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| TissGeneSummary for SPINK2 |
 Gene summary |
| Basic gene information | Gene symbol | SPINK2 |
| Gene name | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) | |
| Synonyms | HUSI-II | |
| Cytomap | UCSC genome browser: 4q12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001271718.1, NM_001271719.1,NM_001271720.1,NM_001271721.1,NM_001271722.1, NM_021114.3,NR_073417.1,NR_073418.1,NR_073419.1, | |
| Description | epididymis tissue protein Li 172serine protease inhibitor Kazal-type 2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605753 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000128040 | ||
| HPRD : 10422 | ||
| Vega : OTTHUMG00000128769 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SPINK2 | |
| BioGPS: 6691 | ||
| Pathway | NCI Pathway Interaction Database: SPINK2 | |
| KEGG: SPINK2 | ||
| REACTOME: SPINK2 | ||
| Pathway Commons: SPINK2 | ||
| Context | iHOP: SPINK2 | |
| ligand binding site mutation search in PubMed: SPINK2 | ||
| UCL Cancer Institute: SPINK2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of SPINK2 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SPINK2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | -1.909285744 | 1.015364256 | -2.92465 | 3.05E-12 | 6.89E-11 |
| THCA | 0.950766342 | -0.936008234 | 1.886774576 | 6.17E-12 | 4.86E-11 |
| LUAD | -0.545953383 | -1.980662004 | 1.434708621 | 5.34E-06 | 1.61E-05 |
| STAD | -2.577080215 | -0.560836465 | -2.01624375 | 0.000161 | 0.001171809 |
| PRAD | -2.26466459 | 0.302541179 | -2.567205769 | 3.68E-05 | 0.000172891 |
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| TissGene-miRNA for SPINK2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SPINK2 |
| TissGeneSNV for SPINK2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P100A | KIRC | 1 |
| p.G43E | BLCA | 1 |
| p.S70C | HNSC | 1 |
| p.G93E | BLCA | 1 |
| p.T64N | READ | 1 |
| p.P83S | PAAD | 1 |
| p.V51L | BRCA | 1 |
| p.R80Q | READ | 1 |
| p.R80X | COAD | 1 |
| p.P133S | PAAD | 1 |
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| TissGeneCNV for SPINK2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SPINK2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | GBM | TCGA-27-1830-01A | PIGG-SPINK2 | Out-of-frame | Chr4:502759 | Chr4:57676350 |
| TCGAfusionPortal | PRADA | HNSC | TCGA-F7-7848-01A | TMPRSS11D-SPINK2 | Out-of-frame | Chr4:68749644 | Chr4:57677960 |
| TCGAfusionPortal | PRADA | LGG | TCGA-HT-7477-01B | SCFD2-SPINK2 | In-frame | Chr4:54011500 | Chr4:57686745 |
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| TissGeneNet for SPINK2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for SPINK2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SPINK2 |
| TissGeneDrug for SPINK2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SPINK2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0007570 | Celiac Disease | 1 | GAD |
| umls:C0023418 | leukemia | 1 | BeFree |
| umls:C0024299 | Lymphoma | 1 | BeFree |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
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