TissGeneSummary for CCDC136 |
Gene summary |
Basic gene information | Gene symbol | CCDC136 |
Gene name | coiled-coil domain containing 136 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 7q33 | |
Type of gene | protein-coding | |
RefGenes | NM_001201372.1, NM_022742.4, | |
Description | coiled-coil domain-containing protein 136nasopharyngeal carcinoma-associated gene 6 protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 611902 | |
HGNC : HGNC | ||
Ensembl : ENSG00000128596 | ||
HPRD : 10887 | ||
Vega : OTTHUMG00000158310 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CCDC136 | |
BioGPS: 64753 | ||
Pathway | NCI Pathway Interaction Database: CCDC136 | |
KEGG: CCDC136 | ||
REACTOME: CCDC136 | ||
Pathway Commons: CCDC136 | ||
Context | iHOP: CCDC136 | |
ligand binding site mutation search in PubMed: CCDC136 | ||
UCL Cancer Institute: CCDC136 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CCDC136 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CCDC136 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -1.328471284 | 0.316980471 | -1.645451754 | 4.28E-28 | 5.02E-27 |
STAD | -0.808848422 | 0.370007828 | -1.17885625 | 0.0131 | 0.042575 |
BLCA | -0.555984442 | 1.226941874 | -1.782926316 | 0.005 | 0.026539379 |
COAD | -1.215834239 | 0.055158068 | -1.270992308 | 0.00745 | 0.017056374 |
KIRP | -1.130557797 | -2.322370297 | 1.1918125 | 3.32E-05 | 0.00012616 |
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TissGene-miRNA for CCDC136 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CCDC136 |
TissGeneSNV for CCDC136 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.K549M | LIHC | 2 |
p.E7G | UCEC | 1 |
p.Q943E | LUAD | 1 |
p.W43L | THYM | 1 |
p.Y773C | HNSC | 1 |
p.E344K | SKCM | 1 |
p.Y800C | COAD | 1 |
p.R378Q | STAD | 1 |
p.R965G | LUAD | 1 |
p.R204W | STAD | 1 |
p.P294L | SKCM | 1 |
p.K206N | LUAD | 1 |
p.E105* | LIHC | 1 |
p.L658W | LIHC | 1 |
p.P1134H | UCEC | 1 |
p.E656K | SARC | 1 |
p.S170F | COAD | 1 |
p.S782N | UCEC | 1 |
p.R400W | LUSC | 1 |
p.D918N | BRCA | 1 |
p.H359Y | SKCM | 1 |
p.E449* | LUAD | 1 |
p.S120Y | BLCA | 1 |
p.D791G | LIHC | 1 |
p.N386D | READ | 1 |
p.E1079* | BLCA | 1 |
p.E324K | COAD | 1 |
p.D845H | BLCA | 1 |
p.G749F | LUAD | 1 |
p.N315K | LIHC | 1 |
p.D294N | COAD | 1 |
p.D1093G | UCEC | 1 |
p.K995E | UCEC | 1 |
p.A978G | ESCA | 1 |
p.R154W | STAD | 1 |
p.A242V | LUAD | 1 |
p.Q356* | HNSC | 1 |
p.Q958E | LUAD | 1 |
p.Q273R | UCEC | 1 |
p.E931* | LUAD | 1 |
p.E190X | TGCT | 1 |
p.L409I | UCEC | 1 |
p.V948A | STAD | 1 |
p.T927I | SKCM | 1 |
p.K485M | STAD | 1 |
p.T989I | BRCA | 1 |
p.S1153L | BLCA | 1 |
p.H397Y | SKCM | 1 |
p.L127V | LUAD | 1 |
p.D663Y | UCEC | 1 |
p.D159H | BLCA | 1 |
p.L519F | SKCM | 1 |
p.E584V | LIHC | 1 |
p.R713Q | ESCA | 1 |
p.R49Q | BLCA | 1 |
p.G749S | LUSC | 1 |
p.A694T | PRAD | 1 |
p.N1127S | LUAD | 1 |
p.R354W | OV | 1 |
p.G749V | LUAD | 1 |
p.E851D | OV | 1 |
p.E133* | UCEC | 1 |
p.Q632K | LUAD | 1 |
p.Q382L | LUAD | 1 |
p.P1113S | SKCM | 1 |
p.R392W | SKCM | 1 |
p.S248N | BRCA | 1 |
p.E951D | UCEC | 1 |
p.G695S | SKCM | 1 |
p.L460H | LUAD | 1 |
p.E155X | LIHC | 1 |
p.K1029Q | LIHC | 1 |
p.C420Y | BRCA | 1 |
p.R340W | UCEC | 1 |
p.A465D | LUAD | 1 |
p.Q888L | KIRP | 1 |
p.P840L | SKCM | 1 |
p.P1108L | SKCM | 1 |
p.R343K | SKCM | 1 |
p.R154W | UCEC | 1 |
p.S1007T | LUAD | 1 |
p.A197T | LGG | 1 |
p.C452Y | PRAD | 1 |
p.R759H | STAD | 1 |
p.G749C | LUAD | 1 |
p.S743F | SKCM | 1 |
p.Q933K | LUAD | 1 |
p.T477M | READ | 1 |
p.T322A | LIHC | 1 |
p.K424N | LUAD | 1 |
p.S126F | SKCM | 1 |
p.D918N | READ | 1 |
p.L216I | UCEC | 1 |
p.E140* | UCEC | 1 |
p.M334I | THCA | 1 |
p.R381K | SKCM | 1 |
p.E382K | SKCM | 1 |
p.M51I | LGG | 1 |
p.K816N | THCA | 1 |
p.R354W | SKCM | 1 |
p.K903T | BRCA | 1 |
p.Q655X | LIHC | 1 |
p.S358F | SKCM | 1 |
p.R340Q | STAD | 1 |
p.R648H | PRAD | 1 |
p.M296I | THCA | 1 |
p.E123* | HNSC | 1 |
p.V657A | COAD | 1 |
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TissGeneCNV for CCDC136 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CCDC136 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-GM-A2DD-01A | ZKSCAN1-CCDC136 | 5UTR-CDS | Chr7:99613349 | Chr7:128444704 |
TCGAfusionPortal | PRADA | LUAD | TCGA-95-7944-01A | NUP205-CCDC136 | Out-of-frame | Chr7:135310103 | Chr7:128441240 |
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TissGeneNet for CCDC136 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CCDC136 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CCDC136 |
TissGeneDrug for CCDC136 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CCDC136 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |