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| TissGeneSummary for SLC22A2 |
 Gene summary |
| Basic gene information | Gene symbol | SLC22A2 |
| Gene name | solute carrier family 22 (organic cation transporter), member 2 | |
| Synonyms | OCT2 | |
| Cytomap | UCSC genome browser: 6q25.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003058.3, NM_153191.1, | |
| Description | organic cation transporter 2solute carrier family 22 member 2 | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 602608 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000112499 | ||
| HPRD : 04008 | ||
| Vega : OTTHUMG00000015950 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SLC22A2 | |
| BioGPS: 6582 | ||
| Pathway | NCI Pathway Interaction Database: SLC22A2 | |
| KEGG: SLC22A2 | ||
| REACTOME: SLC22A2 | ||
| Pathway Commons: SLC22A2 | ||
| Context | iHOP: SLC22A2 | |
| ligand binding site mutation search in PubMed: SLC22A2 | ||
| UCL Cancer Institute: SLC22A2 | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
| Reference showing the relevant tissue of SLC22A2 | Kidney-specific expression of human organic cation transporter 2 (OCT2/SLC22A2) is regulated by DNA methylation. Aoki M, Terada T, Kajiwara M, Ogasawara K, Ikai I, Ogawa O, Katsura T, Inui K. Am J Physiol Renal Physiol. 2008 Jul;295(1):F165-70. doi: 10.1152/ajprenal.90257.2008. Epub 2008 May 28 (pmid:18508876) go to article | |
| Description by TissGene annotations | High usage of specific isoform TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0015695 | organic cation transport | 16024787 | GO:0015695 | organic cation transport | 16024787 |
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| TissGeneExp for SLC22A2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -0.057253835 | 8.694770165 | -8.752024 | 2.39E-14 | 3.90E-13 |
| STAD | -2.499431335 | -1.135618835 | -1.3638125 | 0.000756 | 0.0042669 |
| KIRP | 6.067112415 | 9.067762415 | -3.00065 | 0.000256 | 0.00080273 |
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| TissGene-miRNA for SLC22A2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SLC22A2 |
| TissGeneSNV for SLC22A2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S64F | THYM | 3 |
| p.S85F | THYM | 2 |
| p.E108K | SKCM | 2 |
| p.S292F | SKCM | 2 |
| p.W181* | SKCM | 1 |
| p.R123W | GBM | 1 |
| p.Y128N | SKCM | 1 |
| p.A63S | TGCT | 1 |
| p.M349I | HNSC | 1 |
| p.D337G | LIHC | 1 |
| p.M367I | ESCA | 1 |
| p.R403C | UCEC | 1 |
| p.Y107N | SKCM | 1 |
| p.G56V | LUAD | 1 |
| p.G79R | SKCM | 1 |
| p.S313Y | SKCM | 1 |
| p.R231Q | ESCA | 1 |
| p.P312R | BLCA | 1 |
| p.R213W | SKCM | 1 |
| p.S214G | LIHC | 1 |
| p.G12R | BLCA | 1 |
| p.E324Q | CESC | 1 |
| p.Y377* | ESCA | 1 |
| p.L159P | HNSC | 1 |
| p.P389T | THYM | 1 |
| p.L396F | BLCA | 1 |
| p.S436L | SKCM | 1 |
| p.T397N | LUAD | 1 |
| p.G163R | ESCA | 1 |
| p.S99N | SKCM | 1 |
| p.R231Q | STAD | 1 |
| p.W96X | SKCM | 1 |
| p.S113F | SKCM | 1 |
| p.R403H | UCEC | 1 |
| p.R288S | COAD | 1 |
| p.S271F | SKCM | 1 |
| p.G477V | LUAD | 1 |
| p.L378Q | ESCA | 1 |
| p.G34R | SKCM | 1 |
| p.R186C | SKCM | 1 |
| p.G328A | OV | 1 |
| p.P496Q | ESCA | 1 |
| p.F161L | LUAD | 1 |
