![]() |
TissGeneSummary for SPP2 |
![]() |
Basic gene information | Gene symbol | SPP2 |
Gene name | secreted phosphoprotein 2, 24kDa | |
Synonyms | SPP-24|SPP24 | |
Cytomap | UCSC genome browser: 2q37.1 | |
Type of gene | protein-coding | |
RefGenes | NM_006944.2, | |
Description | secreted phosphoprotein 2, 24kDsecreted phosphoprotein 24 | |
Modification date | 20141207 | |
dbXrefs | MIM : 602637 | |
HGNC : HGNC | ||
Ensembl : ENSG00000072080 | ||
HPRD : 04029 | ||
Vega : OTTHUMG00000059208 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SPP2 | |
BioGPS: 6694 | ||
Pathway | NCI Pathway Interaction Database: SPP2 | |
KEGG: SPP2 | ||
REACTOME: SPP2 | ||
Pathway Commons: SPP2 | ||
Context | iHOP: SPP2 | |
ligand binding site mutation search in PubMed: SPP2 | ||
UCL Cancer Institute: SPP2 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of SPP2 | ||
Description by TissGene annotations | Significant down-regulated DEG TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
![]() |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for SPP2 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
![]() |
![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
![]() |
![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
![]() |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | 0.768703229 | -0.873464013 | 1.642167241 | 5.20E-07 | 1.80E-06 |
LIHC | 8.102026608 | 11.80690461 | -3.704878 | 1.12E-09 | 1.21E-08 |
Top |
TissGene-miRNA for SPP2 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for SPP2 |
TissGeneSNV for SPP2 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
![]() |
![]() |
![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
![]() |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R133H | LGG | 2 |
p.V127G | LUAD | 2 |
p.H158D | LUSC | 1 |
p.I150M | UCEC | 1 |
p.T9M | BLCA | 1 |
p.W25R | LUAD | 1 |
p.A204S | UCEC | 1 |
p.R62W | BLCA | 1 |
p.L155F | LUAD | 1 |
p.D36N | COAD | 1 |
p.Q128H | LUAD | 1 |
p.E172K | STAD | 1 |
p.S57C | PAAD | 1 |
p.E142* | LUSC | 1 |
p.N78K | GBM | 1 |
p.A43V | SARC | 1 |
p.S38F | DLBC | 1 |
p.M22I | BRCA | 1 |
p.R117K | SKCM | 1 |
p.R93K | GBM | 1 |
p.A124T | UCEC | 1 |
p.G152V | LUAD | 1 |
p.R195K | HNSC | 1 |
p.S67L | STAD | 1 |
p.R181W | UCEC | 1 |
p.S137T | HNSC | 1 |
p.F178L | UCEC | 1 |
p.S55P | READ | 1 |
p.D209Y | LGG | 1 |
p.V111M | COAD | 1 |
p.G184W | CESC | 1 |
p.R181Q | LUAD | 1 |
p.W160* | SKCM | 1 |
p.G156E | SKCM | 1 |
p.M149I | SKCM | 1 |
p.M11I | SKCM | 1 |
p.V73F | LUAD | 1 |
Top |
TissGeneCNV for SPP2 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
![]() |
Top |
TissGeneFusions for SPP2 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AF130098 | SPP2-HBG1 | chr2:234971785 | chr11:5269503 |
Top |
TissGeneNet for SPP2 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for SPP2 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
![]() |
Top |
TissGeneClin for SPP2 |
TissGeneDrug for SPP2 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for SPP2 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0029456 | Osteoporosis | 1 | GAD |
umls:C0033860 | Psoriasis | 1 | BeFree |