TissGeneSummary for SLC17A1 |
Gene summary |
Basic gene information | Gene symbol | SLC17A1 |
Gene name | solute carrier family 17 (organic anion transporter), member 1 | |
Synonyms | NAPI-1|NPT-1|NPT1 | |
Cytomap | UCSC genome browser: 6p22.2 | |
Type of gene | protein-coding | |
RefGenes | NM_005074.3, | |
Description | Na(+)/PI cotransporter 1na/Pi-4renal Na(+)-dependent phosphate cotransporter 1renal sodium-dependent phosphate transport protein 1renal sodium-phosphate transport protein 1sodium phosphate transportersodium-dependent phosphate transport protein 1so | |
Modification date | 20141211 | |
dbXrefs | MIM : 182308 | |
HGNC : HGNC | ||
Ensembl : ENSG00000124568 | ||
HPRD : 01661 | ||
Vega : OTTHUMG00000016297 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLC17A1 | |
BioGPS: 6568 | ||
Pathway | NCI Pathway Interaction Database: SLC17A1 | |
KEGG: SLC17A1 | ||
REACTOME: SLC17A1 | ||
Pathway Commons: SLC17A1 | ||
Context | iHOP: SLC17A1 | |
ligand binding site mutation search in PubMed: SLC17A1 | ||
UCL Cancer Institute: SLC17A1 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of SLC17A1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SLC17A1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -2.270745475 | 4.826666525 | -7.097412 | 8.38E-11 | 6.55E-10 |
LIHC | 4.874598525 | 6.325120525 | -1.450522 | 0.000116 | 0.000395147 |
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TissGene-miRNA for SLC17A1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SLC17A1 |
TissGeneSNV for SLC17A1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G344E | SKCM | 2 |
p.G206_splice | UCEC | 1 |
p.S322* | LUSC | 1 |
p.V150A | SKCM | 1 |
p.T273M | ESCA | 1 |
p.F275C | COAD | 1 |
p.Q456X | SKCM | 1 |
p.G132R | SKCM | 1 |
p.G301E | SKCM | 1 |
p.G418A | BRCA | 1 |
p.W75* | SKCM | 1 |
p.I204V | UCEC | 1 |
p.G396V | READ | 1 |
p.S86Y | LUAD | 1 |
p.S305F | SKCM | 1 |
p.W135* | STAD | 1 |
p.I412T | COAD | 1 |
p.G344X | PAAD | 1 |
p.L22M | OV | 1 |
p.I255V | HNSC | 1 |
p.R167Q | STAD | 1 |
p.P57L | SKCM | 1 |
p.W75C | DLBC | 1 |
p.Y73C | LUSC | 1 |
p.M44T | SKCM | 1 |
p.R167L | LUSC | 1 |
p.Q244H | LUAD | 1 |
p.S322* | BLCA | 1 |
p.A266D | SARC | 1 |
p.M436I | LUAD | 1 |
p.Y357C | LIHC | 1 |
p.F340L | SKCM | 1 |
p.S122N | SKCM | 1 |
p.R167Q | SKCM | 1 |
p.R140L | LUAD | 1 |
p.I297V | UCEC | 1 |
p.T442A | UCEC | 1 |
p.G99E | SKCM | 1 |
p.I455L | STAD | 1 |
p.R167* | GBM | 1 |
p.K62N | UCEC | 1 |
p.N329Y | KIRC | 1 |
p.S414F | SKCM | 1 |
p.S322L | LIHC | 1 |
p.Q456K | PCPG | 1 |
p.S427F | SKCM | 1 |
p.W216R | LUAD | 1 |
p.V31A | READ | 1 |
p.W135* | SKCM | 1 |
p.P307L | SKCM | 1 |
p.K62N | COAD | 1 |
p.I111T | LUAD | 1 |
p.G209C | LUAD | 1 |
p.V212A | LUAD | 1 |
p.K460Q | SKCM | 1 |
p.L214F | SKCM | 1 |
p.S332R | OV | 1 |
p.Q456* | SKCM | 1 |
p.T285A | LUAD | 1 |
p.R140Q | BLCA | 1 |
p.V218I | LGG | 1 |
p.T152A | SKCM | 1 |
p.W135X | STAD | 1 |
p.A438V | STAD | 1 |
p.E461K | SKCM | 1 |
p.G55D | SKCM | 1 |
p.F202L | STAD | 1 |
p.P53S | SKCM | 1 |
p.V12_splice | LUSC | 1 |
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TissGeneCNV for SLC17A1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SLC17A1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | LUAD | TCGA-49-4487-01A | LRRC16A-SLC17A1 | In-frame | Chr6:25285137 | Chr6:25820143 |
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TissGeneNet for SLC17A1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SLC17A1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SLC17A1 |
TissGeneDrug for SLC17A1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SLC17A1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0018099 | Gout | 2 | GAD |
umls:C0002395 | Alzheimer's Disease | 1 | GAD |
umls:C0003868 | Arthritis, Gouty | 1 | BeFree |
umls:C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
umls:C0036341 | Schizophrenia | 1 | GAD |
umls:C0085096 | Peripheral Vascular Diseases | 1 | GAD |
umls:C0149896 | Primary gout | 1 | BeFree |
umls:C0282201 | Phosphate Diabetes | 1 | BeFree |
umls:C0700634 | Serum uric acid observed | 1 | GAD |
umls:C0733682 | Hypophosphatemic Rickets, X-Linked Dominant | 1 | BeFree |
umls:C3536984 | Vitamin D-Resistant Rickets, X-Linked | 1 | BeFree |
umls:C3540852 | Rickets, X-Linked Hypophosphatemic | 1 | BeFree |