 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for ACD |
 Gene summary |
| Basic gene information | Gene symbol | ACD |
| Gene name | adrenocortical dysplasia homolog (mouse) | |
| Synonyms | PIP1|PTOP|TINT1|TPP1 | |
| Cytomap | UCSC genome browser: 16q22.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001082486.1, NM_001082487.1,NM_022914.2, | |
| Description | POT1 and TIN2 organizing proteinPOT1 and TIN2-interacting proteinTIN2 interacting protein 1adrenocortical dysplasia protein homolog | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 609377 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000102977 | ||
| HPRD : 12417 | ||
| Vega : OTTHUMG00000137547 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ACD | |
| BioGPS: 65057 | ||
| Pathway | NCI Pathway Interaction Database: ACD | |
| KEGG: ACD | ||
| REACTOME: ACD | ||
| Pathway Commons: ACD | ||
| Context | iHOP: ACD | |
| ligand binding site mutation search in PubMed: ACD | ||
| UCL Cancer Institute: ACD | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | StomachTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | STADTGCT | |
| Reference showing the relevant tissue of ACD | ||
| Description by TissGene annotations | Risk TissGene in RFS TissgsLTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0000723 | telomere maintenance | 15181449 | GO:0051973 | positive regulation of telomerase activity | 17237768 | GO:0060381 | positive regulation of single-stranded telomeric DNA binding | 17237767 | GO:0000723 | telomere maintenance | 15181449 | GO:0051973 | positive regulation of telomerase activity | 17237768 | GO:0060381 | positive regulation of single-stranded telomeric DNA binding | 17237767 |
| Top |
| TissGeneExp for ACD |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | 0.95365318 | -0.05869682 | 1.01235 | 5.55E-17 | 6.08E-15 |
| Top |
| TissGene-miRNA for ACD |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for ACD |
| TissGeneSNV for ACD |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.L51F | SKCM | 3 |
| p.P63L | SKCM | 2 |
| p.L62F | SKCM | 2 |
| p.P61S | SKCM | 1 |
| p.G477E | BLCA | 1 |
| p.H289Y | CESC | 1 |
| p.G44S | SKCM | 1 |
| p.P56L | SKCM | 1 |
| p.P429L | SKCM | 1 |
| p.R490M | HNSC | 1 |
| p.P281L | SKCM | 1 |
| p.P63S | SKCM | 1 |
| p.P352T | SKCM | 1 |
| p.Q268R | STAD | 1 |
| p.R492H | HNSC | 1 |
| p.S252F | ESCA | 1 |
| p.E240X | ESCA | 1 |
| p.P112L | SKCM | 1 |
| p.S413F | SKCM | 1 |
| p.W98* | LUSC | 1 |
| p.W69* | SKCM | 1 |
| p.R469W | COAD | 1 |
| p.L52I | UCEC | 1 |
| p.P411H | LGG | 1 |
| p.G44C | LUAD | 1 |
| p.P432L | SKCM | 1 |
| p.P286A | UVM | 1 |
| p.A405V | KIRC | 1 |
| p.L62F | HNSC | 1 |
| p.A408D | ESCA | 1 |
| p.H292R | THCA | 1 |
| p.Q6* | BLCA | 1 |
| p.A68T | SKCM | 1 |
| p.P470S | STAD | 1 |
| p.P470L | COAD | 1 |
| p.R34* | LUAD | 1 |
| p.P77A | BRCA | 1 |
| p.G369S | STAD | 1 |
| p.E371K | BLCA | 1 |
| p.W69X | SKCM | 1 |
| p.E314Q | BLCA | 1 |
| p.G494S | SARC | 1 |
| p.G480E | BLCA | 1 |
| p.A250T | BLCA | 1 |
| p.R493M | HNSC | 1 |
| p.N74S | STAD | 1 |
| p.E166* | BLCA | 1 |
| p.S351C | BLCA | 1 |
| p.G366C | LUAD | 1 |
| p.S244L | SKCM | 1 |
| p.G538W | UCEC | 1 |
| p.S255F | ESCA | 1 |
| p.V191I | UCEC | 1 |
| p.L62I | HNSC | 1 |
| p.H289R | THCA | 1 |
| p.W488C | STAD | 1 |
| p.A247T | BLCA | 1 |
| p.A408V | KIRC | 1 |
| p.G86V | STAD | 1 |
| p.P384S | UCEC | 1 |
| p.R466W | LGG | 1 |
| p.P504L | SKCM | 1 |
| p.P289A | UVM | 1 |
| p.E333K | CESC | 1 |
| p.C406Y | COAD | 1 |
| p.P359T | BLCA | 1 |
| p.P356T | BLCA | 1 |
| Top |
| TissGeneCNV for ACD |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for ACD |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Top |
| TissGeneNet for ACD |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| ACD, CUL5, HSP90AB1, LDHA, ACTB, ENO2, NUDC, PFKP, IPO5, TBCD, TOMM34, LLGL1, AFAP1L2, TBC1D10A, EIF3G, TAGLN, RECQL4, NCDN, APOBEC3G, SBDS, ANXA8L2 (tumor) | ACD, CUL5, TERF2, USP7, GAPDH, TUBB2A, STUB1, ZNF790, NUDC, TERF2IP, DBN1, TBCD, TOMM34, EIF4B, TBC1D10A, DBNL, EIF3G, RECQL4, ANKMY2, PGM2, PDLIM2 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| ACD, HNF4A, ENO2, TUBB2A, NUDC, TERF2IP, DBN1, IPO5, LASP1, RBKS, TRIM15, LLGL1, ADPRH, TBC1D10A, BAG3, ZFP36L1, EIF3G, TAGLN, NCDN, FAM131B, ANXA8L2 (tumor) | ACD, TINF2, STIP1, S100A9, TERF2, HSP90AB1, USP7, STUB1, NUDC, TERF2IP, TBCD, TOMM34, EIF4B, RGS3, CKB, TBC1D10A, NUDCD2, ZFP36L1, EIF3G, RECQL4, TRIM16 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| ACD, CUL5, USP7, LDHA, STUB1, ZNF790, NUDC, TERF2IP, DBN1, IPO5, TBCD, TOMM34, RGS3, BAG3, EIF3G, TAGLN, PGM2, SULT1C2, TRIM16, PDLIM2, SBDS (tumor) | ACD, CUL5, STIP1, S100A9, TERF2, IVL, USP7, GAPDH, ENO2, STUB1, NUDC, DBN1, TBCD, TOMM34, XRCC6, NUDCD2, ZFP36L1, EIF3G, RECQL4, PGM2, TRIM16 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| ACD, CUL5, POT1, YWHAE, GAPDH, ENO2, NUDC, LASP1, RBKS, AIPL1, LLGL1, DCX, CKB, BAG3, EIF3G, TAGLN, RECQL4, ANKMY2, SULT1C2, APOBEC3G, SBDS (tumor) | ACD, CUL5, POT1, GAPDH, STUB1, ZNF790, TERF1, NUDC, DBN1, IPO5, TOMM34, TRIM15, AFAP1L2, DBNL, EIF3G, RECQL4, ANKMY2, PGM2, FKBP6, PAGE2, PDLIM2 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| ACD, TINF2, CUL5, POT1, USP7, ACTB, ENO2, TUBB2A, STUB1, ZNF790, NUDC, DBN1, PFKP, IPO5, LASP1, LLGL1, DBNL, EIF3G, RECQL4, NCDN, APOBEC3G (tumor) | ACD, CUL5, POT1, GAPDH, ACTB, ENO2, STUB1, TERF1, NUDC, IPO5, TBCD, RGS3, LLGL1, TBC1D10A, DBNL, EIF3G, RECQL4, ANKMY2, PGM2, NCDN, PDLIM2 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| ACD, CUL5, HNF4A, ENO2, NUDC, TERF2IP, DBN1, PFKP, IPO5, RBKS, EIF4B, LLGL1, AFAP1L2, ADPRH, PEX5, DBNL, EIF3G, RECQL4, NCDN, FAM131B, ANXA8L2 (tumor) | ACD, TINF2, CUL5, YWHAE, GAPDH, ACTB, ENO2, STUB1, TERF1, NUDC, TERF2IP, IPO5, TBCD, EIF4B, RGS3, AFAP1L2, DBNL, EIF3G, RECQL4, PGM2, FKBP6 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| ACD, CUL5, HNF4A, USP7, ENO2, STUB1, TERF1, NUDC, DBN1, TBCD, XRCC6, CKB, TBC1D10A, NUDCD2, DBNL, EIF3G, TAGLN, RECQL4, ANKMY2, TRIM16, PDLIM2 (tumor) | ACD, CUL5, STIP1, HNF4A, S100A9, GAPDH, ACTB, ENO2, STUB1, NUDC, TBCD, TOMM34, XRCC6, ZFP36L1, DBNL, EIF3G, RECQL4, NCDN, TRIM16, PAGE2, SBDS (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| ACD, CUL5, HNF4A, LDHA, TUBB2A, STUB1, NUDC, DBN1, LASP1, AIPL1, RGS3, LLGL1, CKB, AFAP1L2, TBC1D10A, TAGLN, RECQL4, NCDN, FAM131B, PDLIM2, ANXA8L2 (tumor) | ACD, CUL5, TERF2, GAPDH, ACTB, ENO2, TUBB2A, STUB1, NUDC, TERF2IP, DBN1, IPO5, TBCD, TOMM34, EIF4B, TRIM15, LLGL1, DBNL, EIF3G, RECQL4, NCDN (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| ACD, CUL5, POT1, IVL, YWHAE, LDHA, ENO2, STUB1, NUDC, DBN1, IPO5, TBCD, LASP1, XRCC6, LLGL1, TBC1D10A, DBNL, EIF3G, RECQL4, PGM2, PDLIM2 (tumor) | ACD, CUL5, S100A9, POT1, TERF2, HSP90AB1, ENO2, TUBB2A, STUB1, NUDC, TERF2IP, DBN1, TBCD, TOMM34, LLGL1, PEX5, ZFP36L1, EIF3G, RECQL4, PGM2, SULT1C2 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| ACD, CUL5, POT1, GAPDH, LDHA, ACTB, ENO2, STUB1, NUDC, TERF2IP, DBN1, PFKP, CKB, ZFP36L1, DBNL, EIF3G, TAGLN, PGM2, NCDN, FAM131B, PDLIM2 (tumor) | ACD, CUL5, USP7, GAPDH, ACTB, ENO2, STUB1, ZNF790, TERF1, NUDC, TERF2IP, TBCD, TOMM34, XRCC6, CKB, TBC1D10A, DBNL, EIF3G, TAGLN, PGM2, PDLIM2 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| ACD, TERF2, IVL, ENO2, STUB1, TERF1, NUDC, TERF2IP, DBN1, PFKP, RGS3, CKB, ADPRH, EIF3G, TAGLN, ANKMY2, NCDN, TRIM16, PDLIM2, LRRC25, ANXA8L2 (tumor) | ACD, CUL5, STIP1, TERF2, USP7, YWHAE, GAPDH, LDHA, ACTB, ENO2, STUB1, NUDC, TERF2IP, LASP1, TOMM34, PEX5, DBNL, EIF3G, RECQL4, PGM2, SULT1C2 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| ACD, CUL5, POT1, GAPDH, ACTB, TUBB2A, STUB1, ZNF790, NUDC, IPO5, TBCD, AIPL1, XRCC6, AFAP1L2, TBC1D10A, DBNL, EIF3G, RECQL4, ANKMY2, APOBEC3G, PDLIM2 (tumor) | ACD, CUL5, POT1, USP7, STUB1, TERF1, NUDC, IPO5, TBCD, TOMM34, TBC1D10A, DBNL, EIF3G, TAGLN, RECQL4, ANKMY2, PGM2, TRIM16, APOBEC3G, PDLIM2, SBDS (normal) |
 |  |
| Top |
| TissGeneProg for ACD |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for ACD |
| TissGeneDrug for ACD |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for ACD |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0027877 | Neuronal Ceroid-Lipofuscinoses | 5 | BeFree |
| umls:C0022340 | Late-Infantile Neuronal Ceroid Lipfuscinosis | 4 | BeFree |
| umls:C0017605 | Angle Closure Glaucoma | 2 | BeFree |
| umls:C0019693 | HIV Infections | 2 | BeFree |
| umls:C0000768 | Congenital Abnormality | 1 | BeFree |
| umls:C0002874 | Aplastic Anemia | 1 | BeFree |
| umls:C0003081 | Anisometropia | 1 | BeFree |
| umls:C0005956 | Bone Marrow Diseases | 1 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 1 | GAD |
| umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 1 | GAD |
| umls:C0007820 | Cerebrovascular Disorders | 1 | GAD |
| umls:C0008626 | Congenital chromosomal disease | 1 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |
| umls:C0023434 | Chronic Lymphocytic Leukemia | 1 | BeFree |
| umls:C0024115 | Lung diseases | 1 | BeFree |
| umls:C0025202 | melanoma | 1 | BeFree |
| umls:C0030312 | Pancytopenia | 1 | BeFree |
| umls:C0221357 | Brachydactyly | 1 | BeFree |
| umls:C0265223 | Cohen syndrome | 1 | BeFree |
| umls:C0265965 | Dyskeratosis Congenita | 1 | BeFree |
| umls:C0334054 | cystic disease | 1 | BeFree |
| umls:C0752125 | Spinocerebellar Ataxia Type 7 | 1 | BeFree |
| umls:C0948008 | Ischemic stroke | 1 | BeFree |
| umls:C1292769 | Precursor B-cell lymphoblastic leukemia | 1 | BeFree |
| umls:C1512419 | Hereditary Melanoma | 1 | BeFree |
| umls:C1846142 | HOYERAAL-HREIDARSSON SYNDROME | 1 | BeFree,ORPHANET |
| umls:C1859974 | GLUCOCORTICOID DEFICIENCY 1 | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C3272363 | Ischemic Cerebrovascular Accident | 1 | BeFree |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |