TissGeneSummary for CCDC168 |
Gene summary |
Basic gene information | Gene symbol | CCDC168 |
Gene name | coiled-coil domain containing 168 | |
Synonyms | C13orf40 | |
Cytomap | UCSC genome browser: 13q33.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001146197.1, | |
Description | coiled-coil domain-containing protein 168 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000175820 | ||
Vega : OTTHUMG00000187287 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CCDC168 | |
BioGPS: 643677 | ||
Pathway | NCI Pathway Interaction Database: CCDC168 | |
KEGG: CCDC168 | ||
REACTOME: CCDC168 | ||
Pathway Commons: CCDC168 | ||
Context | iHOP: CCDC168 | |
ligand binding site mutation search in PubMed: CCDC168 | ||
UCL Cancer Institute: CCDC168 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CCDC168 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for CCDC168 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
Top |
TissGene-miRNA for CCDC168 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for CCDC168 |
TissGeneSNV for CCDC168 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R1209Q | SARC | 2 |
p.K6993R | COAD | 1 |
p.G1532S | LIHC | 1 |
p.R478I | READ | 1 |
p.A4478S | COAD | 1 |
p.F2726L | COAD | 1 |
p.H1508L | LIHC | 1 |
p.R6075H | LIHC | 1 |
p.I190M | COAD | 1 |
p.E2028K | COAD | 1 |
p.A5476T | UCEC | 1 |
p.P6277L | READ | 1 |
p.L1583F | DLBC | 1 |
p.K2302N | COAD | 1 |
p.G4893S | COAD | 1 |
p.K6236R | READ | 1 |
p.D7002N | LIHC | 1 |
p.T5848M | ESCA | 1 |
p.L5587I | READ | 1 |
p.L3151I | THYM | 1 |
p.G5409E | READ | 1 |
p.T1821N | CHOL | 1 |
p.E4242G | DLBC | 1 |
p.A4200S | COAD | 1 |
p.E4545D | COAD | 1 |
p.R6947K | COAD | 1 |
p.D5177A | READ | 1 |
p.R6581T | ESCA | 1 |
p.R5642X | ESCA | 1 |
p.S1416F | ESCA | 1 |
p.L88P | ESCA | 1 |
p.L6011P | LGG | 1 |
p.E1873Q | ESCA | 1 |
p.T6450N | CHOL | 1 |
p.K2150R | CHOL | 1 |
p.W3578R | LIHC | 1 |
p.K6993T | READ | 1 |
p.L1539I | ESCA | 1 |
p.T1035M | COAD | 1 |
p.P3099S | THYM | 1 |
p.E6232X | READ | 1 |
p.R1070S | COAD | 1 |
p.G1532C | DLBC | 1 |
p.K1953N | LIHC | 1 |
p.E3193V | COAD | 1 |
p.D2705N | ESCA | 1 |
p.A3230E | ESCA | 1 |
p.K6094N | COAD | 1 |
p.E344K | UCEC | 1 |
p.S3718I | COAD | 1 |
p.R6437M | COAD | 1 |
p.P5918L | READ | 1 |
p.D2708N | COAD | 1 |
p.D1548Y | READ | 1 |
p.K6582N | LIHC | 1 |
p.R1524C | CESC | 1 |
p.N1704H | COAD | 1 |
p.P6155L | LIHC | 1 |
p.K1179N | KIRC | 1 |
p.Q2196K | ESCA | 1 |
p.N648H | COAD | 1 |
p.A4148S | COAD | 1 |
p.H4433N | UCEC | 1 |
p.T5008I | UCEC | 1 |
p.S1286X | THYM | 1 |
p.E2645X | COAD | 1 |
p.L2582I | COAD | 1 |
p.R822M | LUAD | 1 |
p.K3188R | LIHC | 1 |
p.A2204S | LIHC | 1 |
p.S5519L | READ | 1 |
p.L3088I | READ | 1 |
p.E6327K | READ | 1 |
p.R2187H | UCEC | 1 |
p.K4231R | KIRP | 1 |
p.W1190* | ESCA | 1 |
p.E5692X | COAD | 1 |
p.E1485K | ESCA | 1 |
p.P7014A | ACC | 1 |
p.F3636L | LIHC | 1 |
p.D2914G | COAD | 1 |
p.R1783I | COAD | 1 |
p.E3967X | ACC | 1 |
p.S3576L | READ | 1 |
p.G5011A | DLBC | 1 |
p.I5226L | READ | 1 |
p.V519L | MESO | 1 |
p.T470N | ESCA | 1 |
p.E4239K | LIHC | 1 |
p.S3028Y | COAD | 1 |
p.H164N | ACC | 1 |
p.E3844X | LIHC | 1 |
p.T6112M | DLBC | 1 |
p.A1430V | UCEC | 1 |
p.G5576E | COAD | 1 |
