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| TissGeneSummary for HEPACAM |
 Gene summary |
| Basic gene information | Gene symbol | HEPACAM |
| Gene name | ||
| Synonyms | ||
| Cytomap | UCSC genome browser: | |
| Type of gene | ||
| RefGenes | ||
| Description | ||
| Modification date | ||
| dbXrefs | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HEPACAM | |
| BioGPS: 641654 | ||
| Pathway | NCI Pathway Interaction Database: HEPACAM | |
| KEGG: HEPACAM | ||
| REACTOME: HEPACAM | ||
| Pathway Commons: HEPACAM | ||
| Context | iHOP: HEPACAM | |
| ligand binding site mutation search in PubMed: HEPACAM | ||
| UCL Cancer Institute: HEPACAM | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of HEPACAM | ||
| Description by TissGene annotations | Have significant anti-correlated miRNA TissgsKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for HEPACAM |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | -2.839436133 | -0.770116902 | -2.069319231 | 1.05E-08 | 9.20E-08 |
| PRAD | -2.122889979 | -0.945114979 | -1.177775 | 9.69E-08 | 9.20E-07 |
| KICH | -3.308111518 | -1.306431518 | -2.00168 | 1.18E-10 | 8.94E-10 |
| LIHC | 0.310854482 | 4.734338482 | -4.423484 | 8.58E-09 | 7.62E-08 |
| KIRC | -2.747866796 | -1.465057073 | -1.282809722 | 1.48E-10 | 5.14E-10 |
| BRCA | -1.544883097 | 3.477054623 | -5.021937719 | 5.38E-51 | 4.23E-49 |
| KIRP | -2.995854643 | -1.379351518 | -1.616503125 | 3.27E-07 | 1.82E-06 |
| STAD | -2.252951518 | -0.707845268 | -1.54510625 | 0.000786 | 0.004386387 |
| BLCA | -3.073914676 | -1.56298836 | -1.510926316 | 0.000312 | 0.002797935 |
| HNSC | -2.820472448 | -1.49398175 | -1.326490698 | 2.64E-05 | 0.000136239 |
| Top |
| TissGene-miRNA for HEPACAM |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| ACC | hsa-miR-29a-3p | MIMAT0000086 | 0.0077 | -0.3 | 78 |
| ACC | hsa-miR-29a-3p | MIMAT0000086 | 0.0077 | -0.3 | 78 |
| Top |
| TissGeneMut for HEPACAM |
| TissGeneSNV for HEPACAM |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R298Q | UCEC | 2 |
| p.R64K | SKCM | 1 |
| p.R373W | CESC | 1 |
| p.A293_splice | UCEC | 1 |
| p.V201L | HNSC | 1 |
| p.A345T | LIHC | 1 |
| p.R298X | SKCM | 1 |
| p.T258I | UCEC | 1 |
| p.R98H | HNSC | 1 |
| p.P222L | SKCM | 1 |
| p.L310I | STAD | 1 |
| p.Q81L | SKCM | 1 |
| p.R96G | HNSC | 1 |
| p.L101H | SKCM | 1 |
| p.T258K | LUAD | 1 |
| p.N324S | LGG | 1 |
| p.N221K | LUAD | 1 |
| p.S146L | COAD | 1 |
| p.R298* | SKCM | 1 |
| p.Q81E | LUAD | 1 |
| p.L253F | SKCM | 1 |
| p.N189K | LUAD | 1 |
| p.R100* | BRCA | 1 |
| p.A115T | SKCM | 1 |
| p.R92W | HNSC | 1 |
| p.V87A | UCEC | 1 |
| p.S161R | STAD | 1 |
| p.T130S | LIHC | 1 |
| p.E220Q | BRCA | 1 |
| p.L107V | SKCM | 1 |
| p.V207M | COAD | 1 |
| p.R238K | SKCM | 1 |
| p.T295S | LUAD | 1 |
| p.V40M | UCEC | 1 |
| p.R16H | UCEC | 1 |
| p.P307L | KIRC | 1 |
| p.L273I | LUSC | 1 |
| p.K75T | STAD | 1 |
| p.E86V | COAD | 1 |
| p.P19A | SKCM | 1 |
| p.R288S | LUAD | 1 |
| p.R96L | UCEC | 1 |
| p.R192I | PAAD | 1 |
| p.S146L | STAD | 1 |
| p.V219M | PAAD | 1 |
| p.G226C | LUSC | 1 |
| p.R304Q | BLCA | 1 |
| p.D63V | LUSC | 1 |
| p.S191L | UCS | 1 |
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| TissGeneCNV for HEPACAM |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| Top |
| TissGeneFusions for HEPACAM |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for HEPACAM |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for HEPACAM |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for HEPACAM |
| TissGeneDrug for HEPACAM |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for HEPACAM |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C1858854 | MEGALENCEPHALIC LEUKOENCEPHALOPATHY WITH SUBCORTICAL CYSTS | 9 | BeFree,ORPHANET |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 3 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 3 | BeFree |
| umls:C0279680 | Transitional cell carcinoma of bladder | 3 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 3 | BeFree |
| umls:C1378703 | Renal carcinoma | 3 | BeFree |
| umls:C0023520 | Leukodystrophy | 2 | BeFree |
| umls:C0221355 | Macrocephaly | 2 | BeFree |
| umls:C0270612 | Leukoencephalopathies | 2 | BeFree |
| umls:C0596263 | Carcinogenesis | 2 | BeFree |
| umls:C0740457 | Malignant neoplasm of kidney | 2 | BeFree |
| umls:C2239176 | Liver carcinoma | 2 | BeFree |
| umls:C0004352 | Autistic Disorder | 1 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0007138 | Carcinoma, Transitional Cell | 1 | BeFree |
| umls:C0017636 | Glioblastoma | 1 | BeFree |
| umls:C0025362 | Mental Retardation | 1 | BeFree |
| umls:C0220690 | Macrocephaly, benign familial | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C2145472 | Urothelial Carcinoma | 1 | BeFree |
| umls:C3151355 | MEGALENCEPHALIC LEUKOENCEPHALOPATHY WITH SUBCORTICAL CYSTS 2A | 1 | CLINVAR,UNIPROT |
| umls:C3151356 | MEGALENCEPHALIC LEUKOENCEPHALOPATHY WITH SUBCORTICAL CYSTS 2B, REMITTING, WITH OR WITHOUT MENTAL RETARDATION | 1 | CLINVAR,UNIPROT |
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