TissGeneSummary for SLC34A1 |
Gene summary |
Basic gene information | Gene symbol | SLC34A1 |
Gene name | solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 | |
Synonyms | FRTS2|NAPI-3|NPHLOP1|NPT2|NPTIIa|SLC11|SLC17A2 | |
Cytomap | UCSC genome browser: 5q35 | |
Type of gene | protein-coding | |
RefGenes | NM_001167579.1, NM_003052.4, | |
Description | Na(+)-dependent phosphate cotransporter 2ANa(+)/Pi cotransporter 2ANa+-phosphate cotransporter type IInaPi-2arenal sodium-dependent phosphate transportersodium-dependent phosphate transport protein 2Asodium-phosphate transport protein 2Asodium/phos | |
Modification date | 20141207 | |
dbXrefs | MIM : 182309 | |
HGNC : HGNC | ||
Ensembl : ENSG00000131183 | ||
HPRD : 08918 | ||
Vega : OTTHUMG00000130857 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLC34A1 | |
BioGPS: 6569 | ||
Pathway | NCI Pathway Interaction Database: SLC34A1 | |
KEGG: SLC34A1 | ||
REACTOME: SLC34A1 | ||
Pathway Commons: SLC34A1 | ||
Context | iHOP: SLC34A1 | |
ligand binding site mutation search in PubMed: SLC34A1 | ||
UCL Cancer Institute: SLC34A1 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of SLC34A1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0006817 | phosphate ion transport | 8327470 | GO:0010288 | response to lead ion | 8898024 | GO:0046686 | response to cadmium ion | 8898024 | GO:0046689 | response to mercury ion | 8898024 | GO:0055062 | phosphate ion homeostasis | 8327470 | GO:0006817 | phosphate ion transport | 8327470 | GO:0010288 | response to lead ion | 8898024 | GO:0046686 | response to cadmium ion | 8898024 | GO:0046689 | response to mercury ion | 8898024 | GO:0055062 | phosphate ion homeostasis | 8327470 |
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TissGeneExp for SLC34A1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 2.790021085 | 7.782137751 | -4.992116667 | 1.66E-12 | 6.94E-12 |
KICH | -0.307378915 | 6.881653085 | -7.189032 | 8.64E-10 | 5.52E-09 |
KIRP | 4.17633671 | 9.458902335 | -5.282565625 | 4.43E-08 | 2.93E-07 |
LIHC | 1.576773085 | 3.411495085 | -1.834722 | 1.85E-08 | 1.54E-07 |
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TissGene-miRNA for SLC34A1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SLC34A1 |
TissGeneSNV for SLC34A1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R507H | HNSC | 2 |
p.R638H | UCEC | 2 |
p.T508M | LGG | 1 |
p.R215Q | COAD | 1 |
p.T508K | LUAD | 1 |
p.A395V | COAD | 1 |
p.A470T | SARC | 1 |
p.S318P | PAAD | 1 |
p.R512C | LUAD | 1 |
p.R215W | THYM | 1 |
p.A253D | GBM | 1 |
p.R25X | ESCA | 1 |
p.G65E | LIHC | 1 |
p.S469N | LGG | 1 |
p.L281P | STAD | 1 |
p.R627S | LUAD | 1 |
p.A455V | SKCM | 1 |
p.T198I | COAD | 1 |
p.V491A | UCEC | 1 |
p.K383R | KIRC | 1 |
p.A636V | UCEC | 1 |
p.P492L | SKCM | 1 |
p.L348M | UCEC | 1 |
p.G543S | LUSC | 1 |
p.T157I | PAAD | 1 |
p.N374T | BRCA | 1 |
p.R581H | LGG | 1 |
p.G43R | SKCM | 1 |
p.R627H | LUAD | 1 |
p.A76V | PAAD | 1 |
p.C62* | SKCM | 1 |
p.F274L | UCEC | 1 |
p.S183F | HNSC | 1 |
p.T61P | UCEC | 1 |
p.L445M | LUAD | 1 |
p.Q574H | CESC | 1 |
p.G484S | SKCM | 1 |
p.S324Y | LUAD | 1 |
p.L460Q | STAD | 1 |
p.R25X | COAD | 1 |
p.M535V | COAD | 1 |
p.W576X | LIHC | 1 |
p.E272D | BLCA | 1 |
p.A515T | UCEC | 1 |
p.F479L | CESC | 1 |
p.I247M | LUAD | 1 |
p.S14F | SKCM | 1 |
p.Q386H | LIHC | 1 |
p.M173I | BLCA | 1 |
p.G53S | SKCM | 1 |
p.P92H | LUAD | 1 |
p.A382V | SKCM | 1 |
p.R249Q | BLCA | 1 |
p.P15L | LUAD | 1 |
p.P566L | PRAD | 1 |
p.P609L | ACC | 1 |
p.P11S | SKCM | 1 |
p.Q36E | LUAD | 1 |
p.L204P | LUAD | 1 |
p.R95H | UCEC | 1 |
p.G357R | SKCM | 1 |
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TissGeneCNV for SLC34A1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SLC34A1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SLC34A1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SLC34A1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SLC34A1 |
TissGeneDrug for SLC34A1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SLC34A1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0020438 | Hypercalciuria | 7 | BeFree,CTD_human,RGD |
umls:C0392525 | Nephrolithiasis | 3 | BeFree |
umls:C0022661 | Kidney Failure, Chronic | 2 | GAD,RGD |
umls:C0027709 | Nephrocalcinosis | 2 | BeFree,LHGDN |
umls:C0085682 | Hypophosphatemia | 2 | CTD_human,RGD |
umls:C0001122 | Acidosis | 1 | RGD |
umls:C0005941 | Bone Diseases, Developmental | 1 | CTD_human |
umls:C0020437 | Hypercalcemia | 1 | CTD_human |
umls:C0020550 | Hyperthyroidism | 1 | RGD |
umls:C0020676 | Hypothyroidism | 1 | RGD |
umls:C0022650 | Kidney Calculi | 1 | BeFree |
umls:C0022658 | Kidney Diseases | 1 | GAD |
umls:C0032827 | Potassium Deficiency | 1 | RGD |
umls:C0035126 | Reperfusion Injury | 1 | RGD |
umls:C0041296 | Tuberculosis | 1 | BeFree |
umls:C0041327 | Tuberculosis, Pulmonary | 1 | BeFree |
umls:C0085413 | Polycystic Kidney, Autosomal Dominant | 1 | RGD |
umls:C0268080 | Hypercalcemia, Idiopathic, of Infancy | 1 | BeFree |
umls:C0403447 | Chronic Kidney Insufficiency | 1 | RGD |
umls:C0543800 | Idiopathic hypercalciuria | 1 | BeFree |
umls:C1561643 | Chronic Kidney Diseases | 1 | GWASCAT |
umls:C2676786 | Nephrolithiasis-Osteoporosis, Hypophosphatemic, 1 | 1 | CLINVAR,CTD_human,UNIPROT |
umls:C3536984 | Vitamin D-Resistant Rickets, X-Linked | 1 | BeFree |
umls:C0015624 | Fanconi Syndrome | 0 | CTD_human |
umls:C1853271 | HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA, HEREDITARY | 0 | MGD |
umls:C3150652 | FANCONI RENOTUBULAR SYNDROME 2 | 0 | CLINVAR |