TissGeneSummary for SLC8A2 |
Gene summary |
Basic gene information | Gene symbol | SLC8A2 |
Gene name | solute carrier family 8 (sodium/calcium exchanger), member 2 | |
Synonyms | NCX2 | |
Cytomap | UCSC genome browser: 19q13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_015063.2, | |
Description | Na(+)/Ca(2+)-exchange protein 2Na+/Ca2+-exchanging protein Nac2sodium-calcium exchanger 2sodium/calcium exchanger 2solute carrier family 8 (sodium-calcium exchanger), member 2solute carrier family 8 member 2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 601901 | |
HGNC : HGNC | ||
Ensembl : ENSG00000118160 | ||
HPRD : 15990 | ||
Vega : OTTHUMG00000183529 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLC8A2 | |
BioGPS: 6543 | ||
Pathway | NCI Pathway Interaction Database: SLC8A2 | |
KEGG: SLC8A2 | ||
REACTOME: SLC8A2 | ||
Pathway Commons: SLC8A2 | ||
Context | iHOP: SLC8A2 | |
ligand binding site mutation search in PubMed: SLC8A2 | ||
UCL Cancer Institute: SLC8A2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BrainPancreas | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGGPAAD | |
Reference showing the relevant tissue of SLC8A2 | ||
Description by TissGene annotations | Protective TissGene in RFS Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SLC8A2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
PRAD | 0.813694159 | 2.285796082 | -1.472101923 | 1.74E-08 | 2.04E-07 |
COAD | -0.28436738 | 2.027174928 | -2.311542308 | 0.000763 | 0.002259099 |
STAD | -0.106134206 | 2.762906419 | -2.869040625 | 5.93E-05 | 0.000499497 |
KIRP | -0.527196706 | -2.144190456 | 1.61699375 | 3.33E-05 | 0.000126326 |
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TissGene-miRNA for SLC8A2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
ACC | hsa-miR-133b | MIMAT0000770 | 0.0098 | -0.29 | 78 |
ACC | hsa-miR-133b | MIMAT0000770 | 0.0098 | -0.29 | 78 |
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TissGeneMut for SLC8A2 |
TissGeneSNV for SLC8A2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E188K | STAD | 1 |
p.G887S | STAD | 1 |
p.M648I | LUAD | 1 |
p.G564S | STAD | 1 |
p.S87C | BLCA | 1 |
p.D705N | HNSC | 1 |
p.V777I | HNSC | 1 |
p.L511Q | LIHC | 1 |
p.G222C | LUSC | 1 |
p.R501W | STAD | 1 |
p.T730M | COAD | 1 |
p.A95V | READ | 1 |
p.R122C | SKCM | 1 |
p.T636R | SARC | 1 |
p.W244L | HNSC | 1 |
p.T132M | READ | 1 |
p.A385V | COAD | 1 |
p.S535N | ACC | 1 |
p.A637V | HNSC | 1 |
p.K594N | BLCA | 1 |
p.S139F | SKCM | 1 |
p.P651S | PRAD | 1 |
p.Y444H | LUAD | 1 |
p.A95T | UCEC | 1 |
p.E693* | LUAD | 1 |
p.L653I | COAD | 1 |
p.E422V | STAD | 1 |
p.E106D | LUAD | 1 |
p.T417M | COAD | 1 |
p.G66D | SKCM | 1 |
p.E448Q | HNSC | 1 |
p.G45E | KIRP | 1 |
p.E706D | STAD | 1 |
p.V121A | UCEC | 1 |
p.E407K | SKCM | 1 |
p.G449C | HNSC | 1 |
p.M134I | ESCA | 1 |
p.P26L | SKCM | 1 |
p.A78V | SKCM | 1 |
p.E660Q | LUAD | 1 |
p.E710K | ACC | 1 |
p.R249W | COAD | 1 |
p.G748S | LUAD | 1 |
p.S220F | SKCM | 1 |
p.G499D | LIHC | 1 |
p.G114S | STAD | 1 |
p.E664K | SKCM | 1 |
p.E638K | CESC | 1 |
p.A764T | UCEC | 1 |
p.Q225R | PAAD | 1 |
p.V53M | SKCM | 1 |
p.A490V | STAD | 1 |
p.A894T | COAD | 1 |
p.P741S | ESCA | 1 |
p.S87T | BLCA | 1 |
p.E115K | LUSC | 1 |
p.P51Q | STAD | 1 |
p.G620E | SKCM | 1 |
p.P63L | STAD | 1 |
p.P719L | STAD | 1 |
p.K68N | LUAD | 1 |
p.R432C | STAD | 1 |
p.V166M | COAD | 1 |
p.H326Y | ESCA | 1 |
p.A642T | LUAD | 1 |
p.E98K | SKCM | 1 |
p.A90T | BLCA | 1 |
p.L762I | LUSC | 1 |
p.S102L | PAAD | 1 |
p.K193N | SARC | 1 |
p.G163S | UCEC | 1 |
p.T700M | COAD | 1 |
p.D247N | BLCA | 1 |
p.R190C | PAAD | 1 |
p.V73M | LUAD | 1 |
p.E706D | BLCA | 1 |
p.K594N | UCEC | 1 |
p.D61N | MESO | 1 |
p.S102L | SKCM | 1 |
p.V118M | THYM | 1 |
p.G114D | SKCM | 1 |
p.G152R | LUAD | 1 |
p.A69V | BLCA | 1 |
p.S782A | UCEC | 1 |
p.R851H | STAD | 1 |
p.K670E | SKCM | 1 |
p.R92H | BLCA | 1 |
p.R265C | STAD | 1 |
p.D61N | ESCA | 1 |
p.R122H | LGG | 1 |
p.E706D | UCEC | 1 |
p.E664Q | BLCA | 1 |
p.D668N | SKCM | 1 |
p.E188D | KIRC | 1 |
p.E581V | SKCM | 1 |
p.A112V | LGG | 1 |
p.N606K | SKCM | 1 |
p.S203C | BLCA | 1 |
p.R350H | LIHC | 1 |
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TissGeneCNV for SLC8A2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SLC8A2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | DA080126 | SLC8A2-DHX34 | chr19:47975270 | chr19:47885235 |
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TissGeneNet for SLC8A2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SLC8A2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SLC8A2 |
TissGeneDrug for SLC8A2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SLC8A2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007786 | Brain Ischemia | 2 | BeFree,RGD |
umls:C0017638 | Glioma | 1 | BeFree |
umls:C0035126 | Reperfusion Injury | 1 | RGD |
umls:C0038220 | Status Epilepticus | 1 | RGD |