7, FBLN2, MMP13, MMP3, MMP10, MMP8 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| BCAN, PCBD1, MMP1, MMP2, ADAMTS4, TNR, MMP7, FBLN2, MMP13, MMP3, MMP10, MMP8 (tumor) | BCAN, PCBD1, MMP1, MMP2, ADAMTS4, TNR, MMP7, FBLN2, MMP13, MMP3, MMP10, MMP8 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| BCAN, PCBD1, MMP1, MMP2, ADAMTS4, TNR, MMP7, FBLN2, MMP13, MMP3, MMP10, MMP8 (tumor) | BCAN, PCBD1, MMP1, MMP2, ADAMTS4, TNR, MMP7, FBLN2, MMP13, MMP3, MMP10, MMP8 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| BCAN, PCBD1, MMP1, MMP2, ADAMTS4, TNR, MMP7, FBLN2, MMP13, MMP3, MMP10, MMP8 (tumor) | BCAN, PCBD1, MMP1, MMP2, ADAMTS4, TNR, MMP7, FBLN2, MMP13, MMP3, MMP10, MMP8 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| BCAN, PCBD1, MMP1, MMP2, ADAMTS4, TNR, MMP7, FBLN2, MMP13, MMP3, MMP10, MMP8 (tumor) | BCAN, PCBD1, MMP1, MMP2, ADAMTS4, TNR, MMP7, FBLN2, MMP13, MMP3, MMP10, MMP8 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| BCAN, PCBD1, MMP1, MMP2, ADAMTS4, TNR, MMP7, FBLN2, MMP13, MMP3, MMP10, MMP8 (tumor) | BCAN, PCBD1, MMP1, MMP2, ADAMTS4, TNR, MMP7, FBLN2, MMP13, MMP3, MMP10, MMP8 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| BCAN, PCBD1, MMP1, MMP2, ADAMTS4, TNR, MMP7, FBLN2, MMP13, MMP3, MMP10, MMP8 (tumor) | BCAN, PCBD1, MMP1, MMP2, ADAMTS4, TNR, MMP7, FBLN2, MMP13, MMP3, MMP10, MMP8 (normal) |
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| STAD (tumor) | STAD (normal) |
| BCAN, PCBD1, MMP1, MMP2, ADAMTS4, TNR, MMP7, FBLN2, MMP13, MMP3, MMP10, MMP8 (tumor) | BCAN, PCBD1, MMP1, MMP2, ADAMTS4, TNR, MMP7, FBLN2, MMP13, MMP3, MMP10, MMP8 (normal) |
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| THCA (tumor) | THCA (normal) |
| BCAN, PCBD1, MMP1, MMP2, ADAMTS4, TNR, MMP7, FBLN2, MMP13, MMP3, MMP10, MMP8 (tumor) | BCAN, PCBD1, MMP1, MMP2, ADAMTS4, TNR, MMP7, FBLN2, MMP13, MMP3, MMP10, MMP8 (normal) |
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| TissGeneProg for BCAN |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for BCAN |
| TissGeneDrug for BCAN |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for BCAN |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0017638 | Glioma | 9 | BeFree,LHGDN |
| umls:C0017636 | Glioblastoma | 2 | BeFree,LHGDN |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | BeFree |
| umls:C0007786 | Brain Ischemia | 1 | GAD |
| umls:C0028945 | oligodendroglioma | 1 | BeFree |
| umls:C0038454 | Cerebrovascular accident | 1 | GAD |
| umls:C0555198 | Malignant Glioma | 1 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
| umls:C0750974 | Brain Tumor, Primary | 1 | BeFree |
| umls:C0751396 | Well Differentiated Oligodendroglioma | 1 | BeFree |
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