TissGeneSummary for SPAM1 |
Gene summary |
Basic gene information | Gene symbol | SPAM1 |
Gene name | sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) | |
Synonyms | HEL-S-96n|HYA1|HYAL1|HYAL3|HYAL5|PH-20|PH20|SPAG15 | |
Cytomap | UCSC genome browser: 7q31.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001174044.1, NM_001174045.1,NM_001174046.1,NM_003117.4,NM_153189.2, | |
Description | epididymis secretory sperm binding protein Li 96nhyal-PH20hyaluronidase PH-20hyaluronoglucosaminidase PH-20sperm surface protein PH-20 | |
Modification date | 20141207 | |
dbXrefs | MIM : 600930 | |
HGNC : HGNC | ||
Ensembl : ENSG00000106304 | ||
HPRD : 02958 | ||
Vega : OTTHUMG00000157284 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SPAM1 | |
BioGPS: 6677 | ||
Pathway | NCI Pathway Interaction Database: SPAM1 | |
KEGG: SPAM1 | ||
REACTOME: SPAM1 | ||
Pathway Commons: SPAM1 | ||
Context | iHOP: SPAM1 | |
ligand binding site mutation search in PubMed: SPAM1 | ||
UCL Cancer Institute: SPAM1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of SPAM1 | ||
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SPAM1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for SPAM1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SPAM1 |
TissGeneSNV for SPAM1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E58K | SKCM | 2 |
p.G207E | SKCM | 2 |
p.E66K | SKCM | 2 |
p.R346Q | GBM | 2 |
p.R346Q | SKCM | 2 |
p.P271S | SKCM | 2 |
p.L298H | LUSC | 1 |
p.A83T | OV | 1 |
p.E476* | UCEC | 1 |
p.G62E | SKCM | 1 |
p.A83T | HNSC | 1 |
p.S350Y | SKCM | 1 |
p.E359D | STAD | 1 |
p.E327K | COAD | 1 |
p.G87V | LIHC | 1 |
p.F308I | LUAD | 1 |
p.Q268* | BRCA | 1 |
p.I131V | OV | 1 |
p.Y229F | LGG | 1 |
p.E148K | SKCM | 1 |
p.R305C | SARC | 1 |
p.L210F | LIHC | 1 |
p.D247G | SKCM | 1 |
p.P222S | SKCM | 1 |
p.S18R | LUAD | 1 |
p.L50F | SKCM | 1 |
p.G19R | SKCM | 1 |
p.A294S | LUAD | 1 |
p.A274V | STAD | 1 |
p.P271L | LIHC | 1 |
p.H399Y | SKCM | 1 |
p.E66D | LUAD | 1 |
p.K117N | UCEC | 1 |
p.W216C | LUSC | 1 |
p.R305S | COAD | 1 |
p.V300A | STAD | 1 |
p.K165N | UCEC | 1 |
p.E58K | LUAD | 1 |
p.G326C | LUAD | 1 |
p.E191K | BRCA | 1 |
p.M135T | STAD | 1 |
p.G85R | STAD | 1 |
p.D103N | UCEC | 1 |
p.V24F | UCEC | 1 |
p.D293N | SKCM | 1 |
p.D198N | SKCM | 1 |
p.T185I | SKCM | 1 |
p.L400F | LUSC | 1 |
p.G207R | SKCM | 1 |
p.C458S | LUAD | 1 |
p.D293H | LUAD | 1 |
p.G412S | SKCM | 1 |
p.S180I | THYM | 1 |
p.W216X | SKCM | 1 |
p.S430F | OV | 1 |
p.S119F | SKCM | 1 |
p.D461N | LUAD | 1 |
p.P222L | KIRC | 1 |
p.P115L | SKCM | 1 |
p.P232L | SKCM | 1 |
p.Y229C | LUSC | 1 |
p.L34F | LUAD | 1 |
p.L489I | KIRC | 1 |
p.P212T | PRAD | 1 |
p.G233S | UCEC | 1 |
p.T341A | SKCM | 1 |
p.S78N | KIRC | 1 |
p.R305H | THYM | 1 |
p.G207E | SARC | 1 |
p.D69Y | READ | 1 |
p.D223Y | READ | 1 |
p.D456N | LIHC | 1 |
p.R211W | STAD | 1 |
p.E327* | UCEC | 1 |
p.E66D | STAD | 1 |
p.G236E | SKCM | 1 |
p.R211W | LUAD | 1 |
p.L252W | LUAD | 1 |
p.E66D | UCEC | 1 |
p.R283Q | PRAD | 1 |
p.I44F | LUSC | 1 |
p.K290E | OV | 1 |
p.V369I | LAML | 1 |
p.E476K | SKCM | 1 |
p.P45S | SKCM | 1 |
p.I145T | LUAD | 1 |
p.F6C | OV | 1 |
p.R305H | UCEC | 1 |
p.R279H | CESC | 1 |
p.D162Y | READ | 1 |
p.E327K | SKCM | 1 |
p.L423I | LUAD | 1 |
p.R281Q | GBM | 1 |
p.K205I | STAD | 1 |
p.E424D | UCEC | 1 |
p.E191* | BLCA | 1 |
p.R283W | SKCM | 1 |
p.E255* | UCEC | 1 |
p.V15I | GBM | 1 |
p.R245I | UCEC | 1 |
p.S18T | LUAD | 1 |
p.K126R | THYM | 1 |
p.E359K | SKCM | 1 |
p.Y303N | HNSC | 1 |
p.R346Q | KIRC | 1 |
p.G77E | SKCM | 1 |
p.K129I | SKCM | 1 |
p.R211W | SKCM | 1 |
p.I204V | LUAD | 1 |
p.K244R | LUAD | 1 |
p.D425Y | COAD | 1 |
p.P232T | LUAD | 1 |
p.T328I | SKCM | 1 |
p.E327K | READ | 1 |
p.G419E | SKCM | 1 |
p.N266I | SKCM | 1 |
p.P222L | ESCA | 1 |
p.P152T | LUAD | 1 |
p.P222Q | LUAD | 1 |
p.A447S | UCEC | 1 |
p.G77R | STAD | 1 |
p.W147* | LUAD | 1 |
p.Y397C | BLCA | 1 |
p.R305H | LGG | 1 |
p.R211W | KICH | 1 |
p.W216* | SKCM | 1 |
p.P115S | LUSC | 1 |
p.V506A | UCEC | 1 |
p.P100S | SKCM | 1 |
p.I465T | LUAD | 1 |
p.W51C | LUAD | 1 |
p.L501H | KIRP | 1 |
p.S74P | OV | 1 |
p.P271L | SKCM | 1 |
p.N401K | THCA | 1 |
p.L352F | LUAD | 1 |
p.P31S | SKCM | 1 |
p.R346Q | LGG | 1 |
p.H214Y | SKCM | 1 |
p.G85R | COAD | 1 |
p.S487F | SKCM | 1 |
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TissGeneCNV for SPAM1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SPAM1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SPAM1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SPAM1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SPAM1 |
TissGeneDrug for SPAM1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SPAM1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0005684 | Malignant neoplasm of urinary bladder | 5 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 5 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 5 | BeFree |
umls:C0699885 | Carcinoma of bladder | 5 | BeFree |
umls:C0678222 | Breast Carcinoma | 4 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 3 | BeFree |
umls:C0600139 | Prostate carcinoma | 3 | BeFree |
umls:C0149925 | Small cell carcinoma of lung | 2 | BeFree |
umls:C0005695 | Bladder Neoplasm | 1 | BeFree |
umls:C0007103 | Malignant neoplasm of endometrium | 1 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
umls:C0027533 | Neck Neoplasms | 1 | BeFree |
umls:C0029408 | Degenerative polyarthritis | 1 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
umls:C0036323 | Schistosomiasis | 1 | BeFree |
umls:C0086692 | Benign Neoplasm | 1 | BeFree |
umls:C0178874 | Tumor Progression | 1 | BeFree |
umls:C0476089 | Endometrial Carcinoma | 1 | BeFree |
umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
umls:C0919267 | ovarian neoplasm | 1 | BeFree |
umls:C0936223 | Metastatic Prostate Carcinoma | 1 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
umls:C1883486 | Uterine Corpus Cancer | 1 | BeFree |
umls:C2931852 | Clear-cell metastatic renal cell carcinoma | 1 | BeFree |