TissGeneSummary for STK33 |
Gene summary |
Basic gene information | Gene symbol | STK33 |
Gene name | serine/threonine kinase 33 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 11p15.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001289058.1, NM_001289059.1,NM_001289061.1,NM_030906.3, | |
Description | serine/threonine-protein kinase 33 | |
Modification date | 20141207 | |
dbXrefs | MIM : 607670 | |
HGNC : HGNC | ||
Ensembl : ENSG00000130413 | ||
HPRD : 09642 | ||
Vega : OTTHUMG00000140275 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_STK33 | |
BioGPS: 65975 | ||
Pathway | NCI Pathway Interaction Database: STK33 | |
KEGG: STK33 | ||
REACTOME: STK33 | ||
Pathway Commons: STK33 | ||
Context | iHOP: STK33 | |
ligand binding site mutation search in PubMed: STK33 | ||
UCL Cancer Institute: STK33 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of STK33 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for STK33 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | 0.605880565 | 1.809640909 | -1.203760345 | 1.53E-05 | 4.38E-05 |
PRAD | -0.662280443 | 0.847673403 | -1.509953846 | 1.30E-11 | 4.08E-10 |
COAD | -3.061695828 | -0.725195828 | -2.3365 | 3.88E-06 | 1.94E-05 |
LUSC | -0.854774033 | 1.698792634 | -2.553566667 | 3.77E-12 | 1.65E-11 |
KIRC | -1.476635144 | 1.916814856 | -3.39345 | 1.76E-17 | 1.10E-16 |
STAD | -1.003866741 | 0.308048884 | -1.311915625 | 0.00699 | 0.025561805 |
BLCA | -2.39209684 | -0.149359998 | -2.242736842 | 0.000543 | 0.004375478 |
HNSC | -3.393049227 | -1.706909692 | -1.686139535 | 0.000135 | 0.000584135 |
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TissGene-miRNA for STK33 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for STK33 |
TissGeneSNV for STK33 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D7H | BLCA | 2 |
p.E277K | SKCM | 2 |
p.P35S | SKCM | 2 |
p.E137K | SKCM | 2 |
p.E328K | BLCA | 2 |
p.K461T | PAAD | 1 |
p.W307* | THYM | 1 |
p.G123E | SKCM | 1 |
p.S211X | ESCA | 1 |
p.G432E | SKCM | 1 |
p.K416N | HNSC | 1 |
p.P14S | LUAD | 1 |
p.E199K | THYM | 1 |
p.D23Y | STAD | 1 |
p.G109V | LUSC | 1 |
p.S154I | BLCA | 1 |
p.G94C | HNSC | 1 |
p.W401* | SKCM | 1 |
p.M397I | READ | 1 |
p.P405S | SKCM | 1 |
p.A437T | COAD | 1 |
p.R162Q | SKCM | 1 |
p.Q44H | LGG | 1 |
p.S508F | CESC | 1 |
p.S47I | UCEC | 1 |
p.S388L | SKCM | 1 |
p.R59K | SKCM | 1 |
p.F323I | OV | 1 |
p.G94D | UCEC | 1 |
p.E329D | UCEC | 1 |
p.M398I | HNSC | 1 |
p.V490A | UCEC | 1 |
p.P435R | UVM | 1 |
p.T140M | OV | 1 |
p.P36S | SKCM | 1 |
p.G338* | UCEC | 1 |
p.E113D | ESCA | 1 |
p.V147X | COAD | 1 |
p.S470G | STAD | 1 |
p.V434I | LUAD | 1 |
p.G432R | UCEC | 1 |
p.Y189H | HNSC | 1 |
p.D7N | SKCM | 1 |
p.R336K | HNSC | 1 |
p.R59I | COAD | 1 |
p.D436E | COAD | 1 |
p.E374K | SKCM | 1 |
p.D74N | SKCM | 1 |
p.G483V | LUSC | 1 |
p.E107Q | CESC | 1 |
p.V408L | LUSC | 1 |
p.K385T | UCEC | 1 |
p.V263L | LAML | 1 |
p.S211* | ESCA | 1 |
p.S80* | UCEC | 1 |
p.S56L | SKCM | 1 |
p.V312I | UCEC | 1 |
p.D299N | CESC | 1 |
p.V294I | UCEC | 1 |
p.M485T | ESCA | 1 |
p.G99E | SKCM | 1 |
p.S326I | LGG | 1 |
p.M42L | UCEC | 1 |
p.A223T | STAD | 1 |
p.S420Y | SKCM | 1 |
p.K402E | SKCM | 1 |
p.S77* | HNSC | 1 |
p.R78I | UCEC | 1 |
p.S356I | COAD | 1 |
p.S349F | SARC | 1 |
p.Y289C | LIHC | 1 |
p.R78* | STAD | 1 |
p.S17P | STAD | 1 |
p.N66I | LUAD | 1 |
p.G94D | ESCA | 1 |
p.L194P | UCEC | 1 |
p.G99R | SKCM | 1 |
p.G483E | SKCM | 1 |
p.P102S | SKCM | 1 |
p.I115M | BLCA | 1 |
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TissGeneCNV for STK33 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for STK33 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-AR-A24K-01A | B3GALTL-STK33 | CDS-5UTR | Chr13:31789237 | Chr11:8496613 |
TCGAfusionPortal | PRADA | BRCA | TCGA-B6-A0X7-01A | ALX4-STK33 | In-frame | Chr11:44289044 | Chr11:8414257 |
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TissGeneNet for STK33 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for STK33 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for STK33 |
TissGeneDrug for STK33 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for STK33 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0028754 | Obesity | 2 | BeFree,GAD |
umls:C0004096 | Asthma | 1 | GAD |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | GAD |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0345958 | Large cell carcinoma of lung | 1 | BeFree |
umls:C0684249 | Carcinoma of lung | 1 | BeFree |