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| TissGeneSummary for SLC1A2 |
 Gene summary |
| Basic gene information | Gene symbol | SLC1A2 |
| Gene name | solute carrier family 1 (glial high affinity glutamate transporter), member 2 | |
| Synonyms | EAAT2|GLT-1 | |
| Cytomap | UCSC genome browser: 11p13-p12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001195728.2, NM_001252652.1,NM_004171.3, | |
| Description | excitatory amino acid transporter 2excitotoxic amino acid transporter 2glutamate/aspartate transporter IIsodium-dependent glutamate/aspartate transporter 2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 600300 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000110436 | ||
| HPRD : 02625 | ||
| Vega : OTTHUMG00000044391 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SLC1A2 | |
| BioGPS: 6506 | ||
| Pathway | NCI Pathway Interaction Database: SLC1A2 | |
| KEGG: SLC1A2 | ||
| REACTOME: SLC1A2 | ||
| Pathway Commons: SLC1A2 | ||
| Context | iHOP: SLC1A2 | |
| ligand binding site mutation search in PubMed: SLC1A2 | ||
| UCL Cancer Institute: SLC1A2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of SLC1A2 | ||
| Description by TissGene annotations | Have significant anti-correlated miRNA | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0051938 | L-glutamate import | 7521911 | GO:0070779 | D-aspartate import | 7521911 | GO:0089711 | L-glutamate transmembrane transport | 7521911 | GO:0051938 | L-glutamate import | 7521911 | GO:0070779 | D-aspartate import | 7521911 | GO:0089711 | L-glutamate transmembrane transport | 7521911 |
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| TissGeneExp for SLC1A2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | -1.194768611 | 0.47228433 | -1.667052941 | 1.60E-08 | 4.92E-08 |
| KIRP | -3.64693344 | -1.71837094 | -1.9285625 | 4.81E-09 | 3.91E-08 |
| LUAD | -0.641288828 | 0.919324965 | -1.560613793 | 6.01E-11 | 3.68E-10 |
| THCA | -2.08185791 | -0.570852825 | -1.511005085 | 6.78E-08 | 3.03E-07 |
| ESCA | -0.688382872 | 2.811280765 | -3.499663636 | 0.00192 | 0.02235644 |
| HNSC | -2.368234457 | -1.23490655 | -1.133327907 | 0.00197 | 0.006105372 |
| COAD | -3.104426228 | -1.990245459 | -1.114180769 | 0.000193 | 0.000654587 |
| LIHC | 3.41762731 | 5.44610531 | -2.028478 | 5.73E-05 | 0.000210353 |
| KICH | 0.73975531 | -1.71221269 | 2.451968 | 5.43E-05 | 0.000149971 |
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| TissGene-miRNA for SLC1A2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-miR-17-5p | MIMAT0000070 | 0.032 | -0.29 | 56 |
| LUAD | hsa-miR-27a-3p | MIMAT0000084 | 0.017 | -0.31 | 60 |
| LUAD | hsa-miR-106a-5p | MIMAT0000103 | 0.018 | -0.31 | 60 |
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| TissGeneMut for SLC1A2 |
| TissGeneSNV for SLC1A2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R476K | SKCM | 2 |
| p.R17Q | SKCM | 2 |
| p.I546L | LUSC | 1 |
| p.S560L | BLCA | 1 |
| p.V389I | COAD | 1 |
| p.D382Y | BLCA | 1 |
| p.P289S | LGG | 1 |
| p.R478K | SKCM | 1 |
| p.R173X | READ | 1 |
| p.K43T | UCEC | 1 |
| p.G82W | SKCM | 1 |
| p.R115C | STAD | 1 |
| p.E549* | UCEC | 1 |
| p.V418L | LUAD | 1 |
| p.M398I | LUAD | 1 |
| p.D170N | SKCM | 1 |
| p.S164G | THYM | 1 |
| p.L175I | READ | 1 |
| p.R17* | LGG | 1 |
| p.E568K | UCEC | 1 |
| p.R17* | STAD | 1 |
| p.E376Q | LIHC | 1 |
| p.P81T | UCEC | 1 |
| p.T50M | PAAD | 1 |
| p.G423R | SKCM | 1 |
| p.R17* | UCEC | 1 |
| p.T361I | SKCM | 1 |
| p.G458D | LGG | 1 |
| p.M88V | STAD | 1 |
| p.R373C | LUSC | 1 |
| p.A255T | UCEC | 1 |
| p.V51M | SKCM | 1 |
