TissGeneSummary for GPR135 |
Gene summary |
Basic gene information | Gene symbol | GPR135 |
Gene name | G protein-coupled receptor 135 | |
Synonyms | HUMNPIIY20 | |
Cytomap | UCSC genome browser: 14q23.1 | |
Type of gene | protein-coding | |
RefGenes | NM_022571.5, | |
Description | probable G-protein coupled receptor 135 | |
Modification date | 20141207 | |
dbXrefs | MIM : 607970 | |
HGNC : HGNC | ||
HPRD : 16263 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GPR135 | |
BioGPS: 64582 | ||
Pathway | NCI Pathway Interaction Database: GPR135 | |
KEGG: GPR135 | ||
REACTOME: GPR135 | ||
Pathway Commons: GPR135 | ||
Context | iHOP: GPR135 | |
ligand binding site mutation search in PubMed: GPR135 | ||
UCL Cancer Institute: GPR135 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of GPR135 | ||
Description by TissGene annotations | Have significant anti-correlated miRNA |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for GPR135 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -0.975417291 | 0.791946709 | -1.767364 | 1.06E-09 | 6.60E-09 |
BLCA | -0.690278975 | 0.451184183 | -1.141463158 | 0.00745 | 0.035863203 |
STAD | 0.360925959 | 1.382241584 | -1.021315625 | 0.0039 | 0.015889674 |
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TissGene-miRNA for GPR135 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
LUAD | hsa-miR-33b-5p | MIMAT0003301 | 0.02 | -0.3 | 60 |
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TissGeneMut for GPR135 |
TissGeneSNV for GPR135 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.Q5P | KIRP | 2 |
p.R431* | UCEC | 2 |
p.S206L | STAD | 1 |
p.L273P | LUAD | 1 |
p.P477L | STAD | 1 |
p.L334I | STAD | 1 |
p.A318V | UCEC | 1 |
p.R437Q | LUSC | 1 |
p.R390H | STAD | 1 |
p.P420L | STAD | 1 |
p.A381V | STAD | 1 |
p.R328C | PCPG | 1 |
p.R429H | STAD | 1 |
p.A480T | BLCA | 1 |
p.S366* | LUAD | 1 |
p.E403K | STAD | 1 |
p.V333I | STAD | 1 |
p.R328C | COAD | 1 |
p.R462H | PAAD | 1 |
p.T479M | SARC | 1 |
p.F277S | LUSC | 1 |
p.R462H | UCEC | 1 |
p.G419C | LIHC | 1 |
p.N442Y | LUAD | 1 |
p.R402C | STAD | 1 |
p.Q5P | SKCM | 1 |
p.R407W | SKCM | 1 |
p.A330T | STAD | 1 |
p.Q5P | PRAD | 1 |
p.Q5P | STAD | 1 |
p.I389V | LIHC | 1 |
p.V370M | BLCA | 1 |
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TissGeneCNV for GPR135 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for GPR135 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for GPR135 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for GPR135 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for GPR135 |
TissGeneDrug for GPR135 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for GPR135 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
umls:C0018133 | Graft-vs-Host Disease | 1 | BeFree |
umls:C0155877 | Allergic asthma | 1 | BeFree |
umls:C0553692 | Brain hemorrhage | 1 | GAD |
umls:C0856825 | Acute GVH disease | 1 | BeFree |