| p.Y377X | ESCA | 1 |
| p.M367I | LUSC | 1 |
| p.A316S | LUSC | 1 |
| p.Q546* | SKCM | 1 |
| p.V83G | HNSC | 1 |
| p.R403H | COAD | 1 |
| p.R487Q | PRAD | 1 |
| p.T53M | LGG | 1 |
| p.R231Q | BRCA | 1 |
| p.W75* | SKCM | 1 |
| p.E527K | BLCA | 1 |
| p.P97S | SARC | 1 |
| p.Y71* | LUAD | 1 |
| p.M445I | SKCM | 1 |
| p.F140L | LUAD | 1 |
| p.V38M | PAAD | 1 |
| p.E37K | SKCM | 1 |
| p.E516K | SKCM | 1 |
| p.V104G | HNSC | 1 |
| p.Q319P | HNSC | 1 |
| p.Q19X | SKCM | 1 |
| p.E528K | SKCM | 1 |
| p.P496L | CESC | 1 |
| p.D102N | SKCM | 1 |
| p.G44S | SKCM | 1 |
| p.A278T | SARC | 1 |
| p.S313P | KIRC | 1 |
| p.E227K | LUSC | 1 |
| p.S78N | SKCM | 1 |
| p.Q19* | SKCM | 1 |
| p.I433S | BLCA | 1 |
| p.G58R | SKCM | 1 |
| p.G43C | LUAD | 1 |
| p.T397I | SKCM | 1 |
| p.M328I | HNSC | 1 |
| p.G23S | SKCM | 1 |
| p.D427G | LIHC | 1 |
| p.V467I | GBM | 1 |
| p.N311S | SKCM | 1 |
| p.S133L | STAD | 1 |
| p.N332S | SKCM | 1 |
| p.E530A | HNSC | 1 |
| p.H28N | LUAD | 1 |
| p.M393I | SKCM | 1 |
| p.W202X | SKCM | 1 |
| p.S164Y | ESCA | 1 |
| p.I435T | ACC | 1 |
| p.L371F | SKCM | 1 |
| p.Q322E | BLCA | 1 |
| p.I205M | UCEC | 1 |
| p.S292P | KIRC | 1 |
| p.P496L | UCEC | 1 |
| p.N157S | LIHC | 1 |
| p.Y377S | BLCA | 1 |
| p.R52Q | STAD | 1 |
| p.D81N | SKCM | 1 |
| p.Y332C | LUAD | 1 |
| p.G55R | SKCM | 1 |
| p.M542I | SKCM | 1 |
| p.A81V | UCEC | 1 |
| p.H468Y | SKCM | 1 |
| p.S292Y | SKCM | 1 |
| p.Q153R | UCEC | 1 |
| p.A108D | STAD | 1 |
| p.V17M | PAAD | 1 |
| p.C451F | GBM | 1 |
| p.G466A | LUSC | 1 |
| p.D374G | COAD | 1 |
| p.G439E | SKCM | 1 |
| p.E305K | SKCM | 1 |
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| TissGeneCNV for SLC22A2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SLC22A2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for SLC22A2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SLC22A2, SUMO2, GTF2B, POU2AF1, LSM4, HYAL3, EXT2, CST9L, ETV5 (tumor) | SLC22A2, SUMO2, GTF2B, POU2AF1, LSM4, HYAL3, EXT2, CST9L, ETV5 (normal) |
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| COAD (tumor) | COAD (normal) |
| SLC22A2, SUMO2, GTF2B, POU2AF1, LSM4, HYAL3, EXT2, CST9L, ETV5 (tumor) | SLC22A2, SUMO2, GTF2B, POU2AF1, LSM4, HYAL3, EXT2, CST9L, ETV5 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SLC22A2, SUMO2, GTF2B, POU2AF1, LSM4, HYAL3, EXT2, CST9L, ETV5 (tumor) | SLC22A2, SUMO2, GTF2B, POU2AF1, LSM4, HYAL3, EXT2, CST9L, ETV5 (normal) |
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| KICH (tumor) | KICH (normal) |
| SLC22A2, SUMO2, GTF2B, POU2AF1, LSM4, HYAL3, EXT2, CST9L, ETV5 (tumor) | SLC22A2, SUMO2, GTF2B, POU2AF1, LSM4, HYAL3, EXT2, CST9L, ETV5 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SLC22A2, SUMO2, GTF2B, POU2AF1, LSM4, HYAL3, EXT2, CST9L, ETV5 (tumor) | SLC22A2, SUMO2, GTF2B, POU2AF1, LSM4, HYAL3, EXT2, CST9L, ETV5 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SLC22A2, SUMO2, GTF2B, POU2AF1, LSM4, HYAL3, EXT2, CST9L, ETV5 (tumor) | SLC22A2, SUMO2, GTF2B, POU2AF1, LSM4, HYAL3, EXT2, CST9L, ETV5 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SLC22A2, SUMO2, GTF2B, POU2AF1, LSM4, HYAL3, EXT2, CST9L, ETV5 (tumor) | SLC22A2, SUMO2, GTF2B, POU2AF1, LSM4, HYAL3, EXT2, CST9L, ETV5 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| SLC22A2, SUMO2, GTF2B, POU2AF1, LSM4, HYAL3, EXT2, CST9L, ETV5 (tumor) | SLC22A2, SUMO2, GTF2B, POU2AF1, LSM4, HYAL3, EXT2, CST9L, ETV5 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| SLC22A2, SUMO2, GTF2B, POU2AF1, LSM4, HYAL3, EXT2, CST9L, ETV5 (tumor) | SLC22A2, SUMO2, GTF2B, POU2AF1, LSM4, HYAL3, EXT2, CST9L, ETV5 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| SLC22A2, SUMO2, GTF2B, POU2AF1, LSM4, HYAL3, EXT2, CST9L, ETV5 (tumor) | SLC22A2, SUMO2, GTF2B, POU2AF1, LSM4, HYAL3, EXT2, CST9L, ETV5 (normal) |
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| STAD (tumor) | STAD (normal) |
| SLC22A2, SUMO2, GTF2B, POU2AF1, LSM4, HYAL3, EXT2, CST9L, ETV5 (tumor) | SLC22A2, SUMO2, GTF2B, POU2AF1, LSM4, HYAL3, EXT2, CST9L, ETV5 (normal) |
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| THCA (tumor) | THCA (normal) |
| SLC22A2, SUMO2, GTF2B, POU2AF1, LSM4, HYAL3, EXT2, CST9L, ETV5 (tumor) | SLC22A2, SUMO2, GTF2B, POU2AF1, LSM4, HYAL3, EXT2, CST9L, ETV5 (normal) |
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| TissGeneProg for SLC22A2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SLC22A2 |
| TissGeneDrug for SLC22A2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SLC22A2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 4 | BeFree,GAD |
| umls:C0079731 | B-Cell Lymphomas | 4 | BeFree |
| umls:C1333064 | Classical Hodgkin's Lymphoma | 4 | BeFree |
| umls:C0022661 | Kidney Failure, Chronic | 3 | GAD,RGD |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 3 | BeFree |
| umls:C1565489 | Renal Insufficiency | 3 | BeFree,RGD |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 2 | BeFree |
| umls:C0019829 | Hodgkin Disease | 2 | BeFree |
| umls:C0020538 | Hypertensive disease | 2 | BeFree,GAD,LHGDN |
| umls:C0022658 | Kidney Diseases | 2 | CTD_human,GAD |
| umls:C0024299 | Lymphoma | 2 | BeFree |
| umls:C0026764 | Multiple Myeloma | 2 | BeFree |
| umls:C0035078 | Kidney Failure | 2 | BeFree |
| umls:C0740394 | Hyperuricemia | 2 | GAD,RGD |
| umls:C1292753 | Primary Effusion Lymphoma | 2 | BeFree |
| umls:C2609414 | Acute kidney injury | 2 | RGD |
| umls:C0005398 | Cholestasis, Extrahepatic | 1 | RGD |
| umls:C0008372 | Intrahepatic Cholestasis | 1 | RGD |
| umls:C0011849 | Diabetes Mellitus | 1 | GAD |
| umls:C0011853 | Diabetes Mellitus, Experimental | 1 | RGD |
| umls:C0011881 | Diabetic Nephropathy | 1 | BeFree |
| umls:C0023473 | Myeloid Leukemia, Chronic | 1 | BeFree |
| umls:C0028754 | Obesity | 1 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0031039 | Pericardial effusion | 1 | BeFree |
| umls:C0235598 | Hodgkin's-like | 1 | BeFree |
| umls:C0376618 | Endotoxemia | 1 | RGD |
| umls:C0428279 | Finding of creatinine level | 1 | GWASCAT |
| umls:C0595916 | Toxic nephropathy | 1 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C1261473 | Sarcoma | 1 | BeFree |
| umls:C1334968 | Nodular Lymphocyte Predominant Hodgkin Lymphoma | 1 | BeFree |
| umls:C1561535 | Creatinine finding | 1 | GAD |
| umls:C1561643 | Chronic Kidney Diseases | 1 | GWASCAT |
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