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| TissGeneSummary for AGXT2 |
 Gene summary |
| Basic gene information | Gene symbol | AGXT2 |
| Gene name | alanine--glyoxylate aminotransferase 2 | |
| Synonyms | AGT2|DAIBAT | |
| Cytomap | UCSC genome browser: 5p13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_031900.3, | |
| Description | (R)-3-amino-2-methylpropionate--pyruvate transaminasealanine--glyoxylate aminotransferase 2, mitochondrialbeta-ALAAT IIbeta-alanine-pyruvate aminotransferase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 612471 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000113492 | ||
| HPRD : 10638 | ||
| Vega : OTTHUMG00000090788 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_AGXT2 | |
| BioGPS: 64902 | ||
| Pathway | NCI Pathway Interaction Database: AGXT2 | |
| KEGG: AGXT2 | ||
| REACTOME: AGXT2 | ||
| Pathway Commons: AGXT2 | ||
| Context | iHOP: AGXT2 | |
| ligand binding site mutation search in PubMed: AGXT2 | ||
| UCL Cancer Institute: AGXT2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
| Reference showing the relevant tissue of AGXT2 | ||
| Description by TissGene annotations | TissgsKTS CNV gained TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0009436 | glyoxylate catabolic process | 20018850 | GO:0019265 | glycine biosynthetic process, by transamination of glyoxylate | 20018850 | GO:0019481 | L-alanine catabolic process, by transamination | 20018850 | GO:0045429 | positive regulation of nitric oxide biosynthetic process | 20018850 | GO:0009436 | glyoxylate catabolic process | 20018850 | GO:0019265 | glycine biosynthetic process, by transamination of glyoxylate | 20018850 | GO:0019481 | L-alanine catabolic process, by transamination | 20018850 | GO:0045429 | positive regulation of nitric oxide biosynthetic process | 20018850 |
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| TissGeneExp for AGXT2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -1.87019635 | 6.26005565 | -8.130252 | 1.10E-14 | 2.05E-13 |
| LIHC | 5.99915965 | 8.86585765 | -2.866698 | 1.65E-09 | 1.72E-08 |
| KIRP | 4.944352275 | 7.834371025 | -2.89001875 | 0.000197 | 0.00062827 |
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| TissGene-miRNA for AGXT2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for AGXT2 |
| TissGeneSNV for AGXT2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R502C | SKCM | 3 |
| p.R502C | UCEC | 3 |
| p.D340N | SKCM | 3 |
| p.E405K | SKCM | 2 |
| p.E424K | SKCM | 2 |
| p.T79M | PRAD | 2 |
| p.R233C | SKCM | 2 |
| p.G170S | PCPG | 1 |
| p.C258G | KIRP | 1 |
| p.G474D | STAD | 1 |
| p.V410A | SKCM | 1 |
| p.D445N | SKCM | 1 |
| p.M442I | SKCM | 1 |
| p.A80T | PCPG | 1 |
| p.P145A | BLCA | 1 |
| p.P256S | ESCA | 1 |
| p.F165L | UCEC | 1 |
| p.P365T | LUAD | 1 |
| p.L14M | UCEC | 1 |
| p.E321_splice | UCEC | 1 |
| p.F356C | SKCM | 1 |
| p.N187S | STAD | 1 |
| p.Q83* | SKCM | 1 |
| p.R482H | UCEC | 1 |
| p.E426K | SKCM | 1 |
| p.E151K | SKCM | 1 |
| p.P453S | SKCM | 1 |
| p.V114A | READ | 1 |
| p.V77A | LUAD | 1 |
| p.E151D | COAD | 1 |
| p.D423Y | HNSC | 1 |
| p.E441* | UCEC | 1 |
| p.P50L | UCEC | 1 |
| p.R182T | OV | 1 |
| p.E409K | SKCM | 1 |
| p.P218H | THYM | 1 |
| p.E426* | HNSC | 1 |
| p.A183V | UCS | 1 |
| p.E308K | SARC | 1 |
| p.D495H | LUAD | 1 |
| p.T139N | LAML | 1 |
| p.R502C | BLCA | 1 |
| p.A154V | UCEC | 1 |
| p.A173T | LUAD | 1 |
| p.E441Q | LUAD | 1 |
| p.E216K | STAD | 1 |
| p.C464R | OV | 1 |
| p.W5L | THYM | 1 |
| p.E321G | SKCM | 1 |
| p.E321G | UCEC | 1 |
| p.G211E | SKCM | 1 |
| p.R482H | LGG | 1 |
| p.Q459* | SKCM | 1 |
| p.G330D | KIRP | 1 |
| p.F356V | UCEC | 1 |
| p.G335S | LUAD | 1 |
| p.S185A | SKCM | 1 |
| p.P55S | LGG | 1 |
| p.D189H | LUSC | 1 |
| p.R512K | HNSC | 1 |
| p.R432Q | SKCM | 1 |
| p.S331Y | LUAD | 1 |
| p.A183V | STAD | 1 |
| p.R482H | STAD | 1 |
| p.E267K | PAAD | 1 |
| p.E216G | STAD | 1 |
| p.R454C | COAD | 1 |
| p.L74I | UCEC | 1 |
| p.E287D | SKCM | 1 |
| p.P235L | SKCM | 1 |
| p.H339Y | SKCM | 1 |
| p.R65S | LUAD | 1 |
| p.D106Y | BRCA | 1 |
| p.G351E | SKCM | 1 |
| p.P492R | COAD | 1 |
| p.S192Y | UCEC | 1 |
| p.R6* | LUSC | 1 |
| p.S33F | SKCM | 1 |
| p.T506P | STAD | 1 |
| p.N187K | LUAD | 1 |
| p.A513S | LUAD | 1 |
| p.E148Q | LUAD | 1 |
| p.P288L | SKCM | 1 |
| p.I191N | STAD | 1 |
| p.T363N | SKCM | 1 |
| p.D271N | SKCM | 1 |
| p.R432Q | LUAD | 1 |
| p.V457I | LUAD | 1 |
| p.S201T | OV | 1 |
| p.H43Y | SKCM | 1 |
| p.Q83X | SKCM | 1 |
| p.A349V | HNSC | 1 |
| p.K71N | READ | 1 |
| p.G355D | SKCM | 1 |
| p.A80T | STAD | 1 |
| p.E441K | SKCM | 1 |
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| TissGeneCNV for AGXT2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for AGXT2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for AGXT2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| AGXT2, HNF4A, ALDOB, CYP2E1 (tumor) | AGXT2, HNF4A, ALDOB, CYP2E1 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| AGXT2, HNF4A, ALDOB, CYP2E1 (tumor) | AGXT2, HNF4A, ALDOB, CYP2E1 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| AGXT2, HNF4A, ALDOB, CYP2E1 (tumor) | AGXT2, HNF4A, ALDOB, CYP2E1 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| AGXT2, HNF4A, ALDOB, CYP2E1 (tumor) | AGXT2, HNF4A, ALDOB, CYP2E1 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| AGXT2, HNF4A, ALDOB, CYP2E1 (tumor) | AGXT2, HNF4A, ALDOB, CYP2E1 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| AGXT2, HNF4A, ALDOB, CYP2E1 (tumor) | AGXT2, HNF4A, ALDOB, CYP2E1 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| AGXT2, HNF4A, ALDOB, CYP2E1 (tumor) | AGXT2, HNF4A, ALDOB, CYP2E1 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| AGXT2, HNF4A, ALDOB, CYP2E1 (tumor) | AGXT2, HNF4A, ALDOB, CYP2E1 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| AGXT2, HNF4A, ALDOB, CYP2E1 (tumor) | AGXT2, HNF4A, ALDOB, CYP2E1 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| AGXT2, HNF4A, ALDOB, CYP2E1 (tumor) | AGXT2, HNF4A, ALDOB, CYP2E1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| AGXT2, HNF4A, ALDOB, CYP2E1 (tumor) | AGXT2, HNF4A, ALDOB, CYP2E1 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| AGXT2, HNF4A, ALDOB, CYP2E1 (tumor) | AGXT2, HNF4A, ALDOB, CYP2E1 (normal) |
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| TissGeneProg for AGXT2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for AGXT2 |
| TissGeneDrug for AGXT2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00160 | L-Alanine | Small molecule | Approved|Nutraceutical |
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| TissGeneDisease for AGXT2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0007222 | Cardiovascular Diseases | 2 | BeFree |
| umls:C0020538 | Hypertensive disease | 2 | BeFree |
| umls:C0003850 | Arteriosclerosis | 1 | BeFree |
| umls:C0004153 | Atherosclerosis | 1 | BeFree |
| umls:C0010054 | Coronary Arteriosclerosis | 1 | BeFree |
| umls:C0010068 | Coronary heart disease | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |
| umls:C0021775 | Intermittent Claudication | 1 | BeFree |
| umls:C0025521 | Inborn Errors of Metabolism | 1 | CTD_human |
| umls:C0038454 | Cerebrovascular accident | 1 | BeFree |
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