| p.N159S | LUAD | 1 |
| p.E376Q | CESC | 1 |
| p.I98N | CESC | 1 |
| p.L101F | SKCM | 1 |
| p.A354V | PRAD | 1 |
| p.G298A | ESCA | 1 |
| p.R384H | ESCA | 1 |
| p.A439V | STAD | 1 |
| p.A79G | LGG | 1 |
| p.M86I | SKCM | 1 |
| p.T218I | UCEC | 1 |
| p.E5K | SKCM | 1 |
| p.P201L | BRCA | 1 |
| p.A394V | HNSC | 1 |
| p.G260E | HNSC | 1 |
| p.E560* | BLCA | 1 |
| p.E512A | MESO | 1 |
| p.L359V | LUAD | 1 |
| p.V309A | SKCM | 1 |
| p.L273W | LUAD | 1 |
| p.S346F | LUSC | 1 |
| p.R17X | STAD | 1 |
| p.D548N | MESO | 1 |
| p.I230M | OV | 1 |
| p.S25* | BLCA | 1 |
| p.A409T | HNSC | 1 |
| p.M516T | UCEC | 1 |
| p.I563V | BLCA | 1 |
| p.M450I | COAD | 1 |
| p.T4M | TGCT | 1 |
| p.F270L | CESC | 1 |
| p.A406V | UCS | 1 |
| p.V339G | LUSC | 1 |
| p.T386A | UCEC | 1 |
| p.D382H | HNSC | 1 |
| p.R384C | COAD | 1 |
| p.M121V | STAD | 1 |
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| TissGeneCNV for SLC1A2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SLC1A2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | DA269573 | SLC50A1-SLC1A2 | chr1:155108396 | chr11:35279728 | |
| Chimerdb3.0 | ChiTaRs | NA | BF945510 | SLC1A2-SLC1A2 | chr11:35274000 | chr11:35273514 | |
| Chimerdb3.0 | ChiTaRs | NA | BF922824 | SLC1A2-AP4M1 | chr11:35274643 | chr7:99699510 | |
| Chimerdb3.0 | ChiTaRs | NA | BF945504 | SLC1A2-SLC1A2 | chr11:35273755 | chr11:35273924 | |
| Chimerdb3.0 | ChiTaRs | NA | AW902064 | RNU5F-1-SLC1A2 | chr1:220253908 | chr11:35272802 | |
| Chimerdb3.0 | ChiTaRs | NA | AI280085 | FERMT2-SLC1A2 | chr14:53325166 | chr11:35413659 |
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| TissGeneNet for SLC1A2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SLC1A2, GRB2, PML, MAPT (tumor) | SLC1A2, GRB2, PML, MAPT (normal) |
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| COAD (tumor) | COAD (normal) |
| SLC1A2, GRB2, PML, MAPT (tumor) | SLC1A2, GRB2, PML, MAPT (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SLC1A2, GRB2, PML, MAPT (tumor) | SLC1A2, GRB2, PML, MAPT (normal) |
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| KICH (tumor) | KICH (normal) |
| SLC1A2, GRB2, PML, MAPT (tumor) | SLC1A2, GRB2, PML, MAPT (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SLC1A2, GRB2, PML, MAPT (tumor) | SLC1A2, GRB2, PML, MAPT (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SLC1A2, GRB2, PML, MAPT (tumor) | SLC1A2, GRB2, PML, MAPT (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SLC1A2, GRB2, PML, MAPT (tumor) | SLC1A2, GRB2, PML, MAPT (normal) |
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| LUAD (tumor) | LUAD (normal) |
| SLC1A2, GRB2, PML, MAPT (tumor) | SLC1A2, GRB2, PML, MAPT (normal) |
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| LUSC (tumor) | LUSC (normal) |
| SLC1A2, GRB2, PML, MAPT (tumor) | SLC1A2, GRB2, PML, MAPT (normal) |
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| PRAD (tumor) | PRAD (normal) |
| SLC1A2, GRB2, PML, MAPT (tumor) | SLC1A2, GRB2, PML, MAPT (normal) |
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| STAD (tumor) | STAD (normal) |
| SLC1A2, GRB2, PML, MAPT (tumor) | SLC1A2, GRB2, PML, MAPT (normal) |
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| THCA (tumor) | THCA (normal) |
| SLC1A2, GRB2, PML, MAPT (tumor) | SLC1A2, GRB2, PML, MAPT (normal) |
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| TissGeneProg for SLC1A2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SLC1A2 |
| TissGeneDrug for SLC1A2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SLC1A2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 26 | BeFree,CTD_human,LHGDN |
| umls:C0036341 | Schizophrenia | 12 | BeFree,GAD |
| umls:C0270736 | Essential Tremor | 6 | BeFree,GWASCAT |
| umls:C0002395 | Alzheimer's Disease | 4 | BeFree |
| umls:C0005586 | Bipolar Disorder | 3 | BeFree |
| umls:C0014544 | Epilepsy | 3 | BeFree,CTD_human |
| umls:C0014556 | Epilepsy, Temporal Lobe | 3 | BeFree |
| umls:C0027765 | nervous system disorder | 3 | BeFree,LHGDN |
| umls:C0041696 | Unipolar Depression | 3 | BeFree |
| umls:C0085084 | Motor Neuron Disease | 3 | BeFree |
| umls:C0162557 | Liver Failure, Acute | 3 | BeFree |
| umls:C0524851 | Neurodegenerative Disorders | 3 | BeFree |
| umls:C1269683 | Major Depressive Disorder | 3 | BeFree |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 2 | BeFree,GAD |
| umls:C0004114 | Astrocytoma | 2 | BeFree |
| umls:C0017638 | Glioma | 2 | BeFree |
| umls:C0026769 | Multiple Sclerosis | 2 | BeFree,LHGDN |
| umls:C0027873 | Neuromyelitis Optica | 2 | BeFree |
| umls:C0036572 | Seizures | 2 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 2 | GAD |
| umls:C0338656 | Impaired cognition | 2 | BeFree |
| umls:C1862941 | Amyotrophic Lateral Sclerosis, Sporadic | 2 | BeFree |
| umls:C0003469 | Anxiety Disorders | 1 | BeFree |
| umls:C0004352 | Autistic Disorder | 1 | GAD |
| umls:C0004936 | Mental disorders | 1 | GAD |
| umls:C0006012 | Borderline Personality Disorder | 1 | BeFree |
| umls:C0006287 | Bronchopulmonary Dysplasia | 1 | BeFree |
| umls:C0007785 | Cerebral Infarction | 1 | BeFree |
| umls:C0018681 | Headache | 1 | BeFree |
| umls:C0019151 | Hepatic Encephalopathy | 1 | BeFree |
| umls:C0019693 | HIV Infections | 1 | BeFree |
| umls:C0019829 | Hodgkin Disease | 1 | BeFree |
| umls:C0020179 | Huntington Disease | 1 | BeFree |
| umls:C0023487 | Acute Promyelocytic Leukemia | 1 | BeFree |
| umls:C0023529 | Leukomalacia, Periventricular | 1 | BeFree,LHGDN |
| umls:C0023891 | Liver Cirrhosis, Alcoholic | 1 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0025149 | Medulloblastoma | 1 | BeFree |
| umls:C0026552 | Morphine Dependence | 1 | BeFree |
| umls:C0027746 | Nerve Degeneration | 1 | CTD_human |
| umls:C0027796 | Neuralgia | 1 | BeFree |
| umls:C0030567 | Parkinson Disease | 1 | BeFree |
| umls:C0034152 | Henoch-Schoenlein Purpura | 1 | BeFree |
| umls:C0035258 | Restless Legs Syndrome | 1 | BeFree |
| umls:C0037773 | Spastic Paraplegia, Hereditary | 1 | BeFree |
| umls:C0038356 | Stomach Neoplasms | 1 | CTD_human |
| umls:C0038580 | Substance Dependence | 1 | BeFree |
| umls:C0042900 | Vitiligo | 1 | GWASCAT |
| umls:C0043094 | Weight Gain | 1 | GAD |
| umls:C0085584 | Encephalopathies | 1 | BeFree |
| umls:C0085762 | Alcohol abuse | 1 | GAD |
| umls:C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
| umls:C0265113 | Progressing stroke | 1 | BeFree |
| umls:C0270726 | Alexander Disease | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C0751213 | Tactile Allodynia | 1 | BeFree |
| umls:C0751967 | Multiple Sclerosis, Relapsing-Remitting | 1 | GAD |
| umls:C0917798 | Cerebral Ischemia | 1 | BeFree |
| umls:C0948008 | Ischemic stroke | 1 | BeFree |
| umls:C1510472 | Drug Dependence | 1 | BeFree |
| umls:C1527311 | Brain Edema | 1 | BeFree |
| umls:C1842937 | AURAL ATRESIA, CONGENITAL | 1 | BeFree |
| umls:C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | BeFree |
| umls:C2745900 | Promyelocytic leukemia | 1 | BeFree |
| umls:C2911647 | Weight Gain Adverse Event | 1 | GAD |
| umls:C2936719 | Mechanical Allodynia | 1 | BeFree |
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