TissGeneSummary for DNAI2 |
Gene summary |
Basic gene information | Gene symbol | DNAI2 |
Gene name | dynein, axonemal, intermediate chain 2 | |
Synonyms | CILD9|DIC2 | |
Cytomap | UCSC genome browser: 17q25 | |
Type of gene | protein-coding | |
RefGenes | NM_001172810.1, NM_023036.4, | |
Description | dynein intermediate chain 2, axonemaldynein, axonemal, intermediate polypeptide 2 | |
Modification date | 20141219 | |
dbXrefs | MIM : 605483 | |
HGNC : HGNC | ||
Ensembl : ENSG00000171595 | ||
HPRD : 12019 | ||
Vega : OTTHUMG00000178578 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DNAI2 | |
BioGPS: 64446 | ||
Pathway | NCI Pathway Interaction Database: DNAI2 | |
KEGG: DNAI2 | ||
REACTOME: DNAI2 | ||
Pathway Commons: DNAI2 | ||
Context | iHOP: DNAI2 | |
ligand binding site mutation search in PubMed: DNAI2 | ||
UCL Cancer Institute: DNAI2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of DNAI2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for DNAI2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | 0.32083852 | 3.451178176 | -3.130339655 | 9.54E-10 | 5.05E-09 |
LUSC | -0.385332575 | 3.364367425 | -3.7497 | 7.54E-13 | 3.53E-12 |
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TissGene-miRNA for DNAI2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for DNAI2 |
TissGeneSNV for DNAI2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G15R | COAD | 2 |
p.E217K | SKCM | 2 |
p.G319W | LUAD | 1 |
p.L466V | STAD | 1 |
p.R97W | LIHC | 1 |
p.Q216R | SARC | 1 |
p.K565N | BLCA | 1 |
p.V422I | CHOL | 1 |
p.V6M | PAAD | 1 |
p.E26D | THYM | 1 |
p.L541V | STAD | 1 |
p.E578K | SKCM | 1 |
p.K378N | UCEC | 1 |
p.G239* | BRCA | 1 |
p.E78Q | BLCA | 1 |
p.W81X | SKCM | 1 |
p.V142M | UCEC | 1 |
p.G376V | LUAD | 1 |
p.R516W | SKCM | 1 |
p.P420L | STAD | 1 |
p.N436Y | HNSC | 1 |
p.L598V | STAD | 1 |
p.E160K | SKCM | 1 |
p.A222V | SKCM | 1 |
p.V288L | LUAD | 1 |
p.P483S | COAD | 1 |
p.H363Y | OV | 1 |
p.D87G | SKCM | 1 |
p.G56S | PRAD | 1 |
p.R513M | THYM | 1 |
p.V399I | LGG | 1 |
p.A165V | UCEC | 1 |
p.E589D | COAD | 1 |
p.G393E | LUAD | 1 |
p.R68H | SKCM | 1 |
p.R247Q | UCEC | 1 |
p.G393R | BRCA | 1 |
p.V422I | UCEC | 1 |
p.W349* | SKCM | 1 |
p.G376W | LUAD | 1 |
p.E279K | SKCM | 1 |
p.D230N | CESC | 1 |
p.L485P | KICH | 1 |
p.R446C | LUAD | 1 |
p.E581K | HNSC | 1 |
p.E336K | SKCM | 1 |
p.R518W | PAAD | 1 |
p.T71A | UCEC | 1 |
p.G392* | LUAD | 1 |
p.G399R | SKCM | 1 |
p.E651G | LUAD | 1 |
p.D128A | CESC | 1 |
p.D462A | UCEC | 1 |
p.Q149L | LUAD | 1 |
p.Y267D | LUAD | 1 |
p.I108N | THCA | 1 |
p.W138* | SKCM | 1 |
p.E61* | CESC | 1 |
p.V342I | LGG | 1 |
p.R23S | LUAD | 1 |
p.T488I | SKCM | 1 |
p.K508N | BLCA | 1 |
p.T487I | UCEC | 1 |
p.R80G | LUAD | 1 |
p.F77L | LGG | 1 |
p.R562W | HNSC | 1 |
p.V63M | PAAD | 1 |
p.C243F | STAD | 1 |
p.S253R | SKCM | 1 |
p.E606K | SKCM | 1 |
p.K311R | BLCA | 1 |
p.G296R | SKCM | 1 |
p.D30N | UCEC | 1 |
p.L235* | BLCA | 1 |
p.P229H | PRAD | 1 |
p.R389F | LUAD | 1 |
p.E397* | LUAD | 1 |
p.E638K | HNSC | 1 |
p.L371W | LGG | 1 |
p.S255* | PCPG | 1 |
p.R68S | LUAD | 1 |
p.G365D | SKCM | 1 |
p.V199L | LUAD | 1 |
p.Q188H | LUSC | 1 |
p.K219N | CESC | 1 |
p.R233G | LIHC | 1 |
p.E594K | LUSC | 1 |
p.R429S | SKCM | 1 |
p.E564K | BLCA | 1 |
p.R562Q | SKCM | 1 |
p.R80S | LUAD | 1 |
p.E135Q | BLCA | 1 |
p.Q297H | BLCA | 1 |
p.V231L | LUAD | 1 |
p.E356D | SARC | 1 |
p.R459W | SKCM | 1 |
p.F437Y | UCEC | 1 |
p.S398L | BLCA | 1 |
p.V357G | CESC | 1 |
p.D30G | SKCM | 1 |
p.V422I | ESCA | 1 |
p.V8I | COAD | 1 |
p.V266A | STAD | 1 |
p.F187I | LIHC | 1 |
p.M495L | BLCA | 1 |
p.P572S | STAD | 1 |
p.Q109* | SKCM | 1 |
p.P366T | UCEC | 1 |
p.D350N | LUAD | 1 |
p.S455L | BLCA | 1 |
p.E144Q | CESC | 1 |
p.E586D | LUAD | 1 |
p.I566N | HNSC | 1 |
p.D30N | SKCM | 1 |
p.R572Q | SARC | 1 |
p.R101Q | SKCM | 1 |
p.Y324D | LUAD | 1 |
p.E454* | LUAD | 1 |
p.R23G | LUAD | 1 |
p.G239R | SKCM | 1 |
p.N379Y | HNSC | 1 |
p.E59K | SKCM | 1 |
p.E338K | SKCM | 1 |
p.L270Q | LUAD | 1 |
p.G422D | SKCM | 1 |
p.R505Q | SKCM | 1 |
p.T571M | CESC | 1 |
p.E521K | SKCM | 1 |
p.K368R | BLCA | 1 |
p.R11L | LUAD | 1 |
p.R176G | LIHC | 1 |
p.D87N | SKCM | 1 |
p.A525V | STAD | 1 |
p.L213Q | LUAD | 1 |
p.K162N | CESC | 1 |
p.S56G | ESCA | 1 |
p.R446L | LUAD | 1 |
p.R11S | LUAD | 1 |
p.T285M | COAD | 1 |
p.E395K | SKCM | 1 |
p.I509N | HNSC | 1 |
p.R154W | LIHC | 1 |
p.V479I | ESCA | 1 |
p.I51N | THCA | 1 |
p.D500N | SKCM | 1 |
p.D22E | UCEC | 1 |
p.E503V | LUSC | 1 |
p.R68L | LUAD | 1 |
p.Q52X | SKCM | 1 |
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TissGeneCNV for DNAI2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for DNAI2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-EW-A1PA-01A | TMEM104-DNAI2 | Out-of-frame | Chr17:72791771 | Chr17:72310260 |
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TissGeneNet for DNAI2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for DNAI2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for DNAI2 |
TissGeneDrug for DNAI2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for DNAI2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0022521 | Kartagener Syndrome | 4 | BeFree,CLINVAR,LHGDN |
umls:C0008780 | Ciliary Motility Disorders | 2 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0042769 | Virus Diseases | 1 | BeFree |
umls:C0375023 | Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 1 | BeFree |
umls:C2676235 | CILIARY DYSKINESIA, PRIMARY, 9 | 0 | CLINVAR,CTD_human |