p.E1544K | LIHC | 1 |
p.P1325Q | COAD | 1 |
p.M4723V | DLBC | 1 |
p.L3724V | READ | 1 |
p.S2108Y | COAD | 1 |
p.S2079X | READ | 1 |
p.P4784S | COAD | 1 |
p.S2153G | THYM | 1 |
p.P2385A | ACC | 1 |
p.E4668K | ACC | 1 |
p.L4617V | READ | 1 |
p.T1674A | READ | 1 |
p.K3640N | COAD | 1 |
p.D753Y | SARC | 1 |
p.Y4918D | COAD | 1 |
p.W5819X | ESCA | 1 |
p.E76Q | ESCA | 1 |
p.D4197N | COAD | 1 |
p.P3972H | ACC | 1 |
p.E1280Q | COAD | 1 |
p.R3455T | LIHC | 1 |
p.L1472X | KIRP | 1 |
p.Q3102H | ESCA | 1 |
p.D5829Y | COAD | 1 |
p.S6909R | THYM | 1 |
p.F131L | COAD | 1 |
p.D3441H | LIHC | 1 |
p.E970K | READ | 1 |
p.E1929K | ESCA | 1 |
p.I3630V | UCEC | 1 |
p.M713I | READ | 1 |
p.L2250* | SARC | 1 |
p.E39K | ACC | 1 |
p.L6011P | SKCM | 1 |
p.S5699Y | ESCA | 1 |
p.S4700Y | READ | 1 |
p.D6361Y | COAD | 1 |
p.E5535D | COAD | 1 |
p.E1351* | LIHC | 1 |
p.S1997X | READ | 1 |
p.D6213G | READ | 1 |
p.E327K | COAD | 1 |
p.L1471X | READ | 1 |
p.T1219M | ESCA | 1 |
p.V5913A | DLBC | 1 |
p.G2544D | UCEC | 1 |
p.L3883V | COAD | 1 |
p.M1469I | ESCA | 1 |
p.E276Q | CESC | 1 |
p.Y2058F | LIHC | 1 |
p.K3816N | COAD | 1 |
p.N2278H | COAD | 1 |
p.E3189D | COAD | 1 |
p.M6098I | ESCA | 1 |
p.R5585Q | READ | 1 |
p.E659K | CESC | 1 |
p.E3965V | READ | 1 |
p.D5377N | READ | 1 |
p.A2587T | READ | 1 |
p.R4072M | ESCA | 1 |
p.A4221S | COAD | 1 |
p.L6812I | READ | 1 |
p.S3689L | ESCA | 1 |
p.A2208V | COAD | 1 |
p.A4988T | READ | 1 |
p.S4028I | COAD | 1 |
p.S6045F | ESCA | 1 |
p.G3430V | LIHC | 1 |
p.K2311N | COAD | 1 |
p.E3113K | COAD | 1 |
p.W5819R | COAD | 1 |
p.K605N | KIRP | 1 |
p.R7044I | READ | 1 |
p.P5468T | UCEC | 1 |
p.E3797X | COAD | 1 |
p.K4585E | READ | 1 |
p.D2267Y | COAD | 1 |
p.E3561X | COAD | 1 |
p.E4808D | COAD | 1 |
p.N35K | COAD | 1 |
p.K4679R | UCEC | 1 |
p.S5127L | DLBC | 1 |
p.M2870I | THYM | 1 |
p.A1386S | CESC | 1 |
p.T2009I | LIHC | 1 |
p.Q1695K | ACC | 1 |
p.R5057I | COAD | 1 |
p.S6744Y | COAD | 1 |
p.H1508Q | LIHC | 1 |
p.Q6613R | UCEC | 1 |
p.D3446E | COAD | 1 |
p.N5750S | PRAD | 1 |
p.E5910D | UCEC | 1 |
p.P6117S | UCEC | 1 |
p.E1628D | ESCA | 1 |
p.S1389P | LIHC | 1 |
p.E3948X | COAD | 1 |
p.Q733H | CESC | 1 |
p.D4259N | READ | 1 |
p.E4705Q | ESCA | 1 |
p.S2930F | READ | 1 |
p.Q6101X | COAD | 1 |
p.L4746R | READ | 1 |
p.G4893S | KIRP | 1 |
p.V118A | SARC | 1 |
p.R5838Q | COAD | 1 |
p.E6327K | COAD | 1 |
p.N4639H | READ | 1 |
p.N3650T | LIHC | 1 |
p.S1070Y | ESCA | 1 |
p.Q1480* | UCEC | 1 |
p.F2358S | COAD | 1 |
p.E6670K | COAD | 1 |
p.D403H | COAD | 1 |
p.E2049Q | ESCA | 1 |
p.K5769X | COAD | 1 |
p.P6383L | UCEC | 1 |
p.H1225Y | COAD | 1 |
p.Y1154C | ACC | 1 |
p.E942K | READ | 1 |
p.M3170I | KICH | 1 |
p.E5980X | LIHC | 1 |
p.K2876E | DLBC | 1 |
p.S354R | THYM | 1 |
p.L2250W | SARC | 1 |
Top |
TissGeneCNV for CCDC168 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for CCDC168 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Top |
TissGeneNet for CCDC168 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for CCDC168 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for CCDC168 |
TissGeneDrug for CCDC168 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for CCDC168 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |