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| TissGeneSummary for SPP2 |
 Gene summary |
| Basic gene information | Gene symbol | SPP2 |
| Gene name | secreted phosphoprotein 2, 24kDa | |
| Synonyms | SPP-24|SPP24 | |
| Cytomap | UCSC genome browser: 2q37.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006944.2, | |
| Description | secreted phosphoprotein 2, 24kDsecreted phosphoprotein 24 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602637 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000072080 | ||
| HPRD : 04029 | ||
| Vega : OTTHUMG00000059208 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SPP2 | |
| BioGPS: 6694 | ||
| Pathway | NCI Pathway Interaction Database: SPP2 | |
| KEGG: SPP2 | ||
| REACTOME: SPP2 | ||
| Pathway Commons: SPP2 | ||
| Context | iHOP: SPP2 | |
| ligand binding site mutation search in PubMed: SPP2 | ||
| UCL Cancer Institute: SPP2 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of SPP2 | ||
| Description by TissGene annotations | Significant down-regulated DEG TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SPP2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | 0.768703229 | -0.873464013 | 1.642167241 | 5.20E-07 | 1.80E-06 |
| LIHC | 8.102026608 | 11.80690461 | -3.704878 | 1.12E-09 | 1.21E-08 |
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| TissGene-miRNA for SPP2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SPP2 |
| TissGeneSNV for SPP2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R133H | LGG | 2 |
| p.V127G | LUAD | 2 |
| p.H158D | LUSC | 1 |
| p.I150M | UCEC | 1 |
| p.T9M | BLCA | 1 |
| p.W25R | LUAD | 1 |
| p.A204S | UCEC | 1 |
| p.R62W | BLCA | 1 |
| p.L155F | LUAD | 1 |
| p.D36N | COAD | 1 |
| p.Q128H | LUAD | 1 |
| p.E172K | STAD | 1 |
| p.S57C | PAAD | 1 |
| p.E142* | LUSC | 1 |
| p.N78K | GBM | 1 |
| p.A43V | SARC | 1 |
| p.S38F | DLBC | 1 |
| p.M22I | BRCA | 1 |
| p.R117K | SKCM | 1 |
| p.R93K | GBM | 1 |
| p.A124T | UCEC | 1 |
| p.G152V | LUAD | 1 |
| p.R195K | HNSC | 1 |
| p.S67L | STAD | 1 |
| p.R181W | UCEC | 1 |
| p.S137T | HNSC | 1 |
| p.F178L | UCEC | 1 |
| p.S55P | READ | 1 |
| p.D209Y | LGG | 1 |
| p.V111M | COAD | 1 |
| p.G184W | CESC | 1 |
| p.R181Q | LUAD | 1 |
| p.W160* | SKCM | 1 |
| p.G156E | SKCM | 1 |
| p.M149I | SKCM | 1 |
| p.M11I | SKCM | 1 |
| p.V73F | LUAD | 1 |
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| TissGeneCNV for SPP2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SPP2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AF130098 | SPP2-HBG1 | chr2:234971785 | chr11:5269503 |
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| TissGeneNet for SPP2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for SPP2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SPP2 |
| TissGeneDrug for SPP2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SPP2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0029456 | Osteoporosis | 1 | GAD |
| umls:C0033860 | Psoriasis | 1 | BeFree |
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